Contact Details
- Phone
- +64 3 479 8207
- rosemary.brown@otago.ac.nz
University Links
- Position
- Associate Professor
- Department
- Department of Physiology
- Qualifications
- BSc(Hons) PhD
- Research summary
- Neuroendocrinology
Research
I am interested in how the changing hormones of pregnancy and lactation act on neural circuitry in the maternal brain to influence behaviour. In particular, I focus on maternal behaviour, a complex set of behaviours displayed by a mother that promote the survival and wellbeing of her offspring.
Our work aims to understand how hormones normally act to direct a mother’s behaviour and how these processes may become disrupted. We investigate hormonal actions on neural circuitry underlying parental behaviour using a range of molecular, immunohistochemical and imaging approaches.
I am also interested in how changes in the ability of hormones to access the brain in different physiological or pathological states might underlie changes in hormone function.
Additional details
Major techniques used in our group:
- Use of transgenic mouse and viral technology to study how hormones acting in the brain alter behaviour
- Molecular biology to examine transcriptional changes in neurons during behaviour and In different reproductive states
- Tacking the movement of labelled hormones from the blood into the brain
- Immunohistochemistry and in situ hybridisation to map hormone responsive neurons in the brain
Publications
Hackwell, E., Ladyman, S. R., Clarkson, J., McQuillan, H. J., Boehm, U., Herbison, A. E., Brown, R. S. E., & Grattan, D. R. (2025). Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice. eLIFE, 13, RP94570. doi: 10.7554/eLife.94570.3 Journal - Research Article
Ladyman, S. R., Georgescu, T. R., Stewart, A. M., Khant Aung, Z., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2025). Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy. Cell Reports, 44(4), 115567. doi: 10.1016/j.celrep.2025.115567 Journal - Research Article
Pal, T., McQuillan, H. J., Wragg, L., & Brown, R. S. E. (2025). Hormonal actions in the medial preoptic area governing parental behaviour: Novel insights from new tools. Endocrinology, 166, bqae152. doi: 10.1210/endocr/bqae152 Journal - Research Article
Wragg, L. J., Cheong, I., McQuillan, J., & Brown, R. S. E. (2024, August-September). Progesterone signalling is required for the timely onset of maternal behaviour. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Cheong, I., & Brown, R. S. E. (2024, August-September). Limited bedding and nesting: A model for disrupting early development in pups and postpartum behaviour in dams. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
2025
Journal - Research Article
Hackwell, E., Ladyman, S. R., Clarkson, J., McQuillan, H. J., Boehm, U., Herbison, A. E., Brown, R. S. E., & Grattan, D. R. (2025). Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice. eLIFE, 13, RP94570. doi: 10.7554/eLife.94570.3
Ladyman, S. R., Georgescu, T. R., Stewart, A. M., Khant Aung, Z., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2025). Prolactin modulation of thermoregulatory circuits provides resilience to thermal challenge of pregnancy. Cell Reports, 44(4), 115567. doi: 10.1016/j.celrep.2025.115567
Pal, T., McQuillan, H. J., Wragg, L., & Brown, R. S. E. (2025). Hormonal actions in the medial preoptic area governing parental behaviour: Novel insights from new tools. Endocrinology, 166, bqae152. doi: 10.1210/endocr/bqae152
2024
Journal - Research Article
Menezes, F., Wasinski, F., de Souza, G. O., Nunes, A. P., Bernandes, E. S., dos Santos, S. N., … Brown, R. S. E., … Donato, J., Jr (2024). The pattern of growth hormone action in the mouse brain. Endocrinology, 165, bqae057. doi: 10.1210/endocr/bqae057
Khant Aung, Z., Ladyman, S. R., & Brown, R. S. E. (2024). Transient loss of satiety effects of leptin in middle-aged male mice. Journal of Neuroendocrinology, 36, e13386. doi: 10.1111/jne.13386
Conference Contribution - Poster Presentation (not in published proceedings)
