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Research FellowGabriella Brown

BSc(Biotechnology)(Chalmers), MSc(Biotechnology)(Chalmers), PhD(Otago)

Email gabriella.lindberg@otago.ac.nz

Working at the interface of molecular research, biology, chemistry, material science and technology, Dr Lindberg’s research is in pursuit of a blueprint to bridge the gap between engineered and native tissues.

Dr Lindberg is currently a Postdoctoral Research Fellow in the Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, University of Otago, Christchurch. Her expertise lies in engineering and integrating structure-function relationships by developing bioresponsive hydrogel biomaterials and applying 3D-biofabrication technologies to replace and/or regenerate damaged and diseased cartilage or bone tissues.

Research Interests

Dr Lindberg's research is focused on the design of cell-instructive photo-polymerisable hydrogel bioinks and bioresins that mimics the native architectural organisation and biological niche, capable of adapting to the constantly changing micro-environment as the new tissue is forming.  She further strives to apply these technologies to study how cells respond to being the engineers themselves compared to environmental signals dictated by researchers.

The development of smart chemical and biological toolkits for tissue engineering applications may provide us with a better understanding of cell-material and cell-extra cellular matrix interactions to help engineering constructs with sufficient tissue quality that further replicates the native 3D organisation.

Her research is part of larger collaborative projects involving both national and international collaborators in the likes of Germany, Netherlands and Australia.

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Publications

Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and applications of photo-cross-linking in bioprinting. Chemical Reviews. Advance online publication. doi: 10.1021/acs.chemrev.9b00812

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials, 9, 1901544. doi: 10.1002/adhm.201901544

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Woodfield, T. B. F., Lim, K. S., Lindberg, G. C. J., Cui, S., Alcala-Orozco, C., & Hooper, G. J. (2019, August-September). Biofabrication of the musculoskeletal tissue niche: Tissue spheroid and bioink platiforms. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Journal - Research Article

Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and applications of photo-cross-linking in bioprinting. Chemical Reviews. Advance online publication. doi: 10.1021/acs.chemrev.9b00812

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials, 9, 1901544. doi: 10.1002/adhm.201901544

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404

Brown, G. C. J., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. F. (2017). Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels. Macromolecular Bioscience, 17(12), 1700158. doi: 10.1002/mabi.201700158

Lim, K. S., Schon, B. S., Mekhileri, N. V., Brown, G. C. J., Chia, C. M., Prabakar, S., Hooper, G. J., & Woodfield, T. B. F. (2016). New visible-light photoinitiating system for improved print fidelity in gelatin-based bioinks. ACS Biomaterials Science & Engineering, 2, 1752-1762. doi: 10.1021/acsbiomaterials.6b00149

Massoud, A. A., Langer, V., Gohar, Y. M., Abu-Youssef, M. A. M., Jänis, J., Lindberg, G., … Öhrström, L. (2013). Effects of different substituents on the crystal structures and antimicrobial activities of six Ag(I) quinoline compounds. Inorganic Chemistry, 52, 4046-4060. doi: 10.1021/ic400081v

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Conference Contribution - Published proceedings: Abstract

Bertlein, S., Brown, G. C., Lim, K. S., Juengst, T., Boeck, T., Blunk, T., … Woodfield, T., & Groll, J. (2017). Allyl glycidyl ether modified gelatin as a versatile bioink platform for biofabrication of tissue engineered constructs. Proceedings of the Tissue Engineering and Regenerative Medicine International Society European Chapter Meeting (TERMIS-EU). 0195. Retrieved from http://www.ecmconferences.org

Brown, G., Soliman, B., Bertlein, S., Groll, J., Lim, K., & Woodfield, T. (2017). Photo-curable thiol-ene gelatin based hydrogel bio-inks for 3D-biofabrication of cartilage. Proceedings of the Tissue Engineering and Regenerative Medicine International Society European Chapter Meeting (TERMIS-EU). 0078. Retrieved from http://www.ecmconferences.org

Lim, K., Klotz, B., Brown, G., Melchels, F., Gawlitta, D., & Woodfield, T. (2016). Visible light polymerised hydrogels with improved cell survival and metabolic activity. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.01746

Brown, G. C., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. (2016). Fabrication of gelatin-heparin hydrogels with enhanced chondrogenic differentiation and tunable degradation. Frontiers in Bioengineering & Biotechnology, (WBC2016). doi: 10.3389/conf.FBIOE.2016.01.00613

