Dr Andrea Vernall

Yin, J., Sharma, R., Tyndall, J. D. A., Grimsey, N. L., & Vernall, A. J. (2023). Synthesis and characterization of a cannabinoid type 2 receptor photoactivated prodrug. ChemPhotoChem, e202200291. Advance online publication. doi: 10.1002/cptc.202200291

Journal - Research Article

Faville, S. C., Harris-Handscomb, K., Harker, O., Mattison, S., Tamorite, H., Bristowe, J., Daly, D., Ege, R., He, H., Jones, J., McCorkindale, A., Mei, K., Monson, A., Moree, L., Perkovic, F., Rickerby, G., Robinson, J., Rudkin, F., Whibley, L., Worthington, R., Ennis, C., de la Harpe, S., Brind, T., Hopkins, A., Winefield, K., … Vernall, A. J. (2022). Open synthesis network research in an undergraduate laboratory: Development of benzoxazole amide derivatives against leishmania parasite. Journal of Chemical Education. Advance online publication. doi: 10.1021/acs.jchemed.1c01213

Journal - Research Article

Webb, H. D. J., Finlay, D. B., Chen, S., Vernall, A. J., Sparkes, E., Banister, S. D., Rosengren, R. J., & Glass, M. (2022). Characterisation of AMB-FUBINACA metabolism and CB₁-mediated activity of its acid metabolite. Forensic Toxicology. Advance online publication. doi: 10.1007/s11419-022-00649-3

Journal - Research Article

Whiting, Z. M., Yin, J., de la Harpe, S. M., Vernall, A. J., & Grimsey, N. L. (2022). Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: Past, present, and future. Trends in Pharmacological Sciences. Advance online publication. doi: 10.1016/j.tips.2022.06.010

Journal - Research Article

Lamichhane, R., Munro, F., Harrop, T. W. R., de la Harpe, S. M., Dearden, P. K., Vernall, A. J., McCall, J. L., & Ussher, J. E. (2021). Human liver-derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR-independent activation. European Journal of Immunology, 51, 879-892. doi: 10.1002/eji.202048830

Journal - Research Article

Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2021). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry, 74, 433-442. doi: 10.1071/CH20263

Journal - Research Article

Trinh, P. N. H., Chong, D. J. W., Leach, K., Hill, S. J., Tyndall, J. D. A., May, L. T., Vernall, A. J., & Gregory, K. J. (2021). Development of covalent, clickable probes for adenosine A₁ and A₃ receptors. Journal of Medicinal Chemistry, 64, 8161-8178. doi: 10.1021/acs.jmedchem.0c02169

Journal - Research Article

Lamichhane, R., Galvin, H., Hannaway, R. F., de la Harpe, S. M., Munro, F., Tyndall, J. D. A., Vernall, A. J., McCall, J. L., Husain, M., & Ussher, J. E. (2020). Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology, 50, 178-191. doi: 10.1002/eji.201948279

Journal - Research Article

Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394

Journal - Research Article

Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8⁺ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054

Journal - Research Article

Singh, S., Oyagawa, C. R. M., Macdonald, C., Grimsey, N. L., Glass, M., & Vernall, A. J. (2019). Chromenopyrazole-based high affinity, selective fluorescent ligands for cannabinoid type 2 receptor. ACS Medicinal Chemistry Letters, 10, 209-214. doi: 10.1021/acsmedchemlett.8b00597

Journal - Research Article

Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076

Journal - Research Article

Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j

Journal - Research Article

Oyagawa, C. R. M., de la Harpe, S. M., Saroz, Y., Glass, M., Vernall, A. J., & Grimsey, N. L. (2018). Cannabinoid Receptor 2 signalling bias elicited by 2,4,6-trisubstituted 1,3,5-triazines. Frontiers in Pharmacology, 9, 1202. doi: 10.3389/fphar.2018.01202

Journal - Research Article

Singh, S., Cooper, S. L., Glenn, J. R., Beresford, J., Percival, L. R., Tyndall, J. D. A., … Vernall, A. J. (2018). Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. RSC Advances, 8(29), 16362-16369. doi: 10.1039/C7RA13148H

Journal - Research Article

Cooper, A., Singh, S., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2017). Chemical tools for studying lipid-binding class A G protein-coupled receptors. Pharmacological Reviews, 69(3), 316-353. doi: 10.1124/pr.116.013243

Journal - Research Article

Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195

Journal - Research Article

Stoddart, L. A., Vernall, A. J., Briddon, S. J., Kellam, B., & Hill, S. J. (2015). Direct visualisation of internalization of the adenosine A₃ receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98, 68-77. doi: 10.1016/j.neuropharm.2015.04.013

Journal - Research Article

Vernall, A. J., Hill, S. J., & Kellam, B. (2014). The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. British Journal of Pharmacology, 171(5), 1073-1084. doi: 10.1111/bph.12265

Journal - Research Article

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Ng, H. W., Laughton, C. A., Doughty, S. W., … Kellam, B. (2013). Conversion of a non-selective adenosine receptor antagonist into A₃-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11(34), 5673-5682. doi: 10.1039/c3ob41221k

Journal - Research Article

Stoddart, L. A., Vernall, A. J., Denman, J. L., Briddon, S. J., Kellam, B., & Hill, S. J. (2012). Fragment screening at adenosine-A3 receptors in living cells using a fluorescence-based binding assay. Chemistry & Biology, 19(9), 1105-1115. doi: 10.1016/j.chembiol.2012.07.014

