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Dr Lyvianne Decourtye

University Links

Position
Research Fellow
Department
Department of Biochemistry
Research summary
Developmental biology and genetics

Research

I joined the Cancer Genetics Laboratory in Professor Parry Guilford team in September 2019. I am working on the development of chemoprevention and/or treatment for hereditary and sporadic diffuse gastric cancer, specifically cancer lacking E-cadherin expression. I am particularly focused on the impact of HDAC inhibitors on gastric and mammary cancer carrying CDH1 mutation, using 2D cellular culture and organoids.

Publications

Decourtye-Espiard, L., & Guilford, P. (2023). The chemoprevention of hereditary diffuse gastric cancer. In G. Corso, P. Veronesi & F. Roviello (Eds.), Hereditary gastric and breast cancer syndrome: CDH1: One genotype with multiple phenotypes. (pp. 321-341). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-21317-5_21

Decourtye-Espiard, L., & Guilford, P. (2023). Hereditary diffuse gastric cancer. Gastroenterology. Advance online publication. doi: 10.1053/j.gastro.2023.01.038

Bougen-Zhukov, N., Decourtye-Espiard, L., Mitchell, W., Redpath, K., Perkinson, J., Godwin, T., Black, M. A., & Guilford, P. (2022). E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers, 14, 1609. doi: 10.3390/cancers14071609

Decourtye, L., McCallum-Loudeac, J. A., Zellhuber-McMillan, S., Young, E., Sircombe, K. J., & Wilson, M. J. (2022). Characterization of a novel Lbx1 mouse loss of function strain. Differentiation, 123, 30-41. doi: 10.1016/j.diff.2021.12.001

Brew, T., Bougen-Zhukov, N., Mitchell, W., Decourtye, L., Schulpen, E., Nouri, Y., Godwin, T., & Guilford, P. (2021). Loss of E-cadherin leads to druggable vulnerabilities in sphingolipid metabolism and vesicle trafficking. Cancers, 14(1), 102. doi: 10.3390/ cancers14010102

Decourtye-Espiard, L., & Guilford, P. (2023). The chemoprevention of hereditary diffuse gastric cancer. In G. Corso, P. Veronesi & F. Roviello (Eds.), Hereditary gastric and breast cancer syndrome: CDH1: One genotype with multiple phenotypes. (pp. 321-341). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-21317-5_21

Chapter in Book - Research

Bougen-Zhukov, N., Decourtye-Espiard, L., Mitchell, W., Redpath, K., Perkinson, J., Godwin, T., Black, M. A., & Guilford, P. (2022). E-cadherin-deficient cells are sensitive to the multikinase inhibitor dasatinib. Cancers, 14, 1609. doi: 10.3390/cancers14071609

Journal - Research Article

Decourtye, L., McCallum-Loudeac, J. A., Zellhuber-McMillan, S., Young, E., Sircombe, K. J., & Wilson, M. J. (2022). Characterization of a novel Lbx1 mouse loss of function strain. Differentiation, 123, 30-41. doi: 10.1016/j.diff.2021.12.001

Journal - Research Article

Brew, T., Bougen-Zhukov, N., Mitchell, W., Decourtye, L., Schulpen, E., Nouri, Y., Godwin, T., & Guilford, P. (2021). Loss of E-cadherin leads to druggable vulnerabilities in sphingolipid metabolism and vesicle trafficking. Cancers, 14(1), 102. doi: 10.3390/ cancers14010102

Journal - Research Article

Decourtye-Espiard, L., Bougen-Zhukov, N., Godwin, T., Brew, T., Schulpen, E., Black, M. A., & Guilford, P. (2021). E-cadherin-deficient epithelial cells are sensitive to HDAC inhibitors. Cancers, 14(1), 175. doi: 10.3390/ cancers14010102

Journal - Research Article

Decourtye, L., Clemessy, M., Mire, E., Ledent, T., Périn, L., Robinson, I. C., … Kappeler, L. (2018). Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation. PLoS ONE, 13(2), e0193196. doi: 10.1371/journal. pone.0193196

Journal - Research Article

Decourtye, L., Mire, E., Clemessy, M., Heurtier, V., Ledent, T., Robinson, I. C., … Kappeler, L. (2017). IGF-1 induces GHRH neuronal axon elongation during early postnatal life in mice. PLoS ONE, 12(1), e0170083. doi: 10.1371/journal.pone.0170083

Journal - Research Article

Dumeige, L., Storey, C., Decourtye, L., Nehlich, M., Lhadj, C., Viengchareun, S., … Martinerie, L. (2017). Sex-specificity of mineralocorticoid target gene expression during renal development, and long-term consequences. International Journal of Molecular Sciences, 18(2), 457. doi: 10.3390/ijms18020457

Journal - Research Article

Kappeler, L., Clemessy, M., Saget, S., Decourtye, L., & Le Bouc, Y. (2017). Regulation of growth: Epigenetic mechanisms? [Régulation de la croissance: des mécanismes épigénétiques?]. Annales d'Endocrinologie, 78(2), 92-95. doi: 10.1016/j.ando.2017.04.004

Journal - Research Article

Lecoq, A.-L., Zizzari, P., Hage, M., Decourtye, L., Adam, C., Viengchareun, S., … Kamenický, P. (2016). Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice. Journal of Endocrinology, 231(1), 59-69. doi: 10.1530/JOE-16-0190

Journal - Research Article

Decourtye-Espiard, L., & Guilford, P. (2023). Hereditary diffuse gastric cancer. Gastroenterology. Advance online publication. doi: 10.1053/j.gastro.2023.01.038

Journal - Research Other

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