Wragg, L. J., Cheong, I., McQuillan, J., & Brown, R. S. E. (2024, August-September). Progesterone signalling is required for the timely onset of maternal behaviour. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Cheong, I., & Brown, R. S. E. (2024, August-September). Limited bedding and nesting: A model for disrupting early development in pups and postpartum behaviour in dams. Poster session presented at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Georgescu, T., Stewart, A. M., Sawyer, I. L., Gillett, M. L., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2024, August-September). Investigating the role of prolactin in pregnancy-associated thermoregulatory changes. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
McQuillan, H. J., Perkinson, M. R., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2024, August-September). Transitioning from hostility to caring: Defining a dopamine related neural signature of paternal behaviour in mice. Verbal presentation at the 18th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2023
Journal - Research Article
Brown, R. S. E., Jacobs, I. M., Khant Aung, Z., Knowles, P. J., Grattan, D. R., & Ladyman, S. R. (2023). High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour. Journal of Neuroendocrinology, 35, e13350. doi: 10.1111/jne.13350
Smiley, K. O., Phillipps, H. R., Fang, C., Brown, R. S. E., & Grattan, D. R. (2023). Mating-induced prolactin surge is not required for subsequent neurogenesis in male mice. Frontiers in Behavioral Neuroscience, 17, 1227726. doi: 10.3389/fnbeh.2023.1227726
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2023). Mechanisms of lactation-induced infertility in female mice. Endocrinology, 164(5), bqad049. doi: 10.1210/endocr/bqad049
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2023). Pups and prolactin are rewarding to virgin female and pregnant mice. Journal of Neuroendocrinology, 35, e13232. doi: 10.1111/jne.13232
Conference Contribution - Published proceedings: Abstract
Perkinson, M. R., Deng, F., Li, Y., Brown, R. S. E., & Lonstein, J. S. (2023). Fiber photometric analysis of nucleus accumbens serotonin release during the display of maternal behavior in female mice. Proceedings of the Society for Neuroscience Annual Meeting. PSTR352.13/HH28. Retrieved from https://www.sfn.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Cheong, I., Clarkson, J., & Brown, R. S. E. (2023, August). Dynamic changes in hormone receptor expressionin galanin neurons in the MPOA of pregnant and lactating female mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Pal, T., Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2023, August). Dynamics of MPOA prolactin receptor-expressing neurons in freely behaving mice. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Campbell, G., Brown, R., & Iremonger, K. J. (2023, August). Investigating the influence of postpartum stress on anxiety and maternal motivation in dams and on offspring anxiety outcomes. Poster session presented at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
McQuillan, H. J., Grattan, D. R., & Brown, R. S. E. (2023, August). Investigating the role of prolactin sensitive medial preoptic neurons in driving paternal behaviour in mice: First steps and surprises. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Clarkson, J., Cheong, I., Grattan, D. R., & Brown, R. S. E. (2023, August). Stimulating mothers: Dissecting the maternal behaviour neural circuitry using optogenetics. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2022
Journal - Research Article
Khant Aung, Z., Masih, R. R., Desroziers, E., Campbell, R. E., & Brown, R. S. E. (2022). Enhanced pup retrieval behaviour in a mouse model of polycystic ovary syndrome. Journal of Neuroendocrinology, 34, e13206. doi: 10.1111/jne.13206
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2022). Prolactin action is necessary for parental behavior in male mice. Journal of Neuroscience, 42(44), 8308-8327. doi: 10.1523/jneurosci.0558-22.2022
Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. PNAS, 119(6), e2116972119. doi: 10.1073/pnas.2116972119
