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Dr Kathryn Hally, Department of Surgery and Anaesthesia

Kathyryn Hally image 2021 @2xPhD (VUW), BBMedSc (Hons) (VUW)

Contact details

Department of Surgery & Anaesthesia
Te Tari Hāparapara, Te Tari Whāomoomo
University of Otago, Wellington
PO Box 7343
Wellington South

Tel +64 4 918 5610
Email kathryn.hally@otago.ac.nz

Current roles

  • Postdoctoral Fellow, UOW
  • Adjunct Research Fellow, VUW
  • Scientist, Wellington Cardiovascular Research Group
  • Heart Foundation Research Fellow

Research expertise

  • Translational cardiovascular medicine
  • Innate immunology
  • Platelet biology
  • Flow cytometry

Background

I completed both my undergraduate and postgraduate studies in Biomedical Science at Victoria University of Wellington. I finished my PhD in 2018 and moved to The University of Otago, Wellington, to take up a Postdoctoral Fellow position within the Department of Surgery. My current research is focused on developing inflammation-based risk scores for predicting good myocardial repair following a myocardial infarction. I have extensive technical expertise in full-spectrum flow cytometry and utilize this skillset to interrogate circulating immune cell phenotype for biomarker discovery. If we are able to identify patients that experience bad cardiac repair post-infarction, we can begin to personalize their therapy and rehabilitation to ensure beneficial long-term cardiac health for these individuals.

I work as a part of the Wellington Cardiovascular Research Group, which is a collaborative effort between The University of Otago, Victoria University and Capital and Coast DHB. Combined, we have expertise in both basic science and in clinical practice and work together to ensure the translation of our work from the bench into the clinic.

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Publications

Hally, K. E., Ferrer-Font, L., Pilkington, K. R., & Larsen, P. D. (2022). OMIP 083: A 21-marker 18-color flow cytometry panel for in-depth phenotyping of human peripheral monocytes. Cytometry Part A. Advance online publication. doi: 10.1002/cyto.a.24545

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2022). Increased levels of low density neutrophils (LDNs) in myocardial infarction. Acta Cardiologica. Advance online publication. doi: 10.1080/00015385.2021.2015145

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Shi, B., Harding, S., & Larsen, P. (2021). Using principal component analysis to create prognostic cytokine scores for adverse outcome in acute myocardial infarction. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S57-S58). doi: 10.1016/j.hlc.2021.05.003

Brunton-O'Sullivan, M. M., Holley, A. S., Hally, K. E., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2021). A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction. Scientific Reports, 11, 12705. doi: 10.1038/s41598-021-92108-z

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis. Advance online publication. doi: 10.1055/s-0041-1728763

Yiu, J. Y. T., Hally, K. E., Larsen, P. D., & Holley, A. S. (2022). Increased levels of low density neutrophils (LDNs) in myocardial infarction. Acta Cardiologica. Advance online publication. doi: 10.1080/00015385.2021.2015145

Journal - Research Article

Brunton-O'Sullivan, M. M., Holley, A. S., Hally, K. E., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2021). A combined biomarker approach for characterising extracellular matrix profiles in acute myocardial infarction. Scientific Reports, 11, 12705. doi: 10.1038/s41598-021-92108-z

Journal - Research Article

Hally, K. E., Parker, O. M., Brunton-O'Sullivan, M. M., Harding, S. A., & Larsen, P. D. (2021). Linking neutrophil extracellular traps and platelet activation: A composite biomarker for predicting outcomes after acute myocardial infarction. Thrombosis & Haemostasis. Advance online publication. doi: 10.1055/s-0041-1728763

Journal - Research Article

Hally, K. E., Holley, A. S., Kristono, G. A., Harding, S. A., & Larsen, P. D. (2020). Immunoglobulin G levels predicts risk of recurrent adverse cardiovascular events in myocardial infarction patients. Acta Cardiologica, 75(6), 497-502. doi: 10.1080/00015385.2019.1611189

Journal - Research Article

Kristono, G. A., Holley, A. S., Hally, K. E., Brunton-O'Sullivan, M. M., Shi, B., Harding, S. A., & Larsen, P. D. (2020). An IL-6-IL-8 score derived from principal component analysis is predictive of adverse outcome in acute myocardial infarction. Cytokine: X, 2, 100037. doi: 10.1016/j.cytox.2020.100037

Journal - Research Article

Hally, K. E., Bird, G. K., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation. PLoS ONE, 14(10), e0223444. doi: 10.1371/journal.pone.0223444

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2019). The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: Results of a randomized, cross-over trial. Platelets, 30(5), 599-607. doi: 10.1080/09537104.2018.1479520

Journal - Research Article

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2018). Platelets regulate leucocyte responses to Toll-like receptor stimulation. Clinical & Translational Immunology, 7, e1036. doi: 10.1002/cti2.1036

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2017). Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction. Thrombosis Research, 158, 8-15. doi: 10.1016/j.thromres.2017.07.031

