![david_larsen](https://www.otago.ac.nz/__data/assets/image/0030/248286/david_larsen-669756.jpg)
Tel: 03 479 7816
Location: Science II, 2n11
Email: dlarsen@chemistry.otago.ac.nz
Research Interests
My research interests are primarily in the development of methodology the syntheses of natural products and also in the area of the synthesis of carbohydrates, glycolipids and their analogues.
On-going research projects are:
- Structure, synthesis and biological activity of phosphatidylinositol mannosides from mycobacterium tuberculosis
- Glycolipids as adjuvants for cancer vaccines
- Total synthesis of the angucycline antibiotics
- Carbon monoxide releasing molecules for organ transplant solutions
- Mannosylation of Virus Like Particles
- Bacterial cell wall skeletons as transporters of small molecules to APCs
Publications
Payne, F. M., Nie, S., Diffee, G. M., Wilkins, G. T., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2024). The carbon monoxide prodrug oCOm-21 increases Ca2+ sensitivity of the cardiac myofilament. Physiological Reports, 12(6), e15974. doi: 10.14814/phy2.15974 Journal - Research Article
Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839 Conference Contribution - Published proceedings: Abstract
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry, 11, e202200350. doi: 10.1002/ajoc.202200350 Journal - Research Article
Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry, 20, 5812-5819. doi: 10.1039/d2ob01076c Journal - Research Article
2024
Journal - Research Article
Payne, F. M., Nie, S., Diffee, G. M., Wilkins, G. T., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2024). The carbon monoxide prodrug oCOm-21 increases Ca2+ sensitivity of the cardiac myofilament. Physiological Reports, 12(6), e15974. doi: 10.14814/phy2.15974
2023
Conference Contribution - Published proceedings: Abstract
Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
2022
Journal - Research Article
Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry, 11, e202200350. doi: 10.1002/ajoc.202200350
Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry, 20, 5812-5819. doi: 10.1039/d2ob01076c
Conference Contribution - Verbal presentation and other Conference outputs
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
2021
Journal - Research Article
McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540
Richardson, A. T., McGhie, T. K., Cordiner, S. B., Stephens, T. T. H., Larsen, D. S., Laing, W. A., & Perry, N. B. (2021). 2-O-β-d-Glucopyranosyl L-ascorbic acid, a stable form of vitamin C, is widespread in crop plants. Journal of Agricultural & Food Chemistry, 69, 966-973. doi: 10.1021/acs.jafc.0c06330
Conference Contribution - Published proceedings: Abstract
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2021). Can carbon monoxide protect hypertrophic hearts against ischaemia-reperfusion injury. New Zealand Medical Journal, 134(1535), (pp. 98). Retrieved from https://www.nzma.org.nz/journal
Intellectual Property
Sammut, I. A., Harrison, J. C., Hewitt, R. J., Read, M. I., Stanley, N. J., Woods, L. M., Kueh, J. T. B., … Smith, R. A. J., Giles, G., … Larsen, D. S. (2021). Carbon monoxide releasing norbornenone compounds. (11072584). United States.
2020
Journal - Research Article
Kueh, J. T. B., Seifert-Simpson, J. M., Thwaite, S. H., Rodgers, G. D., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2020). Studies towards non-toxic, water soluble, vasoactive norbornene organic carbon monoxide releasing molecules. Asian Journal of Organic Chemistry, 9, 1-10. doi: 10.1002/ajoc.202000546
Robinson, S. A., Yau, J., Terabe, M., Berzofsky, J. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2020). Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues. Organic & Biomolecular Chemistry, 18, 2739-2746. doi: 10.1039/d0ob00223b
Richardson, A. T., Cho, J., McGhie, T. K., Larsen, D. S., Schaffer, R. J., Espley, R. V., & Perry, N. B. (2020). Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris). Phytochemistry, 173, 112297. doi: 10.1016/j.phytochem.2020.112297
Conference Contribution - Published proceedings: Abstract
Hartley, R., Harrison, J. C., Johnston, H., Larsen, D. S., & Sammut, I. A. (2020). Examination of the cardiac mitochondrial-linked preconditioning mechanism of oCOm-58. New Zealand Medical Journal, 133(1518), (pp. 94-95). Retrieved from https://www.nzma.org.nz/journal
2019
Journal - Research Article
Payne, C. M., Cho, K., & Larsen, D. S. (2019). 5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions. RSC Advances, 9, 30736-30740. doi: 10.1039/c9ra06594f
Kramer, K., Al-Barwani, F., Baird, M. A., Young, V. L., Larsen, D. S., Ward, V. K., & Young, S. L. (2019). Functionalisation of virus-like particles enhances antitumour immune responses. Journal of Immunology Research, 2019, 5364632. doi: 10.1155/2019/5364632
