Interactions of Molecules with Enzymes and Directing Effects of Substituents in Radical Reactions
Part of my research group is involved in the study of enzyme interactions with unusual molecules. Various enzymes are under study, with families of synthetic molecules, in an attempt to correlate enzyme behavior with peculiar molecular structure and conformation. Transient and steady-state techniques are employed. It is our hope that this research will reveal unusual structural motifs that can be incorporated into the design of enzyme inhibitors and structural sensors. In collaboration with Dr. Keith Gordon, we are exploring the use of laser spectroscopy in some enzyme systems through diazo molecular probes.
My research group is also interested in selective radical reactions as they allow the introduction of chemical functionality to otherwise featureless substructures for further manipulation. This technique is particularly applicable to chiral pool compounds as it simplifies the synthesis of enantiomerically pure molecules. Selectivity in radical reactions can be achieved through the use of directing substituents which either activate or inactivate a particular position or stereochemical aspect. For example, the following reaction proceeds with >95% ee in quantitative yield via a bridged chlorine radical intermediate.
We are also trying to capture the imagination of students and the general public by representing molecular structure and function in exciting new ways.
Publications
Fellner, M., Walsh, A., Dela Ahator, S., Aftab, N., Sutherland, B., Tan, E. W., … Lentz, C. S. (2023). Biochemical and cellular characterization of the function of fluorophosphonate-binding hydrolase H (FphH) in Staphylococcus aureus support a role in bacterial stress response. ACS Infectious Diseases. Advance online publication. doi: 10.1021/acsinfecdis.3c00246
Journal - Research Article
Banstola, A., Vautrelle, N., Bergin, D., Gray, J., Murray, E., Mohammad, Y., Rizwan, S., … Tan, E., & Reynolds, J. (2023, June). Translational feasibility of a novel focused ultrasound approach for phasic dopamine receptor stimulation in a sheep model of Parkinson’s disease. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden.
Conference Contribution - Poster Presentation (not in published proceedings)
Wilson, S. A., Laing, R. M., Tan, E., Wilson, C. A., Garagoda Arachchige, P. S., Gordon, K. C., & Fraser-Miller, S. J. (2023). Determining deposits on knit fabrics, yarns, and fibers, from sensor-related treatments. Journal of the Textile Institute. Advance online publication. doi: 10.1080/00405000.2023.2221427
Journal - Research Article
Samanali, G. A. P., Wilson, S., Fraser-Miller, S., Tan, E. W., Laing, R., Wilson, C., & Gordon, K. (2022). Vibrational spectroscopic analysis of graphene treated natural textiles. Proceedings of the Dodd-Walls Centre Dunedin Symposium. Retrieved from https://www.doddwalls.ac.nz/events
Conference Contribution - Published proceedings: Abstract
Nakano, T., Rizwan, S. B., Myint, D. M. A., Gray, J., Mackay, S. M., Harris, P., Perk, C. G., Hyland, B. I., Empson, R., Tan, E. W., … Reynolds, J. N. J., & Wickens, J. R. (2022). An on-demand drug delivery system for control of epileptiform seizures. Pharmaceutics, 14, 468. doi: 10.3390/pharmaceutics14020468
Journal - Research Article
Reynolds, J. N. J., Tan, E. W., Hyland, B. I., Jameson, G. N. L., Myint, M. M. A., Mackay, S. M., & Wickens, J. R. (2021). Acoustic driven drug delivery systems. (11260126). United States.
