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Pharmacy staff profile

Associate Professor Shyamal Das

PositionAssociate Professor
QualificationsMPharm PhD
Research summaryDrug formulation and delivery, drug delivery to the lung
Teaching

Teaching:

  • PHCY211: Fundamental Pharmaceutical Sciences
  • PHCY220: Integrated modules A
  • PHCY310: Integrated modules B
  • PHCY430: Elective Projects B
  • PHCY480: Honours Research Project
  • PHCY485: Applied Pharmacotherapy and Patient Care for Honours
  • Inter Professional education

Co-ordination:

  • Programme Co-ordinator for BPharm(Hons) programme
  • PHCY480: Honours Research Project (Course Co-ordinator)
  • PHCY485: Applied Pharmacotherapy and Patient Care for Honours (Course Co-ordinator)
Memberships
  • Editorial Board: International Journal of Pharmaceutics (Q1, 13th/169 journals in pharmaceutical science, Citescore: 7.6 (Scopus 2019) (2018-Present)
  • Guest editor, International Journal of Pharmaceutics special issue on ‘The respiratory delivery of high dose powders’ (2018)
  • Scientific Advisory Committee member, Drug Delivery to the Lung Conference (2015- Present)
  • The Aerosol Society (2013 to present)
  • Australasian Pharmaceutical Science Association (APSA) (2006 to present)
  • Otago Medical School Research Society: Treasurer (2019 to present), Executive Committee Member (2018)
  • New Zealand Chapter of the Controlled Release Society (2013 to present): Treasurer (May 2019 to present), Executive Committee Member (Oct 2017 to Apr 2019)
  • Otago Global Health Institute: Profiled Network Member (2016 to present)

Research

The research interests of Associate Professor Das revolve around drug delivery, in particular, respiratory drug delivery of powder formulations for treating chronic lung conditions such as COPD, asthma, tuberculosis, lung cancer and lung infections.

His aim is to achieve a fundamental knowledge base on solid state characterisation processes to understand various pharmaceutical processes such as milling, mixing, spray drying, amorphisation, micronisation, crystallisation, relaxation, dissolution, coating and storage. These knowledge and innovating approaches can be used to develop various conventional and controlled release solid dosage forms such as powders for respiratory delivery as well as tablets and capsules for oral delivery.

Associate Professor Das has extensive research networks with collaborators in New Zealand, Australia, Europe, Asia, the United Kingdom and the USA.
For more visit Das laboratory

PhD projects available

Please contact me if you are interested in conducting PhD research in the following areas:

  • Interactions and influence of lung surfactant on dissolution in the lung
  • Solid surface characteristics that influence powder delivery to the lung

Biography

Associate Professor Shyamal Das lectures in Pharmaceutical Science at the School of Pharmacy, University of Otago. He is an internationally recognised formulation expert with over 15 years of experience in dry powder inhaler technology.

Associate Professor Das supervises a large productive research group which focuses on drug delivery to the lung to improve therapy for chronic lung conditions such as asthma, chronic obstructive pulmonary disease, cystic fibrosis and tuberculosis. He is currently contributing to the development of inhalers to treat coronaviruses in collaboration with academia and industries.

Associate Professor Das completed his PhD and research fellowships at Monash Institute of Pharmaceutical Sciences. He was a visiting researcher at the University College London (UK), Imperial College London (UK) and the University of Texas at Austin (USA).

Associate Professor Das is also an award-winning passionate lecturer. He has won multiple awards for best teaching and supervision at the University of Otago.

Additional details

Previous positions

  • Research Fellow, Monash Institute of Pharmaceutical Sciences, Monash University, Australia (2008–2013)
  • Teaching Assistant, Department of Pharmaceutics and Department of Pharmacy Practice, Monash University, Australia (2005–2008)
  • Assistant Professor, Department of Pharmacy, Jahangirnagar University, Bangladesh (2003–2004)
  • Lecturer, Department of Pharmacy, Jahangirnagar University, Bangladesh (2000–2003)

