Professor Christine Winterbourn

2025

Journal - Research Article

Smith-Díaz, C. C., Kumar, A., Das, A., Pace, P., Chitcholtan, K., Magon, N. J., Hossain, S. M., Eccles, M. R., Winterbourn, C. C., & Paumann-Page, M. (2025). Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma. Free Radical Biology & Medicine. Advance online publication. doi: 10.1016/j.freeradbiomed.2025.01.007

2024

Journal - Research Article

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Redox proteomic analysis of H₂O₂ -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radical Biology & Medicine. Advance online publication. doi: 10.1016/j.freeradbiomed.2024.10.314

Pace, P. E., Fu, L., Hampton, M. B., & Winterbourn, C. C. (2024). Effect of peroxiredoxin 1 or peroxiredoxin 2 knockout on the thiol proteome of Jurkat cells. Free Radical Biology & Medicine, 225, 595-604. doi: 10.1016/j.freeradbiomed.2024.10.293

Paumann-Page, M., Obinger, C., Winterbourn, C. C., & Furtmüller, P. G. (2024). Peroxidasin inhibition by phloroglucinol and other peroxidase inhibitors. Antioxidants, 13, 23. doi: 10.3390/antiox13010023

Journal - Research Other

Ashby, L., Chan, L., Winterbourn, C., Woon, S.-T., Keating, P., Heller, R., … Chua, I., & Hsiao, K.-C. (2024). Phenotypic spectrum in a family with a novel RAC2 p.I21S dominant-activating mutation [Case report]. Clinical & Translational Immunology, 13, e1493. doi: 10.1002/cti2.1493

Conference Contribution - Published proceedings: Abstract

Winterbourn, C. (2024). Radicals and redox biology: A journey of discovery [Lifetime Achievement Award Lecture]. Free Radical Biology & Medicine, 224(Suppl. 1), P2. doi: 10.1016/j.freeradbiomed.2024.10.264

2023

Journal - Research Article

Winterbourn, C. C., Peskin, A., Kleffmann, T., Radi, R., & Pace, P. E. (2023). Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide. PNAS, 120(18), e2221047120. doi: 10.1073/pnas.2221047120

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry, 1-2, 100002. doi: 10.1016/j.rbc.2023.100002

Journal - Research Other

Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183

Pace, P., & Winterbourn, C. C. (2023). A cautionary note on using phosphatase inhibitors with hydrogen peroxide. Antioxidants & Redox Signaling, 38(4-6), 316-317. doi: 10.1089/ars.2022.0092

Conference Contribution - Published proceedings: Abstract

Paumann-Page, M., Smith-Diaz, C., Kumar, A., Chitcholtan, K., Hampton, M., & Winterbourn, C. (2023). Peroxidasin: A novel modulator of melanoma cell invasion. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Meotti, F., de Souza, L. F., Dempsey, B., Silva, R., Pinz, M., Cruz, L., Pace, P., Hampton, M., & Winterbourn, C. (2023). Peroxiredoxin 2 interacts with granule stress proteins in proliferative leukemic myeloid cells. Free Radical Biology & Medicine, 208(Suppl. 1), 38. doi: 10.1016/j.freeradbiomed.2023.10.053

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2023, November-December). Free radicals, antioxidants and redox biology. Plenary presentation at the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference, Christchurch, New Zealand.

2022

Journal - Research Other

Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Dick, M. J., … Winterbourn, C. C., … Halliwell, B. (2022). Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nature Metabolism, 4, 651-662. doi: 10.1038/s42255-022-00591-z

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., … Winterbourn, C. (2022). Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology [Expert recommendation]. Nature Reviews Molecular Cell Biology, 23, 499-515. doi: 10.1038/s41580-022-00456-z

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P. E., Peskin, A. V., Winterbourn, C. C., & Hampton, M. B. (2022, August). Disrupting the oligomeric structure of peroxiredoxins in cancer cells using CRISPR. Poster session presented at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2022, December). CO₂/bicarbonate requirement for rapid inactivation of mammalian GAPDH by low concentrations of H₂O₂. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

Hampton, M., Winterbourn, C., Dick, T., & Murphy, M. (2022, December). What are redox signals telling us? Panel discussion at the Society for Free Radical Research (SFRR) Australasia & Japan Conference: Redox Pathways in Biology & Medicine, Christchurch, New Zealand.

2021

Journal - Research Article

Queiroz, R. F., Stanley, C. P., Wolhuter, K., Kong, S. M. Y., Rajivan, R., McKinnon, N., … Winterbourn, C. C., … Stocker, R. (2021). Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation. Nature Communications, 12, 6626. doi: 10.1038/s41467-021-26991-5

Parker, H. A., Jones, H. M., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2021). Neutrophil NET formation with microbial stimuli requires late stage NADPH oxidase activity. Antioxidants, 10, 1791. doi: 10.3390/antiox10111791

Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., … Eccles, M. R., & Winterbourn, C. C. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology, 46, 102090. doi: 10.1016/j.redox.2021.102090

Peskin, A. V., Meotti, F. C., Kean, K. M., Göbl, C., Peixoto, A. S., Pace, P. E., … Winterbourn, C. C. (2021). Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2. Journal of Biological Chemistry, 296, 100494. doi: 10.1016/j.jbc.2021.100494

Peskin, A. V., & Winterbourn, C. C. (2021). The enigma of 2-Cys peroxiredoxins: What are their roles? Biochemistry (Moscow), 86(1), 84-91. doi: 10.1134/S0006297921010089

Königstorfer, A., Ashby, L. V., Bollar, G. E., Billiot, C. E., Gray, M. J., Jakob, U., Hampton, M. B., & Winterbourn, C. C. (2021). Induction of the reactive chlorine-responsive transcription factor RclR in Escherichia coli following ingestion by neutrophils. Pathogens & Disease, 79, ftaa079. doi: 10.1093/femspd/ftaa079

Conference Contribution - Published proceedings: Abstract

Featherston, T., Paumann-Page, M., Dickerhof, N., Kaldor, C., Winterbourn, C. C., & Hampton, M. B. (2021). Measuring and exploiting oxidative stress in metastatic melanoma. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 281). Retrieved from https://www.faobmb2021.org

Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org

Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org

Kettle, A. J., Ashby, L. V., Das, A. B., Dickerhof, N., Hampton, M. B., & Winterbourn, C. C. (2021). What's so super about superoxide? Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 275). Retrieved from https://www.faobmb2021.org

2020

Journal - Research Article

Mohammad, A., Saini, R. V., Kumar, R., Sharma, D., Saini, N. K., Gupta, A., … Winterbourn, C. C., & Saini, A. K. (2020). A curious case of cysteines in human peroxiredoxin I. Redox Biology, 37, 101738. doi: 10.1016/j.redox.2020.101738

Bathish, B., Paumann-Page, M., Paton, L. N., Kettle, A. J., & Winterbourn, C. C. (2020). Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry, 295(36), 12697-12705. doi: 10.1074/jbc.RA120.014504

Peskin, A. V., Meotti, F. C., de Souza, L. F., Anderson, R. F., Winterbourn, C. C., & Salvador, A. (2020). Intra-dimer cooperativity between the active site cysteines during the oxidation of peroxiredoxin 2. Free Radical Biology & Medicine, 158, 115-125. doi: 10.1016/j.freeradbiomed.2020.07.007

O'Connor, K. M., Das, A. B., Winterbourn, C. C., & Hampton, M. B. (2020). Inhibition of DNA methylation in proliferating human lymphoma cells by immune cell oxidants. Journal of Biological Chemistry, 295(23), 7839-7848. doi: 10.1074/jbc.RA120.013092

Winterbourn, C. C. (2020). Biological chemistry of superoxide radicals. ChemTexts, 6, 7. doi: 10.1007/s40828-019-0101-8

Journal - Research Other

Ashby, L. V., Springer, R., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2020). Evaluating the bactericidal action of hypochlorous acid in culture media. Free Radical Biology & Medicine, 159, 119-124. doi: 10.1016/j.freeradbiomed.2020.07.033

Winterbourn, C. C. (2020). Hydrogen peroxide reactivity and specificity in thiol-based cell signalling. Biochemical Society Transactions, 48, 745-754. doi: 10.1042/bst20190049

Conference Contribution - Published proceedings: Abstract

Das, A. B., O'Connor, K. M., Stevens, A. J., Seddon, A. R., & Winterbourn, C. C. (2020). Immune cell oxidants inhibit DNA methylation in proliferating cells [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Chapter in Book - Research

Winterbourn, C. C. (2019). Reactive oxygen species in biological systems. In E. Niki (Ed.), Food chemistry, function and analysis. (pp. 98-117). London, UK: Royal Society of Chemistry. doi: 10.1039/9781788016216-00098

Journal - Research Article

Kumar, R., Mohammad, A., Saini, R. V., Chahal, A., Wong, C.-M., Sharma, D., … Winterbourn, C. C., & Saini, A. K. (2019). Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast. Free Radical Biology & Medicine, 145, 321-329. doi: 10.1016/j.freeradbiomed.2019.09.034

Peskin, A. V., Pace, P. E., & Winterbourn, C. C. (2019). Enhanced hyperoxidation of peroxiredoxin 2 and peroxiredoxin 3 in the presence of bicarbonate/CO₂. Free Radical Biology & Medicine, 145, 1-7. doi: 10.1016/j.freeradbiomed.2019.09.010

Dagnell, M., Cheng, Q., Rizvi, S. H. M., Pace, P. E., Boivin, B., Winterbourn, C. C., & Arnér, E. S. J. (2019). Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades. Journal of Biological Chemistry, 294(33), 12330-12338. doi: 10.1074/jbc.RA119.009001

de Souza, L. F., Pearson, A. G., Pace, P. E., Dafre, A. L., Hampton, M. B., Meotti, F. C., & Winterbourn, C. C. (2019). Peroxiredoxin expression and redox status in neutrophils and HL-60 cells. Free Radical Biology & Medicine, 135, 227-234. doi: 10.1016/j.freeradbiomed.2019.03.007

Journal - Research Other

Winterbourn, C. C. (2019). Regulation of intracellular glutathione. Redox Biology, 22, 101086. doi: 10.1016/j.redox.2018.101086

