Dr Matthias Fellner

2026

Journal - Research Article

Randall, G., Meden, A., Rutledge, M. T., Prestreši, L., Rambaher, M. H., Chen, S., … Fellner, M. (2026). Carbamoyl fluorides as serine hydrolase inhibitors: A case study on FphI from Staphylococcus aureus. Bioorganic Chemistry, 176, 109834. doi: 10.1016/j.bioorg.2026.109834

Jo, J., Upadhyay, T., You, X., Bennett, J. M., Lee, H., Bogyo, M., & Fellner, M. (2026). Unique structural and ligand-binding properties of the Staphylococcus aureus serine hydrolase FphE. PNAS, 123(13), e2532683123. doi: 10.1073/pnas.2532683123

2025

Journal - Research Article

Sun, M., Fellner, M., Lv, C., Carne, A., Zang, J., Zhao, G., Bekhit, A. E.-D. A., & Zhang, T. (2025). Dual mechanisms of digestion-resistant proteins in food systems: Structural resistance and enzyme inhibition. Critical Reviews in Food Science & Nutrition. Advance online publication. doi: 10.1080/10408398.2025.2551784

Upadhyay, T., Woods, E. C., Dela Ahator, S., Julin, K., Faucher, F. F., Uddin, M. J., … Fellner, M., & Bogyo, M. (2025). Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation. Nature Communications, 16, 5046. doi: 10.1038/s41467-025-60367-3

Warring, S., Sisson, H. M., Randall, G., Grimon, D., Dams, D., Gutiérrez, D., Fellner, M., Fagerlund, R. D., … Jackson, S. A., & Fineran, P. C. (2025). Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2025.110224

Wang, S., Woods, E. C., Jo, J., Zhu, J., Hansel-Harris, A., Holcomb, M., … Fellner, M., … Bogyo, M. (2025). An mRNA display approach for covalent targeting of a Staphylococcus aureus virulence factor. Journal of the American Chemical Society. Advance online publication. doi: 10.1021/jacs.4c15713

Fellner, M., Randall, G., Bitac, I. R. C. G., Warrender, A. K., Sethi, A., Jelinek, R., & Kass, I. (2025). Similar but distinct: Biochemical characterization of the Staphylococcus aureus serine hydrolases FphH and FphI. Proteins, 93, 1009-1021. doi: 10.1002/prot.26785

2024

Journal - Research Article

Saseendran Nair, S., Kleffmann, T., Smith, B., Morris, V., Göbl, C., Pletzer, D., & Fellner, M. (2024). Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus. Analytical Biochemistry, 698, 115746. doi: 10.1016/j.ab.2024.115746

Yin, S., Duan, M., Fellner, M., Wang, Z., Lv, C., Zang, J., … Zhang, T. (2024). pH/Glucose dual-responsive protein-based hydrogels with enhanced adhesive and antibacterial properties for diabetic wound healing. Food Innovation & Advances, 3(4), 332-343. doi: 10.48130/fia-0024-0032

Putha, L., Kok, L. K., Fellner, M., Rutledge, M. T., Gamble, A. B., Wilbanks, S. M., Vernall, A. J., & Tyndall, J. D. A. (2024). Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. ChemMedChem, 19, e202400394. doi: 10.1002/cmdc.202400394

Jo, J., Upadhyay, T., Woods, E. C., Park, K. W., Pedowitz, N. J., Jaworek-Korjakowska, J., … Fellner, M., & Bogyo, M. (2024). Development of oxadiazolone activity-based probes targeting FphE for specific detection of Staphylococcus aureus infections. Journal of the American Chemical Society, 146, 6880-6892. doi: 10.1021/jacs.3c13974

Conference Contribution - Published proceedings: Abstract

Randall, G., Meden, A., Uddin, J., Lentz, C., Pletzer, D., Chen, S., & Fellner, M. (2024). Structure guided design of antimicrobials and diagnostic tools against ESKAPE pathogen virulence factors. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. (pp. 185). Retrieved from https://nzic.org.nz/conferences