Conference Contribution - Published proceedings: Abstract
Georgescu, T., Khant Aung, Z., Grattan, D. R., & Brown, R. S. E. (2022). Prolactin-mediated restraint of maternal aggression in lactation. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2022). Prolactin-induced suppression of gonadotrophin secretion during lactation. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 240. Retrieved from https://www.esa-srb-apeg-nzse.org
Brown, R. (2022). Prolactin as a key regulator of maternal care-giving behaviour in mothers. Proceedings of the joint ESA-SRB-APEG-NZSE Annual Scientific Meeting. 224. Retrieved from https://www.esa-srb-apeg-nzse.org
Conference Contribution - Poster Presentation (not in published proceedings)
Clarkson, J., Grattan, D. R., & Brown, R. S. E. (2022, August-September). Dissecting the neural circuitry controlling maternal behaviour. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Wragg, L. J., Cheong, I., & Brown, R. S. E. (2022, August-September). Estrogen regulation of maternal aggression: A role for VMHvl in regulating fertility? Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Brown, R. S. E. (2022, August-September). Novel roles for prolactin in fine-tuning maternal responses. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2021
Journal - Research Article
Swart, J. M., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2021). Changes in maternal motivation across reproductive states in mice: A role for prolactin receptor activation on GABA neurons. Hormones & Behavior, 135, 105041. doi: 10.1016/j.yhbeh.2021.105041
Journal - Research Other
Georgescu, T., Swart, J. M., Grattan, D. R., & Brown, R. S. E. (2021). The prolactin family of hormones as regulators of maternal mood and behavior. Frontiers in Global Women's Health, 2, 767467. doi: 10.3389/fgwh.2021.767467
Conference Contribution - Published proceedings: Abstract
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2021). A novel role for prolactin in paternal behaviour. New Zealand Medical Journal, 134(1544), (pp. 190). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2020). Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse. Journal of Neuroendocrinology, 32, e12908. doi: 10.1111/jne.12908
Gustafson, P., Ladyman, S. R., McFadden, S., Larsen, C., Khant Aung, Z., Brown, R. S. E., Bunn, S. J., & Grattan, D. R. (2020). Prolactin receptor-mediated activation of pSTAT5 in the pregnant mouse brain. Journal of Neuroendocrinology, 32, e12901. doi: 10.1111/jne.12901
Stagkourakis, S., Smiley, K. O., Williams, P., Kakadellis, S., Ziegler, K., Bakker, J., Brown, R. S. E., … Grattan, D. R., & Broberger, C. (2020). A neuro-hormonal circuit for paternal behavior controlled by a hypothalamic network oscillation. Cell, 182, 960-975. doi: 10.1016/j.cell.2020.07.007
Barad, Z., Khant Aung, Z., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2020). Impaired prolactin transport into the brain and functional responses to prolactin in aged male mice. Journal of Neuroendocrinology, 32, e12889. doi: 10.1111/jne.12889
Journal - Research Other
Ladyman, S. R., Hackwell, E. C. R., & Brown, R. S. E. (2020). The role of prolactin in co-ordinating fertility and metabolic adaptations during reproduction. Neuropharmacology, 167, 107911. doi: 10.1016/j.neuropharm.2019.107911
Conference Contribution - Published proceedings: Abstract
Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2020). Identifying a role for lactogenic hormones in maternal motivation. Journal of the Endocrine Society, 4(Suppl. 1), (pp. A1075). doi: 10.1210/jendso/bvaa046.2131
2019
Chapter in Book - Research
Smiley, K. O., Ladyman, S. R., Gustafson, P., Grattan, D. R., & Brown, R. S. E. (2019). Neuroendocrinology and adaptive physiology of maternal care. In L. M. Coolen & D. R. Grattan (Eds.), Neuroendocrine regulation of behavior: Current topics in behavioral neurosciences (Vol. 43). (pp. 161-210). Cham, Switzerland: Springer. doi: 10.1007/7854_2019_122
Journal - Research Article
