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Profile

Professor Peter Dearden

PositionProfessor and Head of Department
DepartmentDepartment of Biochemistry
QualificationsBSc(Hons) PhD
Research summaryEvolution, development, and genome evolution

Research

Evolution and development, genome evolution

Genetic studies have helped us to understand the molecular control of development in a small number of model systems. In Drosophila melanogaster and Caenorhabditis elegans, for example, we can trace the molecular events that pattern specific body parts all the way back to the fertilised egg. What is unclear is how these patterning processes change over evolutionary time to give us the diversity of morphology we see in organisms today.

Our lab aims to understand the molecular basis of morphological evolution by studying how the developmental pathways that regulate embryogenesis evolve to produce different animal morphologies. To study this we use two model systems, the Honeybee (Apis mellifera) and a Rotifer (Brachionus plicatilis).

The evolution of developmental pathways

To understand and model the evolution of developmental pathways we need to study how evolutionary processes affect the complex interactions of genes and proteins that pattern embryos. One of the best model systems for understanding pattern formation is segmentation in the fruit fly Drosophila melanogaster. Twenty years of study of this system has lead to an almost complete understanding of how genes and their product produce the segments of Drosophila. We are studying how this system has evolved by looking at the same segmentation process in the Honeybee. Honeybee segmentation is homologous to segmentation in Drosophila, uses many of the same genes, but is different in its morphological and molecular details. Using RNAi and transgenic Drosophila we are trying to understand how these molecular and morphological changes have come about. This study should give us a better understanding of the way in which developmental processes evolved and will perhaps lead to a predictive theory of the evolution of development.

Deep homology and the evolution of animals

Little is known about the genetic control of development in animals other than the well-studied genetic model systems Drosophila, Caenorhabditis, Zebrafish and mouse. One group of animals that are poorly researched are the Lophotrochozoa, a group of animal phyla including annelids, molluscs, platyhelminths, rotifers and others. Without understanding how these animals regulate development we are unable to develop a clear picture of the evolutionary history of animals. To study the genetic control of development in the Lophotrochozoa we are using a Rotifer, Brachionus plicatilis, as a model system. Rotifers are tiny aquatic animals that are easy to grow in the laboratory and have a short generation time. We have developed technique to examine gene expression and function and are using these to understand development in this animal.

These projects are funded by a Royal Society of New Zealand Marsden Grant and a University of Otago Research Grant.

Awards

  • Peter Dearden
    2016, Best Research Paper of the Year by a BMS Researcher
  • Peter Dearden
    2014, Genetics Society of AustralAsia Ross Crozier Medal
    For outstanding contributions to genetics
  • Peter Dearden
    2014, Callaghan Medal for science communication
    For the outreach activities of Genetics Otago that he helped form and his involvement in communicating his genetics research on honey bees with the beekeeping industry and the public.
  • Peter Dearden and Dr Elizabeth Duncan
    2010, Otago School of Medical Sciences Best Paper Award

Publications

Wold, J. R., Guhlin, J. G., Dearden, P. K., Santure, A. W., & Steeves, T. E. (2023). The promise and challenges of characterising genome-wide structural variants: A case study in a critically endangered parrot. Molecular Ecology Resources. Advance online publication. doi: 10.1111/1755-0998.13783

West, A. G., Digby, A., Kākāpō Recovery Team, Kākāpō Aspergillosis Research Consortium, including Dearden, P. K., Gemmell, N. J., Guhlin, J., Le Lec, M., Quinones Mateu, M., and Taylor, M. D. (2023). The mycobiota of faeces from the critically endangered kākāpō and associated nest litter. New Zealand Journal of Zoology. Advance online publication. doi: 10.1080/03014223.2023.2170428

Digby, A., Eason, D., Catalina, A., Lierz, M., Galla, S., Urban, L., Le Lec, M. F., Guhlin, J., Steeves, T. E., Dearden, P. K., … Kākāpō Recovery Team. (2023). Hidden impacts of conservation management on fertility of the critically endangered kākāpō. PeerJ, 11, e14675. doi: 10.7717/peerj.14675

Lovegrove, M. R., Dearden, P. K., & Duncan, E. J. (2023). Honeybee queen mandibular pheromone induces a starvation response in Drosophila melanogaster. Insect Biochemistry & Molecular Biology, 154, 103908. doi: 10.1016/j.ibmb.2023.103908

