Professor Gary Hooper, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Head of Department

MBChB MD FRACS FRNZOA

Professional interests

Knee injuries and Joint Replacement
Rehabilitation following surgery
Impact of training on outcomes for patients
Regenerative medicine in Orthopaedics
Assessing outcomes following joint replacement

Research interests

Gary's research interests include clinical trials investigating improving outcomes after joint replacement and studies involving bone metabolism and musculoskeletal bioengineering.

Clinical outcomes include:

The wear of highly cross-linked polyethylene in hip replacement
Metal ion production in hard-on-hard bearing surfaces
Long term outcome of unicompartmental knee replacement
Acoustic monitoring of failing joint replacements
The use of larger femoral heads in hip replacement
The implications of increased BMI on the outcome
Bone density changes around implants
New Zealand Joint Registry outcomes

He also studies re-integration into society in multiple trauma patients with special emphasis on earthquake victims.

Gary's bone metabolism studies include bone density changes adjacent to uncemented hip and knee replacements and the implications this has for clinical practice.

He is also studying how to improve fracture healing rates following neck of femur and tibial shaft fracture.

Gary's biomechanical investigations include the building and production of cartilage scaffolds for the treatment of articular cartilage defects and developing titanium implants to fill bone deficits.

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Publications

Li, J., Mutreja, I., Tredinnick, S., Jermy, M., Hooper, G. J., & Woodfield, T. B. F. (2020). Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. Materials Science & Engineering: C, 109, 110562. doi: 10.1016/j.msec.2019.110562

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Baxter-Parker, G., Roffe, L., Cross, S., Frampton, C., Hooper, G. J., & Gieseg, S. (2019). Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin. Clinical Biochemistry, 63, 39-45. doi: 10.1016/j.clinbiochem.2018.11.002

Nugent, M., Wyatt, M. C., Frampton, C. M., & Hooper, G. J. (2019). Despite improved survivorship of uncemented fixation in total knee replacement for osteoarthritis, cemented fixation remains the gold standard: An analysis of a National Joint Registry. Journal of Arthroplasty. Advance online publication. doi: 10.1016/j.arth.2019.03.047

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Chapter in Book - Research
Chapter in Book - Other
Journal - Research Article

Chapter in Book - Research

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

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Chapter in Book - Other

Hooper, G. (2013). Orthopaedic Surgery and Musculoskeletal Medicine. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 38-40). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Nugent, M., May, J. H., Parker, J. D., Kieser, D. C., Douglas, M., Pereira, R., Lim, K. S., & Hooper, G. J. (2019). Does tranexamic acid reduce knee swelling and improve early function following arthroscopic meniscectomy? A double-blind randomized controlled trial. Orthopaedic Journal of Sports Medicine, 7(8), 2325967119866122. doi: 10.1177/2325967119866122

Henzell, I. S., Zhou, L., Frampton, C., Hooper, G., Ackerman, I., & Young, S. W. (2019). Lifetime risk of primary total knee replacement surgery in New Zealand from 2000 to 2015. New Zealand Medical Journal, 132(1489), 48-56. Retrieved from https://www.nzma.org.nz/journal

Wyatt, M. C., Whitehouse, M. R., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2019). Are lipped polyethylene liners associated with increased revision rates in patients with uncemented acetabular components? An observational cohort study. Clinical Orthopaedics & Related Research. Advance online publication. doi: 10.1097/corr.0000000000001039

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2019). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation. Advance online publication. doi: 10.1080/09638288.2018.1542461

Wyatt, M. C., Kieser, D. C., Kemp, M. A., McHugh, G., Frampton, C. M. A., & Hooper, G. J. (2019). Does the femoral offset affect replacements? The results from a National Joint Registry. HIP International, 29(3), 289-298. doi: 10.1177/1120700018780318

Campi, S., Pandit, H., Hooper, G., Snell, D., Jenkins, C., Dodd, C. A. F., Maxwell, R., & Murray, D. W. (2018). Ten-year survival and seven-year functional results of cementless Oxford unicompartmental knee replacement: A prospective consecutive series of our first 1000 cases. Knee, 25(6), 1231-1237. doi: 10.1016/j.knee.2018.07.012

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Kieser, D. C., Ailabouni, R., Kieser, S. C. J., Wyatt, M. C., Armour, P. C., Coates, M. H., & Hooper, G. J. (2018). The use of an Ossis custom 3D-printed tri-flanged acetabular implant for major bone loss: Minimum 2-year follow-up. HIP International, 28(6), 668-674. doi: 10.1177/1120700018760817

