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Pharmacy staff profile

Professor Stephen Duffull

PositionProfessor
QualificationsMPharm PhD(Otago) DipPharm(CIT) FNZCP MPS RegPharmNZ
Research summaryClinical pharmacy; pharmacometrics
Teaching
  • Clinical pharmacy to undergraduate and postgraduate students; including undergraduate papers on Principles of Pharmacy Practice and Quality Use of Medicines.
  • Paper Co-ordinator of Advanced Clinical Pharmacy as part of the Master of Clinical Pharmacy course.

Research

Expertise in pharmacometrics. Pharmacometrics involves the quantitative design, analysis and inference from pharmacological studies. In particular this involves optimal design and population analysis techniques for pharmacokinetic and pharmacodynamic data.

Currently my research involves the development of pharmacological models, modelling of data and the design of clinical studies. These foci essentially revolve around the therapeutic areas of coagulation, malaria and clinical toxicology.

Professor Duffull on Google Scholar

Professor Duffull on PubMed

Publications

Foo, L. K., & Duffull, S. (2017). Designs to balance cost and success rate for an early phase clinical study. Journal of Biopharmaceutical Statistics, 27(1), 148-158. doi: 10.1080/10543406.2016.1148703

Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-017-9527-z

Duffull, S. B., & Hooker, A. C. (2017). Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-017-9552-y

Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-017-0541-5

Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2017). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy. Advance online publication. doi: 10.1016/j.sapharm.2017.04.049

Authored Book - Research

Heydon, S., & Duffull, S. (2013). Pharmacy at Otago: The first 50 years: The school, the profession and the people. Dunedin, New Zealand: National School of Pharmacy, University of Otago, 80p.

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Edited Book - Research

Kimko, H. C., & Duffull, S. B. (Eds.). (2003). Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. New York, NY: Marcel Dekker, 416p.

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Chapter in Book - Research

Vajjah, P., Isbister, G. K., & Duffull, S. B. (2012). Introduction to pharmacokinetics in clinical toxicology. In B. Reisfeld & A. N. Mayeno (Eds.), Computational toxicology: Volume I: Methods in molecular biology (Vol. 929). (pp. 289-312). Humana Press. doi: 10.1007/978-1-62703-050-2_12

Foo, L.-K., & Duffull, S. B. (2011). Optimal design of pharmacokinetic-pharmacodynamic studies. In P. L. Bonate & D. R. Howard (Eds.), Pharmacokinetics in drug development: Advances and applications (Vol. 3). (pp. 175-193). New York: Springer. doi: 10.1007/978-1-4419-7937-7_8

Kimko, H. C., & Duffull, S. B. (2003). Introduction to simulation for design of clinical trials. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 1-16). New York, NY: Marcel Dekker.

Monteleone, J. P. R., & Duffull, S. B. (2003). Choice of best design. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 173-200). New York, NY: Marcel Dekker.

Nestorov, I. A., Graham, G., Aarons, L., & Duffull, S. B. (2003). Model-based integration for clinical trial simulation and design: A phase II case study for naratriptan. In H. C. Kimko & S. B. Duffull (Eds.), Simulation for designing clinical trials: A pharmacokinetic-pharmacodynamic modeling perspective. (pp. 313-325). New York, NY: Marcel Dekker.

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Journal - Research Article

Foo, L. K., & Duffull, S. (2017). Designs to balance cost and success rate for an early phase clinical study. Journal of Biopharmaceutical Statistics, 27(1), 148-158. doi: 10.1080/10543406.2016.1148703

Duffull, S. B., Wright, D. F. B., Marra, C. A., & Anakin, M. G. (2017). A philosophical framework for pharmacy in the 21st century guided by ethical principles. Research in Social & Administrative Pharmacy. Advance online publication. doi: 10.1016/j.sapharm.2017.04.049