2018

Journal - Research Article

Pace, P. E., Peskin, A. V., Konigstorfer, A., Jasoni, C. L., Winterbourn, C. C., & Hampton, M. B. (2018). Peroxiredoxin interaction with the cytoskeletal-regulatory protein CRMP2: Investigation of a putative redox relay. Free Radical Biology & Medicine, 129, 383-393. doi: 10.1016/j.freeradbiomed.2018.10.407

Albrett, A. M., Ashby, L. V., Dickerhof, N., Kettle, A. J., & Winterbourn, C. C. (2018). Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe. Journal of Biological Chemistry, 293(40), 15715-15724. doi: 10.1074/jbc.RA118.004789

Bathish, B., Turner, R., Paumann-Page, M., Kettle, A. J., & Winterbourn, C. C. (2018). Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation. Archives of Biochemistry & Biophysics, 646, 120-127. doi: 10.1016/j.abb.2018.03.038

Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039

Das, A. B., Sadowska-Bartosz, I., Königstorfer, A., Kettle, A. J., & Winterbourn, C. C. (2018). Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast. Free Radical Biology & Medicine, 116, 114-122. doi: 10.1016/j.freeradbiomed.2018.01.001

Journal - Research Other

Winterbourn, C. C., & Cheah, F.-C. (2018). Favism and glucose-6-phosphate dehydrogenase deficiency. New England Journal of Medicine, 378(11), 1067-1068. doi: 10.1056/NEJMc1801271

Conference Contribution - Published proceedings: Abstract

Albrett, A. M., Ashby, L. V., Dickerhof, N., Hampton, M. B., Winterbourn, C. C., & Kettle, A. J. (2018). Detection of hypochlorous acid in neutrophil phagosomes with the probe R19S: Chlorinated product formation and real-time fluorescence. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 112-113). Retrieved from https://www.nzmsconference.org.nz

Parker, H. A., Jones, M. G., Kaldor, C. D., Hampton, M. B., & Winterbourn, C. C. (2018). Timing of reactive oxygen species involvement in formation of neutrophil extracellular traps. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 100). Retrieved from https://www.nzmsconference.org.nz

Vick, K., Kaur, G., Doroshow, J., Winterbourn, C., & Hampton, M. (2018). Peroxiredoxins as markers of oxidative stress in cancer cells. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Paumann-Page, M., Bathish, B., Eccles, M., & Winterbourn, C. (2018). Peroxidasin, a newly identified peroxidase, and its role in invasive metastatic melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Dagnell, M., Cheng, Q., Pace, P. E., Hampton, M. B., Winterbourn, C. C., & Arnér, E. S. J. (2018). Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin. Free Radical Biology & Medicine, 120(Suppl. 1), (pp. S36). doi: 10.1016/j.freeradbiomed.2018.04.123

Conference Contribution - Poster Presentation (not in published proceedings)

Springer, R., Ashby, L., Kettle, A., Winterbourn, C., & Hampton, M. (2018, September). Staphylococcus Aureus survival inside the neutrophil phagosome. Poster session presented at the Otago Spotlight Symposium on Infectious Disease, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2018, August). Free radicals, antioxidants and the complications of prematurity. Verbal presentation at the George Abbott Symposium & Festschrift for Emeritus Professor Brian Darlow, Christchurch, New Zealand.

2017

Journal - Research Article

Green, J. N., Chapman, A. L. P., Bishop, C. J., Winterbourn, C. C., & Kettle, A. J. (2017). Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide. Free Radical Biology & Medicine, 113, 363-371. doi: 10.1016/j.freeradbiomed.2017.10.343

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure. Journal of Biological Chemistry, 292(35), 14371-14380. doi: 10.1074/jbc.M117.793745

Peskin, A. V., & Winterbourn, C. C. (2017). Assay of superoxide dismutase activity in a plate assay using WST-1. Free Radical Biology & Medicine, 103, 188-191. doi: 10.1016/j.freeradbiomed.2016.12.033

Journal - Research Other

Winterbourn, C. C. (2017). Biological production, detection and fate of hydrogen peroxide. Antioxidants & Redox Signaling, 29(6), 541-551. doi: 10.1089/ars.2017.7425

Conference Contribution - Verbal presentation and other Conference outputs

Forbes, L. V., Konigstorfer, A., Gray, M. J., Jakob, U., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2017, July). Bacterial resistance to neutrophil-derived oxidants. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Parker, H., Jones, M., Hampton, M., & Winterbourn, C. (2017, July). Oxidant-dependent steps in the formation of neutrophil extracellular traps. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Chapter in Book - Research

Kettle, A. J., & Winterbourn, C. C. (2016). Myeloperoxidase: Structure and function of the green heme peroxidase of neutrophils. In E. Raven & B. Dunford (Eds.), Heme peroxidases. (pp. 272-308). Cambridge, UK: Royal Society of Chemistry. doi: 10.1039/9781782622628-00272

Journal - Research Article

Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995

Winterbourn, C. C. (2016). Revisiting the reactions of superoxide with glutathione and other thiols. Archives of Biochemistry & Biophysics, 595, 68-71. doi: 10.1016/j.abb.2015.11.028

Bekeschus, S., Winterbourn, C. C., Kolata, J., Masur, K., Hasse, S., Bröker, B. M., & Parker, H. A. (2016). Neutrophil extracellular trap formation is elicited in response to cold physical plasma. Journal of Leukocyte Biology, 100(4), 791-799. doi: 10.1189/jlb.3A0415-165RR

Winterbourn, C. C., & Peskin, A. V. (2016). Kinetic approaches to measuring peroxiredoxin reactivity. Molecules & Cells, 39(1), 26-30. doi: 10.14348/molcells.2016.2325

Poynton, R. A., Peskin, A. V., Haynes, A. C., Lowther, W. T., Hampton, M. B., & Winterbourn, C. C. (2016). Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochemical Journal, 473, 411-421. doi: 10.1042/bj20150572

Peskin, A. V., Pace, P. E., Behring, J. B., Paton, L. N., Soethoudt, M., Bachschmid, M. M., & Winterbourn, C. C. (2016). Glutathionylation of the active site cysteines of peroxiredoxin 2 and recycling by glutaredoxin. Journal of Biological Chemistry, 291(6), 3053-3062. doi: 10.1074/jbc.M115.692798

Journal - Research Other

Winterbourn, C. C., Kettle, A. J., & Hampton, M. B. (2016). Reactive oxygen species and neutrophil function. Annual Review of Biochemistry, 85, 765-792. doi: 10.1146/annurev-biochem-060815-014442

Conference Contribution - Published proceedings: Abstract

Pace, P., Peskin, A. V., Jasoni, C. L., Winterbourn, C., & Hampton, M. (2016). Interaction of peroxiredoxin 2 with collapsin response mediator protein 2. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.126

Dagnell, M., Pace, P., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E., Hampton, M., & Winterbourn, C. (2016). Thioredoxin reductase 1 directly protects protein tyrosine phosphatase 1B from inactivation by H₂O₂. Free Radical Biology & Medicine, 100(Suppl.), (pp. S47). doi: 10.1016/j.freeradbiomed.2016.10.125

Bathish, B., Turner, R., Kettle, T., & Winterbourn, C. (2016). Peroxidasin-catalysed oxidative modifications of proteins in the extracellular matrix. Free Radical Biology & Medicine, 100(Suppl.), (pp. S19-S20). doi: 10.1016/j.freeradbiomed.2016.10.044

2015

Journal - Research Article

Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422

Bayer, S. B., Hampton, M. B., & Winterbourn, C. C. (2015). Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention. Transfusion, 55(8), 1909-1918. doi: 10.1111/trf.13039

Journal - Research Other

Winterbourn, C. C., & Hampton, M. B. (2015). Signaling via a peroxiredoxin sensor. Nature Chemical Biology, 11(1), 5-6. doi: 10.1038/nchembio.1722

Winterbourn, C. C. (2015). Are free radicals involved in thiol-based redox signaling? Free Radical Biology & Medicine, 80, 164-170. doi: 10.1016/j.freeradbiomed.2014.08.017

Conference Contribution - Published proceedings: Abstract

Peskin, A., Pace, P., Behring, J., Paton, L., Soethoudt, M., Bachschmid, M., & Winterbourn, C. (2015). Glutathionylation at the Active Sites of Peroxiredoxin 2 and Recycling by Glutaredoxin. Free Radical Biology & Medicine, 87(Suppl. 1), (pp. 105). doi: 10.1016/j.freeradbiomed.2015.10.276

Nagy, P., Das, A., Nauser, T., Koppenol, W. H., Kettle, A. J., & Winterbourn, C. C. (2015). Superoxide-mediated post-translational modification of tyrosine residues. Free Radical Biology & Medicine, 86(Suppl. 1), (pp. S17-S18). doi: 10.1016/j.freeradbiomed.2015.07.073

2014

Chapter in Book - Research

Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19

Journal - Research Article

Schwarzländer, M., Wagner, S., Ermakova, Y. G., Belousov, V. V., Radi, R., Beckman, J. S., … Winterbourn, C. C., … Murphy, M. P. (2014). The 'mitoflash' probe cpYFP does not respond to superoxide [Brief communication arising]. Nature, 514(7523), E12-E14. doi: 10.1038/nature13858

Soethoudt, M., Peskin, A. V., Dickerhof, N., Paton, L. N., Pace, P. E., & Winterbourn, C. C. (2014). Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radical Biology & Medicine, 77, 331-339. doi: 10.1016/j.freeradbiomed.2014.09.025

Bekeschus, S., Kolata, J., Winterbourn, C., Kramer, A., Turner, R., Weltmann, K. D., … Masur, K. (2014). Hydrogen peroxide: A central player in physical plasma-induced oxidative stress in human blood cells. Free Radical Research, 48(5), 542-549. doi: 10.3109/10715762.2014.892937

Green, J. N., Kettle, A. J., & Winterbourn, C. C. (2014). Protein chlorination in neutrophil phagosomes and correlation with bacterial killing. Free Radical Biology & Medicine, 77, 49-56. doi: 10.1016/j.freeradbiomed.2014.08.013

Nedoboy, P., Morgan, P. E., Mocatta, T. J., Richards, A. M., Winterbourn, C. C., & Davies, M. J. (2014). High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research, 48(10), 1256-1266. doi: 10.3109/10715762.2014.947286

