Centre for Free Radical Research
Advancing health by exploring the biology of oxygen.
We are an internationally-recognised leader in investigating how free radicals affect health and disease.
Free radicals are molecules that contain an unpaired electron. They are very reactive chemicals and are being made all the time inside our bodies via reactions with oxygen. Free radicals can cause damage, and we have antioxidants that provide protection. However, free radicals also play important roles in health, helping to fight infection and transmit signals.
Our mission is to discover what free radicals do inside the body, and how this knowledge can be used to measure and treat human diseases.
Our research is focused on:
- Diseases of childhood
- Diseases of ageing
- Antioxidants in health
Research by the Centre for Free Radical Research
Research areas, with potential applications to cancer, heart disease, arthritis, neurodegenerative disease, cystic fibrosis, inflammatory bowel disease and infectious disease, include:
- Cell antioxidant pathways
- Free radical chemistry and biochemistry
- Vitamin C
- Effect of oxidants on cell signalling pathways
- Regulation of cell death/apoptosis
- Enzyme inhibitors and redox-active drugs
- Bacterial killing by white blood cells
- Novel biomarkers of oxidative stress
- Oxidative stress in inflammatory diseases
Our publications appear in international medical and scientific journals and are widely cited by other researchers.