Snell, D. L., Hipango, J., Sinnott, K. A., Dunn, J. A., Rothwell, A., Hsieh, C. J., … Hooper, G. (2018). Rehabilitation after total joint replacement: A scoping study. Disability & Rehabilitation, 40(14), 1718-1731. doi: 10.1080/09638288.2017.1300947

Smith, J. O., Frampton, C. M. A., Hooper, G. J., & Young, S. W. (2018). The impact of patient and surgical factors on the rate of postoperative infection after total hip arthroplasty: A New Zealand Joint Registry Study. Journal of Arthroplasty, 33(6), 1884-1890. doi: 10.1016/j.arth.2018.01.021

Stewart, R., Kieser, D. C., Scholze, M., Hammer, N., Stone, B., & Hooper, G. (2018). Preliminary biomechanical results of a novel pin configuration for external fixation of vertical shear pelvic fractures. ANZ Journal of Surgery, 88(10), 1051-1055. doi: 10.1111/ans.14822

Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018). A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models. Lab on a Chip, (18), 2757-2775. doi: 10.1039/c8lc00485d

Kieser, D. C., Wyatt, M. C., Beswick, A., Kunutsor, S., & Hooper, G. J. (2018). Does the type of surgical drape (disposable versus non-disposable) affect the risk of subsequent surgical site infection? Journal of Orthopaedics, 15(2), 566-570. doi: 10.1016/j.jor.2018.05.015

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T., Hooper, G. J., & Anderson, T. (2018). Untangling chronic pain and post-concussion symptoms: The significance of depression. Brain Injury, 32(5), 583-592. doi: 10.1080/02699052.2018.1432894

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Storey, R., Frampton, C., Kieser, D., & Hooper, G. (2018). Does orthopaedic training compromise the outcome in knee joint arthroplasty? Journal of Surgical Education, 75(5), 1292-1298. doi: 10.1016/j.jsurg.2018.02.011

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404

Gilchrist, N., Dalzell, K., Pearson, S., Hooper, G., Hoeben, K., Hickling, J., McKie, J., … Gutenstein, M. (2017). Enhanced hip fracture management: Use of statistical methods and dataset to evaluate a fractured neck of femur fast track pathway: Pilot study. New Zealand Medical Journal, 130(1455), 91-101. Retrieved from https://www.nzma.org.nz/journal

Vadei, L., Kieser, D. C., Frampton, C., & Hooper, G. (2017). Survivorship of total hip joint replacements following isolated liner exchange for wear. Journal of Arthroplasty, 32(11), 3484-3487. doi: 10.1016/j.arth.2017.05.055

Roffe, L., FitzPatrick, A. J., Rodgers, G. W., Woodfield, T. B. F., & Hooper, G. J. (2017). Squeaking in ceramic-on-ceramic hips: No evidence of contribution from the trunnion morse taper. Journal of Orthopaedic Research, 35(8), 1793-1798. doi: 10.1002/jor.23458

Brown, G. C. J., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. F. (2017). Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels. Macromolecular Bioscience, 17(12), 1700158. doi: 10.1002/mabi.201700158

Halasi, T., Kieser, D., Frampton, C. M. A., & Hooper, G. J. (2017). Midterm analysis of the seleXys cup with ceramic inlay. Arthroplasty Today, 3, 171-175. doi: 10.1016/j.artd.2016.10.003

Stamp, L. K., Haslett, J., Chapman, P., O'Donnell, J., Raja, R., Rothwell, A., Frampton, C., & Hooper, G. (2017). Rates of joint replacement surgery in New Zealand, 1999-2015: A comparison of rheumatoid arthritis and osteoarthritis. Journal of Rheumatology, 44(12), 1823-1827. doi: 10.3899/jrheum.170551

Inglis, T., Armour, P., Inglis, G., & Hooper, G. (2017). Rationing of hip and knee referrals in the public hospital: The true unmet need. New Zealand Medical Journal, 130(1452), 39-48. Retrieved from https://www.nzma.org.nz/journal

Schouten, R., Malone, A. A., Frampton, C. M., Tiffen, C., & Hooper, G. (2017). Five-year follow-up of a prospective randomised trial comparing ceramic-on-metal and metal-on-metal bearing surfaces in total hip arthroplasty. Bone & Joint Journal, 99-B(10), 1298-1303. doi: 10.1302/0301-620x.99b10.bjj-2016-0905.r1