Brown, R. S. E., Khant Aung, Z., Phillipps, H. R., Barad, Z., Lein, H.-J., Boehm, U., Szawka, R. E., & Grattan, D. R. (2019). Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus. Endocrinology, 160(5), 1323-1332. doi: 10.1210/en.2019-00038
Gustafson, P., Ladyman, S. R., & Brown, R. S. E. (2019). Suppression of leptin transport into the brain contributes to leptin resistance during pregnancy in the mouse. Endocrinology, 160(4), 880-890. doi: 10.1210/en.2018-01065
Phillipps, H. R., Rand, C. J., Brown, R. S. E., Kokay, I. C., Stanton, J.-A., & Grattan, D. R. (2019). Prolactin regulation of insulin-like growth factor 2 gene expression in the adult mouse choroid plexus. FASEB Journal, 33, 6115-6128. doi: 10.1096/fj.201802262R
Conference Contribution - Published proceedings: Abstract
Barad, Z., Grattan, D., & Brown, R. (2019). Prolactin acts on glutamatergic neurons in the ventromedial nucleus of the hypothalamus to modulate maternal aggression. Journal of the Endocrine Society, 3(Suppl. 1), OR06-3. doi: 10.1210/js.2019-OR06-3
Conference Contribution - Poster Presentation (not in published proceedings)
Khant Aung, Z., Jacobs, I., Grattan, D. R., Brown, R. S. E., & Ladyman, S. R. (2019, August-September). Peripartum prolactin and growth hormone concentrations in diet-induced obese mice. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Identifying a novel role for prolactin in the transition to paternal care. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Hackwell, E. C. R., Brown, R. S. E., Ladyman, S. R., & Grattan, D. R. (2019, August-September). Prolactin action on kisspeptin neurons is required for maintaining lactational infertility. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Swart, J. M., Ladyman, S. R., Grattan, D. R., & Brown, R. S. E. (2019, September). The effect of reproductive experience on maternal motivation. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Georgescu, T., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2019, August-September). Investigating the acute effects of prolactin upon hypothalamic prolactin-receptor expressing neurons. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Conference Contribution - Published proceedings: Abstract
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Social Neuroscience 9th Annual Meeting. (pp. 33). Retrieved from https://www.s4sn.org
Smiley, K. O., Brown, R. S. E., & Grattan, D. R. (2018). Identifying prolactin-responsive neurons important for the transition to paternal care. Proceedings of the Society for Neuroscience 48th Annual Meeting. 108.08. SfN. Retrieved from https://www.sfn.org
Phillipps, H. R., Rand, C., Brown, R. S. E., Stanton, J.-A., & Grattan, D. (2018). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 125). Retrieved from http://www.icn2018.org/
Gustafson, P., Ladyman, S. R., Grattan, D., & Brown, R. S. E. (2018). Changing dynamics of prolactin and leptin transport into the brain during pregnancy and with aging. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 124). Retrieved from http://www.icn2018.org/
Brown, R. S. E. (2018). Prolactin signaling in the medial preoptic area is critical for maternal behavior. Proceedings of the 9th International Congress of Neuroendocrinology (ICN). (pp. 64). Retrieved from http://www.icn2018.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, November). Central prolactin action is required for maintaining lactational diestrus in mice. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Phillipps, H. R., Rand, C. J., Brown, R. S. E., Stanton, J.-A., & Grattan, D. R. (2018, November). Insulin-like growth factor 2, a prolactin-responsive gene in the adult mouse choroid plexus. Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, November). Are impairments in prolactin signalling in the brain of obese mice associated with deficits in maternal care? Poster session presented at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Barad, Z., Grattan, D. R., & Brown, R. S. E. (2018, November). Fine-tuning the maternal brain: How hormones modulate a mother's behaviour. Verbal presentation at the Women’s Wellbeing Symposium, Dunedin, New Zealand.
