Red X iconGreen tick iconYellow tick icon

Contact Details

Phone
64 3 479 7869
Email
iain.lamont@otago.ac.nz
Position
Emeritus Professor
Department
Department of Biochemistry
Qualifications
BSc (Edin) DPhil (Oxon)
Research summary
Molecular basis of infectious disease
Teaching
Biochemistry; genetics; molecular biology
Clinical
Interests: cystic fibrosis; bronchiectasis, antibiotic resistance

Research

Iain has a long-standing interest in the molecular genetics of bacteria that cause infectious disease.

He and his research team have a particular focus on the pathogenic bacterium Pseudomonas aeruginosa that causes a wide range of infections such as chronic infections in patients in cystic fibrosis.

During infection the bacteria secrete a number of agents that contribute to the pathogenic process. These include numerous proteins and an iron-scavenging compound called pyoverdine. Iain and his team are also using a wide range of biochemical, molecular biological, and genetic approaches to study the way in which pyoverdine contributes to infection and how it is made.

P. aeruginosa become very resistant to antibiotics during infection and highly resistant strains ("superbugs") are some of the most problematic infectious bacteria on the planet. Iain and his research team are using genetic, bioinformatic and molecular approaches to understand how P. aeruginosa becomes resistant to antibiotics with the long term goal of better management of infections.

Current research areas include:

  • Understanding how P. aeruginosa resists antibiotics

  • How does P. aeruginosa exist in the environment, and during infection?

  • Genomics and comparative genomics of Pseudomonas

Publications

Lyons, N., Wu, W., Jin, Y., Lamont, I. L., & Pletzer, D. (2024). Using host-mimicking conditions and a murine cutaneous abscess model to identify synergistic antibiotic combinations effective against Pseudomonas aeruginosa. Frontiers in Cellular & Infection Microbiology, 14, 1352339. doi: 10.3389/fcimb.2024.1352339 Journal - Research Article

Lamont, I. (2023). Understanding a bacterial gene regulatory pathway: The importance of emerging technologies [Keynote]. Proceedings of the Genetics Otago (GO) Annual Symposium & Workshops. Retrieved from https://blogs.otago.ac.nz/go Conference Contribution - Published proceedings: Abstract

Erdmann, M. B., Gardner, P. P., & Lamont, I. L. (2023). The PitA protein contributes to colistin susceptibility in Pseudomonas aeruginosa. PLoS ONE, 18(10), e0292818. doi: 10.1371/journal.pone.0292818 Journal - Research Article

Wei, X., Gao, J., Xu, C., Pan, X., Jin, Y., Bai, F., … Lamont, I. L., Pletzer, D., & Wu, W. (2023). Murepavadin induces envelope stress response and enhances the killing efficacies of β-lactam antibiotics by impairing the outer membrane integrity of Pseudomonas aeruginosa. Microbiology Spectrum. Advance online publication. doi: 10.1128/spectrum.01257-23 Journal - Research Article

Martin, L. W., Gray, A. R., Brockway, B., & Lamont, I. L. (2023). Pseudomonas aeruginosa is oxygen-deprived during infection in cystic fibrosis lungs, reducing the effectiveness of antibiotics. FEMS Microbiology Letters, fnad076. Advance online publication. doi: 10.1093/femsle/fnad076 Journal - Research Article

Back to top