Teaching and research awards

  • Winner of the Otago University Students’ Association’s 2017 Teaching Excellence Award: Premier Lecturer Award 2017 Division of Health Sciences
  • Winner of the Otago University Students’ Association’s Supervisor of the Year Award 2017 Division of Health Sciences
  • Winner of the School of Pharmacy’s Excellence in Teaching Award 2016
  • Winner of the Otago University Students’ Association’s 2016 Teaching Excellence Award (Top Five Teacher)
  • Winner of the Otago School of Pharmacy’s Emerging Researcher Award 2016
  • Finalist (top five) for the Australasian Pharmaceutical Scientists Association’s 2016 Early Career Investigator Award
  • Health Research Council of New Zealand’s Emerging Researcher First Grant 2015

School of Pharmacy administrative roles

  • Chair, BPharm(Hons) Committee (since 2014)
  • Co-Chair, School of Pharmacy Research Committee (since 2020) and Member since February 2017)
  • Member, Research and Postgraduate Committee (since March 2019)
  • Member, School of Pharmacy Undergraduate Programmes Committee
  • Member, School of Pharmacy BPharm/BPharm(Hons) Curriculum Committee (since November 2017)
  • Self-Review Coordinator of BPharm(Hons) Programme (2018)
  • Member, School of Pharmacy Admission Working Party (June 2016 to June 2018)

Publications

Momin, M. A. M., Adhikari, B. R., Sinha, S., Larson, I., & Das, S. C. (2021). Roflumilast powders for chronic obstructive pulmonary disease: Formulation design and the influence of device, inhalation flow rate, and storage relative humidity on aerosolization. Pharmaceutics, 13, 1254. doi: 10.3390/pharmaceutics13081254

Ameratunga, R., Woon, S.-T., Steele, R., Snell, R., Medlicott, N., Mears, E., … Das, S., … Quiñones‑Mateu, M. E. (2021). The nose and the stomach play a critical role in the NZACE2-Pātari* (modified ACE2) drug treatment project of SARS-CoV-2 infection. Expert Review of Clinical Immunology. Advance online publication. doi: 10.1080/1744666x.2021.1912596

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats. European Journal of Pharmaceutics & Biopharmaceutics. Advance online publication. doi: 10.1016/j.ejpb.2021.02.011

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model. International Journal of Pharmaceutics, 597, 120345. doi: 10.1016/j.ijpharm.2021.120345

Bastola, R., Young, P. M., & Das, S. C. (2021). Simulation of respiratory tract lining fluid for in vitro dissolution study. Expert Opinion on Drug Delivery. Advance online publication. doi: 10.1080/17425247.2021.1882991

Das, S. C., Khadka, P., Shah, R., McGill, S., & Smyth, H. D. C. (2021). Nanomedicine in pulmonary delivery. In P. Kesharwani, S. Taurin & K. Greish (Eds.), Theory and applications of nonparenteral nanomedicines. (pp. 319-354). London, UK: Elsevier. doi: 10.1016/B978-0-12-820466-5.00014-4

Chapter in Book - Research

Hadjittofis, E., Das, S. C., Zhang, G. G. Z., & Heng, J. Y. Y. (2017). Interfacial phenomena. In Y. Qiu, Y. Chen, G. G. Z. Zhang, L. Yu & R. V. Mantri (Eds.), Developing solid oral dosage forms: Pharmaceutical theory & practice. (2nd ed.) (pp. 225-252). London, UK: Academic Press. doi: 10.1016/B978-0-12-802447-8.00008-X

Chapter in Book - Research

Das, S. C., & Stewart, P. J. (2016). Understanding the respiratory delivery of high dose anti-tubercular drugs. In A. J. Hickey, A. Misra & P. B. Fourie (Eds.), Drug delivery systems for tuberculosis prevention and treatment. (pp. 258-274). Chichester, UK: Wiley. doi: 10.1002/9781118943182.ch13

Chapter in Book - Research

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats. European Journal of Pharmaceutics & Biopharmaceutics. Advance online publication. doi: 10.1016/j.ejpb.2021.02.011

Journal - Research Article

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model. International Journal of Pharmaceutics, 597, 120345. doi: 10.1016/j.ijpharm.2021.120345

Journal - Research Article

Momin, M. A. M., Adhikari, B. R., Sinha, S., Larson, I., & Das, S. C. (2021). Roflumilast powders for chronic obstructive pulmonary disease: Formulation design and the influence of device, inhalation flow rate, and storage relative humidity on aerosolization. Pharmaceutics, 13, 1254. doi: 10.3390/pharmaceutics13081254

