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Contact Details

Email
alexander.tups@otago.ac.nz
Position
Associate Professor
Department
Department of Physiology
Qualifications
PhD
Research summary
Neuroendocrinology

Research

  • Neuroendocrine regulation of metabolism; in particular, understanding how the adiposity signals, leptin and insulin interact in the hypothalamus to maintain energy homeostasis.
  • Identification of novel pathways that are involved in the neuroendocrine control of glucose metabolism.
  • Neuroendocrinology of nutrition related diseases: What is the link between type 2 Diabetes and Alzheimer's disease?

Publications

Rizwan, M. Z., Kamstra, K., Pretz, D., Shepherd, P. R., Tups, A., & Grattan, D. R. (2024). Conditional deletion of β-catenin in the mediobasal hypothalamus impairs adaptive energy expenditure in response to high fat diet and exacerbates diet-induced obesity. Journal of Neuroscience. Advance online publication. doi: 10.1523/jneurosci.1666-23.2024 Journal - Research Article

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Perry, N. B., & Tups, A. (2023, August-September). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Verbal presentation at the Queenstown Molecular Biology (QMB) Hypothalamic Neuroscience & Neuroendocrinology Australasia (HNNA) Satellite, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., … Boer, G. A., Perry, N. B., & Tups, A. (2023, August). From mechanistic biomedical research on hypothalamic inflammation to a dietary supplement for glucose support. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Rizwan, M. Z., Kerbus, R., Kamstra, K., Keerthisinghe, P., & Tups, A. (2023). Dietary wheat gluten induces astro- and microgliosis in the hypothalamus of male mice. Journal of Neuroendocrinology, e13326. Advance online publication. doi: 10.1111/jne.13326 Journal - Research Article

Pretz, D., Heyward, P. M., Krebs, J., Gruchot, J., Barter, C., Silcock, P., Downes, N., Rizwan, M. Z., Boucsein, A., Bender, J., Burgess, E. J., Boer, G. A., Keerthisinghe, P., Perry, N. B., & Tups, A. (2023). A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. Life Metabolism, 2(4), load026. doi: 10.1093/lifemeta/load026 Journal - Research Article

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