Professor John Evans is studying gynaecological cancers in collaboration with Peter Sykes. These investigations aim to understand cancers and develop new treatments.
Another set of studies investigates the regulation of the ovulatory cycle. This research is aimed at developing methods of fertility modulation.
Previous investigations of the peptides in cells lining blood vessels have provided new information on vascular disease.
Publications
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics. Advance online publication. doi: 10.1007/s12013-020-00964-9
Sarwar, M., Sykes, P., & Evans, J. J. (2020). A doctrine of ovarian cancer translational research needs revisiting. International Journal of Cancer Management, 13(8), e105436. doi: 10.5812/ijcm.105436
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2020). Extracellular biophysical environment: Guilty of being a modulator of drug sensitivity in ovarian cancer cells [Short communication]. Biochemical & Biophysical Research Communications, 527(1), 180-186. doi: 10.1016/j.bbrc.2020.04.107
Sarwar, M., Sykes, P. H., Chitcholtan, K., Alkaisi, M. M., & Evans, J. J. (2019). The extracellular topographical environment influences ovarian cancer cell behaviour. Biochemical & Biophysical Research Communications, 508, 1188-1194. doi: 10.1016/j.bbrc.2018.12.067
Evans, J. J., Alkaisi, M. M., & Sykes, P. H. (2019). Tumour initiation: A discussion on evidence for a "load-trigger" mechanism [Hypothesis]. Cell Biochemistry & Biophysics, 77, 293-308. doi: 10.1007/s12013-019-00888-z
Journal - Research Article
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021). Deciphering biophysical modulation in ovarian cancer cells. Cell Biochemistry & Biophysics. Advance online publication. doi: 10.1007/s12013-020-00964-9
Sarwar, M., Sykes, P. H., Chitcholtan, K., Alkaisi, M. M., & Evans, J. J. (2019). The extracellular topographical environment influences ovarian cancer cell behaviour. Biochemical & Biophysical Research Communications, 508, 1188-1194. doi: 10.1016/j.bbrc.2018.12.067
Evans, G. E., Phillipson, G. T. M., Sykes, P. H., McNoe, L. A., Print, C. G., & Evans, J. J. (2018). Does the endometrial gene expression of fertile women vary within and between cycles? Human Reproduction, 33(3), 452-463. doi: 10.1093/humrep/dex385
Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2017). Cell-like features imprinted in the physical nano- and micro-topography of the environment modify the responses to anti-cancer drugs of endometrial cancer cells. Biofabrication, 9(1), 015017. doi: 10.1088/1758-5090/aa5c9a
Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2016). The use of substrate materials and topography to modify growth patterns and rates of differentiation of muscle cells. Journal of Biomedical Materials Research Part A, 104A, 1638-1645. doi: 10.1002/jbm.a.35696
Hogg, S. J., Evans, J. J., Sykes, P. H., & Chitcholtan, K. (2015). A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format. Journal of Ovarian Research, 8, 43. doi: 10.1186/s13048-015-0172-0
Tan, L. H., Sykes, P. H., Alkaisi, M. M., & Evans, J. J. (2015). The characteristics of Ishikawa endometrial cancer cells are modified by substrate topography with cell-like features and the polymer surface. International Journal of Nanomedicine, 10, 4883-4895. doi: 10.2147/ijn.s86336
Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002
Yoshida, A., Chitcholtan, K., Evans, J. J., Uemura, S., & Beasley, S. W. (2014). Provision of optimal conditions for in vitro differentiation into peristaltic smooth muscle from a murine induced pluripotent stem cell line. JSM Regenerative Medicine & Bioengineering, 2(1), 1011.
Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Sykes, P. H., Sin, I. L., Lam, E. Y. N., … Evans, J. J. (2014). In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia. Fertility & Sterility, 102(1), 307-317. doi: 10.1016/j.fertnstert.2014.04.005
Murray, L. M., Nock, V., Evans, J. J., & Alkaisi, M. M. (2014). Bioimprinted polymer platforms for cell culture using soft lithography. Journal of Nanobiotechnology, 12, 60. doi: 10.1186/s12951-014-0060-6
Chitcholtan, K., Asselin, E., Parent, S., Sykes, P. H., & Evans, J. J. (2013). Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Experimental Cell Research, 319(1), 75-87. doi: 10.1016/j.yexcr.2012.09.012
Evans, J. J., Wilkinson, T. M., & Wall, D. J. N. (2013). A two-pathway mathematical model of the LH response to GnRH that predicts self-priming. International Journal of Endocrinology, 2013, 410348. doi: 10.1155/2013/410348
Ibrahim, S. N., Murray, L., Nock, V., Evans, J. J., & Alkaisi, M. M. (2012). The quadrupole microelectrode design on a multilayer biochip for dielectrophoretic trapping of single cells. Microelectronic Engineering, 97, 369-374. doi: 10.1016/j.mee.2012.04.018
Chitcholtan, K., Sykes, P. H., & Evans, J. J. (2012). The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. Journal of Translational Medicine, 10(1), 38-53. doi: 10.1186/1479-5876-10-38
Evans, J. J., & Anderson, G. M. (2012). Balancing ovulation and anovulation: Integration of the reproductive and energy balance axes by neuropeptides. Human Reproduction Update, 18(3), 313-332. doi: 10.1093/humupd/dms004
Evans, G. E., Martínez-Conejero, J. A., Phillipson, G. T. M., Simón, C., McNoe, L. A., Sykes, P. H., … Evans, J. J. (2012). Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertility & Sterility, 97(6), 1365-1373. doi: 10.1016/j.fertnstert.2012.03.007
Ibrahim, S. N., Murray, L., Evans, J. J., & Alkaisi, M. M. (2012). Trapping single cells: Comparison between sandwiched insulation with back contact (SIBC) and planar biochip. Materials Science Forum, 700, 188-194. doi: 10.4028/www.scientific.net/MSF.700.188
Evans, G. E., Phillipson, G. T. M., Sin, I. L., Frampton, C. M. A., Kirker, J. A., Bigby, S. M., & Evans, J. J. (2012). Gene expression confirms a potentially receptive endometrium identified by histology in fertile women. Human Reproduction, 27(9), 2747-2755. doi: 10.1093/humrep/des233
Evans, J. J., Chitcholtan, K., Dann, J. M., Guilford, P., Harris, G., Lewis, L. K., Nagase, J., … Sykes, P. H. (2012). Adrenomedullin interacts with VEGF in endometrial cancer and has varied modulation in tumours of different grades. Gynecologic Oncology, 125(1), 214-219. doi: 10.1016/j.ygyno.2011.12.429
Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2011). Microfluidic arrays for bioimprint of cancer cells. Microelectronic Engineering, 88(8), 1828-1831. doi: 10.1016/j.mee.2010.12.042
Samsuri, F., Alkaisi, M. M., Evans, J. J., Chitcholtan, K., & Mitchell, J. S. (2011). Detection of changes in cell membrane structures using the Bioimprint technique. Microelectronic Engineering, 88(8), 1871-1874. doi: 10.1016/j.mee.2010.12.069
Evans, J. J., & Chitcholtan, K. (2011). Extracellular matrix proteins in the anterior pituitary gland. Open Neuroendocrinology Journal, 4, 111-119. doi: 10.2174/1876528901104010111
Nock, V., Murray, L., Samsuri, F., Alkaisi, M. M., & Evans, J. J. (2010). Microfluidics-assisted photo nanoimprint lithography for the formation of cellular bioimprints. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 28(6), C6K17-C6K22. doi: 10.1116/1.3501342
Samsuri, F., Alkaisi, M. M., Mitchell, J. S., & Evans, J. J. (2010). Replication of cancer cells using soft lithography bioimprint technique. Microelectronic Engineering, 87, 699-703. doi: 10.1016/j.mee.2009.12.068
Anderson, G. M., Relf, H.-L., Rizwan, M. Z., & Evans, J. J. (2009). Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology, 150(4), 1834-1840. doi: 10.1210/en.2008-1359
Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2009). Intermedin (Adrenomedullin-2): A potential protective role in human aortic endothelial cells. Cellular Physiology & Biochemistry, 23(1-3), 97-108.
Alkaisi, M. M., Muys, J. J., & Evans, J. J. (2009). Single cell imaging with AFM using Biochip/Bioimprint technology. International Journal of Nanotechnology, 6(3-4), 355-368. doi: 10.1504/IJNT.2009.022925
Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Replication of muscle cell using bioimprint. AIP Conference Proceedings, 1151, 71-74. doi: 10.1063/1.3203250
Samsuri, F., Mitchell, J. S., Alkaisi, M. M., & Evans, J. J. (2009). Formation of nanoscale bioimprints of muscle cells using UV-cured spin-coated polymers. Journal of Nanotechnology, 593410. doi: 10.1155/2009/593410
Peters, E. E. M., Towler, K. L., Mason, D. R., & Evans, J. J. (2009). Effects of galanin and leptin on gonadotropin-releasing hormone-stimulated luteinizing hormone release from the pituitary. Neuroendocrinology, 89(1), 18-26.