Ooi, Q. X., Wright, D. F. B., Tait, R. C., Isbister, G. K., & Duffull, S. B. (2017). A joint model for vitamin K-dependent clotting factors and anticoagulation proteins. Clinical Pharmacokinetics. Advance online publication. doi: 10.1007/s40262-017-0541-5

Duffull, S. B., & Hooker, A. C. (2017). Assessing robustness of designs for random effects parameters for nonlinear mixed-effects models. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-017-9552-y

Hasegawa, C., & Duffull, S. B. (2017). Exploring inductive linearization for pharmacokinetic-pharmacodynamic systems of nonlinear ordinary differential equations. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-017-9527-z

Siripuram, V. K., Wright, D. F. B., Barclay, M. L., & Duffull, S. B. (2017). Deterministic identifiability of population pharmacokinetic and pharmacokinetic-pharmacodynamic models. Journal of Pharmacokinetics & Pharmacodynamics. Advance online publication. doi: 10.1007/s10928-017-9530-4

Saffian, S. M., Duffull, S. B., & Wright, D. F. B. (2017). Warfarin dosing algorithms under-predict dose requirements in patients requiring ≥ 7mg daily: A systematic review and meta-analysis. Clinical Pharmacology & Therapeutics. Advance online publication. doi: 10.1002/cpt.649

Ng, D. P. J., Duffull, S. B., Faed, J. M., Isbister, G. K., & Gulati, A. (2017). An evaluation of a factor Xa-based clotting time test for Enoxaparin: A proof-of-concept study. Clinical & Applied Thrombosis/Hemostasis. Advance online publication. doi: 10.1177/1076029617711802

Kuan, I. H. S., Duffull, S. B., Putt, T. L., Schollum, J. B. W., Walker, R. J., & Wright, D. F. B. (2017). A population pharmacokinetic model for 51Cr EDTA to estimate renal function. Clinical Pharmacokinetics, 56(6), 671-678. doi: 10.1007/s40262-016-0489-x

Foo, L.-K., Duffull, S. B., Calver, L., Schneider, J., & Isbister, G. K. (2016). Population pharmacokinetics of intramuscular droperidol in acutely agitated patients. British Journal of Clinical Pharmacology, 82(6), 1550-1556. doi: 10.1111/bcp.13093

Wright, D. F. B., Duffull, S. B., Merriman, T. R., Dalbeth, N., Barclay, M. L., & Stamp, L. K. (2016). Predicting allopurinol response in patients with gout. British Journal of Clinical Pharmacology, 81(2), 277-289. doi: 10.1111/bcp.12799

Shivva, V., Cox, P. J., Clarke, K., Veech, R. L., Tucker, I. G., & Duffull, S. B. (2016). The population pharmacokinetics of D-β-hydroxybutyrate following administration of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. AAPS Journal, 18(3), 678-688. doi: 10.1208/s12248-016-9879-0

Shivva, V., Tucker, I. G., & Duffull, S. B. (2016). An in silico knockout model for gastrointestinal absorption using a systems pharmacology approach: Development and application for ketones. PLoS ONE, 11(9), e0163795. doi: 10.1371/journal.pone.0163795

Chiew, A. L., Isbister, G. K., Duffull, S. B., & Buckley, N. A. (2016). Evidence for the changing regimens of acetylcysteine. British Journal of Clinical Pharmacology, 81(3), 471-481. doi: 10.1111/bcp.12789

Saffian, S. M., Duffull, S. B., Roberts, R. L., Tait, R. C., Black, L., Lund, K. A., … Wright, D. F. B. (2016). Influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool. Therapeutic Drug Monitoring, 38(6), 677-683. doi: 10.1097/ftd.0000000000000347

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2016). A framework for quantifying the influence of adherence and dose individualization. Clinical Pharmacology & Therapeutics, 99(4), 452-459. doi: 10.1002/cpt.268

