Associate Professor Matt Doogue, Our people, Carney Centre for Pharmacogenomics, University of Otago, New Zealand

Clinical Pharmacologist | Endocrinologist

BSc MB ChB DipPaed FRACP

Matt Doogue is a consultant physician at Christchurch Hospital in Clinical Pharmacology and General Medicine. He is a member of the Department of Medicine, University of Otago, Christchurch and convenes clinical pharmacology teaching.

His interests include adverse drug reactions, pharmacogenetics, applied pharmacokinetics and clinical decision support.

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Publications

Wang, M., Barclay, M. L., Chin, P. K. L., & Doogue, M. P. (2022). Changes in inpatient medicine prescribing during Covid-19 lockdown. Internal Medicine Journal. Advance online publication. doi: 10.1111/imj.15996

Seah, D. S. E., Wilcock, A., Chang, S., Sousa, M. S., Sinnarajah, A., Teoh, C. O., … Doogue, M., … Currow, D. C. (2022). Paracentesis for cancer-related ascites in palliative care: An international, prospective cohort study. Palliative Medicine. Advance online publication. doi: 10.1177/02692163221122326

Pairman, L., Chin, P., Gardiner, S., & Doogue, M. (2022, August-September). The effect of mandatory prescription indications for antibacterials. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

Liau, Y., Maggo, S., Lehnert, K., Doogue, M. P., Scull, A., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2022, August-September). Genomic analysis of angiotensin converting enzyme inhibitor-induced angioedema. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

Hussein, A., Digges, M., Chang, S., Hunt, J., Doogue, M., Rowett, D., … Currow, D. C. (2022). Pharmacovigilance in hospice/palliative care: Net effect of amitriptyline or nortriptyline on neuropathic pain: UTS/IMPACCT Rapid programme international consecutive cohort. Palliative Medicine. Advance online publication. doi: 10.1177/02692163221085855

Beard, M. E. J., Thwaites, J. H., Chambers, S. T., Colls, B. M., Doogue, M., Jeffery, M., … Pithie, A., … Sainsbury, R. (2005). Management guidelines for common medical conditions (11th ed.). Christchurch, NZ: Canterbury District Health Board, 271p.

Authored Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

Edited Book - Other

Journal - Research Article

Livirya, S., Pithie, A., Chua, I., Hamilton, N., Doogue, M., & Isenman, H. (2022). Oral amoxicillin challenge for low risk penicillin allergic patients. Internal Medicine Journal, 52, 295-300. doi: 10.1111/imj.14978

Journal - Research Article

Palmer, D., Soule, S., Gaddam, R. R., Elder, P., Chambers, S., & Doogue, M. (2022). Unbound vitamin D concentrations are not decreased in critically ill patients. Internal Medicine Journal, 52, 89-94. doi: 10.1111/imj.15096

Journal - Research Article

Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1

Journal - Research Article

McNeill, R. P., Zhang, M., Epton, M. J., & Doogue, M. P. (2021). Drub metabolism in severe chronic obstructive pulmonary disease: A phenotyping cocktail study. British Journal of Clinical Pharmacology, 87, 4397-4407. doi: 10.1111/bcp.14862

Journal - Research Article

Chin, P. K. L., Chuah, Q., Crawford, A. M., Clendon, O. R., Drennan, P. G., Dalrymple, J. M., Barclay, M. L., & Doogue, M. P. (2020). Clinical decision support in a hospital electronic prescribing system informed by local data: Experience at a tertiary New Zealand centre. Internal Medicine Journal, 50, 1225-1232. doi: 10.1111/imj.14706

Journal - Research Article

Chin, P. K. L., McNeill, R., Lee, H. K., Zhang, M., Jensen, B., Smith, M., & Doogue, M. P. (2020). Routine therapeutic drug monitoring of dabigatran: Experience at a tertiary center. Therapeutic Drug Monitoring, 42(3), 468-472. doi: 10.1097/ftd.0000000000000713

Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Werno, A., Doogue, M. P., Chambers, S. T., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). A persuasive approach to antimicrobial stewardship in Christchurch hospitals produced a sustained decrease in intravenous clarithromycin dosing and expenditure via a switch to azithromycin orally. New Zealand Medical Journal, 133(1512), 22-30. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

O'Grady, M., Clarke, L., Turner, G., Doogue, M., Purcell, R., Pearson, J., & Frizelle, F. (2020). Statin use and risk of acute diverticulitis: A population-based case-control study. Medicine, 99(20), e20264. doi: 10.1097/md.0000000000020264

Journal - Research Article

Currow, D. C., Ekström, M., Louw, S., Hill, J., Fazekas, B., Clark, K., … Doogue, M., … Agar, M. (2019). Sertraline in symptomatic chronic breathlessness: A double blind, randomised trial. European Respiratory Journal, 53, 1801270. doi: 10.1183/13993003.01270-2018