Intellectual Property
Wilson, S., Laing, R., Tan, E. W., & Wilson, C. (2020). Encapsulation of electrically conductive apparel fabrics: Effects on performance. Sensors, 20, 4243. doi: 10.3390/s20154243
Journal - Research Article
Mackay, S. M., Tan, E. W., & Warren, D. S. (2020). Developing a new generation of scientist communicators through effective public outreach. Communications Chemistry, 3, 76. doi: 10.1038/s42004-020-0315-0
Journal - Research Other
Mackay, S. M., Myint, D. M. A., Easingwood, R. A., Hegh, D. Y., Wickens, J. R., Hyland, B. I., Jameson, G. N. L., Reynolds, J. N. J., & Tan, E. W. (2019). Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes. Communications Chemistry, 2, 122. doi: 10.1038/s42004-019-0226-0
Journal - Research Article
Tan, E. W., Mackay, S., Nakano, T., Reynolds, J. N. J., & Wickens, J. (2018, August). Pulse-modulation drug delivery from lipsomal nanostructures. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Vautrelle, N., Bergin, D. H., Gray, J. P., Bergin, R., Leriche, M., Fuller, J., Hyland, B. I., … Tan, E. W., & Reynolds, J. N. J. (2018). Development of a minimally-invasive technology for spatially- and temporally-controlled drug delivery into the brain. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 66). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Conference Contribution - Published proceedings: Abstract
Craig, A., Smith, R., Stevens-Cullinane, L., Lucas, N. T., Tan, E. W., & Hawkins, B. C. (2016). The synthesis of multifunctionalised 1,3-oxazin-4-Enones from 1-acyl-1-cyclopropyl carboxylic acids. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Conference Contribution - Published proceedings: Abstract
Nakano, T., Mackay, S. M., Tan, E. W., Dani, K. M., & Wickens, J. (2016). Interfacing with neural activity via femtosecond laser stimulation of drug-encapsulating liposomal nanostructures. eNeuro, 3(6), e0107-16.2016. doi: 10.1523/ENEURO.0107-16.2016
Journal - Research Article
Smith, R. J., Craig, A. J., Tan, E. W., Lucas, N. T., & Hawkins, B. C. (2016). Expedient synthesis of 1,3-oxazin-4-ones. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Rodpun, K., Lucas, N. T., Tan, E. W., & Meledandri, C. J. (2016). Colloidal coordination polymer nanocrystals: Synthesis and catalytic activity. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Mackay, S. M., & Tan, E. W. (2016). Spatiotemporal neural modulation by liposomal nanostructures. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Craig, A. J., Smith, R., Stevens-Cullinane, L., Lucas, N. T., Tan, E. W., & Hawkins, B. C. (2016). The synthesis of multifunctionalised 1,3-oxazin-4-enones from 1-acyl-1-cyclopropyl carboxylic acids. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Hegh, D. Y., Mackay, S. M., & Tan, E. W. (2016). Pulsatile release from pH triggered imidazoline switchable surfactant liposomes. RSC Advances, 6, 56859-56866. doi: 10.1039/c6ra08814g
Journal - Research Article
Rodpun, K., Lucas, N. T., Tan, E. W., & Meledandri, C. J. (2016). Development of solvent-dispersible coordination polymer nanocrystals and application as efficient heterogeneous catalysts. Crystal Growth & Design, 16(7), 3940-3946. doi: 10.1021/acs.cgd.6b00502
Journal - Research Article
Smith, R. J., Mills, D. A., Nhu, D., Tan, E. W., Lucas, N. T., & Hawkins, B. C. (2016). The synthesis of multifunctionalized 1,3-oxazin-4-ones from donor-acceptor cyclopropanes. Journal of Organic Chemistry, 81(5), 2099-2105. doi: 10.1021/acs.joc.6b00112
Journal - Research Article
Hinow, P., Radunskaya, A., Mackay, S. M., Reynolds, J. N. J., Schroeder, M., Tan, E. W., & Tucker, I. G. (2016). Signaled drug delivery and transport across the blood-brain barrier. Journal of Liposome Research, 26(3), 233-245. doi: 10.3109/08982104.2015.1102277
Journal - Research Article
Meledandri, C. J., Lucas, N. T., Rodpun, K., & Tan, E. W. (2015, March-April). Synthesis of CuII and ZnII coordination polymer nanocrystals using a microemulsion method. Invited presentation at the 13th International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM), Marrakesh, Morocco.