Tyndall, J. D. A., Putha, L., Kok, L. K., Fellner, M., Rutledge, M. T., Gamble, A. B., Wilbanks, S. M., & Vernall, A. J. (2024). Covalent inhibition of macrophage migration inhibitory factor by isothiocyanates as potential colorectal cancer leads. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. (pp. 67). Retrieved from https://nzic.org.nz/conferences

Conference Contribution - Verbal presentation and other Conference outputs

Tyndall, J. D. A., Putha, L., Kok, L. K., Fellner, M., Rutledge, M. T., Gamble, A. B., Wilbanks, S. M., & Vernall, A. J. (2024, November). Covalent MIF inhibitors as anticancer leads. Verbal presentation at the School of Pharmacy Research Symposium, Dunedin, New Zealand.

2023

Journal - Research Article

Fellner, M., Walsh, A., Dela Ahator, S., Aftab, N., Sutherland, B., Tan, E. W., … Lentz, C. S. (2023). Biochemical and cellular characterization of the function of fluorophosphonate-binding hydrolase H (FphH) in Staphylococcus aureus support a role in bacterial stress response. ACS Infectious Diseases, 9(11), 2119-2132. doi: 10.1021/acsinfecdis.3c00246

Conference Contribution - Published proceedings: Abstract

Fellner, M., Lentz, C. S., & Bogyo, M. (2023). Development of molecular imaging and therapeutic agents for Staphylococcus aureus infections. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Smith-Beech, A., Fellner, M., & Pletzer, D. (2023). A biochemical description of UspN and its function in the anaerobic metabolism of Pseudomonas aeruginosa. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Tessadori, F., Duran, K., Knapp, K., Fellner, M., Makkers, J., Mace, P., Bicknell, L., & van Haaften, G. (2023). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. European Journal of Human Genetics, 31(Suppl. 1), (pp. 71-72). doi: 10.1038/s41431-023-01337-5

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M. (2023, February). Structure based drug design. Verbal presentation at the Maurice Wilkins Centre (MWC) for Molecular Biodiversity Symposium, Dunedin, New Zealand.

2022

Journal - Research Article

Tessadori, F., Duran, K., Knapp, K., Fellner, M., Deciphering Developmental Disorders Study, Smithson, S., … Robertson, S. P., … Mace, P. D., Bicknell, L. S., & van Haaften, G. (2022). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. American Journal of Human Genetics, 109, 750-758. doi: 10.1016/j.ajhg.2022.02.003

Journal - Research Other

Fellner, M. (2022). Newly discovered Staphylococcus aureus serine hydrolase probe and drug targets. ADMET & DMPK, 10(2), 107-114. doi: 10.5599/admet.1137

Other Research Output

Fellner, M. (2022, October). Development of molecular imaging and therapeutic agents for Staphylococcus aureus. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2021

Journal - Research Article

Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Willbanks, S. M., & Ledgerwood, E. C. (2021). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. Biochemical Journal, 478(3), 669-684. doi: 10.1042/bcj20200793

Chen, S., Lovell, S., Lee, S., Fellner, M., Mace, P. D., & Bogyo, M. (2021). Identification of highly selective covalent inhibitors by phage display. Nature Biotechnology, 39, 490-498. doi: 10.1038/s41587-020-0733-7

Conference Contribution - Published proceedings: Abstract

Fellner, M., Lentz, C., Bogyo, M., & Mace, P. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 261). Retrieved from https://www.faobmb2021.org

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. New Zealand Medical Journal, 134(1537), (pp. 114). Retrieved from https://www.nzma.org.nz/journal

2020

Journal - Research Article

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for the inhibitor and substrate specificity of the unique Fph serine hydrolases of Staphylococcus aureus. ACS Infectious Diseases, 6(10), 2771-2782. doi: 10.1021/acsinfecdis.0c00503