Brussee, J. M., Yeo, T. W., Lampah, D. A., Anstey, N. M., & Duffull, S. B. (2016). A pharmacokinetic-pharmacodynamic model for the effect of L-arginine on endothelial function in patients with moderately severe falciparum malaria. Antimicrobial Agents & Chemotherapy, 60(1), 198-205. doi: 10.1128/aac.01479-15

Cooper, J. M., Duffull, S. B., Saiao, A. S., & Isbister, G. K. (2015). The pharmacokinetics of sertraline in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 79(2), 307-315. doi: 10.1111/bcp.12500

Duffull, S. B., & Wright, D. F. B. (2015). What do we learn from repeated population analyses? British Journal of Clinical Pharmacology, 79(1), 40-47. doi: 10.1111/bcp.12233

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). Quantification of the forgiveness of drugs to imperfect adherence. CPT: Pharmacometrics & Systems Pharmacology, 4(3), 204-211. doi: 10.1002/psp4.4

Pan, S., Korell, J., Stamp, L. K., & Duffull, S. B. (2015). Simplification of a pharmacokinetic model for red blood cell methotrexate disposition. European Journal of Clinical Pharmacology, 71(12), 1509-1516. doi: 10.1007/s00228-015-1951-7

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2015). Application of adaptive DP-optimality to design a pilot study for a clotting time test for enoxaparin. Pharmaceutical Research, 32(10), 3391-3402. doi: 10.1007/s11095-015-1715-1

Al-Sallami, H. S., Goulding, A., Grant, A., Taylor, R., Holford, N., & Duffull, S. B. (2015). Prediction of fat-free mass in children. Clinical Pharmacokinetics, 54(11), 1169-1178. doi: 10.1007/s40262-015-0277-z

Assawasuwannakit, P., Braund, R., & Duffull, S. B. (2015). A model-based meta-analysis of the influence of factors that impact adherence to medications. Journal of Clinical Pharmacy & Therapeutics, 40(1), 24-31. doi: 10.1111/jcpt.12219

Nyberg, J., Bazzoli, C., Ogungbenro, K., Aliev, A., Leonov, S., Duffull, S., … Mentré, F. (2015). Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies. British Journal of Clinical Pharmacology, 79(1), 6-17. doi: 10.1111/bcp.12352

Lagishetty, C. V., & Duffull, S. B. (2015). Evaluation of approaches to deal with low-frequency nuisance covariates in population pharmacokinetic analyses. AAPS Journal, 17(6), 1388-1394. doi: 10.1208/s12248-015-9793-x

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2015). Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: A systematic review. BMC Geriatrics, 15, 31. doi: 10.1186/s12877-015-0029-9

Saffian, S. M., Wright, D. F. B., Roberts, R. L., & Duffull, S. B. (2015). Methods for predicting warfarin dose requirements. Therapeutic Drug Monitoring, 37(4), 531-538. doi: 10.1097/ftd.0000000000000177

Salahudeen, M. S., Nishtala, P. S., & Duffull, S. B. (2015). The influence of patient characteristics on anticholinergic events in older people. Dementia & Geriatric Cognitive Disorders Extra, 5(3), 530-541. doi: 10.1159/000441718

Hatah, E., Tordoff, J., Duffull, S. B., Cameron, C., & Braund, R. (2014). Retrospective examination of selected outcomes of Medicines Use Review (MUR) services in New Zealand. International Journal of Clinical Pharmacy, 36(3), 503-512. doi: 10.1007/s11096-014-9913-1

Hatah, E., Tordoff, J., Duffull, S. B., & Braund, R. (2014). Pharmacists' performance of clinical interventions during adherence support medication reviews. Research in Social & Administrative Pharmacy, 10(1), 185-194. doi: 10.1016/j.sapharm.2013.04.008

Korell, J., Duffull, S. B., Dalrymple, J. M., Drake, J., Zhang, M., Barclay, M. L., & Stamp, L. K. (2014). Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. British Journal of Clinical Pharmacology, 77(3), 493-497. doi: 10.1111/bcp.12209

