Dr Miriam Sharpe
Contact Details
- Phone
- +64 3 479 7704
- miriam.sharpe@otago.ac.nz
University Links
- Position
- Website, Publicity and Outreach
- Department
- Department of Biochemistry
- Qualifications
- PhD
- Research summary
- Protein structure and function
Research
In my current role, I explain research carried out in the Biochemistry Department, report on departmental news, and facilitate publicity and outreach activities.
Publications
Watkins, O. C., Sharpe, M. L., Perry, N. B., & Krause, K. L. (2018). New Zealand glowworm (Arachnocampa luminosa) bioluminescence is produced by a firefly-like luciferase but an entirely new luciferin. Scientific Reports, 8(3278). doi: 10.1038/s41598-018-21298-w
Gimenez, G., Metcalf, P., Paterson, N. G., & Sharpe, M. L. (2016). Mass spectrometry analysis and transcriptome sequencing reveal glowing squid crystal proteins are in the same superfamily as firefly luciferase. Scientific Reports, 6, 27638. doi: 10.1038/srep27638
Sharpe, M. L., Dearden, P. K., Gimenez, G., & Krause, K. L. (2015). Comparative RNA seq analysis of the New Zealand glowworm Arachnocampa luminosa reveals bioluminescence-related genes. BMC Genomics, 16, 825. doi: 10.1186/s12864-015-2006-2
Sharpe, M. L., Hastings, J. W., & Krause, K. L. (2014). Luciferases and light-emitting accessory proteins: Structural biology. In eLS. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0003064.pub2
Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury. III, W. J., … Gamblin, S. J. (2009). Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 431, 762-767. doi: 10.1038/nature08398
Watkins, O. C., Sharpe, M. L., Perry, N. B., & Krause, K. L. (2018). New Zealand glowworm (Arachnocampa luminosa) bioluminescence is produced by a firefly-like luciferase but an entirely new luciferin. Scientific Reports, 8(3278). doi: 10.1038/s41598-018-21298-w
Journal - Research Article
Gimenez, G., Metcalf, P., Paterson, N. G., & Sharpe, M. L. (2016). Mass spectrometry analysis and transcriptome sequencing reveal glowing squid crystal proteins are in the same superfamily as firefly luciferase. Scientific Reports, 6, 27638. doi: 10.1038/srep27638
Journal - Research Article
Sharpe, M. L., Dearden, P. K., Gimenez, G., & Krause, K. L. (2015). Comparative RNA seq analysis of the New Zealand glowworm Arachnocampa luminosa reveals bioluminescence-related genes. BMC Genomics, 16, 825. doi: 10.1186/s12864-015-2006-2
Journal - Research Article
Sharpe, M. L., Hastings, J. W., & Krause, K. L. (2014). Luciferases and light-emitting accessory proteins: Structural biology. In eLS. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0003064.pub2
Chapter in Book - Research
Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury. III, W. J., … Gamblin, S. J. (2009). Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 431, 762-767. doi: 10.1038/nature08398
Journal - Research Article
Im, H., Sharpe, M. L., Strych, U., Davlieva, M., & Krause, K. L. (2011). The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design. BMC Microbiology, 11, 116. doi: 10.1186/1471-2180-11-116
Journal - Research Article
Patrick, W. M., Nakatani, Y., Cutfield, S. M., Sharpe, M. L., Ramsay, R. J., & Cutfield, J. F. (2010). Carbohydrate binding sites in Candida albicans exo-β-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance. FEBS Journal, 277, 4549-4561. doi: 10.1111/j.1742-4658.2010.07869.x
Journal - Research Article
Sharpe, M. L., Gao, C., Kendall, S. L., Baker, E. N., & Lott, J. S. (2008). The structure and unusual protein chemistry of hypoxic response protein 1, a latency anitgen and highly expressed member of the DosR regulation in Mycobacterium tuberculosis. Journal of Molecular Biology, 383(4), 822-836. doi: 10.1016/j.jmb.2008.07.001
Journal - Research Article