Professor David Larsen

Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry. Advance online publication. doi: 10.1039/d2ob01076c

Journal - Research Article

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540

Journal - Research Article

Richardson, A. T., McGhie, T. K., Cordiner, S. B., Stephens, T. T. H., Larsen, D. S., Laing, W. A., & Perry, N. B. (2021). 2-O-β-d-Glucopyranosyl L-ascorbic acid, a stable form of vitamin C, is widespread in crop plants. Journal of Agricultural & Food Chemistry, 69, 966-973. doi: 10.1021/acs.jafc.0c06330

Journal - Research Article

Kueh, J. T. B., Seifert-Simpson, J. M., Thwaite, S. H., Rodgers, G. D., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2020). Studies towards non-toxic, water soluble, vasoactive norbornene organic carbon monoxide releasing molecules. Asian Journal of Organic Chemistry, 9, 1-10. doi: 10.1002/ajoc.202000546

Journal - Research Article

Richardson, A. T., Cho, J., McGhie, T. K., Larsen, D. S., Schaffer, R. J., Espley, R. V., & Perry, N. B. (2020). Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris). Phytochemistry, 173, 112297. doi: 10.1016/j.phytochem.2020.112297

Journal - Research Article

Robinson, S. A., Yau, J., Terabe, M., Berzofsky, J. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2020). Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues. Organic & Biomolecular Chemistry, 18, 2739-2746. doi: 10.1039/d0ob00223b

Journal - Research Article

Kramer, K., Al-Barwani, F., Baird, M. A., Young, V. L., Larsen, D. S., Ward, V. K., & Young, S. L. (2019). Functionalisation of virus-like particles enhances antitumour immune responses. Journal of Immunology Research, 2019, 5364632. doi: 10.1155/2019/5364632

Journal - Research Article

Osman, H., Larsen, D. S., & Muralikrishna, A. (2019). A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B. Arabian Journal of Chemistry, 12, 2501-2512. doi: 10.1016/j.arabjc.2015.04.022

Journal - Research Article

Payne, C. M., Cho, K., & Larsen, D. S. (2019). 5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions. RSC Advances, 9, 30736-30740. doi: 10.1039/c9ra06594f

Journal - Research Article

Hogue, R. W., Dhers, S., Hellyer, R. M., Luo, J., Hanan, G. S., Larsen, D. S., Garden, A. L., & Brooker, S. (2017). Self-assembly of cyclohelicate [M₃L₃] triangles over [M₄L₄] squares, despite near-linear bis-terdentate L and octahedral M. Chemistry: A European Journal, 23(57), 14193-14199. doi: 10.1002/chem.201702153

Journal - Research Article

Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f

Journal - Research Article

Malthus, S. J., Wilson, R. K., Aggarwal, A. V., Cameron, S. A., Larsen, D. S., & Brooker, S. (2017). Carbazole-based N₄-donor Schiff base macrocycles: Obtained metal free and as Cu(II) and Ni(II) complexes. Dalton Transactions, 46(10), 3141-3149. doi: 10.1039/c6dt04598g

Journal - Research Article

Moodie, L. W. K., Trepos, R., Cervin, G., Larsen, L., Larsen, D. S., Pavia, H., … Svenson, J. (2017). Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. Journal of Natural Products, 80(2), 515-525. doi: 10.1021/acs.jnatprod.6b01056

Journal - Research Article

Nhu, D., Larsen, L., Perry, N. B., Larsen, D. S., & Hawkins, B. C. (2017). Sweet poisons: Synthetic strategies towards tutin glycosides. Australian Journal of Chemistry, 70(3), 301-306. doi: 10.1071/CH16429

Journal - Research Article

Malthus, S. J., Wilson, R. K., Larsen, D. S., & Brooker, S. (2016). Acridine-based ligands from cobalt(II) mediated rearrangement of diphenylamine-based starting materials. Supramolecular Chemistry, 28(1-2), 98-107. doi: 10.1080/10610278.2015.1091458

Journal - Research Article

Anderson, R. J., Compton, B. J., Tang, C.-W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., … Larsen, D. S., … Weinkove, R., Hermans, I. F., & Painter, G. F. (2015). NKT cell-dependent glycolipid—peptide vaccines with potent anti-tumour activity. Chemical Science, 6(9), 5095-5312. doi: 10.1039/c4sc03599b

Journal - Research Article

Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. O., Hayman, C. M., Larsen, D. S., Hermans, I. F., & Painter, G. F. (2015). Synthesis and activity of 6''-Deoxy-6''-thio-α-GalCer and peptide conjugates. Organic Letters, 17, 5954-5957. doi: 10.1021/acs.orglett.5b02836

Journal - Research Article

Finichiu, P. G., Larsen, D. S., Evans, C., Larsen, L., Bright, T. P., Robb, E. L., … Smith, R. A. J., & Murphy, M. P. (2015). A mitochondria-targeted derivative of ascorbate: MitoC. Free Radical Biology & Medicine, 89, 668-678. doi: 10.1016/j.freeradbiomed.2015.07.160