Putt, T. L., Duffull, S. B., Schollum, J. B. W., & Walker, R. J. (2014). GFR may not accurately predict aspects of proximal tubule drug handling. European Journal of Clinical Pharmacology, 70(10), 1221-1226. doi: 10.1007/s00228-014-1733-7

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2014). Parameterisation affects identifiability of population models. Journal of Pharmacokinetics & Pharmacodynamics, 41, 81-86. doi: 10.1007/s10928-013-9347-8

Pan, S., Stamp, L. K., Duffull, S. B., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Korell, J. (2014). Assessment of the relationship between methotrexate polyglutamates in red blood cells and clinical response in patients commencing methotrexate for rheumatoid arthritis. Clinical Pharmacokinetics, 53(12), 1161-1170. doi: 10.1007/s40262-014-0179-5

Duffull, S. B., & Hegarty, G. (2014). An inductive approximation to the solution of systems of nonlinear ordinary differential equations in pharmacokinetics-pharmacodynamics. Journal of Theoretical & Computational Science, 1(4), 1000119. doi: 10.4172/jtco.1000119

Hatah, E., Braund, R., Tordoff, J., & Duffull, S. B. (2014). A systematic review and meta-analysis of pharmacist-led fee-for-services medication review. British Journal of Clinical Pharmacology, 77(1), 102-115. doi: 10.1111/bcp.12140

Gulati, A., Isbister, G. K., & Duffull, S. B. (2014). Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data. CPT: Pharmacometrics & Systems Pharmacology, 3, e90. doi: 10.1038/psp.2013.67

Salahudeen, M. S., Duffull, S. B., & Nishtala, P. S. (2014). Impact of anticholinergic discontinuation on cognitive outcomes in older people: A systematic review. Drugs & Aging, 31(3), 185-192. doi: 10.1007/s40266-014-0158-4

Shaw, J. P., Print, S. A., & Duffull, S. B. (2013). Development of a postgraduate educational program for pharmacist prescribers in New Zealand. Journal of Pharmacy Practice & Research, 43(2), 122-127.

Gulati, A., Isbister, G. K., & Duffull, S. B. (2013). Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17). Toxicon, 61, 94-104. doi: 10.1016/j.toxicon.2012.11.001

Shivva, V., Korell, J., Tucker, I. G., & Duffull, S. B. (2013). An approach for identifiability of population pharmacokinetic–pharmacodynamic models. CPT: Pharmacometrics & Systems Pharmacology, 2(6), e49. doi: 10.1038/psp.2013.25

Yeo, T. W., Lampah, D. A., Rooslamiati, I., Gitawati, R., Tjitra, E., Kenangalem, E., … Duffull, S. B., & Anstey, N. A. (2013). A randomized pilot study of L-arginine infusion in severe falciparum malaria: Preliminary safety, efficacy and pharmacokinetics. PLoS ONE, 8(7), e69587. doi: 10.1371/journal.pone.0069587

Hatah, E., Braund, R., Duffull, S. B., & Tordoff, J. (2013). General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand. Journal of Primary Health Care, 5(3), 223-233.

Wright, D. F. B., Stamp, L. K., Merriman, T. R., Barclay, M. L., Duffull, S. B., & Holford, N. H. G. (2013). The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology, 69(7), 1411-1421. doi: 10.1007/s00228-013-1478-8

Jamsen, K. M., Duffull, S. B., Tarning, J., Price, R. N., & Simpson, J. (2013). A robust design for identification of the Parasite Clearance Estimator. Malaria Journal, 12, 410. doi: 10.1186/1475-2875-12-410

Wright, D. F. B., & Duffull, S. B. (2013). A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics, 52(1), 59-68. doi: 10.1007/s40262-012-0017-6

Duffull, S. B., & Isbister, G. K. (2013). Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology, 51(8), 772-776. doi: 10.3109/15563650.2013.830733