Conference Contribution - Verbal presentation and other Conference outputs
Hegh, D., Mackay, S., & Tan, E. W. (2015, February). Oxidative triggered release from N-tetradecyl dihydronicotinamide impregnated liposomes. Poster session presented at the Seventh International Conference on Advanced Materials & Nanotechnology (AMN-7), Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Rodpun, K., Lucas, N. T., Tan, E. W., & Meledandri, C. J. (2015, February). Synthesis of nanocrystal CuII and ZnII coordination polymers by a microemulsion method. Poster session presented at the Seventh International Conference on Advanced Materials & Nanotechnology (AMN-7), Nelson, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Rodpun, K., Blackman, A. G., Gardiner, M. G., Tan, E. W., Meledandri, C. J., & Lucas, N. T. (2015). Alkyl linker effects on the coordination topology of ditopic di(2-pyridylmethyl)amine carboxylate ligands with ZnII and CuII: Polymers vs. macrocycles. CrystEngComm, 17(15), 2974-2988. doi: 10.1039/c5ce00375j
Journal - Research Article
Meledandri, C., Lucas, N., Rodpun, K., & Tan, E. (2015, February). Size-controlled, solvent-dispersible coordination polymer nanocrystals: Preparation and catalytic activity. Verbal presentation at the Seventh International Conference on Advanced Materials & Nanotechnology (AMN-7), Nelson, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Craig, A. J., van der Salm, L., Stevens-Cullinane, L., Lucas, N. T., Tan, E. W., & Hawkins, B. C. (2015). Expedient metal-free synthesis of 1,3-oxazinen-4-ones. Organic Letters, 17(2), 234-237. doi: 10.1021/ol503350h
Journal - Research Article
Hegh, D. Y., Mackay, S. M., & Tan, E. W. (2014). CO2-triggered release from switchable surfactant impregnated liposomes. RSC Advances, 4, 31771-31774. doi: 10.1039/c4ra05387g
Journal - Research Article
Nakano, T., Chin, C., Myint, D. M. A., Tan, E. W., Hale, P. J., Krishna M, B. M., Reynolds, J. N. J., … Dani, K. M. (2014). Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems. Scientific Reports, 4, 5398. doi: 10.1038/srep05398
Journal - Research Article
Nakano, T., Chin, C., Myint, D. M. A., Tan, E. W., Hale, P. J., Reynolds, J. N. J., Wickens, J., & Dani, K. M. (2014). Femtosecond laser stimulated nanosystems for neuroscience applications. Proceedings of the Conference on Lasers and Electro-Optics (CLEO): Applications and Technology: Symposium on Novel Light Sources and Photonic Devices in Optical Imaging I. Optical Society. doi: 10.1364/CLEO_AT.2014.ATu2P.6
Conference Contribution - Published proceedings: Full paper
Braund, R., Tong, A., Tan, E., Tremblay, L., Stringer, T., & Peake, B. (2014). Photodegradation of oseltamivir (Tamiflu™) in aqueous solution. Proceedings of the 5th Pharmaceutical Sciences World Congress (PSWC). Retrieved from http://www.fip.org/pswc2014/Melbourne/2041/Programme/
Conference Contribution - Published proceedings: Abstract
Mackay, S. M., Hegh, D. Y., & Tan, E. W. (2013). UV-triggered release from switchable surfactant impregnated liposomes. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Hegh, D. Y., Mackay, S. M., & Tan, E. W. (2013). pH-triggered release from 2-alkylimidazoline surfactant impregnated liposomes. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Jordan, D., Tan, E., & Hegh, D. (2012). Synthesis, characterization and conductivity of quaternary nitrogen surfactants modified by the addition of a hydroxymethyl substrate on the head group. Journal of Surfactants & Detergents, 15(5), 587-592. doi: 10.1007/s11743-012-1360-1
Journal - Research Article
Tong, A. Y. C., Braund, R., Tan, E. W., Tremblay, L. A., Stringer, T., Trought, K., & Peake, B. M. (2011). UV-induced photodegradation of oseltamivir (Tamiflu) in water. Environmental Chemistry, 8(2), 182-189. doi: 10.1071/EN10095
Journal - Research Article
Hegh, D. Y., Tan, E. W., & Jordan, D. K. (2011). Manipulation of vesicle morphology by quaternary ammonium cationic surfactants. Proceedings of the Fifth International Conference on Advanced Materials and Nanotechnology (AMN-5). Retrieved from http://www.confer.co.nz/amn-5/pdf/Posters/FP44.pdf
Conference Contribution - Published proceedings: Abstract
Hegh, D. Y., Tan, E. W., Jordan, D. K., & Hunt, N. (2009, February). The effect of quaternary ammonium cationic surfactants on membrane mimetic liposomes. Poster session presented at the MacDiarmid Institute for Advanced Materials and Nanotechnology Conference (AMN-4), Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Jordan, K., Hegh, D. Y., Tan, E. W., & Bremer, P. (2008). Synthesis and study of Quaternary Nitrogen Species. Proceedings of the New Zealand Microbiological Society Microbiology Conference. (pp. 34). NZMS. Retrieved from http://www.nzmsconference08.org.nz/files/Poster-Abstracts-NZMS-2008.pdf
Conference Contribution - Published proceedings: Abstract
Jordan, D. K., Hegh, D. Y., & Tan, E. W. (2008, November-December). Synthesis, antibacterial activity and CMC studies of cationic surfactants. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Hegh, D. Y., Tan, E. W., Jordan, D. K., & Hunt, N. (2008, November-December). The effect of quaternary ammonium cationic surfactants on membrane mimetic liposomes. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Jordan, D. K., Kitchen, J. A., Hegh, D. Y., Brooker, S., & Tan, E. W. (2008). 1-Tetradecylpyridinium bromide monohydrate. Acta Crystallographica Section E, E64, o2457-02457.
