Dr Shubhra Sinha

2025

Journal - Research Article

Su, C., Saha, T., Sinha, S., Hird, C. P., Smith, S. X. Y., Quiñones-Mateu, M. E., & Das, S. C. (2025). Inhalable spray-dried dry powders combining ivermectin and niclosamide to inhibit SARS-CoV-2 infection in vitro. International Journal of Pharmaceutics, 671, 125302. doi: 10.1016/j.ijpharm.2025.125302

2024

Journal - Research Article

Fan, C., Eedara, B. B., Sinha, S., Udden, M. K. M., Doyle, C., Banu, S., & Das, S. C. (2024). Triple combination dry powder formulation of pretomanid, moxifloxacin, and pyrazinamide for treatment of multidrug-resistant tuberculosis. International Journal of Pharmaceutics, 654, 123984. doi: 10.1016/j.ijpharm.2024.123984

Conference Contribution - Poster Presentation (not in published proceedings)

Sinha, S., Ali, A., Gamble, A., Hook, S., & Katare, R. (2024, August-September). Smart bioscaffold for healing diabetic foot ulcers. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Andimadam Madana Saravanan, J., Sinha, S., Gamble, A., Ali, A., & Katare, R. (2024, August-September). Conductive nanomatrix for cardiovascular tissue engineering and regenerative medicine. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kwangwari, M. R., Sinha, S., & Katare, R. (2024, August-September). In-vitro modulation of microRNAs associated with diabetic wound healing. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kwangwari, M., Sinha, S., & Katare, R. (2024, August). In-vitro modulation of micro-RNAs associated with diabetic wound healing. Verbal presentation at the BMS Postgraduate Symposium, Dunedin, New Zealand.

2023

Journal - Research Article

Eedara, B. B., Fan, C., Sinha, S., Khadka, P., & Das, S. C. (2023). Inhalable combination powder formulations for treating latent and multidrug-resistant tuberculosis: Formulation and in vitro characterization. Pharmaceutics, 15, 2354. doi: 10.3390/pharmaceutics15092354

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2023). Inhalable dry powder containing remdesivir and disulfiram: Preparation and in vitro characterization. International Journal of Pharmaceutics, 645, 123411. doi: 10.1016/j.ijpharm.2023.123411

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2023). Spray-dried inhalable microparticles combining remdesivir and ebselen against SARS-CoV-2 infection. Pharmaceutics, 15, 2229. doi: 10.3390/pharmaceutics15092229

Montgomerie, I., Bird, T. W., Palmer, O. R., Mason, N. C., Pankhurst, T. E., Lawley, B., Hernández, L. C., Harfoot, R., … Sinha, S., Kuang, J., … Ussher, J. E., Quiñones Mateu, M. E., … on behalf of the VAANZ Group. (2023). Incorporation of SARS-CoV-2 spike NTD to RBD protein vaccine improves immunity against viral variants. iScience, 26, 106256. doi: 10.1016/j.isci.2023.106256

Conference Contribution - Published proceedings: Full paper

Das, S. C., Khadka, P., Sinha, S., Katare, R., Hill, P. C., & Dummer, J. (2023). Towards the clinical translation of inhaled rifampicin for tuberculosis. In R. N. Dalby, J. Peart, D. Traini, P. M. Young & J. D. Suman (Eds.), Respiratory drug delivery. 2023, (pp. 11-18). Richmond, VA: RDD Online. [Full Paper]

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2023). Development of inhalable dry powders combining replication and protease inhibitors of SARS-CoV-2. Proceedings of the 34th Drug Delivery to the Lungs (DDL) Conference. 34, (pp. 389-392). doi: 10.60565/rt43-7m33

Conference Contribution - Poster Presentation (not in published proceedings)