FitzPatrick, A. J., Rodgers, G. W., Hooper, G. J., & Woodfield, T. B. F. (2017). Development and validation of an acoustic emission device to measure wear in total hip replacements in-vitro and in-vivo. Biomedical Signal Processing & Control, 33, 281-288. doi: 10.1016/j.bspc.2016.12.011

Rodgers, G. W., Welsh, R., King, L. J., FitzPatrick, A. J., Woodfield, T. B. F., & Hooper, G. J. (2017). Signal processing and event detection of hip implant acoustic emissions. Control Engineering Practice, 58, 287-297. doi: 10.1016/j.conengprac.2016.09.013

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2017). Modular tissue assembly strategies for biofabrication of engineered cartilage. Annals of Biomedical Engineering, 45(1), 100-114. doi: 10.1007/s10439-016-1609-3

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2016). Return to work for severely injured survivors of the Christchurch earthquake: Influences in the first 2 years. Disability & Rehabilitation, 38(10), 987-993. doi: 10.3109/09638288.2015.1070299

Lim, K. S., Schon, B. S., Mekhileri, N. V., Brown, G. C. J., Chia, C. M., Prabakar, S., Hooper, G. J., & Woodfield, T. B. F. (2016). New visible-light photoinitiating system for improved print fidelity in gelatin-based bioinks. ACS Biomaterials Science & Engineering, 2, 1752-1762. doi: 10.1021/acsbiomaterials.6b00149

Tayton, E. R., Frampton, C., Hooper, G. J., & Young, S. W. (2016). The impact of patient and surgical factors on the rate of infection after primary total knee arthroplasty: An analysis of 64 566 joints from the New Zealand Joint Registry. Bone & Joint Journal, 98-B(3), 334-340. doi: 10.1302/0301-620x.98b3.36775

Snell, D. L., Siegert, R. J., Surgenor, L. J., Dunn, J. A., & Hooper, G. J. (2016). Evaluating quality of life outcomes following joint replacement: Psychometric evaluation of a short form of the WHOQOL-Bref. Quality of Life Research, 25, 51-61. doi: 10.1007/s11136-015-1044-1

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2015). Participation and quality of life outcomes among individuals with earthquake-related physical disability: A systematic review. Journal of Rehabilitation Medicine, 47, 385-393. doi: 10.2340/16501977-1965

Selvarajah, E., Hooper, G., Grabowski, K., Frampton, C., Woodfield, T. B. F., & Inglis, G. (2015). The rates of wear of X3 highly cross-linked polyethylene at five years when coupled with a 36 mm diameter ceramic femoral head in young patients. Bone & Joint Journal, 97-B(11), 1470-1474. doi: 10.1302/0301-620x.97b11.35736

Hooper, N., Snell, D., Hooper, G., Maxwell, R., & Frampton, C. (2015). The five-year radiological results of the uncemented Oxford medial compartment knee arthroplasty. Bone & Joint Journal, 97B(10), 1358-1363. doi: 10.1302/0301-620X.97B10.35668

Kempthorne, J. T., Ailabouni, R., Raniga, S., Hammer, D., & Hooper, G. (2015). Occult infection in aseptic joint loosening and the diagnostic role of implant sonication. BioMed Research International, 2015, 946215. doi: 10.1155/2015/946215

Ailabouni, R., Jennings, A., & Hooper, G. (2015). Peri-prosthetic infection: An algorithmic approach to diagnosis and management. Orthopaedics & Trauma, 29(1), 69-76. doi: 10.1016/j.mporth.2014.11.005

Hooper, G., Lee, A. J.-J., Rothwell, A., & Frampton, C. (2014). Current trends and projections in the utilisation rates of hip and knee replacement in New Zealand from 2001 to 2026. New Zealand Medical Journal, 127(1401). Retrieved from http://www.nzma.org.nz/journal

Allen, C. L., Hooper, G. J., Oram, B. J., & Wells, J. E. (2014). Does computer-assisted total knee arthroplasty improve the overall component position and patient function? International Orthopaedics, 38(2), 251-257. doi: 10.1007/s00264-013-1996-0

Wyatt, J. M., Hooper, G., Frampton, C., & Rothwell, A. (2014). Survival outcomes of cemented compared to uncemented stems in primary total hip replacement. World Journal of Orthopedics, 5(5), 591-596. doi: 10.5312/wjo.v5.i5.591

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