Journal - Research Article

Hally, K. E., La Flamme, A. C., Larsen, P. D., & Harding, S. A. (2016). Toll-like receptor 9 expression and activation in acute coronary syndrome patients on dual anti-platelet therapy. Thrombosis Research, 148, 89-95. doi: 10.1016/j.thromres.2016.10.026

Journal - Research Article

Hally, K. E., Ferrer-Font, L., Pilkington, K. R., & Larsen, P. D. (2022). OMIP 083: A 21-marker 18-color flow cytometry panel for in-depth phenotyping of human peripheral monocytes. Cytometry Part A. Advance online publication. doi: 10.1002/cyto.a.24545

Journal - Research Other

Cognasse, F., Hally, K., Fauteux-Daniel, S., Eyraud, M.-A., Arthaud, C.-A., Fagan, J., … Larsen, P. (2021). Effects and side effects of platelet transfusion. Hamostaseologie. Advance online publication. doi: 10.1055/a-1347-6551

Journal - Research Other

Hally, K., Fauteux-Daniel, S., Hamzeh-Cognasse, H., Larsen, P., & Cognasse, F. (2020). Revisiting platelets and Toll-like receptors (TLRs): At the interface of vascular immunity and thrombosis. International Journal of Molecular Sciences, 21(17), 6150. doi: 10.3390/ijms21176150

Journal - Research Other

Hally, K. E., Danielson, K. M., & Larsen, P. D. (2018). Looking to the future: Spotlight on emerging biomarkers for predicting cardiovascular risk. Current Epidemiology Reports, 5, 230-242. doi: 10.1007/s40471-018-0158-8

Journal - Research Other

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Shi, B., Harding, S., & Larsen, P. (2021). Using principal component analysis to create prognostic cytokine scores for adverse outcome in acute myocardial infarction. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S57-S58). doi: 10.1016/j.hlc.2021.05.003

Conference Contribution - Published proceedings: Abstract

Brunton-O'Sullivan, M., Holley, A., Hally, K., Kristono, G., Bird, G., Harding, S., & Larsen, P. (2020). Examining the relationship between infarct size and circulating extracellular matrix biomarkers over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S257-S258). doi: 10.1016/j.hlc.2020.09.495

Conference Contribution - Published proceedings: Abstract

Kristono, G., Holley, A., Hally, K., Brunton-O'Sullivan, M., Harding, S., & Larsen, P. (2020). Trends in inflammatory cytokine levels over acute and chronic phases of myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S293). doi: 10.1016/j.hlc.2020.09.574

Conference Contribution - Published proceedings: Abstract

Yiu, J., Hally, K., Holley, A., & Larsen, P. (2020). Circulating low-density neutrophils in acute myocardial infarction. Heart, Lung & Circulation, 29(Suppl. 2), (pp. S242). doi: 10.1016/j.hlc.2020.09.464

Conference Contribution - Published proceedings: Abstract

Bird, G., Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2019). The role of B cells in acute myocardial infarction. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S18). doi: 10.1016/j.hlc.2019.05.047

Conference Contribution - Published proceedings: Abstract

Brunton-O'Sullivan, M., Holley, A., Hally, K., Harding, S., & Larsen, P. (2019). An exploratory factor analysis of circulating extracellular matrix biomarkers in acute myocardial infarction. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S14). doi: 10.1016/j.hlc.2019.05.039

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2019). Platelet toll-like receptor expression and toll-like receptor-mediated platelet responses in healthy and acute myocardial infarction subjects. Heart, Lung & Circulation, 28(Suppl. 1), (pp. S1-S2). doi: 10.1016/j.hlc.2019.05.007

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Harding, S., & Larsen, P. (2018). Neutrophil activation in response to Toll-like receptor stimulation is regulated by platelets. Heart, Lung & Circulation, 27(Suppl. 2), (pp. S332). doi: 10.1016/j.hlc.2018.06.644

Conference Contribution - Published proceedings: Abstract

Hally, K. E., La Flamme, A. C., Harding, S. A., & Larsen, P. D. (2017). Platelets modulate the leukocyte responses to Toll-like receptor stimulation. Proceedings of the 46th Australasian Society for Immunology (ASI) Annual Scientific Meeting. 242. Retrieved from http://www.asi2017.org/

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Larsen, P., & Harding, S. (2016). Platelet toll-like receptor (TLR)-9 expression increases in acute coronary syndrome (ACS) patients and following platelet activation. Heart, Lung & Circulation, 25(Suppl. 2), (pp. S56). doi: 10.1016/j.hlc.2016.06.127

Conference Contribution - Published proceedings: Abstract

Hally, K., La Flamme, A., Larsen, P., & Harding, S. (2015). Platelet activation by toll-like receptor (TLR)-9 agonism in acute coronary syndrome (ACS) patients on dual anti-platelet therapy. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S159). doi: 10.1016/j.hlc.2015.06.112

Conference Contribution - Published proceedings: Abstract

Hally, K., Johnston, L., Holley, A., Larsen, P., & Harding, S. (2014). Platelet count and platelet function testing in acute coronary syndromes. Heart, Lung & Circulation, 23(Suppl. 1), (pp. e26). doi: 10.1016/j.hlc.2014.04.192

Conference Contribution - Published proceedings: Abstract

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