Journal - Research Article
Yu, P.-S., & Tan, E. W. (2007, March). Structural studies of inden-1-one dimers. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Jordan, D. K., Tan, E. W., Hegh, D. Y., McQuillan, A. J., & Bremer, P. J. (2007, March). Synthesis and study of quaternary nitrogen centers for use in surface antibiofouling coatings. Poster session presented at the Supramolecular Chemistry and Nanoscience Conference, Dunedin, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Gao, Z., Bremer, P. J., Barker, M. F., Tan, E. W., & McQuillan, A. J. (2007). Adhesive secretions of live mussels observed in Situ by attenuated total reflection-infrared spectroscopy. Applied Spectroscopy, 61(1), 55-59.
Journal - Research Article
Jordan, D. K., Tan, E. W., Hegh, D. Y., McQuillan, A. J., Bremer, P. J., Kennedy, M. J., Seale, R. B., & Bailey, K. B. (2006). Synthesis and study of quaternary nitrogen centres for use in surface antibiofouling coatings. In M. Lein (Ed.), Proceedings of the New Zealand Institute of Chemistry Conference.II, (pp. 167). Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Myint, M. A., Price, J. R., & Tan, E. W. (2006). Adamantane-1,2-diol. Acta Crystallographica Section E, E62, o1139-o1140.
Journal - Research Article
Myint, M. A., Blackman, A. G., & Tan, E. W. (2005). (±)-Adamantane-1,2-diyl diacetate. Acta Crystallographica Section E, 61, 3154-3155. doi: 10.1107/S1600536805027509
Journal - Research Article
Bailey, K., & Tan, E. W. (2005). Synthesis and evaluation of bifuntional nitrocatechol inhibitors of pig liver carechol-O-methyltranferase. Bioorganic & Medicinal Chemistry, 13, 5740-5749.
Journal - Research Article
Yu, P.-S., Thomas, G. D., Blackman, A. G., & Tan, E. W. (2005). trans-3-Bromo-2-chloroindan-1-one. Acta Crystallographica Section E, 61, 0651-0652.
Journal - Research Article
Bremer, P., Gao, J., Barker, M., Tan, E. W., & McQuillan, J. (2004). Observing mussel adhesion secretions with in situ infrared spectroscopy. Proceedings of the NZMSS 2004 Conference. (pp. 4). [Abstract]
Conference Contribution - Published proceedings: Abstract
Bailey, K., Cowling, R., Tan, E. W., & Webb, D. (2004). A colormetric assay for catechol-O-methyltransferase. Bioorganic & Medicinal Chemistry, 12, 595-601.
Journal - Research Article
Haghbeen, K., & Tan, E. W. (2003). Direct spectrophotometric assay of monooxygenase and oxidase activities of mushroom tyrosinase in the presence of synthetic and natural substrates. Analytical Biochemistry, 312(1), 23-32.
Journal - Research Article
Tan, E. W., Chan, B., & Blackman, A. G. (2002). A polar Effects Controlled Enantioselective 1,2-Chlorine Atom Migration via a Chlorine-Bridged Radical Intermediate. Journal of the American Chemical Society, 124(10), 2078-2079.
Journal - Research Article
Tan, E. W., & Chan, B. (2001). A polar effects controlled enantioselective chlorine atom migration. Verbal presentation at the New Zealand Institute of Chemistry (NZIC) Conference, Napier, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Chan, B., Tan, E. W., & Blackman, A. G. (2001). Pentafluorophenyl 3-chloro-3-phenylpropanoate. Acta Crystallographica Section E, E57, o725-o726.
Journal - Research Article
Tan, E. W., Chan, B., Wong, L. S., Bennett, C., & Kjaergaard, H. G. (2000). Stereoselective atom trasnfer reactions through chlorine bridging. Verbal presentation at the 11th Royal Australian Chemistry Institute Conference, Canberra.
Conference Contribution - Verbal presentation and other Conference outputs
Wong, E., Chan, B., & Tan, E. W. (2000). Stereoselective radical bromination of α-chloro hydrocinnamic acid derivatives. Tetrahedron Letters, 41, 2671-2674.