Journal - Research Article

Leggett, C., Giles, L., Anderson, J. J. A., Doogue, M., Couper, J., & Pena, A. S. (2019). Adherence to metformin is reduced during school holidays and weekends in children with type 1 diabetes participating in a randomised controlled trial. Archives of Disease in Childhood, 104, 890-894. doi: 10.1136/archdischild-2018-316303

Journal - Research Article

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Wright, D. F. B., Doogue, M. P., Barclay, M. L., Chapman, P. T., Cross, N. B., Irvine, J. H., & Stamp, L. K. (2017). A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis. European Journal of Clinical Pharmacology, 73, 71-78. doi: 10.1007/s00228-016-2133-y

Journal - Research Article

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Journal - Research Article

Khong, J. J., Burdon, K. P., Lu, Y., Laurie, K., Leonardos, L., Baird, P. N., … Doogue, M., … Craig, J. E. (2016). Pooled genome wide association detects association upstream of FCRL3 with Graves' disease. BMC Genomics, 17(1), 939. doi: 10.1186/s12864-016-3276-z

Journal - Research Article

Lewis, B. C., Nair, P. C., Heran, S. S., Somogyi, A. A., Bowden, J. J., Doogue, M. P., & Miners, J. O. (2016). Warfarin resistance associated with genetic polymorphism of VKORC1: Linking clinical response to molecular mechamism using computational modeling. Pharmacogenetics & Genomics, 26(1), 44-50. doi: 10.1097/FPC.0000000000000184

Journal - Research Article

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2016). Pharmacovigilance in hospice/palliative care: Net effect of pregabalin for neuropathic pain. BMJ Supportive & Palliative Care, 6(3), 323-330. doi: 10.1136/bmjspcare-2014-000825

Journal - Research Article

Chinnaratha, M. A., Chaudhary, S., Doogue, M., McCormick, R. J., Woodman, R. J., & Wigg, A. J. (2015). Prevalence of hepatic osteodystrophy and vitamin D deficiency in cirrhosis. Internal Medicine Journal, 45(12), 1230-1235. doi: 10.1111/imj.12866

Journal - Research Article

Dobinson, H. C., Anderson, T. P., Chambers, S. T., Doogue, M. P., Seaward, L., & Werno, A. M. (2015). Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. Journal of Clinical Microbiology, 53(9), 2895-2899. doi: 10.1128/jcm.00760-15

Journal - Research Article

Roberts, G. W., Quinn, S. J., Valentine, N., Alhawassi, T., O'Dea, H., Stranks, S. N., … Doogue, M. P. (2015). Relative hyperglycemia, a marker of critical illness: Introducing the Stress Hyperglycemia Ratio. Journal of Clinical Endocrinology & Metabolism, 100(12), 4490-4497. doi: 10.1210/jc.2015-2660

Journal - Research Article

Sanderson, C., Quinn, S. J., Agar, M., Chye, R., Clark, K., Doogue, M., … Currow, D. C. (2015). Pharmacovigilance in hospice/palliative care: Net effect of gabapentin for neuropathic pain. BMJ Supportive & Palliative Care, 5, 273-280. doi: 10.1136/bmjspcare-2014-000699

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Journal - Research Article

Radhakutty, A., Shen, J., Hooper, A. J., Miller, S. A., Burnett, J. R., Mah, P. M., … Doogue, M. P. (2014). Quantification and genotyping of lipoprotein lipase in patients with diabetic lipaemia. Diabetic Medicine, 31(12), 1702-1707. doi: 10.1111/dme.12565

Journal - Research Article

Snyder, B. D., Rowland, A., Polasek, T. M., Miners, J. O., & Doogue, M. P. (2014). Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions. European Journal of Clinical Pharmacology, 70(9), 1115-1122. doi: 10.1007/s00228-014-1716-8

Journal - Research Article

Burt, M. G., Mangelsdorf, B. L., Rogers, A., Ho, J. T., Lewis, J. G., Inder, W. J., & Doogue, M. P. (2013). Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH_1-24 stimulation in the assessment of pituitary patients. Journal of Clinical Endocrinology & Metabolism, 98(5), 1883-1890. doi: 10.1210/jc.2012-3576

Journal - Research Article

Crawford, G. B., Agar, M., Quinn, S. J., Phillips, J., Lister, C., Michael, N., Doogue, M., … Currow, D. C. (2013). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for delirium. Journal of Palliative Medicine, 16(11), 1335-1341. doi: 10.1089/jpm.2013.0230

Journal - Research Article

Kennedy, N. A., Asser, T. L., Mountifield, R. E., Doogue, M. P., Andrews, J. M., & Bampton, P. A. (2013). Thiopurine metabolite measurement leads to changes in management of inflammatory bowel disease. Internal Medicine Journal, 43(3), 278-286. doi: 10.1111/j.1445-5994.2012.02936.x