Brown, R. S. E. (2018, August). The modulation of maternal behaviour by prolactin. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Tawngdee, Y., Grattan, D. R., Ladyman, S. R., & Brown, R. S. E. (2018, August). The role of prolactin in reward aspects of maternal behaviour. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Jacobs, I., Brown, R. S. E., Grattan, D. R., & Ladyman, S. R. (2018, August). Are impairments in prolactin signaling in the brain of obese mice associated with deficits in maternal care? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Hackwell, E. C. R., Ladyman, S. R., Brown, R. S. E., & Grattan, D. R. (2018, August). Central prolactin action is required for maintaining lactational diestrus in mice. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2017
Journal - Research Article
Brown, R. S. E., Aoki, M., Ladyman, S. R., Phillipps, H. R., Wyatt, A., Boehm, U., & Grattan, D. R. (2017). Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior. PNAS, 114(40), 10779-10784. doi: 10.1073/pnas.1708025114
Ladyman, S. R., MacLeod, M. A., Khant Aung, Z., Knowles, P., Phillipps, H. R., Brown, R. S. E., & Grattan, D. R. (2017). Prolactin receptors in Rip-cre cells, but not in AgRP neurons, are involved in energy homeostasis. Journal of Neuroendocrinology, 29(10), e12474. doi: 10.1111/jne.12474
Conference Contribution - Poster Presentation (not in published proceedings)
Brown, R. S., Barad, Z., & Grattan, D. R. (2017, September). Changes in prolactin responsiveness of glutamate and nNos neurons in the female mouse brain during lactation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2016
Journal - Research Article
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., LeTissier, P., & Grattan, D. R. (2016). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Journal of Neuroscience, 36(35), 9173-9185. doi: 10.1523/jneurosci.1471-16.2016
Brown, R. S. E., Wyatt, A. K., Herbison, R. E., Knowles, P. J., Ladyman, S. R., Binart, N., … Grattan, D. R. (2016). Prolactin transport into mouse brain is independent of prolactin receptor. FASEB Journal, 30(2), 1002-1010. doi: 10.1096/fj.15-276519
Conference Contribution - Published proceedings: Abstract
Brown, R. (2016). Population-specific deletion of hypothalamic prolactin receptors identifies a critical role for maternal behaviour. Proceedings of the Australasian Neuroscience Society (ANS) Annual Scientific Meeting. Retrieved from https://www.ans.org.au
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Gustafson, P. E., Khant Aung, Z., Ladyman, S. R., & Grattan, D. R. (2016). Conditional deletion of prolactin receptor gene reveals remarkable redundancy in feedback regulation of tuberoinfundibular dopamine neurons by prolactin. Endocrine Reviews, 37(2, Suppl.), FRI-504. Retrieved from http://press.endocrine.org/series/endo-meetings
Conference Contribution - Poster Presentation (not in published proceedings)
Lien, R., Brown, R. S. E., Kokay, I. C., & Grattan, D. R. (2016, August). Role of kisspeptin in the prolactin-induced suppression of the pulsatile secretion of luteinizing hormone. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Brown, R. S. E., Kokay, I. C., Phillipps, H. R., Yip, S. H., Gustafson, P., Wyatt, A., Larsen, C. M., Knowles, P., Ladyman, S. R., … Grattan, D. R. (2016, August). Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus. Verbal presentation at the Medical Sciences Congress (MedSci), Nelson, New Zealand.
2015
Journal - Research Article
Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2015). Effects of prolactin and lactation on A15 dopamine neurons in the rostral preoptic area of female mice. Journal of Neuroendocrinology, 27(9), 708-717. doi: 10.1111/jne.12297
Conference Contribution - Verbal presentation and other Conference outputs
Phillipps, H. R., Brown, R. S. E., Rand, C., Stanton, J.-A., & Grattan, D. R. (2015, August). Prolactin influence on the mouse choroid plexus transcriptome. Verbal presentation at the 7th Annual New Zealand Next Generation Sequencing (NGS) Conference, Palmerston North, New Zealand.