Korell, J., & Duffull, S. B. (2013). A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms. Journal of Pharmacokinetics & Pharmacodynamics, 40(4), 469-478. doi: 10.1007/s10928-013-9322-4

Korell, J., Stamp, L. K., Barclay, M. L., Dalrymple, J. M., Drake, J., Zhang, M., & Duffull, S. B. (2013). A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics, 52(6), 475-485. doi: 10.1007/s40262-013-0052-y

Foo, L. K., & Duffull, S. (2012). Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies. Pharmaceutical Research, 29(6), 1530-1543. doi: 10.1007/s11095-011-0659-3

Foo, L. K., McGree, J., & Duffull, S. (2012). A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies. Pharmaceutical Statistics, 11(4), 325-333. doi: 10.1002/pst.1509

Foo, L. K., McGree, J., Eccleston, J., & Duffull, S. (2012). Comparison of robust criteria for D-optimal designs. Journal of Biopharmaceutical Statistics, 22(6), 1193-1205. doi: 10.1080/10543406.2011.580484

Loke, S.-K., Al-Sallami, H. S., Wright, D. F. B., McDonald, J., Jadhav, S., & Duffull, S. B. (2012). Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology, 28(4), 671-683. doi: 10.14742/ajet.834

Alskär, O., Korell, J., & Duffull, S. B. (2012). A pharmacokinetic model for the glycation of albumin. Journal of Pharmacokinetics & Pharmacodynamics, 39(3), 273-282. doi: 10.1007/s10928-012-9249-1

Lagishetty, C. V., Coulter, C. V., & Duffull, S. B. (2012). Design of pharmacokinetic studies for latent covariates. Journal of Pharmacokinetics & Pharmacodynamics, 39(1), 87-97. doi: 10.1007/s10928-011-9231-3

Lagishetty, C. V., Vajjah, P., & Duffull, S. B. (2012). A reduction in between subject variability is not mandatory for selecting a new covariate. Journal of Pharmacokinetics & Pharmacodynamics, 39, 383-392.

McGree, J. M., Drovandi, C. C., Thomson, M. H., Eccleston, J. A., Duffull, S. B., Mengersen, K., … Goggin, T. (2012). Adaptive Bayesian compound designs for dose finding studies. Journal of Statistical Planning & Inference, 142(6), 1480-1482. doi: 10.1016/j.jspi.2011.12.029

Vos, F. E., Schollum, J. B., Coulter, C. V., Manning, P. J., Duffull, S. B., & Walker, R. J. (2012). Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring. Nephrology, 17(2), 182-188. doi: 10.1111/j.1440-1797.2011.01517.x

Duffull, S. B., Graham, G., Mengersen, K., & Eccleston, J. (2012). Evaluation of the pre-posterior distribution of optimized sampling times for the design of pharmacokinetic studies. Journal of Biopharmaceutical Statistics, 22(1), 16-29. doi: 10.1080/10543406.2010.500065

Vajjah, P., & Duffull, S. B. (2012). A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies. Pharmaceutical Statistics, 11(6), 503-510. doi: 10.1002/pst.1542

Gulati, A., Faed, J. M., Isbister, G. K., & Duffull, S. B. (2012). Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharmaceutical Research, 29(1), 225-235. doi: 10.1007/s11095-011-0537-z

van Gorp, F., Duffull, S., Hackett, L. P., & Isbister, G. K. (2012). Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology, 73(3), 402-410. doi: 10.1111/j.1365-2125.2011.04091.x

Hatah, E., Braund, R., Duffull, S., & Tordoff, J. (2012). General practitioners' perceptions of pharmacists' new services in New Zealand. International Journal of Clinical Pharmacy, 34(2), 364-373. doi: 10.1007/s11096-012-9617-3

Korell, J., Coulter, C. V., & Duffull, S. B. (2011). Evaluation of red blood cell labelling methods based on a statistical model for red blood cell survival. Journal of Theoretical Biology, 291, 88-98. doi: 10.1016/j.jtbi.2011.09.016