Journal - Research Article

Adhikari, B. R., Bērziņš, K., Fraser-Miller, S. J., Gordon, K. C., & Das, S. C. (2020). Co-amorphization of kanamycin with amino acids improves aerosolization. Pharmaceutics, 12(8), 715. doi: 10.3390/pharmaceutics12080715

Journal - Research Article

Khadka, P., Hill, P. C., Zhang, B., Katare, R., Dummer, J., & Das, S. C. (2020). A study on polymorphic forms of rifampicin for inhaled high dose delivery in tuberculosis treatment. International Journal of Pharmaceutics, 587, 119602. doi: 10.1016/j.ijpharm.2020.119602

Journal - Research Article

Eedara, B. B., Tucker, I. G., & Das, S. C. (2019). In vitro dissolution testing of respirable size anti-tubercular drug particles using a small volume dissolution apparatus. International Journal of Pharmaceutics, 559, 235-244. doi: 10.1016/j.ijpharm.2019.01.035

Journal - Research Article

Eedara, B. B., Tucker, I. G., & Das, S. C. (2019). A STELLA simulation model for in vitro dissolution testing of respirable size particles. Scientific Reports, 9(1), 18522. doi: 10.1038/s41598-019-55164-0

Journal - Research Article

Eedara, B. B., Tucker, I. G., Zujovic, Z. D., Rades, T., Price, J. R., & Das, S. C. (2019). Crystalline adduct of moxifloxacin with trans-cinnamic acid to reduce the aqueous solubility and dissolution rate for improved residence time in the lungs. European Journal of Pharmaceutical Sciences, 136, 104961. doi: 10.1016/j.ejps.2019.104961

Journal - Research Article

Momin, M. A. M., Rangnekar, B., Larson, I., Sinha, S., & Das, S. C. (2019). Dry powder formulation combining bedaquiline with pyrazinamide for latent and drug-resistant tuberculosis. Advanced Powder Technology, 30(11), 2473-2482. doi: 10.1016/j.apt.2019.07.016

Journal - Research Article

Momin, M. A. M., Rangnekar, B., Sinha, S., Cheung, C.-Y., Cook, G. M., & Das, S. C. (2019). Inhalable dry powder of Bedaquiline for pulmonary tuberculosis: In vitro physiochemical characterization, antimicrobial activity and safety studies. Pharmaceutics, 11(10), 502. doi: 10.3390/pharmaceutics11100502

Journal - Research Article

Momin, M. A. M., Sinha, S., Tucker, I. G., & Das, S. C. (2019). Carrier-free combination dry powder inhaler formulation of ethionamide and moxifloxacin for treating drug-resistant tuberculosis. Drug Development & Industrial Pharmacy, 45(8), 1321-1331. doi: 10.1080/03639045.2019.1609494

Journal - Research Article

Momin, M. A. M., Tucker, I. G., & Das, S. C. (2019). The influence of storage relative humidity on aerosolization of co-spray dried powders of hygroscopic kanamycin with the hydrophobic drug rifampicin. Drug Development & Industrial Pharmacy, 45(7), 1205-1213. doi: 10.1080/03639045.2019.1607869

Journal - Research Article

Rangnekar, B., Momin, M. A. M., Eedara, B. B., Sinha, S., & Das, S. C. (2019). Bedaquiline containing triple combination powder for inhalation to treat drug-resistant tuberculosis. International Journal of Pharmaceutics, 570, 118689. doi: 10.1016/j.ijpharm.2019.118689

Journal - Research Article

Eedara, B. B., Rangnekar, B., Doyle, C., Cavallaro, A., & Das, S. C. (2018). The influence of surface active L-leucine and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) in the improvement of aerosolization of pyrazinamide and moxifloxacin co-spray dried powders. International Journal of Pharmaceutics, 542(1-2), 72-81. doi: 10.1016/j.ijpharm.2018.03.005

Journal - Research Article

Khadka, P., Dummer, J., Hill, P. C., & Das, S. C. (2018). Considerations in preparing for clinical studies of inhaled rifampicin to enhance tuberculosis treatment. International Journal of Pharmaceutics, 548(1), 244-254. doi: 10.1016/j.ijpharm.2018.07.011