Lim, K. S., Brown, G. C., Mekhileri, N. V., Schon, B. S., Hooper, G. J., & Woodfield, T. B. (2015). The effect of oxygen inhibition in biofabrication of photocrosslinked hydrogels. Tissue Engineering Part A, 21(Suppl. 1), (pp. S-32). doi: 10.1089/ten.tea.2015.5000.abstracts

Brown, G., Lim, K., Woodfield, T., & Hooper, G. (2015). Strategies for temporal control of biophysical signals in biomimetic hydrogels for tissue engineering. Tissue Engineering Part A, 21(Suppl. 1), (pp. S-371-S-372). doi: 10.1089/ten.tea.2015.5000.abstracts

Lindberg, G. C. J., Lim, K. S., & Woodfield, T. B. F. (2014). Strategy for fabricating cell-laden ECM derived hydrogels in cartilage tissue engineering. Proceedings of the Alliance for Design and Application in Tissue Engineering 5th Tissue Engineering Symposium: Tissue Engineering for Organ Regeneration. (pp. 33-34). ADATE. Retrieved from http://web.aeromech.usyd.edu.au/ADATE/TESymposium2014.html

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Conference Contribution - Poster Presentation (not in published proceedings)

Lim, K. S., Brown, G. C. J., Soliman, B. G., Hooper, G. J., Groll, J., & Woodfield, T. B. F. (2018, September). Photo-click thiol-ene gelatin based hydrogels as bioinks for bioprinting. Poster session presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) 5th World Congress, Kyoto, Japan.

Secker, D. J., Lim, K. S., Brown, G. C. J., Woodfield, T. B. F., Jiang, L.-H., Jia, X., & Yang, X. B. (2018, September). Crosslinker selection determines the properties of GelNOR hydrogels for tissue engineering applications. Poster session presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) 5th World Congress, Kyoto, Japan.

Brown, G., Longoni, A., Lim, K., Rosenberg, A., Hooper, G., Gawlitta, D., & Woodfield, T. (2018, September). Vitreous humor as an extracellular matrix hydrogel for cartilage tissue engineering applications. Poster session presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) 5th World Congress, Kyoto, Japan.

Lim, K. S., Atienza Roca, P., Brown, G. C. J., Hooper, G. J., & Woodfield, T. B. F. (2018, September). Photo-click gelatin-norbornene hydrogels for tissue vascularisation. Poster session presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) 5th World Congress, Kyoto, Japan.

Brown, G. C. J., Lim, K., Bertlein, S., Hooper, G., Groll, J., & Woodfield, T. (2017, June-July). Covalent incorporation of heparin improves chondrogenic tissue formation for 3D bioprinting of photo-curable thiol-ene gelatin based hydrogel bioinks. Poster session presented at the International Cartilage Repair Society (ICRS) Heritage Summit, Gothenburg, Sweden.

Soliman, B. G., Brown, G. C. J., Lim, K. S., & Woodfield, T. (2016, August). Photo-curable thiol-ene gelatin based hydrogels as bioinks for bioprinting. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Brown, G., Soliman, B., Bertlein, S., Lim, K., Hooper, G., Groll, J., & Woodfield, T. (2016, August-September). Covalent incorporation of heparin improves chondrogenic tissue formation in gelatin based hydrogels designed for cartilage tissue engineering. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Brown, G., Lim, K., Farrugia, B., Hooper, G., & Woodfield, T. (2015, November). Strategies for biofunctionalizing photocurable gelatin methacrylamide hydrogels for cartilage tissue engineering. Poster session presented at the International Conference on Biofabrication, Utrecht, The Netherlands.