Inwood, S., Harrop, T. W. R., & Dearden, P. K. (2023). The venom composition and parthenogenesis mechanism of the parasitoid wasp Microctonus hyperodae, a declining biocontrol agent. Insect Biochemistry & Molecular Biology, 153, 103897. doi: 10.1016/j.ibmb.2022.103897

Cridge, A. G., Dearden, P. K., & Brownfield, L. R. (2019). The developmental hourglass in the evolution of embryogenesis. In L. N. de la Rosa & G. Müller (Eds.), Evolutionary developmental biology: A reference guide. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-33038-9

Chapter in Book - Research

Dearden, P. K. (2019). Hourglass or twisted ribbon? In W. Tworzydlo & S. M. Bilinski (Eds.), Evo-Devo: Non-model species in cell developmental biology: Results and problems in cell differentiation. (pp. 21-29). Cham, Switzerland: Springer. doi: 10.1007/978-3-030-23459-1_2

Chapter in Book - Research

Cridge, A., Harrop, T., Lovegrove, M., Remnant, E., & Dearden, P. (2017). Nutrition and epigenetic change in insects: Evidence and implications. In H. Verlinden (Ed.), Advances in insect physiology (Vol. 53): Insect epigenetics. (pp. 31-54). London, UK: Academic Press. doi: 10.1016/bs.aiip.2017.06.001

Chapter in Book - Research

Osborne, A. J., Duncan, E. J., Cridge, A. G., & Dearden, P. K. (2014). Epigenetics and the maternal germline. In T. Tollefsbol (Ed.), Transgenerational epigenetics: Evidence and debate. (pp. 27-41). London, UK: Academic Press. doi: 10.1016/B978-0-12-405944-3.00004-0

Chapter in Book - Research

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2010). The honeybee Apis mellifera. In Emerging model organisms: A laboratory manual (Vol. 2). (pp. 223-246). Cold Spring Harbor, NY: Cold Spring Harbor Press.

Chapter in Book - Research

Digby, A., Eason, D., Catalina, A., Lierz, M., Galla, S., Urban, L., Le Lec, M. F., Guhlin, J., Steeves, T. E., Dearden, P. K., … Kākāpō Recovery Team. (2023). Hidden impacts of conservation management on fertility of the critically endangered kākāpō. PeerJ, 11, e14675. doi: 10.7717/peerj.14675

Journal - Research Article

Inwood, S., Harrop, T. W. R., & Dearden, P. K. (2023). The venom composition and parthenogenesis mechanism of the parasitoid wasp Microctonus hyperodae, a declining biocontrol agent. Insect Biochemistry & Molecular Biology, 153, 103897. doi: 10.1016/j.ibmb.2022.103897

Journal - Research Article

Lovegrove, M. R., Dearden, P. K., & Duncan, E. J. (2023). Honeybee queen mandibular pheromone induces a starvation response in Drosophila melanogaster. Insect Biochemistry & Molecular Biology, 154, 103908. doi: 10.1016/j.ibmb.2023.103908

Journal - Research Article

West, A. G., Digby, A., Kākāpō Recovery Team, Kākāpō Aspergillosis Research Consortium, including Dearden, P. K., Gemmell, N. J., Guhlin, J., Le Lec, M., Quinones Mateu, M., and Taylor, M. D. (2023). The mycobiota of faeces from the critically endangered kākāpō and associated nest litter. New Zealand Journal of Zoology. Advance online publication. doi: 10.1080/03014223.2023.2170428

Journal - Research Article

Karunaraj, P., Tidswell, O., Duncan, E. J., Lovegrove, M. R., Jefferies, G., Johnson, T. K., Beck, C. W., & Dearden, P. K. (2022). Noggin proteins are multifunctional extracellular regulators of cell signalling. Genetics. Advance online publication. doi: 10.1093/genetics/iyac049

Journal - Research Article

Palmer, S., Dearden, P. K., Mercier, O. R., King-Hunt, A., & Lester, P. J. (2022). Gene drive and RNAi technologies: A bio-cultural review of next-generation tools for pest wasp management in New Zealand. Journal of the Royal Society of New Zealand, 52(5), 508-525. doi: 10.1080/03036758.2021.1985531