Desguin, B., Urdiain-Arraiza, J., Da Costa, M., Fellner, M., Hu, J., Hausinger, R. P., … Soumillion, P. (2020). Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases. Scientific Reports, 10, 18123. doi: 10.1038/s41598-020-74802-6

Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. Journal of Biological Chemistry, 295(24), 8272-8284. doi: 10.1074/jbc.RA120.013227

Fellner, M., Huizenga, K. G., Hausinger, R. P., & Hu, J. (2020). Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Scientific Reports, 10, 5830. doi: 10.1038/s41598-020-62847-6

Journal - Research Other

Reddington, C. J., Fellner, M., Burgess, A. E., & Mace, P. D. (2020). Molecular regulation of the polycomb repressive-deubiquitinase. International Journal of Molecular Sciences, 21(21), 1-15. doi: 10.3390/ijms21217837

Working Paper; Discussion Paper; Technical Report

Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for active-site probes targeting Staphylococcus aureus serine hyrdolase virulence factors. bioRXiv. doi: 10.1101/2020.04.21.054437

Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Wilbanks, S. M., & Ledgerwood, E. C. (2020). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. bioRxiv. doi: 10.1101/2020.06.14.151373

Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and function. bioRxiv. doi: 10.1101/2020.02.25.964783

2019

Conference Contribution - Published proceedings: Abstract

Fellner, M., Lentz, C. S., Bogyo, M. S., & Mace, P. D. (2019). Using structural insight to design new drugs against Staphylococcus aureus serine hydrolases. Proceedings of the 16th Conference of the Asian Crystallographic Association. Retrieved from https://asca2019.org/

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Foglizzo, M., Middleton, A. J., Burgess, A. E., Crowther, J. M., Dobson, R. C. J., … Day, C. L., & Mace, P. D. (2019, August-September). Structure of the polycomb repressive deubiquitinase complex. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Fellner, M., Hausinger, R. P., & Hu, J. (2018). A structural perspective on the PP-loop ATP pyrophosphatase family. Critical Reviews in Biochemistry & Molecular Biology, 53(6), 607-622. doi: 10.1080/10409238.2018.1516728

Fellner, M., Rankin, J. A., Desguin, B., Hu, J., & Hausinger, R. P. (2018). Analysis of the active site cysteine residue of the sacrificial sulfur insertase LarE from Lactobacillus plantarum. Biochemistry, 57(38), 5513-5523. doi: 10.1021/acs.biochem.8b00601

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Desguin, B., Rankin, J. A., Hausinger, R. P., & Hu, J. (2018, August). Lactate racemization: A story of so much more than just a nickel. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M., Desguin, B., Rankin, J., Hausinger, R., & Hu, J. (2018, December). Lactate racemization, a story of so much more than just a nickel. Verbal presentation at the Conference of the Asian Crystallographic Association (AsCA) and the Society of Crystallographers in Australia and New Zealand (SCANZ) (AsCA 2018/CRYSTAL 32), Auckland, New Zealand.

2017

Chapter in Book - Research

Fellner, M., Rankin, J. A., Hu, J., & Hausinger, R. P. (2017). Lactate racemase. In R. A. Scott (Ed.), Encyclopedia of inorganic and bioinorganic chemistry. John Wiley & Sons. doi: 10.1002/9781119951438.eibc2508

Journal - Research Article

Zhang, T., Liu, J., Fellner, M., Zhang, C., Sui, D., & Hu, J. (2017). Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway. Science Advances, 3(8), e1700344. doi: 10.1126/sciadv.1700344

Fellner, M., Desguin, B., Hausinger, R. P., & Hu, J. (2017). Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. PNAS, 114(34), 9074-9079. doi: 10.1073/pnas.1704967114

Martinez, S., Fellner, M., Herr, C. Q., Ritchie, A., Hu, J., & Hausinger, R. P. (2017). Structures and mechanisms of the non-heme Fe(II)- and 2-oxoglutarate-dependent ethylene-forming enzyme: Substrate binding creates a twist. Journal of the American Chemical Society, 139(34), 11980-11988. doi: 10.1021/jacs.7b06186