Lindberg, G., Lim, K., & Woodfield, T. (2014, September). Strategy for biofabricating cell-laden ECM derived hydrogels in cartilage tissue engineering. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Woodfield, T. B. F., Lim, K. S., Lindberg, G. C. J., Cui, S., Alcala-Orozco, C., & Hooper, G. J. (2019, August-September). Biofabrication of the musculoskeletal tissue niche: Tissue spheroid and bioink platiforms. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Soliman, B. G., Lindberg, G. C. J., Woodfield, T. B. F., & Lim, K. S. (2019, August-September). Two-step reuthenium-catalysed bioprinting of low-viscous cell-instructive bioinks as a platform for tissue-specific bioink development. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Woodfield, T., Lim, K. S., Brown, G., Schon, B. S., Mekhileri, N. V., Hooper, G. J., … Groll, J. (2018, August). Designing bio-ink and bio-resin platforms for 3D bioprinting and bioassembly. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Alcala-Orozco, C. R., Mutreja, I., Lim, K. S., Lindberg, G., Hooper, G. J., & Woodfield, T. (2018, October). Strontium-based nanocomposite bioink for 3D-bioprinting of scaffolds with long-term shape retention and improved osteogenic differentiation of mesenchymal stromal cells. Verbal presentation at the International Society for Biofabrication Annual Meeting, Würzburg, Germany.

Lindberg, G., Lim, K., Soliman, B., Bertlein, S., Jungst, T., Hooper, G., … Woodfield, T. (2018, October). Photo-clickable allylated gelatin and thiolated heparin as chondro-instructive bioinks for 3D-biofabrication. Verbal presentation at the International Society for Biofabrication Annual Meeting, Würzburg, Germany.

Lindberg, G. (2018, April). Development of cell-instructive hydrogels for cartilage tissue engineering applications. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand.

Lindberg, G. C. J., Lim, K. S., Soliman, B. G., Hooper, G. J., & Woodfield, T. B. F. (2018, August). Photo-curable thiol-ene gelatin-heparin hydrogels for 3D-biofabrication of functional cartilage. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Lim, K., Lindberg, G. C. J., & Woodfield, T. B. F. (2018, December). Design of chrondro-instructive hydrogels for high-throughput 3D-biofabrication of cartilage tissue modules. Verbal presentation at the 41st Scientific Meeting of the Matrix Biology Society of Australia and New Zealand, Auckland, New Zealand.

Brown, G., Bertlein, S., Lim, K., Groll, J., & Woodfield, T. (2017, April). Photo-curable thiol-ene gelatin based hydrogels as bioink. Verbal presentation at the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) 25th Annual Conference and the 7th Indo-Australian Conference on Biomaterials, Implants, Tissue Engineering and Regenerative Medicine (BiTERM), Canberra, Australia.

Atienza Roca, P., Soliman, B., Anten, J., Brown, G., Woodfield, T., & Lim, K. (2017, September). Photo-click gelatin-norbonene hydrogels for biofabrication of vascularized tissue. Verbal presentation at the Future Investigators of Regenerative Medicine (FIRM) Symposium, Girona, Spain.

Atienza Roca, P., Anten, J., Brown, G., Woodfield, T., & Lim, K. (2017, April). Photo-click gelatin-norbornene hydrogels for tissue vascularisation. Verbal presentation at the Australasian Society for Biomaterials and Tissue Engineering (ASBTE) 25th Annual Conference and the 7th Indo-Australian Conference on Biomaterials, Implants, Tissue Engineering and Regenerative Medicine (BiTERM), Canberra, Australia.

Woodfield, T. B. F., Lim, K., Tredinnick, S., Schon, B., Mekhileri, N., Brown, G., & Hooper, G. J. (2016, August-September). 3D bioprinting and bioassembly of tissue organoids for regeneration of cartilage and bone. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Lim, K. S., Lindberg, G. C. J., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2015, April). Oxygen inhibition in 3D printing of photo-curable hydrogels. Verbal presentation at the 5th International Symposium of Surface and Interface of Biomaterials (ISSIB) and the 24th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Sydney Australia.

Lindberg, G. C. J., Lim, K. S., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2015, April). Covalent incorporation of heparin in gelatin hydrogels for improved chondrocyte re-differentiation. Verbal presentation at the 5th International Symposium of Surface and Interface of Biomaterials (ISSIB) and the 24th Annual Conference of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE), Sydney Australia.

Lindberg, G. (2014, December). Covalent incorporation of heparin in gelatin hydrogels for improved chondrocyte re-differentiation. Verbal presentation at the 6th Annual Mechanobiology Symposium, Auckland, New Zealand.

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Awarded Doctoral Degree

Brown, G. C. J. (2017). Design of cell-instructive photo-polymerisable hydrogels towards functional tissue engineered cartilage (PhD). University of Otago, Dunedin, New Zealand. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/7711

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