Sinha, S., Ali, A., Gamble, A., Hook, S., & Katare, R. (2023, August). Nano formulation incorporated nanomatrix for the treatment of diabetic wound. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Andimadam Madana Saravanan, J., Sinha, S., Gamble, A., Ali, A., & Katare, R. (2023, August). Smart bioscaffolds for cardiovascular tissue engineering and regenerative medicine. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Adhikari, B. R., Sinha, S., Lyons, N., Pletzer, D., Lamont, I., Gordon, K. C., & Das, S. C. (2022). Inhalable ceftazidime-roflumilast powder targeting infection and inflammation: Influence of incorporating roflumilast into ceftazidime-leucine co-amorphous formulation. European Journal of Pharmaceutics & Biopharmaceutics, 180, 260-268. doi: 10.1016/j.ejpb.2022.10.005

Saha, T., Sinha, S., Harfoot, R., Quiñones Mateu, M. E., & Das, S. C. (2022). Manipulation of spray-drying conditions to develop an inhalable ivermectin dry powder. Pharmaceutics, 14(7), 1432. doi: 10.3390/pharmaceutics14071432

Adhikari, B. R., Sinha, S., Gordon, K. C., & Das, S. C. (2022). Amino acids improve aerosolization and chemical stability of potential inhalable amorphous spray-dried ceftazidime for Pseudomonas aeruginosa lung infection. International Journal of Pharmaceutics, 621, 121799. doi: 10.1016/j.ijpharm.2022.121799

Conference Contribution - Published proceedings: Abstract

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2022). Development of remdesivir and ebselen containing inhalable dry powder for COVID-19. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 566. Retrieved from https://www.asceptasm.com

Conference Contribution - Poster Presentation (not in published proceedings)

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2022, November). Inhalable dry powder of synergistic drug combinations to treat COVID-19. Poster session presented at the Otago Global Health Institute (OGHI) 14th Annual Conference: Reimagining Partnerships, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2022, November). Inhalable dry powder containing remdesivir and disulfiram for COVID-19. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2022, November). Remdesivir and ebselen containing inhalable dry powder against SARS-CoV-2. Verbal presentation at the New Zealand Controlled Release Society (NZCRS) Symposium, Auckland, New Zealand.

Saha, T., Sinha, S., Harfoot, R., Quiñones‑Mateu, M. E., & Das, S. C. (2022, November). Inhalable antivirals for SARS-CoV-2 infections. Verbal presentation at the Bioengineering@Otago Showcase, [Online].

2021

Journal - Research Article

Momin, M. A. M., Adhikari, B. R., Sinha, S., Larson, I., & Das, S. C. (2021). Roflumilast powders for chronic obstructive pulmonary disease: Formulation design and the influence of device, inhalation flow rate, and storage relative humidity on aerosolization. Pharmaceutics, 13, 1254. doi: 10.3390/pharmaceutics13081254

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats. European Journal of Pharmaceutics & Biopharmaceutics, 162, 1-11. doi: 10.1016/j.ejpb.2021.02.011

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model. International Journal of Pharmaceutics, 597, 120345. doi: 10.1016/j.ijpharm.2021.120345

Conference Contribution - Published proceedings: Full paper

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2021). High-dose inhaled rifampicin powder formulations: Preparation, in vitro characterization and in vivo evaluation. Proceedings of the Drug Delivery to the Lungs (DDL) Conference (Vol. 32). Retrieved from https://ddl-conference.com

Conference Contribution - Published proceedings: Abstract

Khadka, P., Sinha, S., Hill, P. C., Dummer, J., Tucker, I. G., Katare, R. G., & Das, S. C. (2021). In vitro and in vivo evaluation of high-dose inhaled rifampicin powder formulations for tuberculosis treatment. New Zealand Medical Journal, 134(1547), (pp. 139). Retrieved from https://www.nzma.org.nz/journal

2020

Conference Contribution - Published proceedings: Abstract

Khadka, P., Sinha, S., Tucker, I. G., Dummer, J., Hill, P. C., Katare, R., & Das, S. C. (2020). Safety of a single high-dose inhaled rifampicin in Sprague Dawley rats. Journal of Aerosol Medicine & Pulmonary Drug Delivery, 33(2), (pp. A11). doi: 10.1089/jamp.2020.ab01.abstracts