Kettle, A. J., Turner, R., Gangell, C. L., Harwood, D. T., Khalilova, I. S., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2014). Oxidation contributes to low glutathione in the airways of children with cystic fibrosis. European Respiratory Journal, 44, 122-129. doi: 10.1183/09031936.00170213

Cheah, F.-C., Peskin, A. V., Wong, F.-L., Ithnin, A., Othman, A., & Winterbourn, C. C. (2014). Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants. FASEB Journal, 28(7), 3205-3210. doi: 10.1096/fj.14-250050

Kasperkiewicz, P., Poreba, M., Snipas, S. J., Parker, H., Winterbourn, C. C., Salvesen, G. S., & Drag, M. (2014). Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. PNAS, 111(7), 2518-2523. doi: 10.1073/pnas.1318548111

Das, A. B., Nauser, T., Koppenol, W. H., Kettle, A. J., Winterbourn, C. C., & Nagy, P. (2014). Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition. Free Radical Biology & Medicine, 70, 86-95. doi: 10.1016/j.freeradbiomed.2014.02.006

Ronsein, G. E., Winterbourn, C. C., Di Mascio, P., & Kettle, A. J. (2014). Cross-linking methionine and amine residues with reactive halogen species. Free Radical Biology & Medicine, 70, 278-287. doi: 10.1016/j.freeradbiomed.2014.01.023

Winterbourn, C. C. (2014). The challenges of using fluorescent probes to detect and quantify specific reactive oxygen species in living cells. Biochimica et Biophysica Acta: General Subjects, 1840(2), 730-738. doi: 10.1016/j.bbagen.2013.05.004

Conference Contribution - Published proceedings: Abstract

Winterbourn, C. C., Cheah, F.-C., & Peskin, A. V. (2014). Increased basal oxidation and limited recycling of peroxiredoxin 2 in glucose-6-phosphate dehydrogenase deficient erythrocytes. Free Radical Biology & Medicine, 76(Suppl. 1), (pp. S161). doi: 10.1016/j.freeradbiomed.2014.10.075

Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Free Radical Biology & Medicine, 76(Suppl. 1), (pp. S163). doi: 10.1016/j.freeradbiomed.2014.10.047

Conference Contribution - Verbal presentation and other Conference outputs

Kettle, A., Albrett, A., Forbes, L., Parker, H., Turner, R., Pattemore, P., & Winterbourn, C. (2014, November). Bacterial killing and oxidant production by neutrophils from patients with cystic fibrosis. Verbal presentation at the Society for Free Radical Biology and Medicine (SFRBM) 21st Annual Meeting, Seattle, WA.

Winterbourn, C. (2014, December). Mechanisms and consequences of peroxiredoxin oxidation. Invited presentation at the Society for Free Radical Research Australasia 22nd Annual Scientific Meeting, Melbourne, Australia.

Winterbourn, C. (2014, June). Roger Osborne Memorial Lecture. Verbal presentation at the New Zealand Association of Science Educators (NZASE) Science Conference (SciCon), Dunedin, New Zealand.

2013

Chapter in Book - Research

Winterbourn, C. C. (2013). The biological chemistry of hydrogen peroxide. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen peroxide and cell signaling: Part C (Vol. 528). (pp. 3-25). Waltham, MA: Academic Press. doi: 10.1016/B978-0-12-405881-1.00001-X

Chapter in Book - Other

Winterbourn, C., & Kettle, T. (2013). Centre for Free Radical Research. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 75-78). Christchurch, New Zealand: University of Otago.

Journal - Research Article

Parker, H., & Winterbourn, C. C. (2013). Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps. Frontiers in Immunology, 3, 424. doi: 10.3389/fimmu.2012.00424

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Biochemical Journal, 453, 475-485. doi: 10.1042/BJ20130030

Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. FASEB Journal, 27(8), 3315-3322. doi: 10.1096/fj.13-227298

Peskin, A. V., Dickerhof, N., Poynton, R. A., Paton, L. N., Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2013). Hyperoxidation of peroxiredoxins 2 and 3: Rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine. Journal of Biological Chemistry, 288, 14170-14177. doi: 10.1074/jbc.M113.460881

Kumar, V., Kleffmann, T., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2013). Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biology & Medicine, 58, 109-117. doi: 10.1016/j.freeradbiomed.2013.01.021

Chapman, A. L. P., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I., Paumann-Page, M. E., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013). Ceruloplasmin is an endogenous inhibitor of myeloperoxidase. Journal of Biological Chemistry, 288(9), 6465-6477. doi: 10.1074/jbc.M112.418970

Klebanoff, S. J., Kettle, A. J., Rosen, H., Winterbourn, C. C., & Nauseef, W. M. (2013). Myeloperoxidase: A front-line defender against phagocytosed microorganisms. Journal of Leukocyte Biology, 93(2), 185-198. doi: 10.1189/jlb.0712349

Winterbourn, C. C., & Kettle, A. J. (2013). Redox reactions and microbial killing in the neutrophil phagosome. Antioxidants & Redox Signaling, 18(6), 642-660. doi: 10.1089/ars.2012.4827

Conference Contribution - Published proceedings: Abstract

Kettle, T., Turner, R., Gangell, C., Khalilova, I., Harwood, T., Chapman, A., Winterbourn, C., … on behalf of AREST CF. (2013). The battle between chlorine bleach and glutathione in the lungs of kids with cystic fibrosis. Proceedings of the George Abbott Symposium. Retrieved from http://www.otago.ac.nz/george-abbott

Kettle, A., Turner, R., Gangell, C. L., Khalilova, I., Harwood, D. T., Chapman, A., Winterbourn, C. C., & Sly, P. (2013). Oxidation of glutathione by hypochlorous acid in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62). doi: 10.1016/j.freeradbiomed.2013.10.534

Das, A., Nagy, P., Lecthe, T., Koppenol, W. H., Winterbourn, C. C., & Kettle, A. (2013). Detection of glutathione conjugated to oxidised tyrosine residues on proteins. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S55). doi: 10.1016/j.freeradbiomed.2013.10.520

Conference Contribution - Poster Presentation (not in published proceedings)

Peskin, A. V., Dickerhof, N., Paton, L. N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidation of human peroxiredoxin 2 and 3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pace, P. E., Peskin, A. V., Han, M.-H., Hampton, M. B., & Winterbourn, C. C. (2013, August). Hyperoxidized peroxiredoxin 2 interacts with the protein disulphide isomerase ERp46. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Soethoudt, M., Peskin, A. V., Dickerhof, N., & Winterbourn, C. C. (2013, August). The diterpenoid Adenanthin favors binding to glutathione over peroxiredoxin 2 in erythrocytes. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Poynton, R. A., Peskin, A. V., Dickerhof, N., Lowther, T. W., Betz, A., Winterbourn, C. C., & Hampton, M. B. (2013, August). Kinetics and biochemical properties of peroxiredoxin 3 hyperoxidation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Das, A. B., Nagy, P., Lechte, T., Winterbourn, C. C., & Kettle, A. J. (2013, August). Detection of glutathione conjugated to oxidized tyrosine residues on protein. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bayer, S. B., Maghzal, G., Stocker, R., Hampton, M. B., & Winterbourn, C. C. (2013, August). Neutrophil-mediated oxidation of erythrocyte peroxiredoxin 2 as a potential marker of oxidative stress in inflammation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2013, December). Neutrophils and inflammation: Reactive oxidants and NET production. Verbal presentation at the University of Otago Triple Theme Research Meeting: The Kidney in Health and Disease, Gut Health Network, Arthritis Research, Dunedin, New Zealand.

Winterbourn, C. (2013, August). Detecting and quantifying oxidative stress in biological systems. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2013, August). Neutrophil extracellular traps: Friends or foe. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Winterbourn, C. (2013, February). Characterising the role of free radicals in disease. Verbal presentation at the Christchurch Medical School 40th Anniversary Celebrations, Christchurch, New Zealand.

2012

Chapter in Book - Research

Winterbourn, C. C. (2012). Biological chemistry of reactive oxygen species. In C. Chatgilialoglu & A. Studer (Eds.), Encyclopedia of radicals in chemistry, biology and materials. (pp. 1259-1281). Chichester, UK: Wiley. doi: 10.1002/9781119953678.rad077

Journal - Research Article

Kelso, G. F., Maroz, A., Cochemé, H. M., Logan, A., Prime, T. A., Peskin, A. V., Winterbourn, C. C., James, A. M., … Brooker, S., Porteous, C. M., … Smith, R. A. J. (2012). A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chemistry & Biology, 19(10), 1237-1246. doi: 10.1016/j.chembiol.2012.08.005

Stacey, M. M., Cuddihy, S. L., Hampton, M. B., & Winterbourn, C. C. (2012). Protein thiol oxidation and formation of S-glutathionylated cyclophilin A in cells exposed to chloramines and hypochlorous acid. Archives of Biochemistry & Biophysics, 527(1), 45-54. doi: 10.1016/j.abb.2012.07.011

Nagy, P., Lechte, T. P., Das, A. B., & Winterbourn, C. C. (2012). Conjugation of glutathione to oxidized tyrosine residues in peptides and proteins. Journal of Biological Chemistry, 287(31), 26068-26076. doi: 10.1074/jbc.M112.371690

Parker, H., Dragunow, M., Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (2012). Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 92(4), 841-849. doi: 10.1189/jlb.1211601

Stacey, M. M., Vissers, M. C., & Winterbourn, C. C. (2012). Oxidation of 2-Cys peroxiredoxins in human endothelial cells by hydrogen peroxide, hypochlorous acid and chloramines. Antioxidants & Redox Signaling, 17(3), 411-421. doi: 10.1089/ars.2011.4348

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide. Journal of Leukocyte Biology, 91(3), 369-376. doi: 10.1189/jlb.0711387