2014
Journal - Research Article
Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Prolactin regulation of kisspeptin neurones in the mouse brain and its role in the lactation-induced suppression of kisspeptin expression. Journal of Neuroendocrinology, 26(12), 898-908. doi: 10.1111/jne.12223
Liu, X., Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2014). Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. Endocrinology, 155(1), 193-203. doi: 10.1210/en.2013-1621
Conference Contribution - Published proceedings: Abstract
Grattan, D. R., Kokay, I. C., Brown, R. S. E., Larsen, C. M., Wyatt, A., & Le Tissier, P. R. (2014). Conditional deletion of the prolactin receptor to identify brain-specific actions of prolactin. Endocrine Reviews, 35(3, Suppl.), OR35-4. Retrieved from http://press.endocrine.org/series/endo-meetings
Brown, R. S. E., Larsen, C. M., Cashen, S., Wyatt, A., Kokay, I. C., Knowles, P., … Grattan, D. R. (2014). Prolactin-sensitive GABAergic neurons contribute to the normal postpartum expression of maternal behaviour. Proceedings of the 8th International Congress of Neuroendocrinology (ICN) including the 18th Annual Meeting of the Society for Behavioural Neuroendocrinology. 277. Retrieved from http://icn-2014.p.asnevents.com.au
2013
Conference Contribution - Published proceedings: Abstract
Brown, R. S. E., Banks, W. A., Binart, N., & Grattan, D. R. (2013). Saturable transport of prolactin across the blood-brain barrier is independent of the prolactin receptor. Endocrine Reviews, 34(3, Suppl.), MON-135. Retrieved from http://press.endocrine.org/series/endo-meetings
Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013). Prolactin transport into the brain does not require the prolactin receptor. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 79). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Conference Contribution - Verbal presentation and other Conference outputs
Brown, R. S. E., Banks, W. A., & Grattan, D. R. (2013, August). Prolactin transport into the brain does not require the prolactin receptor. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2012
Journal - Research Article
Brown, R. S. E., Piet, R., Herbison, A. E., & Grattan, D. R. (2012). Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons. Endocrinology, 153(5), 2375-2384. doi: 10.1210/en.2011-2005
Conference Contribution - Published proceedings: Abstract
Brown, R. S., Herbison, A. E., & Grattan, D. R. (2012). The suppression of kisspeptin in the RP3V during lactation in mice. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://am2012.sfn.org/am2012/
2011
Journal - Research Article
Brown, R. S. E., Herbison, A. E., & Grattan, D. R. (2011). Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse. Biology of Reproduction, 84(4), 826-836. doi: 10.1095/biolreprod.110.089185
2010
Journal - Research Article
Brown, R. S. E., Kokay, I. C., Herbison, A. E., & Grattan, D. R. (2010). Distribution of prolactin-responsive neurons in the mouse forebrain. Journal of Comparative Neurology, 518(1), 92-102. doi: 10.1002/cne.22208
Conference Contribution - Verbal presentation and other Conference outputs
Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2010, November-December). Regulation of kisspeptin neurons by prolactin. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Brown, R. (2010, November-December). Kisspeptin regulation of prolactin secretion. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
Awarded Doctoral Degree
Brown, R. (2010). The mechanism of hyperprolactinaemia-induced infertility (PhD). University of Otago, Dunedin, New Zealand. 207p.
2009
Conference Contribution - Published proceedings: Abstract
Brown, R., Kokay, I., Herbison, A., & Grattan, D. (2009). Mechanism of hyperprolactinaemia-induced infertility. New Zealand Medical Journal, 122(1299). Retrieved from http://journal.nzma.org.nz/journal/122-1299/3706/content.pdf
2008
Conference Contribution - Published proceedings: Abstract
Geddes, R. S. E., Herbison, A. E., & Grattan, D. R. (2008). Mechanisms of prolactin induced inhibition of gonadotropin-releasing hormone (GnRH) neurons. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Kokay, I. C., Geddes, R. S. E., & Grattan, D. R. (2008). Characterisation of prolactin-sensitive neurons in regions of the preoptic area and rostral hypothalamus involved in the control of fertility in the rat. Proceedings of the Society for Neuroscience 38th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
2006
Conference Contribution - Published proceedings: Abstract
Geddes, R. S. E., Phipps, S. J., Grattan, D. R., & Anderson, G. M. (2006). Leptin treatment does not activate STAT3 in GnRH neurons: Evidence for indirect regulation. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf
Geddes, R., Grattan, D., & Anderson, G. (2006). Leptin does not act directly on gonadotrophin releasing hormone neurons to regulate fertility in rats. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf