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Louisa ForbesSenior Research Fellow

BSc(Hons)(Cant), PhD(UCL)

Tel +64 3 378 6223

Research interests

Dr Louisa Ashby's research is focused on the biochemistry of the neutrophil, and in particular the enzymology of myeloperoxidase. This enzyme kills microbes by generating chlorine bleach, but during inflammation it can also damage healthy tissue.

She is also interested in the oxidation chemistry of myeloperoxidase in its microbicidal activity, and how to effectively inhibit the enzyme from causing oxidative stress in disease.


Ashby, L., Chan, L., Winterbourn, C., Woon, S.-T., Keating, P., Heller, R., … Chua, I., & Hsiao, K.-C. (2024). Phenotypic spectrum in a family with a novel RAC2 p.I21S dominant-activating mutation [Case report]. Clinical & Translational Immunology, 13, e1493. doi: 10.1002/cti2.1493 Journal - Research Other

Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008 Journal - Research Article

Ashby, L. V., Flannery, M., Chua, I., & Kettle, A. J. (2023). Measuring oxidant production in phagosomes to identify abnormalities in neutrophil function. Free Radical Biology & Medicine, 201(Suppl. 1), (pp. 13). doi: 10.1016/j.freeradbiomed.2023.03.072 Conference Contribution - Published proceedings: Abstract

Kettle, A. J., Ashby, L. V., Winterbourn, C. C., & Dickerhof, N. (2023). Superoxide: The enigmatic chemical chameleon in neutrophil biology [Invited review]. Immunological Reviews, 314, 181-196. doi: 10.1111/imr.13183 Journal - Research Other

Ashby, L. V., Dickerhof, N., Springer, R., Hampton, M. B., & Kettle, A. J. (2022, August). Bacterial resistance to oxidants in neutrophil phagosomes. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

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