Professor Shyamal Das.
The Das Laboratory at the School of Pharmacy investigates formulating and delivering medicines using powder inhalers. The emphasis is on improving the effectiveness of medicines for patients with chronic lung conditions.
Professor Shyamal Das leads the laboratory, he is also a senior lecturer in the School of Pharmacy and Pharamacology and holds numerous responsibilities in teaching and research. He has received many awards for teaching and research achievements and has cultivated national and international collaborators which enable a variety of opportunities for postgraduate research.
His work has attracted funding from:
- Health Research Council of New Zealand
- Otago Medical Research Council
- New Zealand Pharmacy Education Research Foundation
- University of Otago Research Grants
- Laurenson Award
- School of Pharmacy and Pharamacology
- Pharmaceutical industries
Professor Shyamal Das profile
Das Laboratory news
Email shyamal.das@otago.ac.nz
Research interests
The research at the Das Laboratory focuses on drug delivery via the pulmonary / respiratory route using dry powder inhalers (DPI), to improve drug therapy for chronic lung conditions such as:
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Corona viral infection
- Cystic fibrosis
- Lung infections such as bronchiectasis
- Tuberculosis
Successful delivery of powders to the deeper regions of the lung requires a mechanistic understanding of the factors that influence dispersion of fine powders in air (i.e. aerosolisation). After producing powders using techniques such as spray drying, milling and dry coating, the lab studies their surface properties such as chemistry, particle interactions and physical properties using different solid state characterisation techniques to understand powder behaviour before and after delivery to the lung. Professor Das also investigates efficacy, safety and toxicity using both in vitro and in vivo models.
Das Lab research is building a fundamental understanding of powders with the long-term goal of translating this research into clinical applications.
Das Laboratory COVID-19 research
Dry powder inhalers.
In response to COVID-19 Professor Das has extended his research to investigate delivery of drugs to the lungs with dry powder inhalers, nebulizers and soft mist inhalers.
The Das Lab has extensive networks with research collaborators across the globe which further enhances the opportunities for research advancement in this pharmaceutical field:
Das Laboratory research collaborators
More about current and past successes from members of the Das Laboratory:
Das Laboratory news
Research projects
Professor Das describes current research themes:
High dose powders for pulmonary delivery
We focus on both immediate and sustained-release high-dosage powders for treating tuberculosis and other lung infections. Using the spray drying technique to manipulate particle surface chemistry, we have produced powders containing one or more anti-TB drugs, which are highly efficient in delivering up to 80% of a dose. To ensure high dose and sustained release, we produced co-crystals of anti-TB drugs. We then study the stability of the powders.
Prevention and treatment of COVID-19 infection
We have recently focused on research into the prevention and treatment of COVID-19 infection. We are particularly interested in developing an improved hand sanitizer, and developing an inhaled dosage form of drugs and vaccines.
Pulmonary delivery of biologics
We are investigating the pulmonary delivery of micro-RNA as nanocomposite for treating lung diseases, and the delivery of an enzyme to breakdown biofilms in lung infections.
Dissolution of drugs in the lung
We are interested in the influence of lung surfactants on respiratory drug delivery. We have also focused on the influence of lung surfactants and compositions of lung fluids on inhalable powders and clinical studies of high-dose powders for inhalation.
Safety and toxicity of inhaled drugs
We are keen on understanding the safety, toxicity and efficacy of inhaled drugs. We use in vitro cell model as well as in vivo study using rodent model.
Vaping and e-cigarettes
We are also interested in the paradigm shift in social norms for vaping and medicinal cannabis. We have started research on formulations and devices for vaping, and their safety.
Herbal medicines and medicinal cannabis
Das group is interested in formulations and devices as a means of bioactive delivery for drugs derived from herbal sources such as medicinal cannabis.
Powder surface energy characterisation to understand powder de-agglomeration and aerosolisation behaviour
We have developed the method of characterising polar and total surface energy distributions using inverse gas chromatography. Following this, we introduced the concept of powder strength distribution, which has made it possible to understand complex powder de-agglomeration, which was previously difficult to explain.
Postgraduate students research
Within the School of Pharmacy and Pharamacology, Professor Das currently supervises a number of postgraduate students.
The team recently volunteered to produce hand sanitiser for the COVID-19 response:
Lecturer and students volunteer time to make sanitiser
The Das Lab also celebrates the achievement of its alumni:
Das Laboratory alumni
Dr Prakash Khadka
Topic: Inhaled powder for rifampicin
School of Pharmacy and Pharamacology, University of Otago, New Zealand, February 2023 – Present
(Mentors: Professor Shyamal Das, Dr Jack Dummer and Professor Philip Hill)
Komal Taya, PhD student
Topic: Inhaled formulations of cannabidiol
School of Pharmacy, University of Otago, New Zealand, October 2021 – Present
Co-supervisor: Professor Michelle Glass
Prodip Kumar Baral, PhD student
Topic: Inhaled drug delivery for drug resistance Pseudomonas aeruginosa lung infections
School of Pharmacy and Pharamacology, University of Otago, New Zealand, April 2024 – Present
Co-supervisor: Associate Professor Daniel Pletzer
Robiul Islam, PhD student
Topic: Understanding the mechanism and treatment of drug resistant Klebsiella pneumoniae lung infections
Department of Microbiology and Immunology, University of Otago, New Zealand, March 2024 – Present
Supervisor: Associate Professor Daniel Pletzer, Co-supervisor: Professor Shyamal Das
Yin Wang, Phd Student
Topic: Medicinal formulations from food waste
Department of Food Science, University of Otago, New Zealand, March 2025 – Present
Supervisor: Professor Alaa El-Din Ahmed Bekhit, Co-supervisors: Professor Shyamal Das and Dr Matthias Fellner
Reyaj Mikrani, PhD student
Topic: Inhaled drug delivery for treating heart diseases
School of Pharmacy and Pharamacology, University of Otago, New Zealand, June 2025 – Present
Supervisor: Professor Shyamal Das