Conference Contribution - Published proceedings: Abstract

Pujary, U. R., Hampton, M., Winterbourn, C., & Vissers, M. (2012). Hypoxia extends neutrophil survival but does not necessarily retain cell function. Proceedings of the Oxygen Theme Meeting. (pp. 35). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Pace, P., Peskin, A., Hampton, M., & Winterbourn, C. (2012). Hydrogen peroxide-dependent interaction of peroxiredoxin 2 with ERp46. Proceedings of the Oxygen Theme Meeting. (pp. 32). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Parker, H., Albrett, A., Kettle, A., & Winterbourn, C. (2012). Complex roles of reactive oxygen species in the formation and antimicrobial action of neutrophil NETs. Proceedings of the Oxygen Theme Meeting. (pp. 28). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Modulation of HOCl production in neutrophil phagosomes. Proceedings of the Oxygen Theme Meeting. (pp. 24). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Poynton, R., Peskin, A., Dickerhof, N., Paton, L., Winterbourn, C., & Hampton, M. (2012). Kinetics of peroxiredoxin 2 and 3 hyperoxidation. Proceedings of the Oxygen Theme Meeting. (pp. 14). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Das, A. B., Nagy, P., Lechte, T., Kettle, A. J., & Winterbourn, C. C. (2012). Conjugation of glutathione to oxidised tyrosine residues on proteins. Proceedings of the Oxygen Theme Meeting. (pp. 7). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Winterbourn, C. C. (2012). Life with oxygen. Proceedings of the Oxygen Theme Meeting. (pp. 6). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

Winterbourn, C. (2012). Free radicals and biomarkers of oxidative stress in disease. New Zealand Journal of Medical Laboratory Science, 66(3), (pp. 85-86). [Abstract]

Pace, P. E., Peskin, A. V., Hampton, M. B., & Winterbourn, C. C. (2012). Hydrogen peroxide dependent interaction of peroxiredoxin 2 with ERp46. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210). doi: 10.1016/j.freeradbiomed.2012.08.440

Peskin, A. V., Dickerhof, N., Poynton, R. A., Pace, P., Hampton, M. B., & Winterbourn, C. C. (2012). Kinetics of hyperoxidation of human peroxiredoxin 2. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S210-S211). doi: 10.1016/j.freeradbiomed.2012.08.441

Parker, H., Albrett, A. M., Kettle, A. J., & Winterbourn, C. C. (2012). Complex roles of reactive oxygen species in the formation and anti-microbial action of neutrophil NETs. Free Radical Biology & Medicine, 53(Suppl. 1), (pp. S166). doi: 10.1016/j.freeradbiomed.2012.08.349

Conference Contribution - Verbal presentation and other Conference outputs

Hampton, M., Bayer, S., Moran, S., Maghzal, G., Stocker, R., Choe, C. F., Lunt, H., Chambers, S., Peskin, A., & Winterbourn, C. (2012, November). Peroxiredoxins as biomarkers of oxidative stress. Verbal presentation at the Gravida Annual Science Symposium: What Makes the Best Start for a Healthy Life? Palmerston North, New Zealand.

2011

Journal - Research Article

Kettle, A. J., Maroz, A., Woodroffe, G., Winterbourn, C. C., & Anderson, R. F. (2011). Spectral and kinetic evidence for reaction of superoxide with compound I of myeloperoxidase. Free Radical Biology & Medicine, 51(12), 2190-2194. doi: 10.1016/j.freeradbiomed.2011.09.019

Parker, A., Cuddihy, S. L., Son, T. G., Vissers, M. C. M., & Winterbourn, C. C. (2011). Roles of superoxide and myeloperoxidase in ascorbate oxidation in stimulated neutrophils and H₂O₂-treated HL60 cells. Free Radical Biology & Medicine, 51(7), 1399-1405. doi: 10.1016/j.freeradbiomed.2011.06.029

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., … Winterbourn, C. C. (2011). Unraveling the biological roles of reactive oxygen species. Cell Metabolism, 13(4), 361-366. doi: 10.1016/j.cmet.2011.03.010

Karton, A., Nagy, P., Betz, A., Peskin, A. V., Pace, P., O'Reilly, R. J., Hampton, M. B., … Winterbourn, C. C. (2011). Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide; a kinetic and computational study. Journal of Biological Chemistry, 286(20), 18048-18055. doi: 10.1074/jbc.M111.232355

Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2011). Assessment of redox changes to hydrogen peroxide-sensitive proteins during EGF signaling. Antioxidants & Redox Signaling, 15(1), 167-174. doi: 10.1089/ars.2010.3843

Harwood, D. T., Darlow, B. A., Cheah, F. C., McNeill, N., Graham, P., & Winterbourn, C. C. (2011). Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: Association with bacterial infection. Pediatric Research, 69(1), 28-33. doi: 10.1203/PDR.0b013e3181ff2378

Conference Contribution - Published proceedings: Abstract

Nedoboy, P., Morgan, P. E., Mocatta, T. J., Richards, M. A., Winterbourn, C. C., & Davies, M. J. (2011). Plasma levels of myeloperoxidase (MPO) and thiocyanate (SCN^-) predict mortality in patients following acute myocardial infarction. Free Radical Biology & Medicine, 51(Suppl. 1), (pp. S47). doi: 10.1016/j.freeradbiomed.2011.10.118

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2011, September). Redox signalling: Principles, promise and pitfall. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Other Research Output

Winterbourn, C. (2011, June). Living with oxygen. International Year of Chemistry Marie Curie Lecture Series. Palmerston North, New Zealand. [Public Seminar].

2010

Chapter in Book - Research

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Measuring the redox state of cellular peroxiredoxins by immunoblotting. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Thiol redox transitions in cell signaling: Part B: Cellular localization and signaling (Vol. 474). (pp. 51-66). San Diego, CA: Academic Press. doi: 10.1016/S0076-6879(10)74004-0

Nagy, P., & Winterbourn, C. C. (2010). Redox chemistry of biological thiols. In J. C. Fishbein (Ed.), Advances in molecular toxicology (Vol. 4). (pp. 223-266). Amsterdam, The Netherlands: Elsevier.

Journal - Research Article

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2010). Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochemical Journal, 432, 313-321. doi: 10.1042/BJ20101156

Nagy, P., & Winterbourn, C. C. (2010). Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfides. Chemical Research in Toxicology, 23(10), 1541-1543. doi: 10.1021/tx100266a

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C. C., Kettle, A. J., & McClean, D. R. (2010). Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction. American Journal of Cardiology, 106(3), 316-322. doi: 10.1016/j.amjcard.2010.03.028

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2010). Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide. Free Radical Biology & Medicine, 49, 792-799. doi: 10.1016/j.freeradbiomed.2010.05.033

Das, A. B., Nagy, P., Abbott, H. F., Winterbourn, C. C., & Kettle, A. J. (2010). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology & Medicine, 48, 1540-1547. doi: 10.1016/j.freeradbiomed.2010.02.039

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2010). Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochemical Journal, 425(2), 313-325. doi: 10.1042/BJ20091541

Ximenes, V. F., Maghzal, G. J., Turner, R., Kato, Y., Winterbourn, C. C., & Kettle, A. J. (2010). Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochemical Journal, 425(1), 285-293. doi: 10.1042/BJ20090776

Paton, L. N., Mocatta, T. J., Richards, A. M., & Winterbourn, C. C. (2010). Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction. Free Radical Biology & Medicine, 48(2), 223-229. doi: 10.1016/j.freeradbiomed.2009.10.044

Conference Contribution - Published proceedings: Abstract

Stacey, M. M., Vissers, M., & Winterbourn, C. (2010). Oxidation versus hyperoxidation of peroxiredoxins in human endothelial cells exposed to inflammatory oxidants. New Zealand Medical Journal, 123(1324). Retrieved from http://www.nzma.org.nz/journal/123-1324/4402/content.pdf

Cuddihy, S. L., Winterbourn, C. C., & Hampton, M. B. (2010). Redox proteomics of EGF signaling. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S128). doi: 10.1016/j.freeradbiomed.2010.10.350

Winterbourn, C. (2010). Free radical involvement in pain: Some basic concepts. Proceedings of the Australian and New Zealand College of Anaesthetists (ANZCA) Annual Scientific Meeting. Retrieved from http://www.conference.co.nz/index.cfm/anzca10

Conference Contribution - Poster Presentation (not in published proceedings)

Poynton, R. A., Sloboda, D. M., Vickers, M. H., Winterbourn, C. C., & Hampton, M. B. (2010, September). Peroxiredoxin 3 and oxidative stress in mitochondria. Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Parker, H. A., Kettle, A. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Oxidants, MPO and calcium in neutrophil extracellular trap formation. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Kettle, A. J., Turner, R., Gangell, C. L., Khalilova, I. S., Harwood, D. T., Chapman, A. L., Winterbourn, C. C., … on behalf of AREST CF. (2010, November-December). Oxidation of glutathione in the airways of children with cystic fibrosis. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2010, November-December). N-terminal proline of macrophage migration inhibitory factor as a biological target of isothiocyanates. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Chapman, A. L. P., Chen, B., Mocatta, T. J., Winterbourn, C. C., & Kettle, A. J. (2010, November-December). Studying the inhibition of myeloperoxidase by ceruloplasmin. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Winterbourn, C. C. (2010, November-December). The biological chemistry of hydrogen peroxide. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Davies, M. J., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Removal of amino acid, peptide and protein peroxide by reaction with peroxiredoxin 2 and peroxiredoxin 3. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

Pace, P. E., Hampton, M. B., & Winterbourn, C. C. (2010, November-December). Cellular interactions of peroxiredoxin 2. Verbal presentation at the Society for Free Radical Research (SFRR) Australasia 19th Annual Conference, Akaroa, New Zealand.

