Tups Lab

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B., & Tups, A. (2023). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Life Metabolism, load026. Advance online publication. doi: 10.1093/lifemeta/load026

Kamstra, K., & Tups, A. (2023). Neuroendocrine interactions in the control of glucose- and energy homeostasis.  In A. Kleinridders (Ed.), Physiological consequences of brain insulin action. (pp. 63-78). Boca Raton, FL: CRC Press.  doi: 10.1201/9781003079927-5

Kamstra, K., & Tups, A. (2023). Neuroendocrine interactions in the control of glucose- and energy homeostatis.  In A. Kleinridders (Ed.), Physiological consequences of brain insulin action. (pp. 63-78). Boca Raton, FL: CRC Press.  doi: 10.1201/9781003079927

Boer, G. A., Hay, D. L., & Tups, A. (2022). Obesity pharmacotherapy: Incretin action in the central nervous system [Review]. Trends in Pharmacological Sciences, 44(1), 50-63.  doi: 10.1016/j.tips.2022.11.001

Kamstra, K., Rizwan, M. Z., Grattan, D. R., Horsfield, J. A., & Tups, A. (2022). Leptin regulates glucose homeostasis via the canonical Wnt pathway in the zebrafish. FASEB Journal, 36, e22207.  doi: 10.1096/fj.202101764R

Boucsein, A., Kamstra, K., & Tups, A. (2021). Central signalling cross-talk between insulin and leptin in glucose and energy homeostasis [Invited]. Journal of Neuroendocrinology, 33, e12944.  doi: 10.1111/jne.12944

Pretz, D., Le Foll, C., Rizwan, M. Z., Lutz, T. A., & Tups, A. (2021). Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB Journal, 35, e21216.  doi: 10.1096/fj.202001147R

Loehfelm, A., Rizwan, M. Z., & Tups, A. (2021). A New Zealand green-lipped mussel oil-enriched high-fat diet exhibits beneficial effects on body weight and metabolism in mice. British Journal of Nutrition, 125(9), 972-982.  doi: 10.1017/s0007114520002342

Kamstra, K., Horsfield, J. A., & Tups, A. (2020). The effects of leptin mutations and diet-induced obesity on glucose homeostasis in the zebrafish.   New Zealand Medical Journal, 133(1527), (pp. 129).  Retrieved from https://www.nzma.org.nz/journal

Tups, A. (2020). Brain inflammation, circadian timing and a novel nutraceutical: Crucial in the fight against metabolic disease.   Proceedings, 43(2), (pp. 4).  doi: 10.3390/proceedings2020043002

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652.  doi: 10.1096/fj.201902517R

Rizwan, M., Shepherd, P., Tups, A., & Grattan, D. (2019). Region specific deletion of beta-catenin leads to impaired glucose tolerance and increased body weight.   Brain & Neuroscience Advances, 3, PS108.  doi: 10.1177/2398212819855490

Loehfelm, A., & Tups, A. (2019). The saturated fatty acid palmitate negatively affects morphology and function of primary hippocampal and cortical neurons via activation of the insulin pathway.   Brain & Neuroscience Advances, 3, PS086. doi: 10.1177/2398212819855490

Rizwan, M. Z., Shepherd, P. R., Tups, A., & Grattan, D. R. (2019, August-September). Region-specific deletion of β-catenin leads to impaired glucose tolerance and increased bodyweight.  Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kamstra, K., Horsfield, J. A., & Tups, A. (2019, August-September). The effects of leptin mutations and diet-induced weight gain on glucose homeostasis in the zebrafish. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pretz, D., Lutz, T., & Tups, A. (2019, August-September). Beneficial effects of leptin antagonism on glucose homeostasis in DIO mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, August-September). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pretz, D., Lutz, T., & Tups, A. (2019, July). Beneficial effects of leptin antagonism on glucose homeostasis in diet-induced obese mice.  Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.

Kamstra, K., Horsfield, J. A., & Tups, A. (2019, July). The effects of leptin mutations and diet-induced obesity on glucose homeostasis in the zebrafish. Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019, July). Time of day-dependent action of hypothalamic leptin signalling.  Poster session presented at the Society for the Study of Ingestive Behavior (SSIB) 27th Annual Meeting, Utrecht, The Netherlands.

Boucsein, A., Rizwan, M. Z., & Tups, A. (2019). Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB Journal, 33, 12175-12187.  doi: 10.1096/fj.201901004R

Skinner, N. J., Rizwan, M. Z., Grattan, D. R., & Tups, A. (2019). Chronic light cycle disruption alters central insulin and leptin signaling as well as metabolic markers in male mice. Endocrinology, 160(10), 2257-2270.  doi: 10.1210/en.2018-00935

Benzler, M., Benzler, J., Stoehr, S., Hempp, C., Rizwan, M. Z., Heyward, P., & Tups, A. (2019). "Insulin-like" effects of palmitate compromise insulin signalling in hypothalamic neurons. Journal of Comparative Physiology B, 189(3-4), 413-424. doi: 10.1007/s00360-019-01220-0

Loehfelm, A., Boucsein, A., Pretz, D., & Tups, A. (2019). Timing matters: Circadian effects on energy homeostasis and Alzheimer's disease. Trends in Endocrinology & Metabolism, 30(2), 132-143.  doi: 10.1016/j.tem.2018.12.001

Boucsein, A., Rizwan, M., & Tups, A. (2018, February). Circadian regulation of leptin action. Verbal presentation at the 9th Swiss Winter Conference on Ingestive Behavior, St. Moritz, Switzerland.