Osman, H., Larsen, D. S., & Muralikrishna, A. (2019). A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B. Arabian Journal of Chemistry, 12, 2501-2512. doi: 10.1016/j.arabjc.2015.04.022
Conference Contribution - Poster Presentation (not in published proceedings)
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2019, September). Can we protect hypertrophic hearts against ischaemia-reperfusion injury using carbon monoxide? Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
2018
Journal - Research Other
Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2018). MIS416 as a siRNA delivery system with the ability to target antigen-presenting cells [Brief communication]. Nucleic Acid Therapeutics, 28(4), 225-232. doi: 10.1089/nat.2017.0695
Conference Contribution - Published proceedings: Abstract
Sammut, I., Kueh, B., Adams, J., Read, M., Larsen, D., & Harrison, J. (2018). Prophylactic treatment of ischaemically stored organs with novel organic carbon monoxide donor molecules. Cryobiology, 81, (pp. 222). doi: 10.1016/j.cryobiol.2017.12.045
Conference Contribution - Verbal presentation and other Conference outputs
Larsen, D. S., Kueh, J. T. B., Harrison, J. C., & Sammut, I. A. (2018, August). Nornorn-2-en-7-ones as physiologically triggered carbon monoxide-releasing prodrugs. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Journal - Research Article
Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f
Hogue, R. W., Dhers, S., Hellyer, R. M., Luo, J., Hanan, G. S., Larsen, D. S., Garden, A. L., & Brooker, S. (2017). Self-assembly of cyclohelicate [M3L3] triangles over [M4L4] squares, despite near-linear bis-terdentate L and octahedral M. Chemistry: A European Journal, 23(57), 14193-14199. doi: 10.1002/chem.201702153
Malthus, S. J., Wilson, R. K., Aggarwal, A. V., Cameron, S. A., Larsen, D. S., & Brooker, S. (2017). Carbazole-based N4-donor Schiff base macrocycles: Obtained metal free and as Cu(II) and Ni(II) complexes. Dalton Transactions, 46(10), 3141-3149. doi: 10.1039/c6dt04598g
Nhu, D., Larsen, L., Perry, N. B., Larsen, D. S., & Hawkins, B. C. (2017). Sweet poisons: Synthetic strategies towards tutin glycosides. Australian Journal of Chemistry, 70(3), 301-306. doi: 10.1071/CH16429
Moodie, L. W. K., Trepos, R., Cervin, G., Larsen, L., Larsen, D. S., Pavia, H., … Svenson, J. (2017). Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. Journal of Natural Products, 80(2), 515-525. doi: 10.1021/acs.jnatprod.6b01056
Conference Contribution - Poster Presentation (not in published proceedings)
Malthus, S. J., Cameron, S., Aggarwal, V., Wilson, R. K., Larsen, D. S., & Brooker, S. (2017, February). Carbazole-based Schiff base macrocycles and complexes for fluorescence, redox and catalytic properties. Poster session presented at the 2nd Southampton, Australia, New Zealand, Magnetism Workshop (SANZ-O-MAG2), Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Harrison, J. C., Adams, J. R., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Sammut, I. A. (2017, September). Organic carbon monoxide releasing molecules as cardioprotective agents. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Sammut, I. A., Adams, J. R., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Harrison, J. C. (2017, September). oCOms: Organic carbon monoxide donor molecules as pharmacological preconditioning agents. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
2016
Journal - Research Article
Malthus, S. J., Wilson, R. K., Larsen, D. S., & Brooker, S. (2016). Acridine-based ligands from cobalt(II) mediated rearrangement of diphenylamine-based starting materials. Supramolecular Chemistry, 28(1-2), 98-107. doi: 10.1080/10610278.2015.1091458
Conference Contribution - Published proceedings: Abstract
Sammut, I. A., Harrison, J. C., Read, M. I., Kueh, J. T. B., & Larsen, D. S. (2016). Novel organic carbon monoxide donor molecules provide organ protection during ischaemic events. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Robinson, S. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2016). A synthetic methodology for accessing ceramide based iNKT cell agonists. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Hall, E. A., Young, S. L., Ward, V. K., & Larsen, D. S. (2016). Synthesis of mannoside-VLP conjugates for antigen delivery. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Larsen, D. S., Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T., Hayman, C. M., … Painter, G. F. (2016). Synthesis and activity of 6"-deoxy-6"-thio-α-GalCer and peptide conjugates. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Compton, B. J., Anderson, R. J., Hayman, C. M., Tang, C.-w., Osmond, T. L., Larsen, D. S., … Painter, G. F. (2016). NKT cell-dependent glycolipid-peptide conjugates: Towards generating therapeutic vaccines for cancer. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Verbal presentation and other Conference outputs
