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Dr Andrea Vernall

Andrea-Vernall Image 1xPhD BSc(Hons) (Canterbury)

Tel +64 3 479 5214
Location Science II 5n4
Email andrea.vernall@otago.ac.nz

Professional background

  • 2006 – 2009, Research Officer, Institute for Molecular Bioscience, Brisbane
  • 2009 – 2013, Research Fellow, School of Pharmacy, University of Nottingham, UK
  • 2013 – 2020, Lecturer then Senior Lecturer, School of Pharmacy, University of Otago

Research interests

The Vernall research group focuses on the development of heterocyclic small molecules, peptidomimetics and fluorescent tools that target receptors in the human body. The motivation for developing new chemical tools is to better understand disease processes and cell signalling by studying targets implicated in various diseases and conditions. We particularly focus on developing new tools to study G protein-coupled receptors, for example adenosine and cannabinoid receptors. Other Vernall group research includes small molecule ligand development for modulating immune responses and new approaches to studying antibiotic resistance.

Teaching

  • CHEM 202
  • CHEM 205
  • CHEM 305
  • CHEM 461

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Publications

Lamichhane, R., Munro, F., Harrop, T. W. R., de la Harpe, S. M., Dearden, P. K., Vernall, A. J., McCall, J. L., & Ussher, J. E. (2020). Human liver-derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR-independent activation. European Journal of Immunology. Advance online publication. doi: 10.1002/eji.202048830

Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2020). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry. Advance online publication. doi: 10.1071/CH20263

Lamichhane, R., Galvin, H., Hannaway, R. F., de la Harpe, S. M., Munro, F., Tyndall, J. D. A., Vernall, A. J., McCall, J. L., Husain, M., & Ussher, J. E. (2020). Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology, 50, 178-191. doi: 10.1002/eji.201948279

Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394

Singh, S., Oyagawa, C. R. M., Macdonald, C., Grimsey, N. L., Glass, M., & Vernall, A. J. (2019). Chromenopyrazole-based high affinity, selective fluorescent ligands for cannabinoid type 2 receptor. ACS Medicinal Chemistry Letters, 10, 209-214. doi: 10.1021/acsmedchemlett.8b00597

Journal - Research Article

Lamichhane, R., Munro, F., Harrop, T. W. R., de la Harpe, S. M., Dearden, P. K., Vernall, A. J., McCall, J. L., & Ussher, J. E. (2020). Human liver-derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR-independent activation. European Journal of Immunology. Advance online publication. doi: 10.1002/eji.202048830

Schneider, M., Hannaway, R. F., Lamichhane, R., de la Harpe, S. M., Tyndall, J. D. A., Vernall, A. J., Kettle, A. J., & Ussher, J. E. (2020). Neutrophils suppress mucosal-associated invariant T cells in humans. European Journal of Immunology, 50, 643-655. doi: 10.1002/eji.201948394

Lamichhane, R., Galvin, H., Hannaway, R. F., de la Harpe, S. M., Munro, F., Tyndall, J. D. A., Vernall, A. J., McCall, J. L., Husain, M., & Ussher, J. E. (2020). Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology, 50, 178-191. doi: 10.1002/eji.201948279

Singh, S., Liddle, I., Macdonald, C., Tyndall, J. D. A., Glass, M., & Vernall, A. (2020). Development of chromenopyrazole-based selective cannabinoid 2 receptor agonists. Australian Journal of Chemistry. Advance online publication. doi: 10.1071/CH20263

Singh, S., Oyagawa, C. R. M., Macdonald, C., Grimsey, N. L., Glass, M., & Vernall, A. J. (2019). Chromenopyrazole-based high affinity, selective fluorescent ligands for cannabinoid type 2 receptor. ACS Medicinal Chemistry Letters, 10, 209-214. doi: 10.1021/acsmedchemlett.8b00597

Lamichhane, R., Schneider, M., de la Harpe, S. M., Harrop, T. W. R., Hannaway, R. F., Dearden, P. K., Kirman, J. R., Tyndall, J. D. A., Vernall, A. J., & Ussher, J. E. (2019). TCR- or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses. Cell Reports, 28(12), 3061-3076.e5. doi: 10.1016/j.celrep.2019.08.054

Singh, S., Cooper, S. L., Glenn, J. R., Beresford, J., Percival, L. R., Tyndall, J. D. A., … Vernall, A. J. (2018). Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools. RSC Advances, 8(29), 16362-16369. doi: 10.1039/C7RA13148H

Oyagawa, C. R. M., de la Harpe, S. M., Saroz, Y., Glass, M., Vernall, A. J., & Grimsey, N. L. (2018). Cannabinoid Receptor 2 signalling bias elicited by 2,4,6-trisubstituted 1,3,5-triazines. Frontiers in Pharmacology, 9, 1202. doi: 10.3389/fphar.2018.01202

Cooper, A. G., Oyagawa, C. R. M., Manning, J. J., Singh, S., Hook, S., Grimsey, N. L., Glass, M., Tyndall, J. D. A., & Vernall, A. J. (2018). Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffold. MedChemComm, 9(12), 2055-2067. doi: 10.1039/c8md00448j

Cooper, A. G., MacDonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2018). Alkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment. European Journal of Medicinal Chemistry, 145, 770-789. doi: 10.1016/j.ejmech.2017.11.076

Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195

Cooper, A., Singh, S., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2017). Chemical tools for studying lipid-binding class A G protein-coupled receptors. Pharmacological Reviews, 69(3), 316-353. doi: 10.1124/pr.116.013243

Stoddart, L. A., Vernall, A. J., Briddon, S. J., Kellam, B., & Hill, S. J. (2015). Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98, 68-77. doi: 10.1016/j.neuropharm.2015.04.013