2009

Journal - Research Article

Nagy, P., Jameson, G. N. L., & Winterbourn, C. C. (2009). Kinetics and mechanisms of the reaction of hypothiocyanous acid with 5-thio-2-nitrobenzoic acid and reduced glutathione. Chemical Research in Toxicology, 22(11), 1833-1840. doi: 10.1021/tx900249d

Brown, K. K., Blaikie, F. H., Smith, R. A. J., Tyndall, J. D. A., Lue, H., Bernhagen, J., Winterbourn, C. C., & Hampton, M. B. (2009). Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. Journal of Biological Chemistry, 284(47), 32425-32433. doi: 10.1074/jbc.M109.047092

Peskin, A. V., Turner, R., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2009). Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils. Biochemistry, 48(42), 10175-10182. doi: 10.1021/bi901266w

Stacey, M. M., Peskin, A. V., Vissers, M. C., & Winterbourn, C. C. (2009). Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2. Free Radical Biology & Medicine, 47(10), 1468-1476. doi: 10.1016/j.freeradbiomed.2009.08.022

Palmer, B. R., Devereaux, C. L., Dhamrait, S. S., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Skelton, L., Yandle, T. G., Winterbourn, C. C., Richards, A. M., … Cameron, V. A. (2009). The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarction. Cardiovascular Diabetology, 8. doi: 10.1186/1475-2840-8-31

Cox, A. G., Peskin, A. V., Paton, L. N., Winterbourn, C. C., & Hampton, M. B. (2009). Redox potential and peroxide reactivity of human peroxiredoxin 3. Biochemistry, 48(27), 6495-6501. doi: 10.1021/bi900558g

Cox, A. G., Pearson, A. G., Pullar, J. M., Jönsson, T. J., Lowther, W. T., Winterbourn, C. C., & Hampton, M. B. (2009). Mitochondrial peroxiredoxin 3 is more resilient to hyperoxidation than cytoplasmic peroxiredoxins. Biochemical Journal, 421(1), 51-58. doi: 10.1042/BJ20090242

Harwood, D. T., Kettle, A. J., Brennan, S., & Winterbourn, C. C. (2009). Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 877, 3393-3399. doi: 10.1016/j.jchromb.2009.04.018

Kumar, V., Kitaeff, N., Hampton, M. B., Cannell, M. B., & Winterbourn, C. C. (2009). Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Letters, 583(6), 997-1000. doi: 10.1016/j.febslet.2009.02.018

Cuddihy, S. L., Baty, J. W., Brown, K. K., Winterbourn, C. C., & Hampton, M. B. (2009). Proteomic detection of oxidized and reduced thiol proteins in cultured cells. Methods in Molecular Biology, 519, 363-375. doi: 10.1007/978-1-59745-281-6_23

Nagy, P., Kettle, A. J., & Winterbourn, C. C. (2009). Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer. Journal of Biological Chemistry, 284(22), 14723-14733. doi: 10.1074/jbc.M809396200

Conference Contribution - Published proceedings: Abstract

Thai, T., Rees, M., Dang, L., Harwood, D. T., Winterbourn, C. C., Kettle, A. J., Maghzal, G., … Thomas, S. R. (2009). Myeloperoxidase and endothelial dysfunction. Journal of Vascular Research, 46(Suppl. 2), (pp. 10). doi: 10.1159/000230992

Darlow, B. A., Harwood, D. T., McNeill, N., & Winterbourn, C. C. (2009). Glutathione sulphonamide is a specific marker of neutrophil induced inflammation in tracheal aspirates from preterm infants. Proceedings of the Pediatric Academic Societies (PAS) Annual Meeting. E-PAS2009:3860.176. [Abstract]

Winterbourn, C. (2009). Hydrogen peroxide metabolism by peroxiredoxins. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Stacey, M. M., Vissers, M. C. M., & Winterbourn, C. C. (2009). Characterization of peroxiredoxin oxidation mediated by inflammatory oxidants in human endothelial cells. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009). Peroxiredoxin 3 is a key regulator of mitochondrial hydrogen peroxide. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Harwood, D. T., Darlow, B. A., McNeill, N., & Winterbourn, C. C. (2009). Glutathione sulphonamide is a specific marker of neutrophil induced inflammation in tracheal aspirates from preterm infants. Journal of Paediatrics & Child Health, 45(Suppl. 1), (pp. A54). doi: 10.1111/j.1440-1754.2009.01474.x

Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009). Reactions of superoxide with the myoglobin tyrosyl radical. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S74). [Abstract]

Stacey, M., Vissers, M., & Winterbourn, C. (2009). Characterization of peroxiredoxin oxidation mediated by inflammatory oxidants in human endothelial cells. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S82). [Abstract]

Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, M. J., & Winterbourn, C. C. (2009). Rapid removal of amino acid, peptide and protein peroxides. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S150-S151). [Abstract]

Harwood, T., Darlow, B., Cheah, F.-C., McNeill, N., & Winterbourn, C. (2009). Glutathione sulfonamide detects Hocl-mediated GSH oxidaton in tracheal aspirates from preterm infants and shows promise for detecting lung infection. Free Radical Biology and Medicine. 47(Suppl. 1), (pp. S105-S106). [Abstract]

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 3), (pp. S119-S120). doi: 10.1016/j.hlc.2009.05.270

Marshall, C. J., Nallaratnam, M., Mocatta, T., Smyth, D., Richards, A. M., Elliott, J. M., Blake, J., Winterbourn, C., Kettle, A. J., & McClean, D. R. (2009). Plasma myeloperoxidase at the culprit coronary lesion in acute myocardial infarction. Heart, Lung & Circulation, 18(Suppl. 2), (pp. S22-S23). doi: 10.1016/j.hlc.2009.04.052

Conference Contribution - Poster Presentation (not in published proceedings)

Pace, P., Hampton, M., & Winterbourn, C. (2009, December). Cellular interactions of peroxiredoxins. Poster session presented at the 5th Joint Meeting of the Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

Winterbourn, C. (2009, November). Glutathione sulfonamide detects hocl-mediated gsh oxidaton in tracheal. Poster session presented at the Society for Free Radical Biology and Medicine (SFRBM) 16th Annual Meeting, San Francisco, CA.

Das, A. B., Nagy, P., Abbott, H., Winterbourn, C. C., & Kettle, A. J. (2009, September). Superoxide mediated protein oxidation: A potential mechanism for superoxide toxicity. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2009, December). Thiol chemistry and specificity in redox signalling. Verbal presentation at the 5th Joint Meeting of The Societies for Free Radical Research Australasia and Japan & Mutagenesis and Experimental Pathology Society of Australia, Sydney, Australia.

Winterbourn, C. (2009, December). Hydrogen peroxide metabolism by peroxiredoxins. Keynote presentation at the ComBio2009 Conference, Christchurch, New Zealand.

Winterbourn, C. (2009, June). Oxidative brain injury and neuroinflammation. Verbal presentation at the Brain Health and Repair Research Centre Conference, Dunedin, New Zealand.

2008

Journal - Research Article

Winterbourn, C. C. (2008). Reconciling the chemistry and biology of reactive oxygen species. Nature Chemical Biology, 4(5), 278-286. doi: 10.1038/nchembio.85

Winterbourn, C. C., & Hampton, M. B. (2008). Thiol chemistry and specificity in redox signaling. Free Radical Biology & Medicine, 45(5), 549-561. doi: 10.1016/j.freeradbiomed.2008.05.004

Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2008). Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxidants & Redox Signaling, 10(9), 1621-1629. doi: 10.1089/ars.2008.2081

Fraser, M., Bennet, L., Van Zijl, P. L., Mocatta, T. J., Williams, C. E., Gluckman, P. D., Winterbourn, C. C., & Gunn, A. J. (2008). Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep. Journal of Neurochemistry, 105(6), 2214-2223. doi: 10.1111/j.1471-4159.2008.05313.x

Cuddihy, S. L., Parker, A., Harwood, D. T., Vissers, M. C. M., & Winterbourn, C. C. (2008). Ascorbate interacts with reduced glutathione to scavenge phenoxyl radicals in HL60 cells. Free Radical Biology & Medicine, 44(8), 1637-1644. doi: 10.1016/j.freeradbiomed.2008.01.021

Harwood, D. T., Nimmo, S. L., Kettle, A. J., Winterbourn, C. C., & Ashby, M. T. (2008). Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid. Chemical Research in Toxicology, 21(5), 1011-1016.

Conference Contribution - Published proceedings: Abstract

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2008). Impact of oxidative stress on DNA methylation. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Stacey, M. M., Winterbourn, C. C., & Vissers, M. C. (2008). Prx II provides protection against neutrophil-derived oxidants in human erythrocytes. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf

Nallaratnam, M., Mocatta, T., Marshall, C., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., Kettle, A. J., & McClean, D. R. (2008). Local leukocyte elastase release at site of occlusive plaque rupture predicts downstream microvascular reperfusion injury and impaired left ventricular function in ST elevation myocardial infarction. JACC, 1(2 (Suppl. B)), (pp. B64). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Winterbourn, C. (2008, November). Formation of tyrosine hydroperoxides and methionine sulfoxide on peptides by superoxide addition and intramolecular oxygen transfer. Verbal presentation at the Society for Free Radical Research Australasia Conference, Melbourne, Australia.

2007

Chapter in Book - Research

Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Neutrophil methods and protocols. (pp. 319-332). Totowa, USA: Humana Press.

Journal - Research Article

Åkerström, B., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2007). The lipocalin α₁-microglobulin has radical scavenging activity. Journal of Biological Chemistry, 282(43), 31493-31503.

Mocatta, T. J., Pilbrow, A. P., Cameron, V. A., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. JACC, 49(20), 1993-2000. doi: 10.1016/j.jacc.2007.02.040

Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897.

Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617.

Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H₂O₂ is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892.

Conference Contribution - Published proceedings: Abstract

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Plasma myeloperoxidase levels are highest in the Infarct-Related Artery (IRA) in patients with ST Elevation MI. Heart, Lung & Circulation, 16(Suppl. 2), (pp. S25). doi: 10.1016/j.hlc.2007.06.065

Nallaratnam, M., Mocatta, T., Kettle, A. J., Smyth, D., Winterbourn, C., Elliott, J., Richards, M., & McClean, D. (2007). Heparin, but not bilvalirudin, liberates endothelial myeloperoxidase in patients with ST Elevation Myocardial Infarction (STEMI). Heart, Lung & Circulation, 16(Suppl. 2), (pp. S24-S25). doi: 10.1016/j.hlc.2007.06.064

Conference Contribution - Verbal presentation and other Conference outputs

Brown, K. M., Winterbourn, C. C., & Hampton, M. B. (2007, August). Impact of oxidative stress on DNA methylation. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2006

Chapter in Book - Research

Hampton, M. B., Baty, J. W., & Winterbourn, C. C. (2006). Use of a proteomic technique to identify oxidant-sensitive thiol proteins in cultured cells. In I. Dalle-Donne, A. Scaloni & D. A. Butterfield (Eds.), Redox Proteomics: From protein modifications to cellular dysfunction and diseases. (pp. 253-265). Hoboken, NJ: John Wiley & Sons.