Harrison, J. C., Read, M. I., Kueh, J. T. B., Larsen, D. S., & Sammut, I. A. (2016, August-September). Novel organic carbon monoxide releasing molecules protect the heart against ischaemia reperfusion injury. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Larsen, D. S., Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. L., Hayman, C. M., … Painter, G. F. (2016, August-September). Synthesis and activity of 6ʺ-deoxy-6ʺ-thio-α-GalCer and peptide conjugates. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Painter, G. F., Tang, C., Anderson, R. J., Compton, B. J., Osmond, T., Farrand, K. J., … Larsen, D. S., … Hermans, I. F. (2016, August-September). Bioorthogonal synthesis and antitumour activity of CD1d dependent glycolipid-peptide vaccines. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403
Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. O., Hayman, C. M., Larsen, D. S., Hermans, I. F., & Painter, G. F. (2015). Synthesis and activity of 6''-Deoxy-6''-thio-α-GalCer and peptide conjugates. Organic Letters, 17, 5954-5957. doi: 10.1021/acs.orglett.5b02836
Finichiu, P. G., Larsen, D. S., Evans, C., Larsen, L., Bright, T. P., Robb, E. L., … Smith, R. A. J., & Murphy, M. P. (2015). A mitochondria-targeted derivative of ascorbate: MitoC. Free Radical Biology & Medicine, 89, 668-678. doi: 10.1016/j.freeradbiomed.2015.07.160
Anderson, R. J., Compton, B. J., Tang, C.-W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., … Larsen, D. S., … Weinkove, R., Hermans, I. F., & Painter, G. F. (2015). NKT cell-dependent glycolipid—peptide vaccines with potent anti-tumour activity. Chemical Science, 6(9), 5095-5312. doi: 10.1039/c4sc03599b
Zheng, T., Luo, D., Compton, B. J., Painter, G. F., Alley, M. R., Larsen, D. S., … Heiser, A. (2015). Adjuvanticity of a synthetic phosphatidylinositol dimannoside to a subvirion influenza vaccine in an influenza mouse model. Journal of Vaccines & Vaccination, 6(2), 1000277. doi: 10.4172/2157-7560.1000277
Kueh, J. T. B., Moodie, L. W. K., Lucas, N. T., & Larsen, D. S. (2015). Synthesis of acyloxy-semicyclic dienes using an enyne metathesis/ring closing metathesis approach. European Journal of Organic Chemistry, 2015(7), 1485-1490. doi: 10.1002/ejoc.201403482
Jiménez-Dalmaroni, M. J., Radcliffe, C. M., Harvey, D. J., Wormald, M. R., Verdino, P., Ainge, G. D., Larsen, D. S., … Wilson, I. A. (2015). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity, 21(2), 175-193. doi: 10.1177/1753425914524077
Conference Contribution - Published proceedings: Abstract
Painter, G., Tang, C., Anderson, R., Compton, B., Authier-Hall, A., Hayman, C., … Farrand, K., … Larsen, D., Weinkove, R., & Hermans, I. (2015). Bioorthagonal synthesis and biological activity of CD1d dependent glycolipid-peptide vaccines. Proceedings of the 250th National American Chemical Society (ACS) Fall Meeting. Retrieved from https://www.acs.org
Larsen, D. S., Sammut, I., Harrison, J., Anderson, R., Compton, B. J., Harper, J. L., … Painter, G. F. (2015). Development of immuno-regulatory molecules for cancer and atopic disorders. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070
Harrison, J. C., Diwan, V., Read, M. I., Larsen, L., Kueh, B., Hewitt, R. J., Stanley, N., Larsen, D., & Sammut, I. A. (2015). Novel carbon monoxide releasing molecules improve renal outcomes in a model of transplant reperfusion. Proceedings of the World Congress of Nephrology. Retrieved from http://www.wcn2015.org/
Other Research Output
Larsen, D. (2015, November). Therapeutic molecules from sweet sugars to poisonous gases. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2014
Journal - Research Article
Lee, A. M. M., Painter, G. F., Compton, B. J., & Larsen, D. S. (2014). Resolution of orthogonally protected myo-inositols with Novozym 435 providing an enantioconvergent Pathway to Ac2PIM1. Journal of Organic Chemistry, 79(22), 10916-10931. doi: 10.1021/jo5019188
Anderson, R. J., Tang, C.-w., Daniels, N. J., Compton, B. J., Hayman, C. M., Johnston, K. A., … Larsen, D. S., … Hermans, I. F. (2014). A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology, 10, 943-949. doi: 10.1038/nchembio.1640
Al-Barwani, F., Young, S. L., Baird, M. A., Larsen, D. S., & Ward, V. K. (2014). Mannosylation of virus-like particles enhances internalization by antigen presenting cells. PLoS ONE, 9(8), e104523. doi: 10.1371/journal.pone.0104523
Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y