Journal - Research Article

Momin, M. A. M., Rangnekar, B., & Das, S. C. (2018). Development and validation of a RP-HPLC method for simultaneous quantification of bedaquiline (TMC207), moxifloxacin and pyrazinamide in a pharmaceutical powder formulation for inhalation. Journal of Liquid Chromatography & Related Technologies, 41(8), 415-421. doi: 10.1080/10826076.2018.1437748

Journal - Research Article

Momin, M. A. M., Tucker, I. G., & Das, S. C. (2018). High dose dry powder inhalers to overcome the challenges of tuberculosis treatment. International Journal of Pharmaceutics, 550(1-2), 398-417. doi: 10.1016/j.ijpharm.2018.08.061

Journal - Research Article

Momin, M. A. M., Tucker, I. G., Doyle, C. S., Denman, J. A., & Das, S. C. (2018). Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug. International Journal of Pharmaceutics, 543, 318-327. doi: 10.1016/j.ijpharm.2018.04.003

Journal - Research Article

Momin, M. A. M., Tucker, I. G., Doyle, C. S., Denman, J. A., Sinha, S., & Das, S. C. (2018). Co-spray drying of hygroscopic kanamycin with the hydrophobic drug rifampicin to improve the aerosolization of kanamycin powder for treating respiratory infections. International Journal of Pharmaceutics, 541(1-2), 26-36. doi: 10.1016/j.ijpharm.2018.02.026

Journal - Research Article

Momin, M. A. M., Sinha, S., Tucker, I. G., Doyle, C., & Das, S. C. (2017). Dry powder formulation of kanamycin with enhanced aerosolization efficiency for drug-resistant tuberculosis. International Journal of Pharmaceutics, 528(1-2), 107-117. doi: 10.1016/j.ijpharm.2017.06.004

Journal - Research Article

Momin, M. A. M., Thien, S. J., Krittaphol, W., & Das, S. C. (2017). Simultaneous HPLC assay for pretomanid (PA-824), moxifloxacin and pyrazinamide in an inhaler formulation for drug-resistant tuberculosis. Journal of Pharmaceutical & Biomedical Analysis, 135, 133-139. doi: 10.1016/j.jpba.2016.11.046

Journal - Research Article

Das, S. C., & Stewart, P. J. (2016). The influence of lung surfactant liquid crystalline nanostructures on respiratory drug delivery. International Journal of Pharmaceutics, 514(2), 465-474. doi: 10.1016/j.ijpharm.2016.06.029

Journal - Research Article

Eedara, B. B., Tucker, I. G., & Das, S. C. (2016). Phospholipid-based pyrazinamide spray-dried inhalable powders for treating tuberculosis. International Journal of Pharmaceutics, 506(1-2), 174-183. doi: 10.1016/j.ijpharm.2016.04.038

Journal - Research Article

Das, S. C., Tucker, I. G., & Stewart, P. J. (2015). Surface energy determined by inverse gas chromatography as a tool to investigate particulate interactions in dry powder inhalers. Current Pharmaceutical Design, 21(27), 3932-3944. Retrieved from http://europepmc.org/abstract/MED/26290201

Journal - Research Article

Das, S., Tucker, I., & Stewart, P. (2015). Inhaled dry powder formulations for treating tuberculosis. Current Drug Delivery, 12(1), 26-39.

Journal - Research Article

Shi, J., Das, S., Morton, D., & Stewart, P. (2015). The kinetics of de-agglomeration of magnesium stearate dry-coated salbutamol sulphate powders. KONA Powder & Particle Journal, (32), 131-142. doi: 10.14356/kona.2015001

Journal - Research Article

Tucker, I. G., Das, S. C., & Stewart, P. J. (2015). A view on the less-than-rational development of drug delivery systems: The example of dry powder inhalers. Journal of Drug Delivery Science & Technology, 30, 310-317. doi: 10.1016/j.jddst.2015.06.008

Journal - Research Article

Allahham, A., Stewart, P. J., & Das, S. C. (2013). Improving the de-agglomeration and dissolution of a poorly water soluble drug by decreasing the agglomerate strength of the cohesive powder. International Journal of Pharmaceutics, 457(1), 101-109. doi: 10.1016/j.ijpharm.2013.09.030