Journal - Research Article

Shain, D. H., Iakovenko, N. S., Cridge, A. G., Novis, P. M., Plášek, V., & Dearden, P. K. (2022). Microinvertebrate colonization of New Zealand’s thermally extreme environments. Evolutionary Biology. Advance online publication. doi: 10.1007/s11692-022-09578-w

Journal - Research Article

Taylor, S. E., & Dearden, P. K. (2022). The Nasonia pair-rule gene regulatory network retains its function over 300 million years of evolution. Development, 149, dev199632. doi: 10.1242/dev.199632

Journal - Research Article

Winter, D. J., Weir, B. S., Glare, T., Rhodes, J., Perrott, J., Fisher, M. C., … Dearden, P. K., & Cox, M. P. (2022). A single fungal strain was the unexpected cause of a mass aspergillosis outbreak in the world’s largest and only flightless parrot. iScience, 25, 105470. doi: 10.1016/j.isci.2022.105470

Journal - Research Article

Zawierucha, K., Stec, D., Dearden, P. K., & Shain, D. H. (2022). Two new tardigrade genera from New Zealand’s Southern Alp glaciers display morphological stasis and parallel evolution. Molecular Phylogenetics & Evolution. Advance online publication. doi: 10.1016/j.ympev.2022.107634

Journal - Research Article

Dussex, N., van der Valk, T., Morales, H. E., Wheat, C. W., Díez-del-Molino, D., von Seth, J., Foster, Y., … Le Lec, M. F., Dearden, P. K., … Knapp, M., Gemmell, N. J., Robertson, F., … Robertson, B. C., & Dalén, L. (2021). Population genomics of the critically endangered kākāpō. Cell Genomics, 1, 100002. doi: 10.1016/j.xgen.2021.100002

Journal - Research Article

Lamichhane, R., Munro, F., Harrop, T. W. R., de la Harpe, S. M., Dearden, P. K., Vernall, A. J., McCall, J. L., & Ussher, J. E. (2021). Human liver-derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR-independent activation. European Journal of Immunology, 51, 879-892. doi: 10.1002/eji.202048830

Journal - Research Article

Leask, M., Lovegrove, M., Romeril, A., Duncan, E., & Dearden, P. (2021). Evolution and genomic organization of the insect sHSP gene cluster and coordinate regulation in phenotypic plasticity. BMC Ecology & Evolution, 21, 154. doi: 10.1186/s12862-021-01885-8

Journal - Research Article

McCulloch, G. A., Foster, B. J., Dutoit, L., Harrop, T. W. R., Guhlin, J., Dearden, P. K., & Waters, J. M. (2021). Genomics reveals widespread ecological speciation in flightless insects. Systematic Biology, 70(5), 863-876. doi: 10.1093/sysbio/syaa094

Journal - Research Article

McCulloch, G. A., Guhlin, J., Dutoit, L., Harrop, T. W. R., Dearden, P. K., & Waters, J. M. (2021). Genomic signatures of parallel alpine adaptation in recently-evolved flightless insects. Molecular Ecology, 30, 6677-6686. doi: 10.1111/mec.16204

Journal - Research Article

Petersen, G. E. L., Fennessy, P. F., & Dearden, P. K. (2021). Management tools for genetic diversity in an isolated population of the honeybee (Apis mellifera) in New Zealand. Animal Production Science, 61, 1856-1862. doi: 10.1071/An21102

Journal - Research Article

Shain, D., Novis, P. M., Cridge, A. G., Zawierucha, K., Geneva, A. J., & Dearden, P. K. (2021). Five animal phyla in glacier ice reveal unprecedented biodiversity in New Zealand's Southern Alps. Scientific Reports, 11(1), 3898. doi: 10.1038/s41598-021-83256-3

Journal - Research Article

Duncan, E. J., Leask, M. P., & Dearden, P. K. (2020). Genome architecture facilitates phenotypic plasticity in the honeybee (Apis mellifera). Molecular Biology & Evolution, 37(7), 1964-1978. doi: 10.1093/molbev/msaa057

Journal - Research Article

Harrop, T. W. R., Guhlin, J., McLaughlin, G. M., Permina, E., Stockwell, P., Gilligan, J., Le Lec, M. F., Gruber, M. A. M., … Lovegrove, M., … Dearden, P. K. (2020). High-quality assemblies for three invasive social wasps from the Vespula genus. Genes Genomes Genetics, 10, 3479-3488. doi: 10.1534/g3.120.401579

