Professor John Evans is studying gynaecological cancers in collaboration with Peter Sykes. These investigations aim to understand cancers and develop new treatments.
Another set of studies investigates the regulation of the ovulatory cycle. This research is aimed at developing methods of fertility modulation.
Previous investigations of the peptides in cells lining blood vessels have provided new information on vascular disease.
Publications
Evans, G. E., Mahajan, V., Wakeman, S., Slatter, T., Ponnampalam, A. P., Anderson, T. P., Sarwar, M., & Evans, J. J. (2023). A pilot study using unique targeted testing of the urogenital microbiome has potential as a predictive test during IVF for implantation outcome. Archives of Gynecology & Obstetrics. Advance online publication. doi: 10.1007/s00404-023-06987-w
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2022). Collagen I dysregulation is pivotal for ovarian cancer progression. Tissue & Cell, 74, 101704. doi: 10.1016/j.tice.2021.101704
Wahid, N. A. A., Hashemi, A., Evans, J. J., & Alkaisi, M. M. (2021). Conductive bioimprint using soft lithography technique based on PEDOT:PSS for biosensing. Bioengineering, 8, 204. doi: 10.3390/bioengineering8120204
Sarwar, M., & Evans, J. J. (2021). Bioimprinting: Bringing together 2D and 3D in dissecting cancer biology [Expert opinion]. Biotechniques, 71(5), 543-546. doi: 10.2144/btn-2021-0058
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics, 79, 375-386. doi: 10.1007/s12013-020-00964-9
Evans, G. E., Mahajan, V., Wakeman, S., Slatter, T., Ponnampalam, A. P., Anderson, T. P., Sarwar, M., & Evans, J. J. (2023). A pilot study using unique targeted testing of the urogenital microbiome has potential as a predictive test during IVF for implantation outcome. Archives of Gynecology & Obstetrics. Advance online publication. doi: 10.1007/s00404-023-06987-w
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2022). Collagen I dysregulation is pivotal for ovarian cancer progression. Tissue & Cell, 74, 101704. doi: 10.1016/j.tice.2021.101704
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics, 79, 375-386. doi: 10.1007/s12013-020-00964-9
Journal - Research Article
Wahid, N. A. A., Hashemi, A., Evans, J. J., & Alkaisi, M. M. (2021). Conductive bioimprint using soft lithography technique based on PEDOT:PSS for biosensing. Bioengineering, 8, 204. doi: 10.3390/bioengineering8120204
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., Alkaisi, M. M., & Evans, J. J. (2019). The extracellular topographical environment influences ovarian cancer cell behaviour. Biochemical & Biophysical Research Communications, 508, 1188-1194. doi: 10.1016/j.bbrc.2018.12.067
Journal - Research Article
Evans, G. E., Phillipson, G. T. M., Sykes, P. H., McNoe, L. A., Print, C. G., & Evans, J. J. (2018). Does the endometrial gene expression of fertile women vary within and between cycles? Human Reproduction, 33(3), 452-463. doi: 10.1093/humrep/dex385
Journal - Research Article
Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a
Journal - Research Article
Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2016). The use of substrate materials and topography to modify growth patterns and rates of differentiation of muscle cells. Journal of Biomedical Materials Research Part A, 104A, 1638-1645. doi: 10.1002/jbm.a.35696
Journal - Research Article
Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0
Journal - Research Article
Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002
Journal - Research Article
Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2015). The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface. International Journal of Nanomedicine, 10, 4883-4895. doi: 10.2147/ijn.s86336
Journal - Research Article
Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Sykes, P. H., Sin, I. L., Lam, E. Y. N., … Evans, J. J. (2014). In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia. Fertility & Sterility, 102(1), 307-317. doi: 10.1016/j.fertnstert.2014.04.005
Journal - Research Article
Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2014). Bioimprinted polymer platforms for cell culture using soft lithography. Journal of Nanobiotechnology, 12, 60. doi: 10.1186/s12951-014-0060-6
Journal - Research Article
Yoshida, A., Chitcholtan, K., Evans, J. J., Uemura, S., & Beasley, S. W. (2014). Provision of optimal conditions for in vitro differentiation into peristaltic smooth muscle from a murine induced pluripotent stem cell line. JSM Regenerative Medicine & Bioengineering, 2(1), 1011.
Journal - Research Article
Chitcholtan, K., Asselin, E., Parent, S., Sykes, P. H., & Evans, J. J. (2013). Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental Cell Research, 319(1), 75-87. doi: 10.1016/j.yexcr.2012.09.012
Journal - Research Article
Evans, J. J., Wilkinson, T. M., & Wall, D. J. N. (2013). A two-pathway mathematical model of the LH response to GnRH that predicts self-priming. International Journal of Endocrinology, 2013, 410348. doi: 10.1155/2013/410348
Journal - Research Article
Chitcholtan, K., Sykes, P. H., & Evans, J. J. (2012). The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. Journal of Translational Medicine, 10(1), 38-53. doi: 10.1186/1479-5876-10-38
Journal - Research Article
Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Simón, C., McNoe, L. A., Sykes, P. H., … Evans, J. J. (2012). Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility & Sterility, 97(6), 1365-1373. doi: 10.1016/j.fertnstert.2012.03.007
Journal - Research Article
Evans, G. E., Phillipson, G. T. M., Sin, I. L., Frampton, C. M. A., Kirker, J. A., Bigby, S. M., & Evans, J. J. (2012). Gene expression confirms a potentially receptive endometrium identified by histology in fertile women. Human Reproduction, 27(9), 2747-2755. doi: 10.1093/humrep/des233
Journal - Research Article
Evans, J. J., & Anderson, G. M. (2012). Balancing ovulation and anovulation: Integration of the reproductive and energy balance axes by neuropeptides. Human Reproduction Update, 18(3), 313-332. doi: 10.1093/humupd/dms004
Journal - Research Article
Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429
Journal - Research Article
Ibrahim, S. N., Murray, L., Evans, J. J., & Alkaisi, M. M. (2012). Trapping single cells: Comparison between sandwiched insulation with back contact (SIBC) and planar biochip. Materials Science Forum, 700, 188-194. doi: 10.4028/www.scientific.net/MSF.700.188
Journal - Research Article
Ibrahim, S. N., Murray, L., Nock, V., Evans, J. J., & Alkaisi, M. M. (2012). The quadrupole microelectrode design on a multilayer biochip for dielectrophoretic trapping of single cells. Microelectronic Engineering, 97, 369-374. doi: 10.1016/j.mee.2012.04.018
Journal - Research Article
Evans, J. J., & Chitcholtan, K. (2011). Extracellular matrix proteins in the anterior pituitary gland. Open Neuroendocrinology Journal, 4, 111-119. doi: 10.2174/1876528901104010111
Journal - Research Article
Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2011). Microfluidic arrays for bioimprint of cancer cells. Microelectronic Engineering, 88(8), 1828-1831. doi: 10.1016/j.mee.2010.12.042
Journal - Research Article
Samsuri, F., Alkaisi, M. M., Evans, J. J., Chitcholtan, K., & Mitchell, J. S. (2011). Detection of changes in cell membrane structures using the Bioimprint technique. Microelectronic Engineering, 88(8), 1871-1874. doi: 10.1016/j.mee.2010.12.069
Journal - Research Article
Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2010). Microfluidics-assisted photo nanoimprint lithography for the formation of cellular bioimprints. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 28(6), C6K17-C6K22. doi: 10.1116/1.3501342
Journal - Research Article
Samsuri, F., Alkaisi, M. M., Mitchell, J. S., & Evans, J. J. (2010). Replication of cancer cells using soft lithography bioimprint technique. Microelectronic Engineering, 87, 699-703. doi: 10.1016/j.mee.2009.12.068
Journal - Research Article
Alkaisi, M. M., Muys, J. J., & Evans, J. J. (2009). Single cell imaging with AFM using Biochip/Bioimprint technology. International Journal of Nanotechnology, 6(3-4), 355-368. doi: 10.1504/IJNT.2009.022925
Journal - Research Article
Anderson, G. M., Relf, H.-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359
Journal - Research Article
Dann, J. M., Sykes, P. H., Mason, D. R., & Evans, J. J. (2009). Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecologic Oncology, 113(3), 374-378.
