2024
Journal - Research Article
Putha, L., Kok, L. K., Fellner, M., Rutledge, M. T., Gamble, A. B., Wilbanks, S. M., Vernall, A. J., & Tyndall, J. D. A. (2024). Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments. ChemMedChem. Advance online publication. doi: 10.1002/cmdc.202400394
Jo, J., Upadhyay, T., Woods, E. C., Park, K. W., Pedowitz, N. J., Jaworek-Korjakowska, J., … Fellner, M., & Bogyo, M. (2024). Development of oxadiazolone activity-based probes targeting FphE for specific detection of Staphylococcus aureus infections. Journal of the American Chemical Society. Advance online publication. doi: 10.1021/jacs.3c13974
2023
Journal - Research Article
Fellner, M., Walsh, A., Dela Ahator, S., Aftab, N., Sutherland, B., Tan, E. W., … Lentz, C. S. (2023). Biochemical and cellular characterization of the function of fluorophosphonate-binding hydrolase H (FphH) in Staphylococcus aureus support a role in bacterial stress response. ACS Infectious Diseases. Advance online publication. doi: 10.1021/acsinfecdis.3c00246
Conference Contribution - Published proceedings: Abstract
Fellner, M., Lentz, C. S., & Bogyo, M. (2023). Development of molecular imaging and therapeutic agents for Staphylococcus aureus infections. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Smith-Beech, A., Fellner, M., & Pletzer, D. (2023). A biochemical description of UspN and its function in the anaerobic metabolism of Pseudomonas aeruginosa. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference
Tessadori, F., Duran, K., Knapp, K., Fellner, M., Makkers, J., Mace, P., Bicknell, L., & van Haaften, G. (2023). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. European Journal of Human Genetics, 31(Suppl. 1), (pp. 71-72). doi: 10.1038/s41431-023-01337-5
2022
Journal - Research Article
Tessadori, F., Duran, K., Knapp, K., Fellner, M., Deciphering Developmental Disorders Study, Smithson, S., … Robertson, S. P., … Mace, P. D., Bicknell, L. S., & van Haaften, G. (2022). Recurrent de novo missense variants across multiple histone H4 genes underlie a neurodevelopmental syndrome. American Journal of Human Genetics, 109, 750-758. doi: 10.1016/j.ajhg.2022.02.003
Journal - Research Other
Fellner, M. (2022). Newly discovered Staphylococcus aureus serine hydrolase probe and drug targets. ADMET & DMPK, 10(2), 107-114. doi: 10.5599/admet.1137
Other Research Output
Fellner, M. (2022, October). Development of molecular imaging and therapeutic agents for Staphylococcus aureus. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2021
Journal - Research Article
Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Willbanks, S. M., & Ledgerwood, E. C. (2021). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. Biochemical Journal, 478(3), 669-684. doi: 10.1042/bcj20200793
Chen, S., Lovell, S., Lee, S., Fellner, M., Mace, P. D., & Bogyo, M. (2021). Identification of highly selective covalent inhibitors by phage display. Nature Biotechnology, 39, 490-498. doi: 10.1038/s41587-020-0733-7
Conference Contribution - Published proceedings: Abstract
Fellner, M., Lentz, C., Bogyo, M., & Mace, P. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 261). Retrieved from https://www.faobmb2021.org
Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2021). Structural basis for active-site probes targeting Staphylococcus aureus serine hydrolase virulence factors. New Zealand Medical Journal, 134(1537), (pp. 114). Retrieved from https://www.nzma.org.nz/journal
2020
Journal - Research Article
Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for the inhibitor and substrate specificity of the unique Fph serine hydrolases of Staphylococcus aureus. ACS Infectious Diseases, 6(10), 2771-2782. doi: 10.1021/acsinfecdis.0c00503
Desguin, B., Urdiain-Arraiza, J., Da Costa, M., Fellner, M., Hu, J., Hausinger, R. P., … Soumillion, P. (2020). Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases. Scientific Reports, 10, 18123. doi: 10.1038/s41598-020-74802-6
Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. Journal of Biological Chemistry, 295(24), 8272-8284. doi: 10.1074/jbc.RA120.013227
Fellner, M., Huizenga, K. G., Hausinger, R. P., & Hu, J. (2020). Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Scientific Reports, 10, 5830. doi: 10.1038/s41598-020-62847-6
Journal - Research Other