Journal - Research Article

Jiménez-Dalmaroni, M. J., Radcliffe, C. M., Harvey, D. J., Wormald, M. R., Verdino, P., Ainge, G. D., Larsen, D. S., … Wilson, I. A. (2015). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity, 21(2), 175-193. doi: 10.1177/1753425914524077

Journal - Research Article

Kueh, J. T. B., Moodie, L. W. K., Lucas, N. T., & Larsen, D. S. (2015). Synthesis of acyloxy-semicyclic dienes using an enyne metathesis/ring closing metathesis approach. European Journal of Organic Chemistry, 2015(7), 1485-1490. doi: 10.1002/ejoc.201403482

Journal - Research Article

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403

Journal - Research Article

Zheng, T., Luo, D., Compton, B. J., Painter, G. F., Alley, M. R., Larsen, D. S., … Heiser, A. (2015). Adjuvanticity of a synthetic phosphatidylinositol dimannoside to a subvirion influenza vaccine in an influenza mouse model. Journal of Vaccines & Vaccination, 6(2), 1000277. doi: 10.4172/2157-7560.1000277

Journal - Research Article

Al-Barwani, F., Young, S. L., Baird, M. A., Larsen, D. S., & Ward, V. K. (2014). Mannosylation of virus-like particles enhances internalization by antigen presenting cells. PLoS ONE, 9(8), e104523. doi: 10.1371/journal.pone.0104523

Journal - Research Article

Anderson, R. J., Tang, C.-w., Daniels, N. J., Compton, B. J., Hayman, C. M., Johnston, K. A., … Larsen, D. S., … Hermans, I. F. (2014). A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology, 10, 943-949. doi: 10.1038/nchembio.1640

Journal - Research Article

Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y

Journal - Research Article

Lee, A. M. M., Painter, G. F., Compton, B. J., & Larsen, D. S. (2014). Resolution of orthogonally protected myo-inositols with Novozym 435 providing an enantioconvergent Pathway to Ac₂PIM₁. Journal of Organic Chemistry, 79(22), 10916-10931. doi: 10.1021/jo5019188

Journal - Research Article

Moodie, L. W. K., & Larsen, D. S. (2014). A ring-closing enyne metathesis approach to functionalized semicyclic dienes: The total synthesis of (–)-tetrangomycin. European Journal of Organic Chemistry, 2014(8), 1684-1694. doi: 10.1002/ejoc.201301627

Journal - Research Article

Nakatani, Y., Larsen, D. S., Cutfield, S. M., & Cutfield, J. F. (2014). Major change in regiospecificity for the exo-1,3-β-glucanase from Candida albicans following its conversion to a glycosynthase. Biochemistry, 53(20), 3318-3326. doi: 10.1021/bi500239m

Journal - Research Article

Pun, P. B. L., Logan, A., Darley-Usmar, V., Chacko, B., Johnson, M. S., Huang, G. W., … Larsen, L., Larsen, D. S., … Smith, R. A. J., & Murphy, M. P. (2014). A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes. Free Radical Biology & Medicine, 67, 437-450. doi: 10.1016/j.freeradbiomed.2013.11.025

Journal - Research Article

Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a

Journal - Research Article

Logan, A., Cochemé, H. M., Li Pun, P. B., Apostolova, N., Smith, R. A. J., Larsen, L., Larsen, D. S., … Murphy, M. P. (2013). Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), 923-930. doi: 10.1016/j.bbagen.2013.05.026

Journal - Research Article

Rankin, G. M., Maxwell-Cameron, I., Painter, G. F., & Larsen, D. S. (2013). The Dimethoxyphenylbenzyl Protecting Group: An alternative to the p-methoxybenzyl group for protection of carbohydrates. Journal of Organic Chemistry, 5264-5272. doi: 10.1021/jo4004184

Journal - Research Article

Rankin, G. M., Compton, B. J., Johnston, K. A., Hayman, C. M., Painter, G. F., & Larsen, D. S. (2012). Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides. Journal of Organic Chemistry, 77(16), 6743-6759. doi: 10.1021/jo301189y

Journal - Research Article

Ainge, G. D., Compton, B. J., Hayman, C. M., Martin, W. J., Toms, S. M., Larsen, D. S., Harper, J. L., & Painter, G. F. (2011). Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside. Journal of Organic Chemistry, 76(12), 4941-4951. doi: 10.1021/jo200588u

Journal - Research Article

Ainge, G. D., Martin, W. J., Compton, B. J., Hayman, C. M., Larsen, D. S., Yoon, S.-I., … Painter, G. F. (2011). Synthesis and toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. Journal of Medicinal Chemistry, 54(20), 7268-7279. doi: 10.1021/jm2008419