2016

Journal - Research Article

Tchesnokov, E. P., Faponle, A. S., Davies, C. G., Quesne, M. G., Turner, R., Fellner, M., Souness, R. J., Wilbanks, S. M., … Jameson, G. N. L. (2016). An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase. Chemical Communications, 52, 8814-8817. doi: 10.1039/c6cc03904a

Fellner, M., Siakkou, E., Faponle, A. S., Tchesnokov, E. P., de Visser, S. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Influence of cysteine 164 on active site structure in rat cysteine dioxygenase. Journal of Biological Inorganic Chemistry, 21, 501-510. doi: 10.1007/s00775-016-1360-0

Fellner, M., Aloi, S., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Substrate and pH-dependent kinetic profile of 3-mercaptopropionate dioxygenase from Pseudomonas aeruginosa. Biochemistry, 55(9), 1362-1371. doi: 10.1021/acs.biochem.5b01203

2015

Journal - Research Article

Tchesnokov, E. P., Fellner, M., Siakkou, E., Kleffmann, T., Martin, L. W., Aloi, S., Lamont, I. L., Wilbanks, S. M., & Jameson, G. N. L. (2015). The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase. Journal of Biological Chemistry, 290(40), 24424-24437. doi: 10.1074/jbc.M114.635672

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Tchesnokov, E. P., Souness, R. J., Wilbanks, S. M., & Jameson, G. N. L. (2015, August-September). Crystallographic analysis of an unusual posttranslation modification, a cysteine-tyrosine crosslink, in thiol dioxygenases. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Davies, C. G., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). The Cys-Tyr crosslink of cysteine dioxygenase changes the optimal pH of the reaction without structural change. Biochemistry, 53(50), 7961-7968. doi: 10.1021/bi501277a

Fellner, M., Doughty, L. M., Jameson, G. N. L., & Wilbanks, S. M. (2014). A chromogenic assay of substrate depletion by thiol dioxygenases. Analytical Biochemistry, 459, 56-60. doi: 10.1016/j.ab.2014.05.008

Conference Contribution - Published proceedings: Abstract

Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). Implications of cysteine-tyrosine crosslink in cysteine dioxygenase. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 74). Retrieved from http://www.crystal29.com/

Conference Contribution - Poster Presentation (not in published proceedings)

Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014, September). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M. (2014, June-July). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Verbal presentation at the New Zealand Structural Biology Meeting, Hanmer Springs, New Zealand.

Fellner, M. (2014, July). A chromogenic assay of substrate depletion by thiol diosygenases. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.

Tchesnokov, E. P., Turner, R., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2014, November-December). Rapid single turnover dioxygenation by substrate-bound cysteine dioxygenase. Invited presentation at the 7th Asian Biological Inorganic Chemistry Conference, Gold Coast, Australia.

2013

Conference Contribution - Published proceedings: Abstract

Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Proceedings of the 246th American Chemical Society (ACS) National Meeting & Exposition. ACS. Retrieved from http://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html

Conference Contribution - Poster Presentation (not in published proceedings)

Tchesnokov, E. P., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Mechanism of thiol dioxygenation: Dioxygen binding in the absence of thiols. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Doughty, L. M., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Modification of cysteine dioxygenase in the search for reactive intermediates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Fellner, M., Gruber, L., & Steiner, I. (2012). Migrationspotenzial von Kaffeefilter-Papieren. Deutsche Lebensmittel-Rundschau, 108(6), 305-312.

Conference Contribution - Published proceedings: Abstract

Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012). Cysteine dioxygenase unfaithful: And why we are excited about that. Proceedings of the Oxygen Theme Meeting. (pp. 31). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012, November). Cysteine dioxygenase unfaithful: And why we are excited about that. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.