Reddington, C. J., Fellner, M., Burgess, A. E., & Mace, P. D. (2020). Molecular regulation of the polycomb repressive-deubiquitinase. International Journal of Molecular Sciences, 21(21), 1-15. doi: 10.3390/ijms21217837
Working Paper; Discussion Paper; Technical Report
Fellner, M., Lentz, C. S., Jamieson, S. A., Brewster, J. L., Chen, L., Bogyo, M., & Mace, P. D. (2020). Structural basis for active-site probes targeting Staphylococcus aureus serine hyrdolase virulence factors. bioRXiv. doi: 10.1101/2020.04.21.054437
Fellner, M., Parakra, R., McDonald, K. O., Kass, I., Jameson, G. N. L., Wilbanks, S. M., & Ledgerwood, E. C. (2020). Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. bioRxiv. doi: 10.1101/2020.06.14.151373
Good, N. M., Fellner, M., Demirer, K., Hu, J., Hausinger, R. P., & Martinez-Gomez, N. C. (2020). Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and function. bioRxiv. doi: 10.1101/2020.02.25.964783
2019
Conference Contribution - Published proceedings: Abstract
Fellner, M., Lentz, C. S., Bogyo, M. S., & Mace, P. D. (2019). Using structural insight to design new drugs against Staphylococcus aureus serine hydrolases. Proceedings of the 16th Conference of the Asian Crystallographic Association. Retrieved from https://asca2019.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Fellner, M., Foglizzo, M., Middleton, A. J., Burgess, A. E., Crowther, J. M., Dobson, R. C. J., … Day, C. L., & Mace, P. D. (2019, August-September). Structure of the polycomb repressive deubiquitinase complex. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2018
Journal - Research Article
Fellner, M., Hausinger, R. P., & Hu, J. (2018). A structural perspective on the PP-loop ATP pyrophosphatase family. Critical Reviews in Biochemistry & Molecular Biology, 53(6), 607-622. doi: 10.1080/10409238.2018.1516728
Fellner, M., Rankin, J. A., Desguin, B., Hu, J., & Hausinger, R. P. (2018). Analysis of the active site cysteine residue of the sacrificial sulfur insertase LarE from Lactobacillus plantarum. Biochemistry, 57(38), 5513-5523. doi: 10.1021/acs.biochem.8b00601
Conference Contribution - Poster Presentation (not in published proceedings)
Fellner, M., Desguin, B., Rankin, J. A., Hausinger, R. P., & Hu, J. (2018, August). Lactate racemization: A story of so much more than just a nickel. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Fellner, M., Desguin, B., Rankin, J., Hausinger, R., & Hu, J. (2018, December). Lactate racemization, a story of so much more than just a nickel. Verbal presentation at the Conference of the Asian Crystallographic Association (AsCA) and the Society of Crystallographers in Australia and New Zealand (SCANZ) (AsCA 2018/CRYSTAL 32), Auckland, New Zealand.
2017
Chapter in Book - Research
Fellner, M., Rankin, J. A., Hu, J., & Hausinger, R. P. (2017). Lactate racemase. In R. A. Scott (Ed.), Encyclopedia of inorganic and bioinorganic chemistry. John Wiley & Sons. doi: 10.1002/9781119951438.eibc2508
Journal - Research Article
Zhang, T., Liu, J., Fellner, M., Zhang, C., Sui, D., & Hu, J. (2017). Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway. Science Advances, 3(8), e1700344. doi: 10.1126/sciadv.1700344
Fellner, M., Desguin, B., Hausinger, R. P., & Hu, J. (2017). Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE. PNAS, 114(34), 9074-9079. doi: 10.1073/pnas.1704967114
Martinez, S., Fellner, M., Herr, C. Q., Ritchie, A., Hu, J., & Hausinger, R. P. (2017). Structures and mechanisms of the non-heme Fe(II)- and 2-oxoglutarate-dependent ethylene-forming enzyme: Substrate binding creates a twist. Journal of the American Chemical Society, 139(34), 11980-11988. doi: 10.1021/jacs.7b06186
2016
Journal - Research Article
Tchesnokov, E. P., Faponle, A. S., Davies, C. G., Quesne, M. G., Turner, R., Fellner, M., Souness, R. J., Wilbanks, S. M., … Jameson, G. N. L. (2016). An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase. Chemical Communications, 52, 8814-8817. doi: 10.1039/c6cc03904a
Fellner, M., Siakkou, E., Faponle, A. S., Tchesnokov, E. P., de Visser, S. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Influence of cysteine 164 on active site structure in rat cysteine dioxygenase. Journal of Biological Inorganic Chemistry, 21, 501-510. doi: 10.1007/s00775-016-1360-0