Journal - Research Article

Winterbourn, C. C., Hampton, M. B., Livesey, J. H., & Kettle, A. J. (2006). Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: Implications for microbial killing. Journal of Biological Chemistry, 281(52), 39860-39869.

Cameron, V. A., Mocatta, T. J., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension, 47(6), 1155-1161.

Midwinter, R. G., Cheah, F.-C., Moskovitz, J., Vissers, M. C., & Winterbourn, C. C. (2006). IκB is a sensitive target for oxidation by cell-permeable chloramines: Inhibition of NF-κB activity by glycine chloramine through methionine oxidation. Biochemical Journal, 396, 71-78.

Harwood, D. T., Kettle, A. J., & Winterbourn, C. C. (2006). Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method. Biochemical Journal, 399, 161-168.

Peskin, A. V., & Winterbourn, C. C. (2006). Taurine chloramine is more selective than hypochlorous acid at targeting critical cysteines and inactivating creatine kinase and glyceraldehyde-3-phosphate dehydrogenase. Free Radical Biology & Medicine, 40, 45-53.

van Dalen, C. J., Winterbourn, C. C., & Kettle, A. J. (2006). Mechanism of nitrite oxidation by eosinophil peroxidase: Implications for oxidant production and nitration by eosinophils. Biochemical Journal, 394, 707-713.

Journal - Professional & Other Non-Research Articles

Cheah, F.-C., Darlow, B. A., & Winterbourn, C. C. (2006). Association of hydrogen peroxide in exhaled breath condensates from infants with respiratory distress syndrome with the development of chronic lung disease. Archives of Disease in Childhood: Fetal & Neonatal Edition, 91, 155.

Conference Contribution - Published proceedings: Abstract

Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract]

Cameron, V. A., Pilbrow, A. P., Palmer, B. R., Mocatta, T. J., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2006). Oxidative stress levels in human heart disease are correlated with angiotensin type-1 receptor A1166C gene polymorphism. Proceedings of the New Zealand Society of Endocrinology Annual Meeting. NZSE. Retrieved from http://nzse.rsnz.org/NZSE%20Abstracts%202006.pdf

2005

Journal - Research Article

Kalogerakis, G., Baker, A. M., Christov, S., Rowley, K. G., Dwyer, K., Winterbourn, C., … Jenkins, A. J. (2005). Oxidative stress and high-density lipoprotein function in type 1 diabetes and end-stage renal disease. Clinical Science, 108, 497-506.

Ellison, V. J., Mocatta, T. J., Winterbourn, C. C., Darlow, B. A., Volpe, J. J., & Inder, T. E. (2005). The relationship of CSF and plasma cytokine levels to cerebral white matter injury in the premature newborn. Pediatric Research, 57(2), 282-286.

Cheah, F. C., Winterbourn, C. C., Darlow, B. A., Mocatta, T. J., & Vissers, M. C. M. (2005). Nuclear factor κB activation in pulmonary leukocytes from infants with hyaline membrane disease: Associations with chorioamnionitis and Ureaplasma urealyticum colonization. Pediatric Research, 57(5), 616-623. doi: 10.1203/01.PDR.0000156209.37627.82

Kettle, A. J., & Winterbourn, C. C. (2005). Do neutrophils produce ozone? An appraisal of current evidence. BioFactors, 24, 41-45.

Cheah, F. C., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2005). Detection of apoptosis by caspase-3 activation in tracheal aspirate neurophils from premature infants: Relationship with NF-_KB activation. Journal of Leukocyte Biology, 77, 432-437.

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2005). Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells. Biochemical Journal, 390(3), 785-795.

Darlow, B. A., Buss, H., McGill, F., Fletcher, L., Graham, P., & Winterbourn, C. C. (2005). Vitamin C supplementation in very preterm infants: A randomised controlled trial. Archives of Disease in Childhood: Fetal & Neonatal Edition, 90(2), F117-F122. doi: 10.1136/adc.2004.056440

Peskin, A. V., Midwinter, R. G., Harwood, D. T., & Winterbourn, C. C. (2005). Chlorine transfer between glycine, taurine, and histamine: Reaction rates and impact on cellular reactivity [Erratum version of the 2004 publication of the same title]. Free Radical Biology & Medicine, 38(3), 397-405.

Conference Contribution - Published proceedings: Abstract

Cameron, V. A., Pilbrow, A. P., Mocatta, T. J., Palmer, B. R., Frampton, C. M., Troughton, R. W., Richards, A. M., & Winterbourn, C. C. (2005). Elevated oxidative stress levels in heart disease and association with angiotensin receptor genotype. Proceedings of the Medical Sciences Congress. (pp. 39). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Pullar, J. M., Baty, J. W., Csordas, A., Winterbourn, C. C., & Hampton, M. B. (2005, December). Oxidation of thiol proteins in cultured cells: Comparison of H₂O₂ with receptor-mediated signalling. Verbal presentation at the 3rd Joint Meeting of the Society for Free Radical Research Australasia and Japan, Queensland, Australia.

2004

Journal - Research Article

Winterbourn, C. C., Parsons-Mair, H. N., Gebicki, S., Gebicki, J. M., & Davies, M. J. (2004). Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides. Biochemical Journal, 381, 241-248.

Midwinter, R. G., Peskin, A. V., Vissers, M. C. M., & Winterbourn, C. C. (2004). Extracellular oxidation by taurine chloramine activates ERK via the epidermal growth factor receptor. Journal of Biological Chemistry, 279(31), 32205-32211.

Kettle, A. J., Clark, B. M., & Winterbourn, C. C. (2004). Superoxide converts indigo carmine to isatin sulfonic acid. Journal of Biological Chemistry, 279(18), 18521-18525.

Munday, R., Munday, C. M., & Winterbourn, C. C. (2004). Inhibition of copper-catalyzed cysteine oxidation by nanomolar concentrations of iron salts. Free Radical Biology & Medicine, 36(6), 757-764. Elsevier.

Winterbourn, C. C., & Kettle, A. J. (2004). Reactions of superoxide with myeloperoxidase and its products. Japanese Journal of Infectious Diseases, 57, S31-S33.

Mocatta, T., Winterbourn, C. C., Inder, T. E., & Darlow, B. A. (2004). The effect of gestational age and labour on markers of lipid and protein oxidation in cord plasma. Free Radical Research, 38(2), 185-191.

Conference Contribution - Published proceedings: Abstract

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Pediatric Research. 56(3), (pp. 474). [Abstract]

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hampton, M. B., & Vissers, M. C. M. (2004). NF-KAPPA B activation and apoptosis in lung neutrophils from infants with hyaline membrane disease. Proceedings of the Perinatal Society of Australia and New Zealand: 8th Annual Congress. (pp. P133). Sydney, Australia: PSANZ. [Abstract]

2003

Chapter in Book - Research

Winterbourn, C. C. (2003). Radical scavenging by thiols: Biological significance and implications for redox signaling and antioxidant defense. In C. Gitler & A. Danon (Eds.), Cellular implications of redox signaling. (pp. 175-190). London: Imperial College Press.

Journal - Research Article

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: Association with adverse respiratory outcome. Pediatric Research, 53(3), 455-462.

Chapman, A. L. P., Winterbourn, C. C., Brennan, S., Jordan, T. W., & Kettle, A. J. (2003). Characterization of non-covalent oligomers of proteins treated with hypochlorous acid. Biochemical Journal, 375, 33-40.

Cheah, F. C., Darlow, B. A., & Winterbourn, C. C. (2003). Problems associated with collecting breath condensate for the measurement of exhaled hydrogen peroxide from neonates on respiratory support. Biology of the Neonate, 84, 338-341.

Peskin, A. V., & Winterbourn, C. C. (2003). Histamine chloramine reactivity with thiol compounds, ascorbate, and methionine and with intracellular glutathione. Free Radical Biology & Medicine, 35(10), 1252-1260.

Winterbourn, C. C., Bonham, M. J. D., Buss, I. H., Abu-Zidan, F. M., & Windsor, J. A. (2003). Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis. Pancreatology, 3, 375-382.

Winterbourn, C. C., & Kettle, A. J. (2003). Radical-radical reactions of superoxide: A potential route to toxicity. Biochemical & Biophysical Research Communications, 305, 729-736.

Conference Contribution - Published proceedings: Abstract

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Hunter, L. A., Mogridge, N., & Vissers, M. C. M. (2003). Nuclear factor-kappa B activation is expressed in tracheal aspriate cells of premature infants born with evidence of histologic chorioamnionitis. Proceedings of the 7th Annual Congress of the Perinatal Society of Australia and New Zealand. [Abstract]

Darlow, B. A., Buss, I. H., McGill, F. M., Mogridge, N., Graham, P., & Winterbourn, C. C. (2003). Optimal vitamin C supplementation in very preterm infants: A randomised controlled trial of three different regimes. Pediatric Research. 53. [Abstract]

Cheah, F. C., Darlow, B. A., Winterbourn, C. C., Mocatta, T. J., Mogridge, N., & Vissers, M. C. (2003). Nuclear factor-κB activation is expressed in tracheal aspirate cells of premature infants born with evidence of histologic chorioamnionitis. Pediatric Research. 53. [Abstract]

Cheah, F. C., Winterbourn, C. C., Darlow, B. A., Mocatta, T. J., Harwood, D. T., & Vissers, M. C. (2003). NF-Kappa B activation in pulmonary neutrophils was associated with elevated TNF-alpha levels in tracheal aspirates of infants with HMD. American Journal of Respiratory and Critical Care Medicine. 167. [Abstract]

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Kettle, A. J., & Winterbourn, C. C. (2003). Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants - association with adverse respiratory outcome. Proceedings of the 7th Annual Congress of the Perinatal Society of Australia and New Zealand. [Abstract]

2002

Chapter in Book - Research

Buss, I. H., Winterbourn, C. C., & Armstrong, D. A. (2002). Protein carbonyl measurement by ELISA. In Free Radicals and Antioxidants Protocols, Volume 186, Totowa. (pp. 123-128). Gainsville, Florida: The Humana Press Inc.

Journal - Research Article

Hampton, M. B., & Winterbourn, C. C. (2002). Redox regulation of neutrophil function. Antioxidants & Redox Signaling, 4(1), 1-3.

Pullar, J., Winterbourn, C. C., & Vissers, M. C. M. (2002). The effect of hypochlorous acid on the expression of adhesion molecules and activation of NF-_κ in cultured human endothelial cells. Antioxidants & Redox Signaling, 4(1), 5-15.