Journal - Research Article
Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology & Biochemistry, 23(1-3), 97-108.
Journal - Research Article
Peters, E. E. M., Towler, K. L., Mason, D. R., & Evans, J. J. (2009). Effects of galanin and leptin on gonadotropin-releasing hormone-stimulated luteinizing hormone release from the pituitary. Neuroendocrinology, 89(1), 18-26.
Journal - Research Article
Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Formation of nanoscale bioimprints of muscle cells using UV-cured spin-coated polymers. Journal of Nanotechnology, 593410. doi: 10.1155/2009/593410
Journal - Research Article
Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Replication of muscle cell using bioimprint. AIP Conference Proceedings, 1151, 71-74. doi: 10.1063/1.3203250
Journal - Research Article
Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2008). Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides, 29(6), 1057-1061.
Journal - Research Article
Savigny, P., Evans, J., & McGrath, K. M. (2007). Cell membrane structures during exocytosis. Endocrinology, 148(8), 3863-3874. doi: 10.1210/en.2006-1644
Journal - Research Article
Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Bioimprint: Nanoscale analysis by replication of cellular topography using soft lithography. Journal of Biomedical Nanotechnology, 2(1), 1-5.
Journal - Research Article
Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Cellular replication and atomic force microscope imaging using a UV-Bioimprint technique. Nanomedicine, 2, 169-176.
Journal - Research Article
Muys, J. J., Alkaisi, M. M., Melville, D. O. S., Nagase, J., Sykes, P., Parguez, G. M., & Evans, J. J. (2006). Cellular transfer and AFM imaging of cancer cells using Bioimprint. Journal of Nanobiotechnology, 4. Retrieved from http://www.jnanobiotechnology.com/content/4/1/1
Journal - Research Article
Pearson, L. J., Rait, C., Nicholls, M. G., Yandle, T. G., & Evans, J. J. (2006). Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II. Journal of Endocrinology, 191(1), 171-177.
Journal - Research Article
Muys, J., Alkaisi, M. M., Evans, J. J., & Nagase, J. (2005). Biochip: Cellular analysis by atomic force microscopy using dielectrophoretic manipulation. Japanese Journal of Applied Physics, 44(7B), 5717-5723.
Journal - Research Article
Abbas, M. M., Evans, J. J., Sykes, P. H., & Benny, P. S. (2004). Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells. Fertility & Sterility, 82(Suppl. 3), 1048-1053.
Journal - Research Article
Abbas, M. M., Evans, J. J., Sin, I. L., Gooneratne, A., Hill, A., & Benny, P. S. (2003). Vascular endothelial growth factor and leptin: Regulation in human cumulus cells and in follicles. Acta Obstetricia et Gynecologica Scandinavica, 82(11), 997-1003.
Journal - Research Article
Evans, J. J., Reid, R. A., Wakeman, S., Croft, L. B., & Benny, P. S. (2003). Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women. Human Reproduction, 18(7), 1428-1431.
Journal - Research Article
Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.
Journal - Research Article
Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.
Journal - Research Article
Evans, J. J. (2002). Peptides interact in gonadotrophin regulation. Archives of Physiology & Biochemistry, 110, 154-161.
Journal - Research Article
Evans, J. J. (2002). The anterior pituitary gland is mysterious, alluring and useful. Archives of Physiology & Biochemistry, 110, 3-8.
Journal - Research Article
Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2002). Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. Journal of Endocrinology, 175, 225-232.
Journal - Research Article