Dann, J. M., Sykes, P. H., Mason, D. R., & Evans, J. J. (2009). Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecologic Oncology, 113(3), 374-378.
Pearson, L. J., Yandle, T. G., Nicholls, M. G., & Evans, J. J. (2008). Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides, 29(6), 1057-1061.
Savigny, P., Evans, J., & McGrath, K. M. (2007). Cell membrane structures during exocytosis. Endocrinology, 148(8), 3863-3874. doi: 10.1210/en.2006-1644
Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Cellular replication and atomic force microscope imaging using a UV-Bioimprint technique. Nanomedicine, 2, 169-176.
Pearson, L. J., Rait, C., Nicholls, M. G., Yandle, T. G., & Evans, J. J. (2006). Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II. Journal of Endocrinology, 191(1), 171-177.
Muys, J. J., Alkaisi, M. M., & Evans, J. J. (2006). Bioimprint: Nanoscale analysis by replication of cellular topography using soft lithography. Journal of Biomedical Nanotechnology, 2(1), 1-5.
Muys, J. J., Alkaisi, M. M., Melville, D. O. S., Nagase, J., Sykes, P., Parguez, G. M., & Evans, J. J. (2006). Cellular transfer and AFM imaging of cancer cells using Bioimprint. Journal of Nanobiotechnology, 4. Retrieved from http://www.jnanobiotechnology.com/content/4/1/1
Muys, J., Alkaisi, M. M., Evans, J. J., & Nagase, J. (2005). Biochip: Cellular analysis by atomic force microscopy using dielectrophoretic manipulation. Japanese Journal of Applied Physics, 44(7B), 5717-5723.
Abbas, M. M., Evans, J. J., Sykes, P. H., & Benny, P. S. (2004). Modulation of vascular endothelial growth factor and thymidine phosphorylase in normal human endometrial stromal cells. Fertility & Sterility, 82(Suppl. 3), 1048-1053.
Abbas, M. M., Evans, J. J., Sin, I. L., Gooneratne, A., Hill, A., & Benny, P. S. (2003). Vascular endothelial growth factor and leptin: Regulation in human cumulus cells and in follicles. Acta Obstetricia et Gynecologica Scandinavica, 82(11), 997-1003.
Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2003). Endothelin-1 directly modulates its own secretion: Studies utilising the cell immunoblot technique. Regulatory Peptides, 113, 149-153.
Evans, J. J., Reid, R. A., Wakeman, S., Croft, L. B., & Benny, P. S. (2003). Evidence that oxytocin is a physiological component of LH regulation in non-pregnant women. Human Reproduction, 18(7), 1428-1431.
Evans, J. J., Youssef, A. H., Yandle, T. G., Lewis, L. K., & Nicholls, M. G. (2002). Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. Journal of Endocrinology, 175, 225-232.
Cameron, V. A., Autelitano, D. J., Evans, J. J., Ellmers, L. J., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (2002). Adrenomedullin expression in rat uterus is correlated with plasma estradiol. American Journal of Physiology: Endocrinology & Metabolism, 282, E139-E146.
Evans, J. J. (2002). The anterior pituitary gland is mysterious, alluring and useful. Archives of Physiology & Biochemistry, 110, 3-8.
Hamill, J., Maoate, K., Beasley, S. W., Corbett, R., & Evans, J. (2002). Familial parathyroid carcinoma in a child. Journal of Paediatrics & Child Health, 38(3), 314-317.
Evans, J. J. (2002). Peptides interact in gonadotrophin regulation. Archives of Physiology & Biochemistry, 110, 154-161.
Evans, J. J., Pragg, F. L., & Mason, D. R. (2001). Release of luteinizing hormone from the anterior pituitary gland in vitro can be concurrently regulated by at least three peptides: Gonadotropin-releasing hormone, oxytocin and neuropeptide Y. Neuroendocrinology, 73, 408-416.
Evans, J. J. (2000). Oxytocin - a luteinising hormone regulating peptide. Obstetrics & Gynaecology Communications, 2, 17-22.