Nakatani, Y., Larsen, D. S., Cutfield, S. M., & Cutfield, J. F. (2014). Major change in regiospecificity for the exo-1,3-β-glucanase from Candida albicans following its conversion to a glycosynthase. Biochemistry, 53(20), 3318-3326. doi: 10.1021/bi500239m
Moodie, L. W. K., & Larsen, D. S. (2014). A ring-closing enyne metathesis approach to functionalized semicyclic dienes: The total synthesis of (–)-tetrangomycin. European Journal of Organic Chemistry, 2014(8), 1684-1694. doi: 10.1002/ejoc.201301627
Pun, P. B. L., Logan, A., Darley-Usmar, V., Chacko, B., Johnson, M. S., Huang, G. W., … Larsen, L., Larsen, D. S., … Smith, R. A. J., & Murphy, M. P. (2014). A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes. Free Radical Biology & Medicine, 67, 437-450. doi: 10.1016/j.freeradbiomed.2013.11.025
Journal - Professional & Other Non-Research Articles
Al-Barwani, F., Larsen, D. S., Baird, M. A., Young, S. L., & Ward, V. K. (2014). Enhancing the functionality of RHDV virus-like particles. CRS Newsletter, 31(4), 10-13.
Conference Contribution - Poster Presentation (not in published proceedings)
Lee, A. M. M., Larsen, D. S., & Compton, B. J. (2014, August). Chemoenzymatic approaches to phosphatidylinositol mannosides and other phospholipids. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Journal - Research Article
Logan, A., Cochemé, H. M., Li Pun, P. B., Apostolova, N., Smith, R. A. J., Larsen, L., Larsen, D. S., … Murphy, M. P. (2013). Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), 923-930. doi: 10.1016/j.bbagen.2013.05.026
Rankin, G. M., Maxwell-Cameron, I., Painter, G. F., & Larsen, D. S. (2013). The Dimethoxyphenylbenzyl Protecting Group: An alternative to the p-methoxybenzyl group for protection of carbohydrates. Journal of Organic Chemistry, 5264-5272. doi: 10.1021/jo4004184
Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a
Conference Contribution - Published proceedings: Abstract
Lee, A. M. M., Larsen, D. S., & Compton, B. J. (2013). Chemoenzymatic approaches to phosphatidylinositol mannosides and other phospholipids. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Larsen, D. S., & Moodie, L. W. K. (2013). A ring-closing enyne metathesis approach to functionalised semi-cyclic dienes: The total synthesis of (-)-tetrangomycin. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Painter, G. F., Tang, C., Anderson, R. J., Compton, B. J., Hayman, C. M., Johnston, K. A., Young, K., Hook, S., Larsen, D. S., & Hermans, I. F. (2013). Synthetic self-adjuvanting peptide vaccines. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Zheng, T., Luo, D., Compton, B., Painter, G., Larsen, D., Buddle, B., & Heiser, A. (2013). Phosphatidylinositol di-mannosides and aluminium hydroxide enhance protection of a subvirion influenza vaccine in a mouse influenza challenge model. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 162). Retrieved from http://www.asi2013.org/
Al-Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2013). Enhancement of VLP functionality though mannosylation. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 69). Retrieved from http://www.asi2013.org/
Al Barwani, F., Baird, M., Young, S., Larsen, D., & Ward, V. (2013). Mannosylated VLP: Potent antigen delivery vehicles. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/
Al Barwani, F., Young, S., Baird, M., Kirman, J., Larsen, D., & Ward, V. (2013). The sweetening of VLP. Proceedings of 15th Conference on Formulation and Delivery of Bioactives: Found in Translation. Retrieved from http://bioactives.otago.ac.nz/
2012
Journal - Research Article
Rankin, G. M., Compton, B. J., Johnston, K. A., Hayman, C. M., Painter, G. F., & Larsen, D. S. (2012). Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides. Journal of Organic Chemistry, 77(16), 6743-6759. doi: 10.1021/jo301189y
Conference Contribution - Published proceedings: Abstract
Al Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2012). The sweetening of VLP. Proceedings of the Virus-Like Particle & Nano-Particle Vaccines (VLPNPV) International Conference. [CD-ROM] [Abstract]
Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., & Rades, T. (2012). Investigating the interfacial behaviour of novel PIM Mimetics in pure and mixed monolayers using the Langmuir-trough technique. Proceedings of the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives. Retrieved from http://bioactives.otago.ac.nz/
Conference Contribution - Poster Presentation (not in published proceedings)
Cameron, S. A., Larsen, D. S., & Brooker, S. (2012, January-February). Toward new families of expanded porphyrin-like ligands and complexes. Poster session presented at the 7th International Symposium on Macrocyclic and Supramolecular Chemistry (ISMSC), Dunedin, New Zealand.