Journal - Research Article

Harrop, T. W. R., Le Lec, M. F., Jauregui, R., Taylor, S. E., Inwood, S. N., van Stijn, T., … Skelly, J., … Dearden, P. K. (2020). Genetic diversity in invasive populations of Argentine stem weevil associated with adaptation to biocontrol. Insects, 11(7), 441. doi: 10.3390/insects11070441

Journal - Research Article

Lester, P. J., Bulgarella, M., Baty, J. W., Dearden, P. K., Guhlin, J., & Kean, J. M. (2020). The potential for a CRISPR gene drive to eradicate or suppress globally invasive social wasps. Scientific Reports, 10, 12398. doi: 10.1038/s41598-020-69259-6

Journal - Research Article

Lovegrove, M. R., Knapp, R. A., Duncan, E. J., & Dearden, P. K. (2020). Drosophila melanogaster and worker honeybees (Apis mellifera) do not require olfaction to be susceptible to honeybee queen mandibular pheromone. Journal of Insect Physiology, 127, 104154. doi: 10.1016/j.jinsphys.2020.104154

Journal - Research Article

Oliphant, A., Hawkes, M. K. N., Cridge, A. G., & Dearden, P. K. (2020). Transcriptomic characterisation of neuropeptides and their putative cognate G protein-coupled receptors during late embryo and stage-1 juvenile development of the Aotearoa-New Zealand crayfish, Paranephrops zealandicus. General & Comparative Endocrinology, 292, 113443. doi: 10.1016/j.ygcen.2020.113443

Journal - Research Article

Petersen, G. E. L., Fennessy, P. F., Van Stijn, T. C., Clarke, S. M., Dodds, K. G., & Dearden, P. K. (2020). Genotyping-by-sequencing of pooled drone DNA for the management of living honeybee (Apis mellifera) queens in commercial beekeeping operations in New Zealand. Apidologie, 51, 545-556. doi: 10.1007/s13592-020-00741-w

Journal - Research Article

Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054

Journal - Research Article

Lovegrove, M. R., Dearden, P. K., & Duncan, E. J. (2019). Ancestral hymenopteran queen pheromones do not share the broad phylogenetic repressive effects of honeybee queen mandibular pheromone. Journal of Insect Physiology, 119, 103968. doi: 10.1016/j.jinsphys.2019.103968

Journal - Research Article

McCulloch, G. A., Foster, B. J., Dutoit, L., Ingram, T., Hay, E., Veale, A. J., Dearden, P. K., & Waters, J. M. (2019). Ecological gradients drive insect wing loss and speciation: The role of the alpine treeline. Molecular Ecology, 28, 3141-3150. doi: 10.1111/mec.15114

Journal - Research Article

McCulloch, G. A., Oliphant, A., Dearden, P. K., Veale, A. J., Ellen, C. W., & Waters, J. M. (2019). Comparative transcriptomic analysis of a wing-dimorphic stonefly reveals candidate wing loss genes. EvoDevo, 10, 21. doi: 10.1186/s13227-019-0135-4

Journal - Research Article

Panfilio, K. A., Vargas Jentzsch, I. M., Benoit, J. B., Erezyilmaz, D., Suzuki, Y., Colella, S., … Duncan, E. J., … Cridge, A. G., … Dearden, P. K., … Leask, M., … Lovegrove, M. R., … Tidswell, O., … Richards, S. (2019). Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome. Genome Biology, 20, 64. doi: 10.1186/s13059-019-1660-0

Journal - Research Article

Skelly, J., Pushparajan, C., Duncan, E. J., & Dearden, P. K. (2019). Evolution of the Torso activation cassette, a pathway required for terminal patterning and moulting. Insect Molecular Biology, 28(3), 392-408. doi: 10.1111/imb.12560

Journal - Research Article

Taylor, S. E., Tuffery, J., Bakopoulos, D., Lequeux, S., Warr, C. G., Johnson, T. K., & Dearden, P. K. (2019). The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation. Biology Open, 8(9), bio046284. doi: 10.1242/bio.046284

Journal - Research Article

Pushparajan, C., Goswami, S. K., McAdam, C. J., Hanton, L. R., Dearden, P. K., Moratti, S. C., & Cridge, A. G. (2018). A mechanically strengthened polyacrylamide gel matrix fully compatible with electrophoresis of proteins and nucleic acids. Electrophoresis, 39(5-6), 824-832. doi: 10.1002/elps.201700303