Vernall, A. J., Hill, S. J., & Kellam, B. (2014). The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. British Journal of Pharmacology, 171(5), 1073-1084. doi: 10.1111/bph.12265

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Ng, H. W., Laughton, C. A., Doughty, S. W., … Kellam, B. (2013). Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11(34), 5673-5682. doi: 10.1039/c3ob41221k

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012). Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. Journal of Medicinal Chemistry, 55(4), 1771-1782. doi: 10.1021/jm201722y

Stoddart, L. A., Vernall, A. J., Denman, J. L., Briddon, S. J., Kellam, B., & Hill, S. J. (2012). Fragment screening at adenosine-A3 receptors in living cells using a fluorescence-based binding assay. Chemistry & Biology, 19(9), 1105-1115. doi: 10.1016/j.chembiol.2012.07.014

Vernall, A. J., Cassidy, P., & Alewood, P. F. (2009). A single α-helical turn stabilized by replacement of an internal hydrogen bond with a covalent ethylene bridge. Angewandte Chemie International Edition, 48(31), 5675-5678. doi: 10.1002/anie.200901059

Vernall, A. J., Ballet, S., & Abell, A. D. (2008). Cross-metathesis and ring-closing metathesis reactions of amino acid-based substrates. Tetrahedron, 64(18), 3980-3997. doi: 10.1016/j.tet.2008.02.043

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Conference Contribution - Published proceedings: Abstract

Singh, S., Glenn, J. R., Hill, S. J., Tyndall, J. D. A., & Vernall, A. J. (2016). Illuminating the life of A1 adenosine receptor. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of tools for studying cannabinoid type 2 receptor: Design, synthesis and pharmacological evaluation of fluorescent ligands and intermediates. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 709. Retrieved from http://www.asceptasm.com/

Singh, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of selective fluorescent ligands for A1AR as pharmacological tools. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Cooper, A., Hook, S., Tyndall, J. D. A., & Vernall, A. (2015). Development of fluorescent ligands as tools for studying the cannabinoid type 2 receptor. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Kellam, B., & Hill, S. J. (2014). New fluorescent antagonists for the histamine H1-receptor. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Molecular Pharmacology of G Protein-Coupled Receptors (MPGPCR) Joint Scientific Meeting. (pp. 115). Retrieved from http://www.asceptasm.com/

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2013). Fluorescent probes as drug discovery tools. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html

Vernall, A., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012). Highly potent and selective fluorescent antagonist of the adenosine A3 receptor: Use as an imaging tool. Proceedings of the 243rd ACS National Meeting & Exposition. Retrieved from http://abstracts.acs.org/chem/243nm/program/view.php

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Conference Contribution - Poster Presentation (not in published proceedings)

Putha, L., Kok, L. K., Chen, K., Sagatova, A. A., Wilbanks, S. M., Gamble, A. B., Vernall, A. J., & Tyndall, J. D. (2018, August). New isothiocyanates: Covalent inhibitors of macrophage migration inhibitory factor. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. (2017, November). Differences in the effector function of MR1- and cytokine stimulated MAIT cells. Poster session presented at the 10th International CD1-MR1 Workshop, Napa, USA.

Cooper, A., Macdonald, C., Manning, J., Glass, M., Hook, S., Tyndall, J., & Vernall, A. (2017, September). Design, synthesis and pharmacological evaluation of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the 19th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK.

Singh, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of selective fluorescent ligands for A1 adenosine receptor as pharmacological tools. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Cooper, A. G., Macdonald, C., Glass, M., Hook, S., Tyndall, J. D. A., & Vernall, A. J. (2016, August-September). Development of fluorescent ligands as tools for studying cannabinoid type 2 receptor. Poster session presented at the European Federation for Medicinal Chemistry (EFMC) International Symposium on Medicinal Chemistry, Manchester, UK.

Vernall, A. J., Stoddart, L. A., Briddon, S. J., Hill, S. J., & Kellam, B. (2012, December). Conversion of non-selective adenosine receptor ligands to subtype selective higher affinity fluorescent probes using peptide-based linkers. Poster session presented at the Seventh Molecular Pharmacology of G Protein-coupled Receptors International Meeting, Melbourne, Australia.

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Conference Contribution - Verbal presentation and other Conference outputs

Singh, S., Oyagawa, C. R. M., Grimsey, N. L., Tyndall, J. D. A., Glass, M., & Vernall, A. J. (2019, August-September). Chromenopyrazole-based chemical tools to study cannabinoid type 2 receptor. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lamichhane, R., de la Harpe, S., Harrop, T., Vernall, A., Tyndall, J., Dearden, P., Kirman, J., & Ussher, J. E. (2018, August). Differential regulation of MR1- and cytokine stimulated MAIT cells. Verbal presentation at the Queenstown Molecular Biology (QMB) and Australasian Society for Immunology New Zealand Branch (ASI-NZ) Joint Meeting, Queenstown, New Zealand.

Oyagawa, C. R. M., de la Harpe, S., Woodhouse, B. J., Glass, M., Vernall, A. J., & Grimsey, N. L. (2017, September). Utilising novel ligands to investigate an unusual trafficking phenotype: Agonist-induced surface upregulation of cannabinoid receptor 2. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT-NZ) New Zealand Annual Scientific Meeting, Queenstown, New Zealand.

Ussher, J., Williams, T., Lamichhane, R., de la Harpe, S., Tyndall, J., & Vernall, A. (2017, November). Bacteria license antigen presenting cells for MR1-mediated MAIT cell activation. Verbal presentation at the 10th International CD1-MR1 Workshop, Napa, USA.

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