Inder, T. E., Mocatta, T., Darlow, B. A., Spencer, C., Volpe, J. J., & Winterbourn, C. C. (2002). Elevated free radical products in the cerebrospinal fluid of VLBW infants with cerebral white matter injury. Pediatric Research, 52(2), 213-218.

Chapman, A. L. P., Hampton, M. B., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2002). Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. Journal of Biological Chemistry, 277(12), 9757-9762.

Winterbourn, C. C., Peskin, A. V., & Parsons-Mair, H. N. (2002). Thiol oxidase activity of copper, zinc superoxide dismutase. Journal of Biological Chemistry, 277(3), 1906-1911.

Winterbourn, C. C. (2002). Biomarkers to probe oxidative damage by myeloperoxidase. Toxicology, 181(2), 223-227.

Inder, T. E., Mocatta, T., Darlow, B. A., Spencer, C. A., Senthilmohan, R., Winterbourn, C. C., & Volpe, J. J. (2002). Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia. Journal of Pediatrics, 140(5), 617-621.

Hampton, M. B., Vissers, M. C., Keenan, J. I., & Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. Journal of Leukocyte Biology, 71(5), 775-781.

Hampton, M. B., Stamenkovic, G., & Winterbourn, C. C. (2002). Interaction with substrate sensitises caspase-3 to inactivation by hydrogen peroxide. FEBS Letters, 517, 229-232.

Baty, J. W., Hampton, M. B., & Winterbourn, C. C. (2002). Detection of oxidant-sensitive thiol proteins by fluorescent labeling and two dimensional electrophoresis. Proteomics, 2, 1261-1266.

Conference Contribution - Published proceedings: Full paper

Darlow, B. A., Buss, H., McGill, F. M., Mogridge, N., Han, D. Y., Graham, P. J., & Winterbourn, C. C. (2002). Optimal vitamin C supplementation in very preterm infants: a randomised controlled trial of three different regimes. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch. [Full Paper]

Buss, I. H., Senthilmohan, R., Darlow, B. A., Mogridge, N., Cheah, F. C., Kettle, A. J., & Winterbourn, C. C. (2002). 3-Chlorotyrosine in tracheal aspirate samples from very-low-birthweight infants: Associations with myeloperoxidase, protein carbonyls and clinical outcome. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch, New Zealand. [Full Paper]

Cheah, F. C., Mocatta, T., Winterbourn, C. C., Darlow, B. A., & Vissers, M. C. (2002). NF-kappa B activation in pulmonary inflammatory cells is associated with TNF-alpha elevation in tracheal aspirates from infants with respiratory distress syndrome. Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch. [Full Paper]

Cheah, F. C., Darlow, B. A., & Winterbourn, C. C. (2002). Exhaled hydrogen peroxide as a marker of airway inflammation and oxidative injury in neonates on respiratory support - a reliable measure? Proceedings of the 4th Annual Congress of the Perinatal Society of Australia and New Zealand. Christchurch. [Full Paper]

Conference Contribution - Verbal presentation and other Conference outputs

Thomson, S. J., Pullar, J., Baty, J. W., & Winterbourn, C. C. (2002, November). Monitoring oxidation of the thiol proteins during apoptosis. Verbal presentation at the Microbes and Molecules Conference, Christchurch, New Zealand.

2001

Journal - Research Article

Buss, I. H., McGill, F. M., Darlow, B. A., & Winterbourn, C. C. (2001). Vitamin C is reduced in human milk after storage. Acta Paediatrica, 90, 813-815.

Kettle, A. J., & Winterbourn, C. C. (2001). A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry, 40, 10204-10212.

Vissers, M. C. M., Carr, A. C., & Winterbourn, C. C. (2001). Fatty acid chlorohydrins and bromohydrins are cytotoxic to human endothelial cells. Redox Report, 6, 49-55. doi: 10.1179/135100001101536030

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001). Glutathione oxidation by hypochlorous acid in endothelial cells produces glutathione sulfonamide as a major product but not glutathione disulfide. Journal of Biological Chemistry, 276(25), 22120-22125. doi: 10.1074/jbc.M102088200

Peskin, A. V., & Winterbourn, C. C. (2001). Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate. Free Radical Biology & Medicine, 30, 572-579.

Midwinter, R. G., Vissers, M. C. M., & Winterbourn, C. C. (2001). Hypochlorous acid stimulation of the MAP-kinase pathway enhances cell survival. Archives of Biochemistry & Biophysics, 394(1), 13-20. doi: 10.1006/abbi.2001.2530

Silvers, K. M., Sluis, K. B., Darlow, B. A., McGill, F. M., Stocker, R., & Winterbourn, C. C. (2001). Limiting light-induced lipid peroxidation and vitamin loss in infant parenteral nutrition by adding multivitamin preparations to Intralipid. Acta Paediatrica, 90, 242-249.

Silvers, K. M., Darlow, B. A., & Winterbourn, C. C. (2001). Lipid peroxide and hydrogen peroxide formation in parenteral nutrition solutions containing multivitamins. Journal of Parenteral & Enteral Nutrition, 25, 14-17.

Journal - Professional & Other Non-Research Articles

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Changing drugs - only when necessary. New Zealand Medical Journal, 114, 536.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Medical education : Investment or cost? New Zealand Medical Journal, 114, 459.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). The work-force crisis, funding and the bureaucracies. New Zealand Medical Journal, 114, 417.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Health care plans in the United Kingdom and New Zealand. New Zealand Medical Journal, 114, 369.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). And now the failure of cervical screening. New Zealand Medical Journal, 114, 221-222.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Now Gisborne hospital. New Zealand Medical Journal, 114, 173-174.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Patient safety : A fence at the top of the cliff? New Zealand Medical Journal, 114, 77.

Bagshaw, P. F., Begg, E. J., Moller, P. W., Nicholls, M. G., Toop, L. J., & Winterbourn, C. C. (2001). Reaffirming professionalism in medicine. New Zealand Medical Journal, 114, 347-348.

Conference Contribution - Published proceedings: Abstract

Senthilmohan, R., Mocatta, T., Buss, H., Darlow, B. A., Wagner, J., Kettle, A. J., & Winterbourn, C. C. (2001). Oxidative modification of protein in cystic fibrosis and in chronic lung disease of preterm infants. The 8th Annual Meeting of the Oxygen Society. 31(269 (Suppl 1)), (pp. S89). Free Radical Biology and Medicine. [Abstract]

2000

Chapter in Book - Research

Winterbourn, C. C., van Dalen, C. J., Hampton, M. B., & Kettle, A. J. (2000). Reactions of myeloperoxidase and production of hypochlorous acid in neutrophil phagosomes. In P. E. Petrides & W. M. Nauseef (Eds.), The Peroxidase Multigene Family of Enzymes. (pp. 58-67). Berlin: Springer.

Journal - Research Article

Winterbourn, C. C., Chan, T., Buss, H., Inder, T. E., Mogridge, N., & Darlow, B. A. (2000). Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: Associations with chronic lung disease and retinopathy and effects of selenium supplementation. Pediatric Research, 48, 84-90.

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2000). Living with a killer: The effects of hypochlorous acid on mammalian cells. IUBMB Life, 50, 259-266.

Winterbourn, C. C., Buss, I. H., Chan, T., Plank, L. D., Clark, M. A., & Windsor, J. A. (2000). Protein carbonyl measurements show evidence of early oxidative stress in critically ill patients. Critical Care Medicine, 28, 143-149.

Winterbourn, C. C., & Kettle, A. J. (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biology & Medicine, 29, 403-409.

van Dalen, C. J., Winterbourn, C. C., Senthilmohan, R., & Kettle, A. J. (2000). Nitrite as a substrate and inhibitor of myeloperoxidase: Implications for nitration and hypochlorous acid production at sites of inflammation. Journal of Biological Chemistry, 275, 11638-11644.

Peskin, A., & Winterbourn, C. C. (2000). A microtiter plate assay for superoxide dismutase using a water soluble tetrazolium salt (WST-1). Clinica Chimica Acta, 293, 157-166.

Chapman, A. L. P., Senthilmohan, R., Winterbourn, C. C., & Kettle, A. J. (2000). Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins. Archives of Biochemistry & Biophysics, 377(1), 95-100.

Darlow, B. A., Winterbourn, C. C., Inder, T. E., Graham, P. J., Harding, J. E., Weston, P. J., Austin, N. C., Elder, D. E., Mogridge, N., Buss, I. H., & Sluis, K. B. (2000). The effect of selenium supplementation on outcome in very low birth weight infants: A randomized controlled trial. Journal of Pediatrics, 136, 473-480.

Buss, I. H., Darlow, B. A., & Winterbourn, C. C. (2000). Elevated protein carbonyls and lipid peroxidation products correlating with myeloperoxidase in tracheal aspirates from premature infants. Pediatric Research, 47, 640-645.

Journal - Research Other

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (2000). Medical training in crisis. New Zealand Medical Journal, 113(155).

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (2000). Malpractice and our responses [Editorial]. New Zealand Medical Journal, 113(345).

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (2000). Patients, professionalism and politics: A new beginning [Editorial]. New Zealand Medical Journal, 113(23).

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (2000). The case for doubling investment in biomedical research [Editorial]. New Zealand Medical Journal, 113(389).

Nicholls, M. G., Bagshaw, P., Begg, E. J., Moller, P. W., Toop, L., & Winterbourn, C. (2000). Getting health back on track [Editorial]. New Zealand Medical Journal, 113(369).

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (2000). Everything is new! [Editorial]. New Zealand Medical Journal, 113(1).

Winterbourn, C. C., Vissers, M. C., & Kettle, A. J. (2000). Myeloperoxidase. Current Opinion in Hematology, 7, 53-58. [Review].

1999

Journal - Research Article

Abu-Zidan, F. M., Winterbourn, C. C., Bonham, M. J. D., Simovic, M. O., Buss, H., & Windsor, J. A. (1999). Small bowel ischaemia-reperfusion increases plasma concentrations of oxidised proteins in rats. European Journal of Surgery, 165, 383-389.

Winterbourn, C. C., & Buss, H. (1999). Protein Carbonyl Measurement by Enzyme-Linked Immunosorbent Assay. Methods in Enzymology, 300, 106-111.