Journal - Research Article

Veale, A. J., Foster, B. J., Dearden, P. K., & Waters, J. M. (2018). Genotyping-by-sequencing supports a genetic basis for wing reduction in an alpine New Zealand stonefly. Scientific Reports, 8, 16275. doi: 10.1038/s41598-018-34123-1

Journal - Research Article

Cridge, A. G., Lovegrove, M. R., Skelly, J. G., Taylor, S. E., Petersen, G. E. L., Cameron, R. C., & Dearden, P. K. (2017). The honeybee as a model insect for developmental genetics. Genesis, 55(5), e23019. doi: 10.1002/dvg.23019

Journal - Research Article

Wu, C., Jordan, M. D., Newcomb, R. D., Gemmell, N. J., Bank, S., Meusemann, K., Dearden, P. K., … Grosser, S., … Buckley, T. R. (2017). Analysis of the genome of the New Zealand giant collembolan (Holacanthella duospinosa) sheds light on hexapod evolution. BMC Genomics, 18, 795. doi: 10.1186/s12864-017-4197-1

Journal - Research Article

Cridge, A. G., Dearden, P. K., & Brownfield, L. R. (2016). Convergent occurrence of the developmental hourglass in plant and animal embryogenesis? Annals of Botany, 117(5), 833-843. doi: 10.1093/aob/mcw024

Journal - Research Article

Duncan, E. J., Hyink, O., & Dearden, P. K. (2016). Notch signalling mediates reproductive constraint in the adult worker honeybee. Nature Communications, 7, 12427. doi: 10.1038/ncomms12427

Journal - Research Article

Pires, C. V., de Paula Freitas, F. C., Cristino, A. S., Dearden, P. K., & Simões, Z. L. P. (2016). Transcriptome analysis of honeybee (Apis mellifera) haploid and diploid embryos reveals early zygotic transcription during cleavage. PLoS ONE, 11(1), e0146447. doi: 10.1371/journal.pone.0146447

Journal - Research Article

Smith, L. M., Parr-Brownlie, L. C., Duncan, E. J., Black, M. A., Gemmell, N. J., Dearden, P. K., & Reynolds, J. N. J. (2016). Striatal mRNA expression patterns underlying peak dose L-DOPA-induced dyskinesia in the 6-OHDA hemiparkinsonian rat. Neuroscience, 324, 238-251. doi: 10.1016/j.neuroscience.2016.03.012

Journal - Research Article

Cridge, A. G., Leask, M. P., Duncan, E. J., & Dearden, P. K. (2015). What do studies of insect polyphenisms tell us about nutritionally-triggered epigenomic changes and their consequences? Nutrients, 7(3), 1787-1797. doi: 10.3390/nu7031787

Journal - Research Article

Dearden, P. K. (2015). Origin and evolution of the enhancer of split complex. BMC Genomics, 16, 712. doi: 10.1186/s12864-015-1926-1

Journal - Research Article

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oelling, C. A., Winter, K. L., … Dearden, P. K., … McGowan, S. (2015). Stonefish toxin defines an ancient branch of the perforin-like superfamily. PNAS, 112(50), 15360-15365. doi: 10.1073/pnas.1507622112

Journal - Research Article

Paten, A. M., Duncan, E. J., Pain, S. J., Peterson, S. W., Kenyon, P. R., Blair, H. T., & Dearden, P. K. (2015). Functional development of the adult ovine mammary gland: Insights from gene expression profiling. BMC Genomics, 16, 748. doi: 10.1186/s12864-015-1947-9

Journal - Research Article

Sadd, B. M., Barribeau, S. M., Bloch, G., de Graaf, D. C., Dearden, P., Elsik, C. G., … Cridge, A. G., … Duncan, E., … Irvine, F., … Leask, M., Lockett, G. A., … Nair, A., … Blommaert, J., … Worley, K. C. (2015). The genomes of two key bumblebee species with primitive eusocial organization. Genome Biology, 16, 76. doi: 10.1186/s13059-015-0623-3

Journal - Research Article

Sharpe, M. L., Dearden, P. K., Gimenez, G., & Krause, K. L. (2015). Comparative RNA seq analysis of the New Zealand glowworm Arachnocampa luminosa reveals bioluminescence-related genes. BMC Genomics, 16, 825. doi: 10.1186/s12864-015-2006-2