Mainini, F., Eccles, M., Young, S., Larsen, D., & Webster, G. (2012, August). Development of a new microparticle vaccine adjuvant with the ability to deliver peptides to dendritic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Hubert, M., Rades, T., Larsen, D., Hayman, C., Compton, B., & Hook, S. (2012, March). Physicochemical and biological characterization of PIM mimetics, novel immune modulating agents. Poster session presented at the 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey.
Conference Contribution - Verbal presentation and other Conference outputs
Larsen, D. S., Rankin, G. M., Ainge, G. D., Dyer, B. S., Compton, B. J., Hayman, C. M., … Painter, G. F. (2012, August). Mannosylated phospolipids for the mycobacterial cell wall: Synthesis and immune-regulating properties. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Ainge, G. D., Martin, W. J., Compton, B. J., Hayman, C. M., Larsen, D. S., Yoon, S.-I., … Painter, G. F. (2011). Synthesis and toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. Journal of Medicinal Chemistry, 54(20), 7268-7279. doi: 10.1021/jm2008419
Feltham, H. L. C., Klöwer, F., Cameron, S. A., Larsen, D. S., Lan, Y., Tropiano, M., … Powell, A. K., & Brooker, S. (2011). A family of 13 tetranuclear zinc(II)-lanthanide(III) complexes of a [3 + 3] Schiff-base macrocycle derived from 1‚4-diformyl-2‚3-dihydroxybenzene. Dalton Transactions, 40, 11425-11432. doi: 10.1039/c1dt11038a
Ainge, G. D., Compton, B. J., Hayman, C. M., Martin, W. J., Toms, S. M., Larsen, D. S., Harper, J. L., & Painter, G. F. (2011). Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside. Journal of Organic Chemistry, 76(12), 4941-4951. doi: 10.1021/jo200588u
Harper, J. L., Hayman, C. M., Larsen, D. S., Painter, G. F., & Singh-Gill, G. (2011). A PIM2 analogue suppresses allergic airway disease. Bioorganic & Medicinal Chemistry, 19, 2, 917-925. doi: 10.1016/j.bmc.2010.11.058
Conference Contribution - Poster Presentation (not in published proceedings)
Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2011, October). Investigating the interfacial behavior of novel PIM mimetics in pure and mixed monolayers using the Langmuir-trough technique. Poster session presented at the American Association of Pharmaceutical Sciences (AAPS) Annual Meeting and Exposition, Washington, D.C.
Conference Contribution - Verbal presentation and other Conference outputs
Larsen, D. (2011, December). The synthesis, structure and immune regulatory properties of phosphatidylinositol mannosides. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.
Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2011, February). Monolayer study of PIM mimetics: Novel immunomodulating agents. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 13th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2010
Journal - Research Article
Kitchen, J. A., Larsen, D. S., & Brooker, S. (2010). Alkylations of N4-(4-Pyridyl)-3,5-di(2-pyridyl)-1,2,4-triazole: First observation of room-temperature rearrangement of an N4-substituted triazole to the N1 analogue. Chemistry: An Asian Journal, 5(4), 910-918. doi: 10.1002/asia.200900485
Conference Contribution - Published proceedings: Abstract
Brooker, S., Feltham, H. L., Cameron, S. A., Sanyal, R., Kitchen, J. A., Milway, V. A., Larsen, D. S., Kloewer, F., … Clerac, R. (2010). Magnetically and electrochemically interesting di- and poly-metallic complexes of new generation Schiff-base macrocycles. Proceedings of the International Chemical Congress of Pacific Basin Societies (Pacifichem). Retrieved from http://pacifichem.abstractcentral.com/planner
Hubert, M., Hook, S., Larsen, D., Hayman, C., Painter, G., Rendle, P., & Rades, T. (2010). Synthesis and physical characterisation of PIM mimetics as novel immunomodulating agents. In L. Emmerton, A. Peters, D. Ross & B. Ross (Eds.), Proceedings of the Australasian Pharmaceutical Science Association (APSA) Annual Conference: Focus on the Future: Research and Education for a Healthier Community. (pp. 33). APSA. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Hubert, M., Hook, S., Rades, T., Hayman, C., Painter, G., Rendle, P., & Larsen, D. (2010, February). Formulation and immunological characterization of novel carbohydrate containing immunopharmaceuticals. Poster session presented at the New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2009
Journal - Research Article