Journal - Research Article

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012). Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. Journal of Medicinal Chemistry, 55(4), 1771-1782. doi: 10.1021/jm201722y

Journal - Research Article

Vernall, A. J., Cassidy, P., & Alewood, P. F. (2009). A single α-helical turn stabilized by replacement of an internal hydrogen bond with a covalent ethylene bridge. Angewandte Chemie International Edition, 48(31), 5675-5678. doi: 10.1002/anie.200901059

Journal - Research Article

Vernall, A. J., Ballet, S., & Abell, A. D. (2008). Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates. Tetrahedron, 64(18), 3980-3997. doi: 10.1016/j.tet.2008.02.043

Journal - Research Article

Liddle, I., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2022). Covalent cannabinoid receptor ligands: Structural insight and selectivity challenges. RSC Medicinal Chemistry. Advance online publication. doi: 10.1039/D2MD00006G

Journal - Research Other

Smoum, R., Grether, U., Karsak, M., Vernall, A. J., Park, F., Hillard, C. J., & Pacher, P. (2022). Therapeutic potential of the cannabinoid CB2 receptor. Frontiers in Pharmacology, 13, 1039564. doi: 10.3389/fphar.2022.1039564

Journal - Research Other

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of tools for studying cannabinoid type 2 receptor: Design, synthesis and pharmacological evaluation of fluorescent ligands and intermediates. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Conference Contribution - Published proceedings: Abstract

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 709. Retrieved from http://www.asceptasm.com/

Conference Contribution - Published proceedings: Abstract

Singh, S., Glenn, J. R., Hill, S. J., Tyndall, J. D. A., & Vernall, A. J. (2016). Illuminating the life of A₁ adenosine receptor. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Conference Contribution - Published proceedings: Abstract

Cooper, A., Hook, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of fluorescent ligands as tools for studying the cannabinoid type 2 receptor. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Conference Contribution - Published proceedings: Abstract

Singh, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of selective fluorescent ligands for A1AR as pharmacological tools. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Conference Contribution - Published proceedings: Abstract

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Kellam, B., & Hill, S. J. (2014). New fluorescent antagonists for the histamine H₁-receptor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Molecular Pharmacology of G Protein-Coupled Receptors (MPGPCR) Joint Scientific Meeting. (pp. 115). Retrieved from http://www.asceptasm.com/

Conference Contribution - Published proceedings: Abstract

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2013). Fluorescent probes as drug discovery tools. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html

Conference Contribution - Published proceedings: Abstract

Vernall, A., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012). Highly potent and selective fluorescent antagonist of the adenosine A3 receptor: Use as an imaging tool. Proceedings of the 243rd ACS National Meeting & Exposition. Retrieved from http://abstracts.acs.org/chem/243nm/program/view.php

Conference Contribution - Published proceedings: Abstract

Wedlock, L., Lamichhane, R., de la Harpe, S. M., Vernall, A. J., & Ussher, J. E. (2022, August). The regulation of mucosal-associated invariant T (MAIT) cell activation by bacteria. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Putha, L., Kok, L. K., Chen, K., Sagatova, A. A., Wilbanks, S. M., Gamble, A. B., Vernall, A. J., & Tyndall, J. D. (2018, August). New isothiocyanates: Covalent inhibitors of macrophage migration inhibitory factor. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Cooper, A., Macdonald, C., Manning, J., Glass, M., Hook, S., Tyndall, J., & Vernall, A. (2017, September). Design, synthesis and pharmacological evaluation of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the 19th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK.

Conference Contribution - Poster Presentation (not in published proceedings)

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. (2017, November). Differences in the effector function of MR1- and cytokine stimulated MAIT cells. Poster session presented at the 10th International CD1-MR1 Workshop, Napa, USA.

Conference Contribution - Poster Presentation (not in published proceedings)

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the European Federation for Medicinal Chemistry (EFMC) International Symposium on Medicinal Chemistry, Manchester, UK.

Conference Contribution - Poster Presentation (not in published proceedings)

Singh, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of selective fluorescent ligands for A₁ adenosine receptor as pharmacological tools. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012, December). Conversion of non-selective adenosine receptor ligands to subtype selective higher affinity fluorescent probes using peptide-based linkers. Poster session presented at the Seventh Molecular Pharmacology of G Protein-coupled Receptors International Meeting, Melbourne, Australia.

Conference Contribution - Poster Presentation (not in published proceedings)

Singh, S., Oyagawa, C. R. M., Grimsey, N. L., Tyndall, J. D. A., Glass, M., & Vernall, A. J. (2019, August-September). Chromenopyrazole-based chemical tools to study cannabinoid type 2 receptor. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. E. (2018, August). Differential regulation of MR1- and cytokine stimulated MAIT cells. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Oyagawa, C. R. M., de la Harpe, S., Woodhouse, B. J., Glass, M., Vernall, A. J., & Grimsey, N. L. (2017, September). Utilising novel ligands to investigate an unusual trafficking phenotype: Agonist-induced surface upregulation of cannabinoid receptor 2. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT-NZ) New Zealand Annual Scientific Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Ussher, J., Williams, T., Lamichhane, R., de la Harpe, S., Tyndall, J., & Vernall, A. (2017, November). Bacteria license antigen presenting cells for MR1-mediated MAIT cell activation. Verbal presentation at the 10th International CD1-MR1 Workshop, Napa, USA.

Conference Contribution - Verbal presentation and other Conference outputs