Journal - Research Article

Chipman, A. D., Ferrier, D. E. K., Brena, C., Qu, J., Hughes, D. S. T., Schröder, R., … Dearden, P. K., … Duncan, E. J., … Kenny, N. J., … Richards, S. (2014). The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. PLoS Biology, 12(11), e1002005. doi: 10.1371/journal.pbio.1002005

Journal - Research Article

Dearden, P. K. (2014). Expression pattern of empty-spiracles, a conserved head-patterning gene, in honeybee (Apis mellifera) embryos. Gene Expression Patterns, 15(2), 142-148. doi: 10.1016/j.gep.2014.06.003

Journal - Research Article

Duncan, E. J., Gluckman, P. D., & Dearden, P. K. (2014). Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype? Journal of Experimental Zoology Part B: Molecular & Developmental Evolution, 322(4), 208-220. doi: 10.1002/jez.b.22571

Journal - Research Article

Kenny, N. J., Namigai, E. K. O., Dearden, P. K., Hui, J. H. L., Grande, C., & Shimeld, S. M. (2014). The lophotrochozoan TGF-β signalling cassette: Diversification and conservation in a key signalling pathway. International Journal of Developmental Biology, 58, 533-549. doi: 10.1387/ijdb.140080nk

Journal - Research Article

Paten, A. M., Paine, S.-J., Peterson, S. W., Blair, H. T., Kenyon, P. R., Dearden, P. K., & Duncan, E. J. (2014). Identification of reference genes for RT-qPCR in ovine mammary tissue during late-pregnancy, lactation and in response to maternal nutritional programming. Physiological Genomics, 46, 560-570. doi: 10.1152/physiolgenomics.00030.2014

Journal - Research Article

Wilson, M. J., Kenny, N. J., & Dearden, P. K. (2014). Components of the dorsal-ventral pathway also contribute to anterior-posterior patterning in honeybee embryos (Apis mellifera). EvoDevo, 5, 11. doi: 10.1186/2041-9139-5-11

Journal - Research Article

Cameron, R. C., Duncan, E. J., & Dearden, P. K. (2013). Biased gene expression in early honeybee larval development. BMC Genomics, 14, 903. doi: 10.1186/1471-2164-14-903

Journal - Research Article

Cameron, R. C., Duncan, E. J., & Dearden, P. K. (2013). Stable reference genes for the measurement of transcript abundance during larval caste development in the honeybee. Apidologie, 44(4), 357-366. doi: 10.1007/s13592-012-0187-0

Journal - Research Article

Duncan, E. J., Benton, M. A., & Dearden, P. K. (2013). Canonical terminal patterning is an evolutionary novelty. Developmental Biology, 377, 245-261. doi: 10.1016/j.ydbio.2013.02.010

Journal - Research Article

Duncan, E. J., Leask, M. P., & Dearden, P. K. (2013). The pea aphid (Acyrthosiphon pisum) genome encodes two divergent early developmental programs. Developmental Biology, 377, 262-274. doi: 10.1016/j.ydbio.2013.01.036

Journal - Research Article

Hyink, O., Laas, F., & Dearden, P. K. (2013). Genetic tests for alleles of complementary-sex-determiner to support honeybee breeding programmes. Apidologie, 44(3), 306-313. doi: 10.1007/s13592-012-0181-6

Journal - Research Article

Kenny, N. J., & Dearden, P. K. (2013). NMDA receptor expression and C terminus structure in the rotifer Brachionus plicatilis and long-term potentiation across the Metazoa. Invertebrate Neuroscience, 13, 125-134. doi: 10.1007/s10158-013-0154-0

Journal - Research Article

Wilson, M. J., & Dearden, P. K. (2013). RNA localization in the honeybee (Apis mellifera) oocyte reveals insights about the evolution of RNA localization mechanisms. Developmental Biology, 375(2), 193-201. doi: 10.1016/j.ydbio.2013.01.001

Journal - Research Article

Chua, J. P. S., Wallace, E. J. S., Yardley, J. A., Duncan, E. J., Dearden, P. K., & Summerfield, T. C. (2012). Gene expression indicates a zone of heterocyst differentiation within the thallus of the cyanolichen Pseudocyphellaria crocata. New Phytologist, 196(3), 862-872. doi: 10.1111/j.1469-8137.2012.04272.x