Coulter, C. V., Farquhar, S. E., McSherry, C. M., Isbister, G. K., & Duffull, S. B. (2011). Methanol and ethylene glycol acute poisonings: Predictors of mortality. Clinical Toxicology, 49(10), 900-906. doi: 10.3109/15563650.2011.630320

Loke, S.-K., Tordoff, J., Winikoff, M., McDonald, J., Vlugter, P., & Duffull, S. (2011). SimPharm: How pharmacy students made meaning of a clinical case differently in paper- and simulation-based workshops. British Journal of Educational Technology, 42(5), 865-874. doi: 10.1111/j.1467-8535.2010.01113.x

Korell, J., Vos, F. E., Coulter, C. V., Schollum, J. B., Walker, R. J., & Duffull, S. B. (2011). Modeling red blood cell survival data. Journal of Pharmacokinetics & Pharmacodynamics, 38(6), 797-801. doi: 10.1007/s10928-011-9220-6

Wright, D. F. B., Winter, H. R., & Duffull, S. B. (2011). Understanding the time course of pharmacological effect: A PKPD approach. British Journal of Clinical Pharmacology, 71(6), 815-823. doi: 10.1111/j.1365-2125.2011.03925.x

Denman, N. G., McGree, J. M., Eccleston, J. A., & Duffull, S. B. (2011). Design of experiments for bivariate binary responses modelled by Copula functions. Computational Statistics & Data Analysis, 55(4), 1509-1520. doi: 10.1016/j.csda.2010.07.025

Wright, D. F. B., & Duffull, S. B. (2011). Development of a Bayesian forecasting method for warfarin dose individualisation. Pharmaceutical Research, 28(5), 1100-1111. doi: 10.1007/s11095-011-0369-x

Pavan Kumar, V. V., Isbister, G. K., & Duffull, S. B. (2011). The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose. British Journal of Clinical Pharmacology, 72(1), 125-132. doi: 10.1111/j.1365-2125.2011.03934.x

Joy, J. P., Coulter, C. V., Duffull, S. B., & Isbister, G. K. (2011). Prediction of Torsade de Pointes from the QT interval: Analysis of a case series of amisulpride overdoses. Clinical Pharmacology & Therapeutics, 90(2), 243-245. doi: 10.1038/clpt.2011.107

Young, S., & Duffull, S. B. (2011). A learning-based approach for performing an in-depth literature search using medline. Journal of Clinical Pharmacy & Therapeutics, 36(4), 504-512. doi: 10.1111/j.1365-2710.2010.01204.x

Duffull, S. B., Wright, D. F. B., & Winter, H. R. (2011). Interpreting population pharmacokinetic-pharmacodynamic analyses: A clinical viewpoint. British Journal of Clinical Pharmacology, 71(6), 807-814. doi: 10.1111/j.1365-2125.2010.03891.x

Wright, D. F. B., Pavan Kumar, V. V., Al-Sallami, H. S., & Duffull, S. B. (2011). The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Basic & Clinical Pharmacology & Toxicology, 109(6), 494-498. doi: 10.1111/j.1742-7843.2011.00757.x

Shen, F., Coulter, C. V., Isbister, G. K., & Duffull, S. B. (2011). A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose. Clinical Toxicology, 49(7), 643-647. doi: 10.3109/15563650.2011.604034

Vos, F. E., Schollum, J. B., Coulter, C. V., Doyle, T. C. A., Duffull, S. B., & Walker, R. J. (2011). Red blood cell survival (RBC) in patients on long-term dialysis. Nephrology, 16(Suppl. 1), 74. doi: 10.1111/j.1440-1797.2011.01493_7.x

Pavan Kumar, V. V., & Duffull, S. B. (2011). Evaluation of graphical diagnostics for assessing goodness of fit of logistic regression models. Journal of Pharmacokinetics & Pharmacodynamics, 38(2), 205-222. doi: 10.1007/s10928-010-9189-6