2019

Journal - Research Article

Momin, M. A. M., Rangnekar, B., Sinha, S., Cheung, C.-Y., Cook, G. M., & Das, S. C. (2019). Inhalable dry powder of Bedaquiline for pulmonary tuberculosis: In vitro physiochemical characterization, antimicrobial activity and safety studies. Pharmaceutics, 11(10), 502. doi: 10.3390/pharmaceutics11100502

Rangnekar, B., Momin, M. A. M., Eedara, B. B., Sinha, S., & Das, S. C. (2019). Bedaquiline containing triple combination powder for inhalation to treat drug-resistant tuberculosis. International Journal of Pharmaceutics, 570, 118689. doi: 10.1016/j.ijpharm.2019.118689

Momin, M. A. M., Rangnekar, B., Larson, I., Sinha, S., & Das, S. C. (2019). Dry powder formulation combining bedaquiline with pyrazinamide for latent and drug-resistant tuberculosis. Advanced Powder Technology, 30(11), 2473-2482. doi: 10.1016/j.apt.2019.07.016

Momin, M. A. M., Sinha, S., Tucker, I. G., & Das, S. C. (2019). Carrier-free combination dry powder inhaler formulation of ethionamide and moxifloxacin for treating drug-resistant tuberculosis. Drug Development & Industrial Pharmacy, 45(8), 1321-1331. doi: 10.1080/03639045.2019.1609494

Conference Contribution - Published proceedings: Abstract

Khadka, P., Sinha, S., Katare, R., & Das, S. C. (2019). Identification of suitable polymorphic forms of rifampicin for inhaled high dose delivery. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Annual Conference: Working Together Toward Better Health Outcomes. (pp. 20). Retrieved from http://www.apsa-online.org

Momin, M. A. M., Sinha, S., Tucker, I. G., & Das, S. C. (2019). High dose spray-dried powders for treating tuberculosis. Journal of Aerosol Medicine & Pulmonary Drug Delivery, 32(2), (pp. A23). doi: 10.1089/jamp.2019.ab01.abstracts

2018

Journal - Research Article

Eedara, B. B., Rangnekar, B., Sinha, S., Doyle, C., & Cavallaro, A. (2018). Development and characterization of high payload combination dry powders of anti-tubercular drugs for treating pulmonary tuberculosis. European Journal of Pharmaceutical Sciences, 118, 216-226. doi: 10.1016/j.ejps.2018.04.003

Momin, M. A. M., Tucker, I. G., Doyle, C. S., Denman, J. A., Sinha, S., & Das, S. C. (2018). Co-spray drying of hygroscopic kanamycin with the hydrophobic drug rifampicin to improve the aerosolization of kanamycin powder for treating respiratory infections. International Journal of Pharmaceutics, 541(1-2), 26-36. doi: 10.1016/j.ijpharm.2018.02.026

2017

Journal - Research Article

Sinha, S., Kuo, C.-Y., Ho, J. K., White, P. J., Jazayeri, J. A., & Pouton, C. W. (2017). A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration. Vaccine, 35(40), 5115-5122. doi: 10.1016/j.vaccine.2017.08.014

Momin, M. A. M., Sinha, S., Tucker, I. G., Doyle, C., & Das, S. C. (2017). Dry powder formulation of kanamycin with enhanced aerosolization efficiency for drug-resistant tuberculosis. International Journal of Pharmaceutics, 528(1-2), 107-117. doi: 10.1016/j.ijpharm.2017.06.004

Conference Contribution - Published proceedings: Full paper

Das, S. C., Fan, C., Eedara, B. B., & Sinha, S. (2017). A triple combination anti-tubercular dry powder formulation for treating both drug susceptible and multidrug resistant tuberculosis: Formulation and in vitro characterization. Proceedings of the Drug Delivery to the Lungs (DDL) Conference: Shaping the Next 25 Years of Nasal and Pulmonary Drug Delivery. (pp. 206-209). Retrieved from https://ddl-conference.com