Journal - Research Article

Das, S. C., Behara, S. R. B., Morton, D. A. V., Larson, I., & Stewart, P. J. (2013). Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders. Powder Technology, 249, 297-303. doi: 10.1016/j.powtec.2013.08.034

Journal - Research Article

Das, S. C., & Stewart, P. J. (2012). Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution. Journal of Pharmacy & Pharmacology, 64(9), 1337-1348. doi: 10.1111/j.2042-7158.2012.01533.x

Journal - Research Article

Das, S. C., Behara, S. R. B., Bulitta, J. B., Morton, D. A. V., Larson, I., & Stewart, P. J. (2012). Powder strength distributions for understanding de-agglomeration of lactose powders. Pharmaceutical Research, 29(10), 2926-2935. doi: 10.1007/s11095-012-0799-0

Journal - Research Article

Das, S. C., Larson, I., Morton, D. A. V., & Stewart, P. J. (2011). Determination of the polar and total surface energy distributions of particulates by inverse gas chromatography. Langmuir, 27(2), 521-523. doi: 10.1021/la104135z

Journal - Research Article

Das, S. C., Zhou, Q., Morton, D. A. V., Larson, I., & Stewart, P. J. (2011). Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. European Journal of Pharmaceutical Sciences, 43(4), 325-333. doi: 10.1016/j.ejps.2011.05.012

Journal - Research Article

Zhou, Q., Denman, J. A., Gengenbach, T., Das, S., Qu, L., Zhang, H., … Morton, D. A. V. (2011). Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. Journal of Pharmaceutical Sciences, 100(8), 3421-3430. doi: 10.1002/jps.22547

Journal - Research Article

Das, S., Larson, I., Young, P., & Stewart, P. (2010). Understanding lactose behaviour during storage by monitoring surface energy change using inverse gas chromatography. Dairy Science & Technology, 90(2-3), 271-285. doi: 10.1051/dst/2009051

Journal - Research Article

Tay, T., Das, S., & Stewart, P. (2010). Magnesium stearate increases salbutamol sulphate dispersion: What is the mechanism? International Journal of Pharmaceutics, 383(1-2), 62-69. doi: 10.1016/j.ijpharm.2009.09.006

Journal - Research Article

Das, S., Larson, I., Young, P., & Stewart, P. (2009). Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity. European Journal of Pharmaceutical Sciences, 37(3-4), 442-450. doi: 10.1016/j.ejps.2009.03.016

Journal - Research Article

Das, S., Larson, I., Young, P., & Stewart, P. (2009). Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation. Journal of Pharmaceutical Sciences, 98(3), 1015-1027. doi: 10.1002/jps.21500

Journal - Research Article

Das, S., Larson, I., Young, P., & Stewart, P. (2009). Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH. European Journal of Pharmaceutical Sciences, 38(4), 347-354. doi: 10.1016/j.ejps.2009.08.007

Journal - Research Article

Ameratunga, R., Woon, S.-T., Steele, R., Snell, R., Medlicott, N., Mears, E., … Das, S., … Quiñones‑Mateu, M. E. (2021). The nose and the stomach play a critical role in the NZACE2-Pātari* (modified ACE2) drug treatment project of SARS-CoV-2 infection. Expert Review of Clinical Immunology. Advance online publication. doi: 10.1080/1744666x.2021.1912596

Journal - Research Other

Bastola, R., Young, P. M., & Das, S. C. (2021). Simulation of respiratory tract lining fluid for in vitro dissolution study. Expert Opinion on Drug Delivery. Advance online publication. doi: 10.1080/17425247.2021.1882991

Journal - Research Other

Ameratunga, R., Lehnert, K., Leung, E., Comoletti, D., Snell, R., Woon, S.-T., … Medlicott, N., Das, S., … Quiñones‑Mateu, M., … Jordan, A. (2020). Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection. New Zealand Medical Journal, 133(1515), 112-118. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Das, S. C., Stewart, P. J., & Tucker, I. G. (2018). The respiratory delivery of high dose dry powders. International Journal of Pharmaceutics, 550, 486-487. doi: 10.1016/j.ijpharm.2018.09.014

Journal - Research Other

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