Journal - Research Article

Feltham, H. L. C., Klöwer, F., Cameron, S. A., Larsen, D. S., Lan, Y., Tropiano, M., … Powell, A. K., & Brooker, S. (2011). A family of 13 tetranuclear zinc(II)-lanthanide(III) complexes of a [3 + 3] Schiff-base macrocycle derived from 1‚4-diformyl-2‚3-dihydroxybenzene. Dalton Transactions, 40, 11425-11432. doi: 10.1039/c1dt11038a

Journal - Research Article

Harper, J. L., Hayman, C. M., Larsen, D. S., Painter, G. F., & Singh-Gill, G. (2011). A PIM₂ analogue suppresses allergic airway disease. Bioorganic & Medicinal Chemistry, 19, 2, 917-925. doi: 10.1016/j.bmc.2010.11.058

Journal - Research Article

Kitchen, J. A., Larsen, D. S., & Brooker, S. (2010). Alkylations of N⁴-(4-Pyridyl)-3,5-di(2-pyridyl)-1,2,4-triazole: First observation of room-temperature rearrangement of an N⁴-substituted triazole to the N¹ analogue. Chemistry: An Asian Journal, 5(4), 910-918. doi: 10.1002/asia.200900485

Journal - Research Article

Denis, M., Ainge, G. D., Larsen, D. S., Severn, W. B., & Painter, G. F. (2009). A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant. Immunopharmacology & Immunotoxicology, 31(4), 577-582. doi: 10.3109/08923970902824862

Journal - Research Article

Driessen, N. N., Ummels, R., Maaskant, J. J., Gurcha, S. S., Besra, G. S., Ainge, G. D., Larsen, D. S., … Appelmelk, B. J. (2009). Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN. Infection & Immunity, 77(10), 4538-4547. doi: 10.1128/iai.01256-08

Journal - Research Article

Feltham, H. L. C., Larsen, D. S., & Brooker, S. (2009). A hexanuclear iron(III) complex of a hexadentate fully conjugated diimine ligand derived from 1,4-diformyl-2,3-dihydroxybenzene. New Journal of Chemistry, 33, 2001-2003. doi: 10.1039/b9nj00347a

Journal - Research Article

Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009). Cobalt and silver complexes of terdentate pyrazine-based amide ligands and assembly of monocobalt building blocks through a silver connector. European Journal of Inorganic Chemistry, (9), 1162-1171. doi: 10.1002/ejic.200801187

Journal - Research Article

Jimenez-Dalmaroni, M. J., Xiao, N., Corper, A. L., Verdino, P., Ainge, G. D., & Larsen, D. S. (2009). Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE, 4(10), e7411. doi: 10.1371/journal.pone.0007411

Journal - Research Article

Osman, H., Larsen, D. S., & Simpson, J. (2009). Synthesis of orthogonally protected D-olivoside, 1,3-di-O-acetyl-4-O-benzyl-2,6-dideoxy-D-arabinopyranose, as a C-glycosyl donor. Tetrahedron, 65(21), 4092-4098. doi: 10.1016/j.tet.2009.03.092

Journal - Research Article

Compton, B. J., Larsen, D. S., Larsen, L., & Weavers, R. T. (2008). Reactive diene for synthesis of substituted catechols. Tetrahedron Letters, 49(2), 219-221. doi: 10.1016/j.tetlet.2007.11.085

Journal - Research Article

Osman, H., Larsen, D. S., Hanton, L. R., & Simpson, J. (2008). Phenyl 2,3-O-isopropylidene-1-thio-α-D-rhamnopyranoside. Acta Crystallographica Section E, E64, o24-o25. doi: 10.1107/S1600536807061004

Journal - Research Article

Parlane, N. A., Denis, M., Severn, W. B., Skinner, M. A., Painter, G. F., La Flamme, A. C., Ainge, G. D., Larsen, D. S., & Buddle, B. M. (2008). Phosphatidylinositol mannosides are efficient mucosal adjuvants. Immunological Investigations, 37(2), 129-142. doi: 10.1080/08820130701690782

Journal - Research Article

Ainge, G. D., Parlane, N. A., Denis, M., Dyer, B. S., Härer, A., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2007). Phosphatidylinositol mannoside ether analogues: Syntheses and interleukin-12-inducing properties. Journal of Organic Chemistry, 72(14), 5291-5296. doi: 10.1021/jo070639m

Journal - Research Article

de Geest, D. J., Noble, A., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007). Dicopper(II) complexes of a new pyrazolate-containing Schiff-base macrocycle and related acyclic ligand. Dalton Transactions, 467-475.

Journal - Research Article

Dyer, B. S., Jones, J. D., Ainge, G. D., Denis, M., Larsen, D. S., & Painter, G. F. (2007). Synthesis and structure of phosphatidylinositol dimannoside. Journal of Organic Chemistry, 72, 3282-3288.

Journal - Research Article