Winterbourn, C. C., & Metodiewa, D. (1999). Reactivity of biologically relevant thiol compounds with superoxide and hydrogen peroxide. Free Radical Biology & Medicine, 27, 322-328.

Pullar, J. M., Winterbourn, C. C., & Vissers, M. C. M. (1999). Loss of GSH and thiol enzymes in endothelial cellls exposed to sublethal concentrations of hypochlorous acid. American Journal of Physiology: Heart & Circulatory Physiology, 277, H1505-H1512.

Hampton, M. B., & Winterbourn, C. C. (1999). Methods for quantifying phagocytosis and bacterial killing by human neutrophils. Journal of Immunological Methods, 232, 15-22.

Bonham, M. J. D., Abu-Zidan, F. M., Simovic, M. O., Sluis, K. B., Winterbourn, C. C., Wilkinson, A., & Windsor, J. A. (1999). Early ascorbic acid depletion is related to the severity of acute pancreatitis. British Journal of Surgery, 86, 1296-1301.

Journal - Research Other

Nicholls, G., Bagshaw, P., Begg, E., Moller, P., Toop, L., & Winterbourn, C. (1999). [Editorial The Journal: Into the new millenium]. New Zealand Medical Journal, 112, 415.

Conference Contribution - Verbal presentation and other Conference outputs

Senthilmohan, R., Chapman, A. L. P., Winterbourn, C. C., & Kettle, A. J. (1999, December). A gas chromatographic-mass spectral assay for the simultaneous quantification of modified Tyrosyl residues and Hydroxylated phenylalanine residues in biological samples. Verbal presentation at the Oxidative Pathways in Health and Disease Conference, Sydney, Australia.

1998

Journal - Research Article

Silvers, K. M., Darlow, B. A., & Winterbourn, C. C. (1998). Pharmacological levels of heparin do not destabilize neonatal parenteral nutrition. Journal of Parenteral & Enteral Nutrition, 22, 311-314.

Vollebregt, M., Hampton, M. B., & Winterbourn, C. C. (1998). Activation of NF-KB in human neutrophils during phagocytosis of bacteria independently of oxidant generation. FEBS Letters, 432, 40-44.

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase and bacterial killing. Blood, 92, 3007-3017.

Carr, A., van den Berg, J. J. M., & Winterbourn, C. C. (1998). Differential reactivities of hypochlorous and hypobromous acids with purified E.coli phospholipid: formation of haloamines and halohydrins. Biochimica et Biophysica Acta: General Subjects, 1392, 254-264.

Inder, T. E., Graham, P. J., Winterbourn, C. C., Austin, N. C., & Darlow, B. A. (1998). Plasma vitamin A levels in the very low birthweight infant - relationship to respiratory outcome. Early Human Development, 52, 155-168.

Journal - Professional & Other Non-Research Articles

Winterbourn, C. C. (1998). Free radicals in biology: a personal perspective. New Zealand Science Review, 54, 67-69.

Silvers, K. M., Winterbourn, C. C., & Darlow, B. A. (1998). The destabilisation of total parenteral nutrition by heparin. How real is the problem? New Zealand Medical Journal, 386(10 Oct), 386.

Conference Contribution - Published proceedings: Abstract

Darlow, B. A., Inder, T. E., Sluis, K. B., Buss, H., Graham, P. J., Mogridge, N., & Winterbourn, C. C. (1998). New Zealand Neonatal Study Group. Randomised controlled trial of selenium supplementation in New Zealand infants. Pediatric Research. 43, (pp. 258A). [Abstract]

1997

Chapter in Book - Research

McPherson, K. G., Kettle, A. J., & Winterbourn, C. C. (1997). Mechanism of activation of NFKB by hydrogen peroxide in Jurkat JR cells. In L. Montagnier, R. Olivier & C. Pasquier (Eds.), Oxidative Stress and Redox Regulation: Cellular Signalling, Aids, Cancer and Other Diseases. (pp. 83-87). New York: Marcel Dekker.

Journal - Research Article

Darlow, B. A., Sluis, K. B., Inder, T. E., & Winterbourn, C. C. (1997). Endotracheal suctioning of the neonate: comparison of two methods as a source of mucus material for research. Pediatric Pulmonology, 23(3), 217-221.

Winterbourn, C. C., Pichorner, H., & Kettle, A. J. (1997). Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils. Archives of Biochemistry & Biophysics, 338(1), 15-21.

Winterbourn, C. C., & Brennan, S. O. (1997). Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid. Biochemical Journal, 326(1), 87-92.

Van Dalen, C. J., Whitehead, M. W., Winterbourn, C. C., & Kettle, A. J. (1997). Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochemical Journal, 327(2), 487-492.

Kettle, A. J., Gedye, C. A., & Winterbourn, C. C. (1997). Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochemical Journal, 321(2), 503-508.

Domigan, N. M., Carr, A. C., Lewis, J. G., Elder, P. A., & Winterbourn, C. C. (1997). A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury. Redox Report, 3(2), 111-117.

Carr, A., & Winterbourn, C. C. (1997). Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid. Biochemical Journal, 327(1), 275-281.

Carr, A., Winterbourn, C. C., Blunt, J. W. W., Phillips, A., & Abell, A. D. (1997). Nuclear magnetic resonance characterization of 6a-chloro-5b-cholestane-3b, 5-diol formed from the reaction of hypochlorous acid with cholesterol. Lipids, 32(4), 363-367.

Buss, H., Chan, T. P., Sluis, K. B., Domigan, N. M., & Winterbourn, C. C. (1997). Protein carbonyl measurement by a sensitive Elisa method. Free Radical Biology & Medicine, 23(3), 361-366.

Carr, A. C., Vissers, M. C., Domigan, N. M., & Winterbourn, C. C. (1997). Modification of red cell membrane lipids by hypochlorus acid and haemolysis by preformed lipid chlorohydrins. Redox Report, 3, 263-271.

Journal - Research Other

Kettle, A. J., & Winterbourn, C. C. (1997). Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Report, 3(1), 3-15. doi: 10.1080/13510002.1997.11747085

Journal - Professional & Other Non-Research Articles

Kettle, A. J., Van Dalen, C. J., & Winterbourn, C. C. (1997). Peroxynitrite and myeloperoxidase leave the same foorprint in protein nitration. Redox Report, 3, 257-258.

1996

Chapter in Book - Research

Winterbourn, C. C. (1996). Free radicals, oxidants and antioxidants. In R. D. G. Milner (Ed.), Perinatal and Pediatric Pathophysiology: A Clinical Perspective. 2nd edn. (pp. 108-115). London: Edward Arnold.

Kettle, A. J., & Winterbourn, C. C. (1996). Reaction mechanisms of myeloperoxidase. In C. Obinger, U. Burner, R. Ebermann, C. Penel & H. Greppin (Eds.), Plant Peroxidases: Biochemistry and Physiology. (pp. 134-139). Geneva: University of Geneva.

Journal - Research Article

Inder, T. E., Darlow, B. A., Sluis, K. B. M., Winterbourn, C. C., Graham, P. J. M., Sanderson, K. J., & Taylor, B. J. (1996). The correction of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant. Acta Paediatrica, 85, 1116-1122.

Winterbourn, C. C. (1996). Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicology Letters, 82/83, 969-974.

Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1996). Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Straphuylococcus aureus by neutrophils. Infection & Immunity, 64(9), 3512-3517.

Carr, A., Winterbourn, C. C., & van den Berg, J. J. M. (1996). Peroxidase-mediated bromination of unsaturated fatty acids to form bromohydrins. Archives of Biochemistry & Biophysics, 327, 227-233.

Carr, A., van den Berg, J. J. M., & Winterbourn, C. C. (1996). Chlorination of cholesterol in cell membranes by hypochlorous acid. Archives of Biochemistry & Biophysics, 332, 63-69.

1995

Journal - Research Article

Inder, T. E., Carr, A. C., Winterbourn, C. C., Austin, N. C., & Darlow, B. A. (1995). Vitamin A and E status in very low birth weight infants: Development of an improved parenteral delivery system. Journal of Pediatrics, 126(1), 128-131. doi: 10.1016/S0022-3476(95)70515-5

Darlow, B. A., Inder, T. E., Sluis, K. B. M., Nuthall, G., Mogridge, N., & Winterbourn, C. C. (1995). Selenium status of New Zealand infants fed either a selenium supplemented or a standard formula. Journal of Paediatrics & Child Health, 31, 339-344.

Darlow, B. A., Inder, T. E., Graham, P. J., Sluis, K. B., Malpas, T. J., Taylor, B. J., & Winterbourn, C. C. (1995). The relationship of selenium status to respiratory outcome in the very low birth weight infant: relationship to maternal status, infant nutrition and respiratory outcome. Pediatrics, 96, 314-319.

Pichorner, H., Metodiewa, D., & Winterbourn, C. C. (1995). Generation of superoxide and tyrosine peroxide as a result of tyrosyl radical scavenging by glutathione. Archives of Biochemistry & Biophysics, 323, 429-437.

Winterbourn, C. C. (1995). Free radical toxicology and antioxidant defence. Clinical & Experimental Pharmacology & Physiology, 22, 877-880.

Winterbourn, C. C. (1995). Nutritional antioxidants: their role in disease prevention. New Zealand Medical Journal, 95, 447-449.

1994

Journal - Research Article

Kettle, A. J., Carr, A. C., & Winterbourn, C. C. (1994). Assays using horseradish peroxidase and phenolic substrates require superoxide dismutase for accurate determination of hydrogen peroxide production by neutrophils. Free Radical Biology & Medicine, 17(2), 161-164.

Thomas, C., Carr, A. C., & Winterbourn, C. C. (1994). Free radical inactivation of rabbit muscle creatinine kinase: Catalysis by physiological and hydrolized ICRF-187 (ICRF-198) iron chelates. Free Radical Research, 21(6), 387-397.

1993

Journal - Research Article

Winterbourn, C. C., & Carr, A. C. (1993). Myeloperoxidase-dependent loss of malondialdehyde: A limitation for detecting neutrophil-mediated lipid peroxidation. Archives of Biochemistry & Biophysics, 302(2), 461-467. doi: 10.1006/abbi.1993.1240