Jimenez-Dalmaroni, M. J., Xiao, N., Corper, A. L., Verdino, P., Ainge, G. D., & Larsen, D. S. (2009). Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE, 4(10), e7411. doi: 10.1371/journal.pone.0007411
Denis, M., Ainge, G. D., Larsen, D. S., Severn, W. B., & Painter, G. F. (2009). A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant. Immunopharmacology & Immunotoxicology, 31(4), 577-582. doi: 10.3109/08923970902824862
Feltham, H. L. C., Larsen, D. S., & Brooker, S. (2009). A hexanuclear iron(III) complex of a hexadentate fully conjugated diimine ligand derived from 1,4-diformyl-2,3-dihydroxybenzene. New Journal of Chemistry, 33, 2001-2003. doi: 10.1039/b9nj00347a
Driessen, N. N., Ummels, R., Maaskant, J. J., Gurcha, S. S., Besra, G. S., Ainge, G. D., Larsen, D. S., … Appelmelk, B. J. (2009). Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN. Infection & Immunity, 77(10), 4538-4547. doi: 10.1128/iai.01256-08
Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009). Cobalt and silver complexes of terdentate pyrazine-based amide ligands and assembly of monocobalt building blocks through a silver connector. European Journal of Inorganic Chemistry, (9), 1162-1171. doi: 10.1002/ejic.200801187
Osman, H., Larsen, D. S., & Simpson, J. (2009). Synthesis of orthogonally protected D-olivoside, 1,3-di-O-acetyl-4-O-benzyl-2,6-dideoxy-D-arabinopyranose, as a C-glycosyl donor. Tetrahedron, 65(21), 4092-4098. doi: 10.1016/j.tet.2009.03.092
Conference Contribution - Published proceedings: Abstract
Larsen, D. S., Ainge, G. D., Dyer, B. S., Denis, M., Rendle, P., & Painter, G. F. (2009). The structure, chemical syntheses and adjuvant properties of phosphatidylinositol mannosides from mycobacteria. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Cowan, M. G., Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009, February). Self-organisation of supramolecular building blocks via silver bridges. Poster session presented at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.
Cameron, S. A., Larsen, D. S., & Brooker, S. (2009, February). Towards new families of expanded porphyrin-like ligands and complexes. Poster session presented at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kitchen, J. A., White, N. G., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., & Brooker, S. (2009, February). Generating magnetically interesting dinuclear iron(II) complexes with designer 1,2,4-triazole ligands. Verbal presentation at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.
Intellectual Property
Snow, A. D., Nguyen, B. P., Castillo, G. M., Sanders, V. J., Lake, T. P., Larsen, L., Weavers, R. T., Lorimer, S. D., Larsen, D. S., … Coffen, C. (2009). Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease. (US 7,514,583).
2008
Journal - Research Article
Compton, B. J., Larsen, D. S., Larsen, L., & Weavers, R. T. (2008). Reactive diene for synthesis of substituted catechols. Tetrahedron Letters, 49(2), 219-221. doi: 10.1016/j.tetlet.2007.11.085
Parlane, N. A., Denis, M., Severn, W. B., Skinner, M. A., Painter, G. F., La Flamme, A. C., Ainge, G. D., Larsen, D. S., & Buddle, B. M. (2008). Phosphatidylinositol mannosides are efficient mucosal adjuvants. Immunological Investigations, 37(2), 129-142. doi: 10.1080/08820130701690782
Osman, H., Larsen, D. S., Hanton, L. R., & Simpson, J. (2008). Phenyl 2,3-O-isopropylidene-1-thio-α-D-rhamnopyranoside. Acta Crystallographica Section E, E64, o24-o25. doi: 10.1107/S1600536807061004
Conference Contribution - Poster Presentation (not in published proceedings)
Larsen, D., Dyer, B., Ainge, G., & Painter, G. (2008, November-December). Synthesis and structure of PIMS. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Moodie, L., & Larsen, D. (2008, November-December). The synthesis of Angucycline antibiotics. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Kitchen, J. A., White, N. G., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., & Brooker, S. (2008, November-December). Spin crossover and anion •••€ interactions in iron(II) triazole complexes. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Painter, G. F., Ainge, G. D., Denis, M., & Larsen, D. S. (2008, November-December). Synthetic phosphatidylinositol mannoside analogues: Potent vaccine adjuvants. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Kitchen, J. A., White, N., Moubaraki, B., Murray, K. S., Grunert, C. M., Reiman, S., … Larsen, D. S., … Brooker, S. (2008, April). Spin crossover complexes. Verbal presentation at the 3rd Korea-New Zealand Material Science Workshop, Dunedin, New Zealand.
