Senior Research FellowBSc(Hons) (London, UK), PhD (Cambridge, UK)
Dr Paul Pace previously worked at Imperial College of Science and Technology in London, before moving to the Laboratory of Molecular Biology in Cambridge, where he obtained his PhD studying DNA repair mechanisms.
His expertise is in molecular biology (cloning, mutagenesis, CRISPR applications), protein biochemistry (protein expression and purification, antibody generation and purification, immunocytochemistry, immunoprecipitation, analytical methods) and cell biology (cell culture, transfection, lentiviral expression). He teaches part of the BBiomedSc(Hons) programme, has supervised two summer students, and currently co-supervises two PhD students.
His current projects include studying the biochemistry of peroxiredoxins, including their roles in cell signalling, including the redox regulation of phosphorylation-dependent cell migration and transformation in cancer.
Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00208-23
Winterbourn, C. C., Peskin, A., Kleffmann, T., Radi, R., & Pace, P. E. (2023). Carbon dioxide/bicarbonate is required for sensitive inactivation of mammalian glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide. PNAS, 120(18), e2221047120. doi: 10.1073/pnas.2221047120
Shearer, H. L., Parker, H. A., Pace, P. E., Hampton, M. B., & Dickerhof, N. (2022, August). Sensitising Streptococcus pneumoniae to oxidative stress. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Pace, P. E., Peskin, A. V., Winterbourn, C. C., & Hampton, M. B. (2022, August). Disrupting the oligomeric structure of peroxiredoxins in cancer cells using CRISPR. Poster session presented at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Pace, P., & Winterbourn, C. C. (2022). A cautionary note on using phosphatase inhibitors with hydrogen peroxide. Antioxidants & Redox Signaling. Advance online publication. doi: 10.1089/ars.2022.0092