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Contact Details

Email
craig.marshall@otago.ac.nz
Position
Associate Professor
Department
Department of Biochemistry
Qualifications
BSc (Hons) PhD (Otago)
Research summary
Biochemistry, physiology and ecology of cold adaptation

Research

Our major goal in this work is to improve our understanding of the structural and functional adaptations of the enzymes that fit them for function in Antarctic fish and how these adaptations compare with those of related fish from more temperate waters. In the long-term we plan to examine a number of proteins so that we can produce a general picture of how low temperature affects protein structure and function. This work will also deepen our understanding of the mechanisms by which ligands interact with enzymes and will improve our knowledge of how proteins fold.

In addition to the general question of how proteins fold to allow activity at low temperatures, we are interested in the specific question of the nature of the structure of antifreeze glycopeptides. We wish to answer this question by growing crystals of these proteins and solving the structure by X-ray crystallography.

Publications

Morris, J., Liddy, M., & Marshall, C. J. (2024). Ice shell purification of ice-active compounds. In R. Drori & C. A. Stevens (Eds.), Ice binding proteins: Methods and protocols: Methods in molecular biology (Vol. 2730). (pp. 25-34). New York, NY: Humana Press. doi: 10.1007/978-1-0716-3503-2_2 Chapter in Book - Research

Morgan-Richards, M., Marshall, C. J., Biggs, P. J., & Trewick, S. A. (2023). Insect freeze-tolerance Downunder: The microbial connection. Insects, 14(1), 89. doi: 10.3390/insects14010089 Journal - Research Article

Wilson, P. W., Marshall, C., Bayer-Giraldi, M., & Mateo, M. A. (2020). Evidence for transition of metastable ice to hexagonal ice in bulk solutions at relatively high temperatures. International Journal of Geosciences, 11(8), 493-500. doi: 10.4236/ijg.2020.118025 Journal - Research Article

Zawierucha, K., Marshall, C. J., Wharton, D., & Janko, K. (2019). A nematode in the mist: Scottnema lindsayae is the only soil metazoan in remote Antarctic deserts, at greater densities with altitude. Polar Research, 38, 1-12. doi: 10.33265/polar.v38.3494 Journal - Research Article

Tate, W. P., & Marshall, C. J. (2018). Post-dormancy transcription and translation in the brine shrimp. In R. A. Browne, P. Sorgeloos & C. N. A. Trotman (Eds.), Artemia biology. (pp. 21-36). Boca Raton, FL: Taylor & Francis. doi: 10.1201/9781351069892 Chapter in Book - Other

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