Journal - Research Article

Polasek, T. M., Patel, F., Jensen, B. P., Sorich, M. J., Wiese, M. D., & Doogue, M. P. (2013). Predicted metabolic drug clearance with increasing adult age. British Journal of Clinical Pharmacology, 75(4), 1019-1028. doi: 10.1111/j.1365-2125.2012.04446.x

Journal - Research Article

To, T. H. M., Agar, M., Shelby-James, T., Abernethy, A. P., Doogue, M., Rowett, D., … Currow, D. C. (2013). Off-label prescribing in palliative care: A cross-sectional national survey of palliative medicine doctors. Palliative Medicine, 27(4), 320-328. doi: 10.1177/0269216312464263

Journal - Research Article

Currow, D. C., Vella-Brincat, J., Fazekas, B., Clark, K., Doogue, M., & Rowett, D. (2012). Pharmacovigilance in hospice/palliative care: Rapid report of net clinical effect of metoclopramide. Journal of Palliative Medicine, 15(10), 1071-1075. doi: 10.1089/jpm.2012.0111

Journal - Research Article

Joseph, S. P., Ho, J. T., Doogue, M. P., & Burt, M. G. (2012). Perioperative management of the hypothalamic-pituitary-adrenal axis in patients with pituitary adenomas: An Australasian survey. Internal Medicine Journal, 42(10), 1120-1124. doi: 10.1111/j.1445-5994.2011.02582.x

Journal - Research Article

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x

Journal - Research Article

Schouten, B. J., Doogue, M. P., Soule, S. G., & Hunt, P. J. (2009). Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Annals of Clinical Biochemistry, 46(2), 167-169. doi: 10.1258/acb.2008.008151

Journal - Research Article

Gardiner, S. J., Doogue, M. P., Zhang, M., & Begg, E. J. (2006). Quantification of infant exposure to celecoxib through breast milk. British Journal of Clinical Pharmacology, 61(1), 101-104. doi: 10.1111/j.1365-2125.2005.02520.x

Journal - Research Article

Lewis, J. G., möpert, B., Shand, B. I., Doogue, M. P., Soule, S. G., Frampton, C. M., & Elder, P. A. (2006). Plasma variation of corticosteroid-binding globulin and sex hormone-binding globulin. Hormone & Metabolic Research, 38, 241-245.

Journal - Research Article

Jackson, N. W., Doogue, M. P., & Elliott, J. M. (1999). Priority points and cardiac events while waiting for coronary bypass surgery. Heart, 81(4), 367-373. doi: 10.1136/hrt.81.4.367

Journal - Research Article

Doogue, M. P., Choong, C. K., & Frizelle, F. A. (1998). Recurrent gallstone ileus. Australian & New Zealand Journal of Surgery, 68, 755-757.

Journal - Research Article

Doogue, M. P., Brett, C. N. H., & Elliott, J. M. (1997). Life and death on the waiting list for coronary bypass surgery. New Zealand Medical Journal, 110(1037).

Journal - Research Article

Mortensen, J. S., Jensen, B. P., & Doogue, M. (2022). Pre-analytical stability of flucloxacillin, piperacillin, tazobactam, meropenem, cefalexin, cefazolin, and ceftazidime in therapeutic drug monitoring: A structured review. Therapeutic Drug Monitoring, 44(6), 709-719. doi: 10.1097/ftd.0000000000000975

Journal - Research Other

Walter, T., Connor, S., Stedman, C., & Doogue, M. (2022). A case of acute necrotising pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine. British Journal of Clinical Pharmacology, 88, 1385-1386. doi: 10.1111/bcp.15039

Journal - Research Other

Wilkinson, T., Soule, S., & Doogue, M. (2021). Syndrome of inappropriate anti-diuretic hormone secondary to transient global amnesia. Internal Medicine Journal, 51(7), 1186-1187. doi: 10.1111/imj.15410

Journal - Research Other

Falconer, N., Spinewine, A., Doogue, M. P., & Barras, M. (2020). Identifying medication harm in hospitalised patients: A bimodal, targeted approach. Therapeutic Advances in Drug Safety, 11, 1-5. doi: 10.1177/2042098620975516

Journal - Research Other

Hunt, J., Brown, L., Fazekas, B., Doogue, M., Rowett, D., Luckett, T., … Currow, D. C. (2020). Evaluation of the IMPACCT Rapid Program: A cross-sectional survey of international site investigators. Journal of Palliative Care, 23(10), 1292-1293. doi: 10.1089/jpm.2020.0239

Journal - Research Other

Sinnappah, K. A., Kuan, I. H. S., Thynne, T. R. J., Doogue, M. P., & Wright, D. F. B. (2020). The pharmacokinetics of metformin in patients receiving intermittent haemodialysis [Short report]. British Journal of Clinical Pharmacology, 86, 1430-1443. doi: 10.1111/bcp.14244

Journal - Research Other

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