2007
Journal - Research Article
Ainge, G. D., Parlane, N. A., Denis, M., Dyer, B. S., Härer, A., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2007). Phosphatidylinositol mannoside ether analogues: Syntheses and interleukin-12-inducing properties. Journal of Organic Chemistry, 72(14), 5291-5296. doi: 10.1021/jo070639m
Dyer, B. S., Jones, J. D., Ainge, G. D., Denis, M., Larsen, D. S., & Painter, G. F. (2007). Synthesis and structure of phosphatidylinositol dimannoside. Journal of Organic Chemistry, 72, 3282-3288.
de Geest, D. J., Noble, A., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007). Dicopper(II) complexes of a new pyrazolate-containing Schiff-base macrocycle and related acyclic ligand. Dalton Transactions, 467-475.
Hellyer, R. M., Joule, J. A., Larsen, D. S., & Brooker, S. (2007). 4-(Pyrrol-1-yl)-1,2,4-triazole. Acta Crystallographica Section C, C63, o358-o360.
Conference Contribution - Poster Presentation (not in published proceedings)
Hellyer, R. M., Larsen, D. S., & Brooker, S. (2007, March). Mixed-metal Ag(I)-Co(III) complexes. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.
Noble, A., de Geest, D. J., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007, March). Macrocyclic and acyclic pyrazolate-containing Schiff-base dicopper(II) complexes. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.
2006
Journal - Research Article
Larsen, D. S., Osman, H., Caygill, G. B., McFarlane, B. S., & McMorran, D. A. (2006). rac-Hatomarubigin C. Acta Crystallographica Section E, E62, o5748-o5750.
Ainge, G. D., Parlane, N. A., Denis, M., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2006). Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides. Bioorganic & Medicinal Chemistry, 14, 7615-7624.
Hayman, C. M., Larsen, D. S., Simpson, J., Bailey, K. B., & Gill, G. S. (2006). A stereoselective synthesis of 6,6,6-trifluoro-L-daunosamine and 6,6,6-trifluoro-L-acosamine. Organic & Biomolecular Chemistry, 4, 2794-2800.
Ainge, G. D., Hudson, J., Larsen, D. S., Painter, G. F., Gill, G. S., & Harper, J. L. (2006). Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease. Bioorganic & Medicinal Chemistry, 14, 5632-5642.
2004
Journal - Research Article
Li, R., Evans, L. S., Larsen, D. S., Gale, P. A., & Brooker, S. (2004). Synthesis and anion binding behaviour of diamide derivatives of pyrrole-2,5-diacetic acid. New Journal of Chemistry, 28, 1340-1343.
Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2004). Studies related to carba-pyranoses: A radical decarboxylation approach to monocarba-disaccharides. Organic & Biomolecular Chemistry, 2, 1934-1942.
2003
Journal - Research Article
Li, R., Larsen, D. S., & Brooker, S. (2003). Syntheses, structures and tautomers of 2,5-disubstituted pyrroles. New Journal of Chemistry, 27, 1353-1359.
Landells, J. S., Larsen, D. S., & Simpson, J. (2003). Remote stereochemical control in asymmetric Diels-Alder reactions: Synthesis of the angucycline antibiotics, (-)-tetrangomycin and MM 47755. Tetrahedron Letters, 44, 5193-5196.
2002
Journal - Research Article
Dufour, J.-P., Wierda, R., Leus, M., Lissens, G., Delvaux, F., Derdelinckx, G., & Larsen, D. S. (2002). Quantitative analysis of beer aromatic alcohols using stable isotope dilution assay. Journal of the American Society of Brewing Chemists, 60(2), 88-96.
2001
Journal - Research Article
Caygill, G. B., Larsen, D. S., & Brooker, S. (2001). Total synthesis of (+)-Hatomarubigin B. Journal of Organic Chemistry, 66, 7427-7431.
Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2001). Studies related to carba-pyranoses: a strategy for the synthesis of β-1,3-glycosidically linked aminomonocarba-disaccharides. Journal of the Chemical Society, Perkin Transactions 1, 1(18), 2204-2212. doi: 10.1039/B105374B
Conference Contribution - Published proceedings: Abstract
Wierda, R., Dufour, J.-P., Leus, M., Lissens, G., Delvaux, F., David, L., & Larsen, D. S. (2001). Quantitative analysis of beer aromatic alcohols using stable isotope dilution assay. NZIFST Annual Conference - 2001: A Food Odyssey. (pp. 32). Dunedin: NZIFST. [Abstract]
Conference Contribution - Poster Presentation (not in published proceedings)
Brooker, S., Larsen, D. S., & Li, R. (2001, December). Synthesis of, and tautomerism in, 2,5-disubstituted pyrroles. Poster session presented at the New Zealand Institute of Chemestry ″Molecules for Life″ Conference, Napier.