Journal - Research Article

Wilson, M. J., & Dearden, P. K. (2012). Pair-rule gene orthologues have unexpected maternal roles in the honeybee (Apis mellifera). PLoS ONE, 7(9), e46490. doi: 10.1371/journal.pone.0046490

Journal - Research Article

Zondag, L., Dearden, P. K., & Wilson, M. J. (2012). Deep sequencing and expression of microRNAs from early honeybee (Apis mellifera) embryos reveals a role in regulating early embryonic patterning. BMC Evolutionary Biology, 12, 211. doi: 10.1186/1471-2148-12-211

Journal - Research Article

Wilson, M. J., & Dearden, P. K. (2011). Diversity in insect axis formation: Two orthodenticle genes and hunchback act in anterior patterning and influence dorsoventral organization in the honeybee (Apis mellifera). Development, 138(16), 3497-3507. doi: 10.1242/dev.067926

Journal - Research Article

Wilson, M. J., Abbott, H., & Dearden, P. K. (2011). The evolution of oocyte patterning in insects: Multiple cell-signaling pathways are active during honeybee oogenesis and are likely to play a role in axis patterning. Evolution & Development, 13(2), 127-137. doi: 10.1111/j.1525-142X.2011.00463.x

Journal - Research Article

Duncan, E. J., & Dearden, P. K. (2010). Evolution of a genomic regulatory domain: The role of gene co-option and gene duplication in the enhancer of split complex. Genome Research, 20, 917-928. doi: 10.1101/gr.104794.109

Journal - Research Article

Shigenobu, S., Bickel, R. D., Brisson, J. A., Butts, T., Chang, C.-C., Christiaens, O., … Duncan, E. J., … Smith, J., … Wilson, M. J., Dearden, P. K., & Stern, D. L. (2010). Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: Frequent lineage-specific duplications and losses of developmental genes. Insect Molecular Biology, 19(Suppl. 2), 47-62. doi: 10.1111/j.1365-2583.2009.00944.x

Journal - Research Article

Smith, J. M., Cridge, A. G., & Dearden, P. K. (2010). Germ cell specification and ovary structure in the rotifer Brachionus plicatilis. EvoDevo, 1, 5. doi: 10.1186/2041-9139-1-5

Journal - Research Article

The International Aphid Genomics Consortium, including Smith, J., Wilson, M., Dearden, P., & Duncan, E. J. (2010). Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS Biology, 8(2), e1000313. doi: 10.1371/journal.pbio.1000313

Journal - Research Article

Wilson, M. J., Havler, M., & Dearden, P. K. (2010). Giant, Krüppel, and caudal act as gap genes with extensive roles in patterning the honeybee embryo. Developmental Biology, 339(1), 200-211. doi: 10.1016/j.ydbio.2009.12.015

Journal - Research Article

Wilson, M. J., McKelvey, B. H., van der Heide, S., & Dearden, P. K. (2010). Notch signaling does not regulate segmentation in the honeybee, Apis mellifera. Development Genes & Evolution, 220(7-8), 179-190. doi: 10.1111/j.1365-2826.2010.02100.x

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Fixation and storage of honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5224

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Immunohistochemistry on honeybee (Apis mellifera) embryos. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5227

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). In situ hybridization of sectioned honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5226

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Rna interference (RNAi) in honeybee (Apis mellifera) embryos. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5228

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). The honeybee Apis mellifera. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.emo123

Journal - Research Article

Dearden, P. K., Duncan, E. J., & Wilson, M. J. (2009). Whole-mount in situ hybridization of honeybee (Apis mellifera) tissues. Cold Spring Harbor Protocols, 4(6). doi: 10.1101/pdb.prot5225

Journal - Research Article

Specht, D., Wu, S.-b., Turner, P., Dearden, P., Koentgen, F., Wolfrum, U., Maw, M., … tom Dieck, S. (2009). Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses. Investigative Ophthalmology & Visual Science, 50(2), 505-515. doi: 10.1167/iovs.08-2758

Journal - Research Article

Wilson, M. J., & Dearden, P. K. (2009). Tailless patterning functions are conserved in the honeybee even in the absence of Torso signaling. Developmental Biology, 335(1), 276-287. doi: 10.1016/j.ydbio.2009.09.002

Journal - Research Article

Duncan, E. J., Wilson, M. J., Smith, J. M., & Dearden, P. K. (2008). Evolutionary origin and genomic organisation of runt-domain containing genes in arthropods. BMC Genomics, 9, 588. doi: 10.1186/1471-2164-9-558