Journal - Research Article
Chan, B., Wong, E., Simpson, J., & Tan, E. W. (2000). (+)-(2R,3S)-3-bromo-2-chloro-N,N-diisopropyl-3-phenylpropanamide and (+)-(2R,3S)-3-bromo-2-chloro-N-(4-nitrophenyl)-3-phenylpropanamide. Acta Crystallographica Section C, 56, 354-355.
Journal - Research Article
Bailey, K. B., & Tan, E. W. (1998, July). Polyfunctional competitive substrates/inhibitors of Catechol-O-Methyltransferase. Verbal presentation at the 16th National Organic Conference, Leura, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Tan, E. W., Chan, B., Fowler, S., Kjaergaard, H. G., & Shaw, J. P. (1998, July). Controlling stereoselectivity in free radical brominations of A-substituted carboxylic acids. Verbal presentation at the 16th National Organic Conference, Leura, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Tan, E. W., & Thomas, G. D. (1998, July). Exploring selective radical functionalisations of cyclic a-amino acid derivatives. Verbal presentation at the 16th National Organic Conference, Leura, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Haghbeen, K., & Tan, E. W. (1998). Facile synthesis of catechol azo dyes. Journal of Organic Chemistry, 63, 4503-4505.
Journal - Research Article
Tan, E. W., & Shaw, J. P. (1997). Controlling selectivity of radical reactions in a substituted carboxylic acid derivatives. Proceedings of the 35th National Organic Conference. (pp. W338). [Abstract]
Conference Contribution - Published proceedings: Abstract
Brevitt, S. E., & Tan, E. W. (1997). Synthesis and in vitro evaluation of two progressive series of bifunctional polyhydroxybenzamide catechol-O-methyltransferase inhibitors. Journal of Medicinal Chemistry, 40(13), 2035-2039.
Journal - Research Article
Tan, E. W., & Shaw, J. P. (1997). Controlling stereoselectivity in free radical brominations of alpha-substituted carboxylic acids. 35th National Organic Chemistry Symposium, June 22-26, 1997, Trinity University, San Antonio, Texas. San Antonio, USA. [Abstract]
Conference Contribution - Published proceedings: Abstract
Shaw, J. P., & Tan, E. W. (1996). Selective bromination of α-chloro and α-bromo carboxylic acid derivatives. Journal of Organic Chemistry, 61(16), 5635-5637. doi: 10.1021/jo960311l
Journal - Research Article
Shaw, J. P., Tan, E. W., & Blackman, A. G. (1996). Methyl 2-Benzoyloxy-3-oxo-3-phenylpropanoate. Acta Crystallographica Section C, 52(11), 2883-2885. doi: 10.1107/S0108270196008323
Journal - Research Article
Tan, E. W., & Thomas, G. D. (1996). Exploring selective radical functionalisation of cyclic alpha-amino acid derivatives. Molecules for the Future: National Conference of the New Zealand Institute of Chemistry and the New Zealand Society of Biochemistry and Molecular Biology, University of Otago, Dunedin, 2-6 December 1996: Programme and Abstracts. (pp. 105). Dunedin: The institute. [Abstract]
Conference Contribution - Published proceedings: Abstract
Bailey, K. B., & Tan, E. W. (1996). Polyfunctional competitive substrates/inhibitors of catechol-o-methyltransferase. Molecules for the Future: National Conference of the New Zealand Institute of Chemistry and the New Zealand Society of Biochemistry and Molecular Biology, University of Otago, Dunedin, 2-6 December 1996: Programme and Abstracts. (pp. 128). Dunedin: The Institute. [Abstract]
Conference Contribution - Published proceedings: Abstract
Haghbeen, K., & Tan, E. W. (1996). A facile method for synthesising Diazo Catechol dyes used as chromophoric substrates for tyrosinase. Molecules for the Future: National Conference of the New Zealand Institute of Chemistry and the New Zealand Society of Biochemistry and Molecular Biology, University of Otago, Dunedin, 2-6 December 1996: Programme and Abstracts. (pp. 64). Dunedin: The Institute. [Abstract]
Conference Contribution - Published proceedings: Abstract
Tan, E. W., & Shaw, J. P. (1996). Controlling selectivity of radical reactions in alpha-substituted carboxylic acid derivatives. Molecules for the Future: National Conference of the New Zealand Institute of Chemistry and the New Zealand Society of Biochemistry and Molecular Biology, University of Otago, Dunedin, 2-6 December 1996: Programme and Abstracts. (pp. 56). Dunedin: The Institute. [Abstract]
Conference Contribution - Published proceedings: Abstract