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Contact Details

Email
lyvianne.decourtye@otago.ac.nz
Position
Research Fellow
Department
Department of Biochemistry
Research summary
Developmental biology and genetics

Research

I joined the Cancer Genetics Laboratory in Professor Parry Guilford team in September 2019. I am working on the development of chemoprevention and/or treatment for hereditary and sporadic diffuse gastric cancer, specifically cancer lacking E-cadherin expression. I am particularly focused on the impact of HDAC inhibitors on gastric and mammary cancer carrying CDH1 mutation, using 2D cellular culture and organoids.

Publications

Decourtye-Espiard, L., Godwin, T., & Guilford, P. (2025). Hereditary diffuse gastric cancer: the evolution of a cancer syndrome*. Journal of the Royal Society of New Zealand. Advance online publication. doi: 10.1080/03036758.2025.2511007 Journal - Research Other

Redpath, K. J., Bougen-Zhukov, N., Vaessen, C., Decourtye-Espiard, L., Schulpen, E., Godwin, T., McElroy, K., Black, M. A., & Guilford, P. (2024). Single-cell RNA-seq reveals candidate synergistic treatments for the chemoprevention of hereditary diffuse gastric cancer. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org Conference Contribution - Published proceedings: Abstract

Redpath, K., Vaessen, C., Decourtye-Espiard, L., Schulpen, E., Godwin, T., Bougen-Zhukov, N., McElroy, K., Black, M., & Guilford, P. (2023). Single-cell RNA-Seq reveals candidate synergistic treatments for the chemoprevention of hereditary diffuse gastric cancer. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract

Decourtye-Espiard, L., & Guilford, P. (2023). The chemoprevention of hereditary diffuse gastric cancer. In G. Corso, P. Veronesi & F. Roviello (Eds.), Hereditary gastric and breast cancer syndrome: CDH1: One genotype with multiple phenotypes. (pp. 321-341). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-21317-5_21 Chapter in Book - Research

Decourtye-Espiard, L., & Guilford, P. (2023). Hereditary diffuse gastric cancer. Gastroenterology, 164, 719-735. doi: 10.1053/j.gastro.2023.01.038 Journal - Research Other

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