Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Science staff profile

 

Associate Professor Merilyn Hibma

PositionAssociate Professor
DepartmentDepartment of Pathology (DSM)
QualificationsBSc MSc PhD(Otago)
Research summaryImmune regulation and its contribution to skin pathogenesis

Research

Merilyn is an Associate Professor in the Department of Pathology, Dunedin School of Medicine. She worked for the Imperial Cancer Research Fund in University of Cambridge with Lionel Crawford (FRS), before being awarded an HRC Repatriation Fellowship and returning to the Department of Microbiology and Immunology at the University of Otago. In 2014 she was appointed to the Department of Pathology.

Her research interests include viral regulation of cell function and immunity in the skin, with a particular emphasis on human papillomavirus (HPV) and cancer. HPV causes persistent infections of cutaneous and mucosal skin and is the causal agent of cervical cancer. Although an effective prophylactic vaccine has been developed for the major cancer-causing HPV types, there is a continuing need for better therapeutics for HPV to address the health needs of individuals who are already infected with this high-prevalence virus. Understanding viral regulation of immunity by HPV and developing better immunotherapeutics to treat HPV are the focus of her research.

Publications

Warif, N. M. A., Stoitzner, P., Leggatt, G. R., Mattarollo, S. R., Frazer, I. H., & Hibma, M. H. (2015). Langerhans cell homeostasis and activation Is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS ONE, 10(5), e0127155. doi: 10.1371/journal.pone.0127155

Jemon, K., Young, V., Wilson, M., McKee, S., Ward, V., Baird, M., Young, S., & Hibma, M. (2013). An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. PLoS ONE, 8(6), e66866. doi: 10.1371/journal.pone.0066866

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012). Transcriptional repression of e-cadherin by human papillomavirus type 16 E6. PLoS ONE, 7(11), e48954. doi: 10.1371/journal.pone.0048954

Hibma, M. H. (2012). The immune response to papillomavirus during infection persistence and regression. Open Virology Journal, 6(Suppl. 2), 241-248. doi: 10.2174/1874357901206010241

D'Costa, Z. J., Leong, C.-M., Shields, J., Matthews, C., & Hibma, M. H. (2012). Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression. Investigational New Drugs, 30(6), 2236-2251. doi: 10.1007/s10637-012-9803-0

Journal - Research Article

Warif, N. M. A., Stoitzner, P., Leggatt, G. R., Mattarollo, S. R., Frazer, I. H., & Hibma, M. H. (2015). Langerhans cell homeostasis and activation Is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS ONE, 10(5), e0127155. doi: 10.1371/journal.pone.0127155

Jemon, K., Young, V., Wilson, M., McKee, S., Ward, V., Baird, M., Young, S., & Hibma, M. (2013). An enhanced heterologous virus-like particle for human papillomavirus type 16 tumour immunotherapy. PLoS ONE, 8(6), e66866. doi: 10.1371/journal.pone.0066866

D'Costa, Z. J., Leong, C.-M., Shields, J., Matthews, C., & Hibma, M. H. (2012). Screening of drugs to counteract human papillomavirus 16 E6 repression of E-cadherin expression. Investigational New Drugs, 30(6), 2236-2251. doi: 10.1007/s10637-012-9803-0

Dutton, S., Fleming, S. B., Ueda, N., Heath, D. D., Hibma, M. H., & Mercer, A. A. (2012). Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus. Parasite Immunology, 34(6), 312-317. doi: 10.1111/j.1365-3024.2012.01360.x

Rose, S. B., Lawton, B. A., Lanumata, T. S., Hibma, M., & Baker, M. G. (2012). Predictors of intent to vaccinate against HPV/cervical cancer: A multi-ethnic survey of 769 parents in New Zealand. New Zealand Medical Journal, 125(1350). Retrieved from http://journal.nzma.org.nz/journal/125-1350/5077/content.pdf

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012). Transcriptional repression of e-cadherin by human papillomavirus type 16 E6. PLoS ONE, 7(11), e48954. doi: 10.1371/journal.pone.0048954

Hibma, M. H. (2012). The immune response to papillomavirus during infection persistence and regression. Open Virology Journal, 6(Suppl. 2), 241-248. doi: 10.2174/1874357901206010241

Leong, C. M., Doorbar, J., Nindl, I., Yoon, H.-S., & Hibma, M. H. (2010). Loss of epidermal Langerhans cells occurs in human papillomavirus α, γ, and μ but not β genus infections. Journal of Investigative Dermatology, 130(2), 472-480. doi: 10.1038/jid.2009.266

Leong, C.-M., Doorbar, J., Nindl, I., Yoon, H.-S., & Hibma, M. H. (2010). Deregulation of E-cadherin by human papillomavirus is not confined to high-risk, cancer-causing types. British Journal of Dermatology, 163(6), 1253-1263. doi: 10.1111/j.1365-2133.2010.09968.x

Rose, S. B., Lawton, B. A., Lanumata, T., Hibma, M., & Baker, M. G. (2010). HPV/cervical cancer vaccination: Parental preferences on age, place and information needs. Journal of Primary Health Care, 2(3), 190-198.

Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1

Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016

Heinemann, L., Woodfield, L., Amer, M., & Hibma, M. (2008). Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. Viral Immunology, 21(2), 225-233. doi: 10.1089/vim.2007.0101

Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188.

Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M. K., Jerram, J., Mercer, A. A., & Hibma, M. (2007). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Journal of General Virology, 88, 803-813.

More publications...