2000
Journal - Research Article
Watt, D. K., Brasch, D. J., Larsen, D. S., Melton, L. D., & Simpson, J. (2000). Oligosaccharides related to xyloglucan: Synthesis and X-ray crystal structure of methyl α-L-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-D-xylopyranoside and the synthesis of methyl α-L-fucopyranosyl-(1→2)- β-D-galactopyranosy1]-(1→2)-β-D-xylopyranoside. Carbohydrate Research, 325, 300-312.
Landells, J. S., Kerr, J. L., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis of water soluble O-glycosides of N-(hydroxyalkyl)-aminomethylferrocenes. Journal of the Chemical Society, Dalton Transactions, 1403-1409.
Kerr, J. L., Landells, J. S., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis and structure of N-ferrocenylglycosylamines; redox chemistry of O-ferrocenylglycosides and N-ferrocenylglycosylamines. Journal of the Chemical Society, Dalton Transactions, 9, 1411-1417.
Trotter, N. S., Larsen, D. S., Stoodley, R. J., & Brooker, S. (2000). A Diels-Alder strategy to 1,4-glycosidically linked monocarba-disaccharides. Tetrahedron Letters, 41, 8957-8962.
Sum Idris, M., Larsen, D. S., Pritchard, R. G., Schofield, A., Stoodley, R. J., & Tiffin, P. D. (2000). Regio- and stereo-selective bromo(alkoxylation)s of (E)-α-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxymethylene) carbonyl compounds; A route to near-stereopure α-bromo α-dioxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 1(14), 2195-2204. doi: 10.1039/B002749I
Andrews, F. L., Larsen, D. S., & Larsen, L. (2000). Synthetic approaches to the angucycline antibiotics. A route to C-Glycosidic Benz[a]anthraquinones. Australian Journal of Chemistry, 53, 15-24.
Conference Contribution - Published proceedings: Abstract
Dufour, J.-P., Leus, M., Lissens, G., Wierda, R., Delvaux, F., & Larsen, D. (2000). Quantitative analysis of beer aromatic alcohols using stable isotope dilution analysis. American Society of Brewing Chemists, News Letter. 60, (pp. 33). [Abstract]
1999
Journal - Research Article
Watts, D. K., Brasch, D. J., Larsen, D. S., & Melton, L. D. (1999). Isolation, characterization, and NMR study of xyloglucan from enzymically depectinized and non-depectinized apple pomace. Carbohydrate Polymers, 39, 165-180.
Hayman, C. M., Hanton, L. R., Larsen, D. S., & Guthrie, J. M. (1999). A stereoselective synthesis of 2,6-dideoxy-6,6,6-trifluoro-arabino-hexoses via an asymmetric Diels-Alder strategy. Australian Journal of Chemistry, 52, 921-927.
1998
Journal - Research Article
Hayman, C. M., Larsen, D. S., & Brooker, S. (1998). A facile synthesis of 2,6-dideoxy,6,6,6-trifluorinated carbohydrate analogues. Australian Journal of Chemistry, 51, 545-553.
1997
Journal - Research Article
Larsen, D. S., Rutledge, P. S., & Woodgate, P. D. (1997). Iodination of thallium (I) salts of phenols. Australian Journal of Chemistry, 50(7), 767-769.
Caygill, G. B., Larsen, D. S., & McFarlane, B. S. (1997). Synthetic approaches to the angucycline antibiotics: a synthesis of (+/-) hatomarubigin B and C. Australian Journal of Chemistry, 50(4), 301-308.
1996
Journal - Research Article
Larsen, D. S., Schofield, A. E. M., Stoodley, R. J., & Tiffin, P. D. (1996). Diastereoselective hydrogenations of a-alkyl a-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyloxy)methylene carbonyl compounds. New route to stereopure a-alkyl a-oxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 2487-2493.
Larsen, D. S., & O'Shea, M. D. (1996). Synthetic approaches to the angucycline antiobiotics: a concise entry to the ring system of PD 116740 and TAN 1085. Journal of Organic Chemistry, 61, 5681-5683.
Watt, D. W., Brasch, D. J. A., Larsen, D. S., Melton, L. D., & Simpson, J. (1996). Oligosaccharides related to xyloglucan: synthesis and x-ray crystal structure of methyl 2O(a-L-fucopyranosyl)-b-D-galactopyranoside. Carbohydrate Research, 285, 1-15.
Larsen, D. S., O'Shea, M. D., & Brooker, S. (1996). Total syntheses of the angucyclinone antibiotics (+)-emycin A and (+)-ochromycinone. Chemical Communications, 203-204.