Fellner, M., Aloi, S., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2016). Substrate and pH-dependent kinetic profile of 3-mercaptopropionate dioxygenase from Pseudomonas aeruginosa. Biochemistry, 55(9), 1362-1371. doi: 10.1021/acs.biochem.5b01203
2015
Journal - Research Article
Tchesnokov, E. P., Fellner, M., Siakkou, E., Kleffmann, T., Martin, L. W., Aloi, S., Lamont, I. L., Wilbanks, S. M., & Jameson, G. N. L. (2015). The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase. Journal of Biological Chemistry, 290(40), 24424-24437. doi: 10.1074/jbc.M114.635672
Conference Contribution - Poster Presentation (not in published proceedings)
Fellner, M., Tchesnokov, E. P., Souness, R. J., Wilbanks, S. M., & Jameson, G. N. L. (2015, August-September). Crystallographic analysis of an unusual posttranslation modification, a cysteine-tyrosine crosslink, in thiol dioxygenases. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Journal - Research Article
Davies, C. G., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). The Cys-Tyr crosslink of cysteine dioxygenase changes the optimal pH of the reaction without structural change. Biochemistry, 53(50), 7961-7968. doi: 10.1021/bi501277a
Fellner, M., Doughty, L. M., Jameson, G. N. L., & Wilbanks, S. M. (2014). A chromogenic assay of substrate depletion by thiol dioxygenases. Analytical Biochemistry, 459, 56-60. doi: 10.1016/j.ab.2014.05.008
Conference Contribution - Published proceedings: Abstract
Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014). Implications of cysteine-tyrosine crosslink in cysteine dioxygenase. Proceedings of the CRYSTAL29: 29th Biennial Conference of the Society of Crystallographers in Australia and New Zealand (SCANZ). (pp. 74). Retrieved from http://www.crystal29.com/
Conference Contribution - Poster Presentation (not in published proceedings)
Fellner, M., Souness, R. J., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2014, September). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Fellner, M. (2014, June-July). Implications of the cysteine-tyrosine crosslink in cysteine dioxygenase. Verbal presentation at the New Zealand Structural Biology Meeting, Hanmer Springs, New Zealand.
Fellner, M. (2014, July). A chromogenic assay of substrate depletion by thiol diosygenases. Verbal presentation at the Oxygen Theme Meeting, Christchurch, New Zealand.
Tchesnokov, E. P., Turner, R., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2014, November-December). Rapid single turnover dioxygenation by substrate-bound cysteine dioxygenase. Invited presentation at the 7th Asian Biological Inorganic Chemistry Conference, Gold Coast, Australia.
2013
Conference Contribution - Published proceedings: Abstract
Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Proceedings of the 246th American Chemical Society (ACS) National Meeting & Exposition. ACS. Retrieved from http://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html
Conference Contribution - Poster Presentation (not in published proceedings)
Tchesnokov, E. P., Fellner, M., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Mechanism of thiol dioxygenation: Dioxygen binding in the absence of thiols. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Fellner, M., Tchesnokov, E. P., Siakkou, E., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Cysteine dioxygenase from Pseudomonas aeruginosa is a true thiol dioxygenase. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Doughty, L. M., Fellner, M., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2013, August). Modification of cysteine dioxygenase in the search for reactive intermediates. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2012
Journal - Research Article
Fellner, M., Gruber, L., & Steiner, I. (2012). Migrationspotenzial von Kaffeefilter-Papieren. Deutsche Lebensmittel-Rundschau, 108(6), 305-312.
Conference Contribution - Published proceedings: Abstract
Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012). Cysteine dioxygenase unfaithful: And why we are excited about that. Proceedings of the Oxygen Theme Meeting. (pp. 31). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Fellner, M., Siakkou, E., Tchesnokov, E. P., Wilbanks, S. M., & Jameson, G. N. L. (2012, November). Cysteine dioxygenase unfaithful: And why we are excited about that. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.