Journal - Research Article

Wilson, M. J., & Dearden, P. K. (2008). Evolution of the insect Sox genes. BMC Evolutionary Biology, 8, 120. doi: 10.1186/1471-2148-8-120

Journal - Research Article

Young, J. M., Juengel, J. L., Dodds, K. G., Laird, M., Dearden, P. K., McNeilly, A. S., … Wilson, T. (2008). The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures. Journal of Endocrinology, 196(2), 251-261. doi: 10.1677/JOE-07-0148

Journal - Research Article

Dearden, P. K. (2006). Germ cell development in the Honeybee (Apis mellifera); Vasa and Nanos expression. BMC Developmental Biology, 6, 6. doi: 10.1186/1471-213X-6-6

Journal - Research Article

Dearden, P. K., Wilson, M. J., Sablan, L., Osborne, P. W., Havler, M., McNaughton, E., … Beye, M. (2006). Patterns of conservation and change in honey bee developmental genes. Genome Research, 16(11), 1376-1384. doi: 10.1101/gr.5108606

Journal - Research Article

Sabater-Muñoz, B., Legeai, F., Rispe, C., Bonhomme, J., Dearden, P., Dossat, C., … Tagu, D. (2006). Large-scale gene discovery in the pea aphid Acyrthosiphon pisum (Hemiptera). Genome Biology, 7(R21). doi: 10.1186/gb-2006-7-3-r21

Journal - Research Article

The Honeybee Genome Sequencing Consortium, including Beggs, K. T., Mercer, A. R., Dearden, P. K., & Wilson, M. J. (2006). Insights into social insects from the genome of the honeybee Apis mellifera. Nature, 443, 931-949.

Journal - Research Article

Hemara-Wahanui, A., Berjukow, S., Hope, C. I., Dearden, P. K., Wu, S.-B., Wilson-Wheeler, J., … Maw, M. A. (2005). A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of CaV1.4 channel activation. PNAS, 102(21), 7553-7558.

Journal - Research Article

Osborne, P. W., & Dearden, P. K. (2005). Expression of Pax group III genes in the honeybee (Apis mellifera). Development Genes & Evolution, 215(10), 499-508. doi: 10.1007/s00427-005-0008-9

Journal - Research Article

Osborne, P., & Dearden, P. K. (2005). Non-radioactive in-situ hybridisation to honeybee embryos and ovaries. Apidologie, 36, 113-118.

Journal - Research Article

Dearden, P., Grbic, M., & Donly, C. (2003). Vasa expression and germ-cell specification in the spider mite Tetranychus urticae. Development Genes & Evolution, 212, 599-603.

Journal - Research Article

Chang, C.-C., Dearden, P., & Akam, M. (2002). Germ line development in the grasshopper Schistocerca gregaria: vasa as a marker. Developmental Biology, 252, 100-118.

Journal - Research Article

Dearden, P., Donly, C., & Grbic, M. (2002). Expression of pair-rule gene homologues in a chelicerate: Early patterning of the two-spotted spider mite Tetranychus urticae. Development, 129, 5461-5472.

Journal - Research Article

Dearden, P., & Akam, M. (2001). Early embryo patterning in the grasshopper, Schistocerca gregaria; wingless, dpp and caudal expression. Development, 128(18), 3435-3444.

Journal - Research Article

Lawrence, N., Dearden, P., Hartley, D., Roose, J., Clevers, H., & Martinez-Arias, A. A. (2001). Groucho protein that lacks the WD40 repeats modulates Wingless signalling during the development and patterning of the wing in Drosophila. International Journal of Developmental Biology, 44(7), 749-756.

Journal - Research Article

Dearden, P., & Akam, M. (2000). A role for Fringe in segment morphogenesis but not segment formation in the grasshopper, Schistocerca gregaria. Development Genes & Evolution, 210(7), 329-336.

Journal - Research Article

Dearden, P., & Akam, M. (2000). Segmentation in silico. Nature, 406(6792), 131-132.

Journal - Research Article

Dearden, P., Falciani, F., & Akam, M. (2000). Maternal and early Zygotic expression of the Hox3/zen gene of the grasshopper Schistocerca gregaria. Evolution & Development, 2(5), 261-270.

Journal - Research Article

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