Vos, F. E., Schollum, J. B., Coulter, C. V., Doyle, T. C. A., Duffull, S. B., & Walker, R. J. (2011). Red blood cell survival in long-term dialysis patients. American Journal of Kidney Diseases, 58(4), 591-598. doi: 10.1053/j.ajkd.2011.03.031

Jamsen, K. M., Duffull, S. B., Tarning, J., Lindegardh, N., White, N. J., & Simpson, J. A. (2011). Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria. Malaria Journal, 10, 181. doi: 10.1186/1475-2875-10-181

Nath, C. E., Shaw, P. J., Trotman, J., Zeng, L., Duffull, S. B., Hegarty, G., … Earl, J. (2010). Population pharmacokinetics of melphalan in patients with multiple myeloma undergoing high dose therapy. British Journal of Clinical Pharmacology, 69(5), 484-497. doi: 10.1111/j.1365-2125.2010.03638.x

Foo, L.-K., & Duffull, S. (2010). Methods of robust design of nonlinear models with an application to pharmacokinetics. Journal of Biopharmaceutical Statistics, 20(4), 886-902. doi: 10.1080/10543401003618918

Isbister, G. K., Balit, C. R., MacLeod, D., & Duffull, S. B. (2010). Amisulpride overdose is frequently associated with QT prolongation and Torsades de pointes. Journal of Clinical Psychopharmacology, 30(4), 391-395. doi: 10.1097/JCP.0b013e3181e5c14c

Al-Sallami, H. S., Barras, M. A., Green, B., & Duffull, S. B. (2010). Routine plasma anti-Xa monitoring is required for low-molecular-weight heparins. Clinical Pharmacokinetics, 49(9), 567-571. doi: 10.2165/11532960-000000000-00000

Korell, J., Coulter, C. V., & Duffull, S. B. (2010). A statistical model for red blood cell survival. Journal of Theoretical Biology, 268, 39-49. doi: 10.1016/j.jtbi.2010.10.010

Barras, M. A., Duffull, S. B., Atherton, J. J., & Green, B. (2010). Individualized dosing of enoxaparin for subjects with renal impairment is superior to conventional dosing at achieving therapeutic concentrations. Therapeutic Drug Monitoring, 32(4), 482-488. doi: 10.1097/FTD.0b013e3181e64846

Yeo, T. W., Lampah, D. A., Tjitra, E., Gitawati, R., Darcy, C. J., Jones, C., … Duffull, S. B., … Anstey, N. M. (2010). Increased asymmetric dimethylarginine in severe falciparum malaria: Association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathogens, 6(4), e1000868. doi: 10.1371/journal.ppat.1000868

Zin, C. S., Nissen, L. M., O'Callaghan, J. P., Duffull, S. B., Smith, M. T., & Moore, B. J. (2010). A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin. Journal of Pain, 11(5), 462-471. doi: 10.1016/j.jpain.2009.09.003

Yeo, T. W., Lampah, D. A., Tjitra, E., . . ., Duffull, S. B., & et al (2009). Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. Journal of Infectious Diseases, 200(10), 1522-1529. doi: 10.1086/644641

Isbister, G. K., & Duffull, S. B. (2009). Quetiapine overdose: Predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. International Clinical Psychopharmacology, 24(4), 174-180. doi: 10.1097/YIC.0b013e32832bb078

Al-Sallami, H. S., Kumar, V. V. P., Landersdorfer, C. B., Bulitta, J. B., & Duffull, S. B. (2009). The time course of drug effects. Pharmaceutical Statistics, 8, 176-185. doi: 10.1002/pst.393

Waterhouse, T. H., Eccleston, J. A., & Duffull, S. B. (2009). Optimal design criteria for discrimination and estimation in nonlinear models. Journal of Biopharmaceutical Statistics, 19(2), 386-402. doi: 10.1080/10543400802677257

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