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Gary HooperHead of Department

MBChB MD FRACS FRNZOA

Email gary.hooper@otago.ac.nz

Professional interests

  • Knee injuries and Joint Replacement
  • Rehabilitation following surgery
  • Impact of training on outcomes for patients
  • Regenerative medicine in Orthopaedics
  • Assessing outcomes following joint replacement

Research interests

Gary's research interests include clinical trials investigating improving outcomes after joint replacement and studies involving bone metabolism and musculoskeletal bioengineering.

Clinical outcomes include:

  • The wear of highly cross-linked polyethylene in hip replacement
  • Metal ion production in hard-on-hard bearing surfaces
  • Long term outcome of unicompartmental knee replacement
  • Acoustic monitoring of failing joint replacements
  • The use of larger femoral heads in hip replacement
  • The implications of increased BMI on the outcome
  • Bone density changes around implants
  • New Zealand Joint Registry outcomes

He also studies re-integration into society in multiple trauma patients with special emphasis on earthquake victims.

Gary's bone metabolism studies include bone density changes adjacent to uncemented hip and knee replacements and the implications this has for clinical practice.

He is also studying how to improve fracture healing rates following neck of femur and tibial shaft fracture.

Gary's biomechanical investigations include the building and production of cartilage scaffolds for the treatment of articular cartilage defects and developing titanium implants to fill bone deficits.

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Publications

Tay, M. L., Young, S. W., Frampton, C. M., & Hooper, G. J. (2022). The lifetime revision risk of unicompartmental knee arthroplasty. Bone & Joint Journal, 104-B(6), 672-679. doi: 10.1302/0301-620X.104B6.BJJ-2021-1744.R1

Foxall-Smith, M., Wyatt, M. C., Frampton, C., Kieser, D., & Hooper, G. (2022). The 45-year evolution of the Mathys RM monoblock cups: Have the paradigm shifts been worthwhile? HIP International. Advance online publication. doi: 10.1177/11207000211067507

Shum, J. M., Gadomski, B. C., Tredinnick, S. J., Fok, W., Fernandez, J., Nelson, B., … Hooper, G., Puttlitz, C., … Woodfield, T. B. F. (2022). Enhanced bone formation in locally-optimised, low-stiffness additive manufactured titanium implants: An in silico and in vivo tibial advancement study. Acta Biomaterialia. Advance online publication. doi: 10.1016/j.actbio.2022.04.006

Cui, X., Alcala-Orozco, C. R., Baer, K., Li, J., Murphy, C. A., Durham, M., Lindberg, G., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). 3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs. Biofabrication, 14(3), 034101. doi: 10.1088/1758-5090/ac61a3

Li, J., Cui, X., Lindberg, G. C. J., Alcala-Orozco, C. R., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). Hybrid fabrication of photo-clickable vascular hydrogels with additive manufactured titanium implants for enhanced osseointegration and vascularized bone formation. Biofabrication, 14(3), 034103. doi: 10.1088/1758-5090/ac6051

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

Chapter in Book - Research

Hooper, G. (2013). Orthopaedic Surgery and Musculoskeletal Medicine. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 38-40). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair. Bone, 154, 116198. doi: 10.1016/j.bone.2021.116198

Journal - Research Article

Cui, X., Alcala-Orozco, C. R., Baer, K., Li, J., Murphy, C. A., Durham, M., Lindberg, G., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). 3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs. Biofabrication, 14(3), 034101. doi: 10.1088/1758-5090/ac61a3

Journal - Research Article

FitzPatrick, A. J., Rodgers, G. W., Fernandez, J. W., & Hooper, G. J. (2022). Synchronized acoustic emission and gait analysis of total hip replacement patients. Biomedical Signal Processing & Control, 74, 103488. doi: 10.1016/j.bspc.2022.103488

Journal - Research Article

Foxall-Smith, M., Wyatt, M. C., Frampton, C., Kieser, D., & Hooper, G. (2022). The 45-year evolution of the Mathys RM monoblock cups: Have the paradigm shifts been worthwhile? HIP International. Advance online publication. doi: 10.1177/11207000211067507

Journal - Research Article

Li, J., Cui, X., Lindberg, G. C. J., Alcala-Orozco, C. R., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). Hybrid fabrication of photo-clickable vascular hydrogels with additive manufactured titanium implants for enhanced osseointegration and vascularized bone formation. Biofabrication, 14(3), 034103. doi: 10.1088/1758-5090/ac6051

Journal - Research Article

Pullen, A., Kieser, D. C., & Hooper, G. (2022). Ballistic gelatin calibration standardisation. BMJ Military Health, 168, 124-127. doi: 10.1136/bmjmilitary-2020-001430

Journal - Research Article

Qiao, K., Xu, L., Tang, J., Wang, Q., Lim, K. S., Hooper, G., Woodfield, T. B. F., … Cui, X. (2022). The advances in nanomedicine for bone and cartilage repair. Journal of Nanobiotechnology, 20, 141. doi: 10.1186/s12951-022-01342-8

Journal - Research Article

Rahardja, R., Morris, A. J., Hooper, G. J., Grae, N., Frampton, C. M., & Young, S. W. (2022). Surgical helmet systems are associated with a lower rate of prosthetic joint infection following total knee arthroplasty: Combined results from the New Zealand Joint Registry and Surgical Site Infection Improvement Programme. Journal of Arthroplasty. Advance online publication. doi: 10.1016/j.arth.2022.01.046

Journal - Research Article

Shum, J. M., Gadomski, B. C., Tredinnick, S. J., Fok, W., Fernandez, J., Nelson, B., … Hooper, G., Puttlitz, C., … Woodfield, T. B. F. (2022). Enhanced bone formation in locally-optimised, low-stiffness additive manufactured titanium implants: An in silico and in vivo tibial advancement study. Acta Biomaterialia. Advance online publication. doi: 10.1016/j.actbio.2022.04.006

Journal - Research Article

Stone, B., Nugent, M., Young, S. W., Frampton, C., & Hooper, G. J. (2022). The lifetime risk of revision following total knee arthroplasty: A New Zealand Joint Registry study. Bone & Joint Journal, 104B(2), 235-241. doi: 10.1302/0301-620x.104b2.Bjj-2021-0890.R1

Journal - Research Article

Tay, M. L., Young, S. W., Frampton, C. M., & Hooper, G. J. (2022). The lifetime revision risk of unicompartmental knee arthroplasty. Bone & Joint Journal, 104-B(6), 672-679. doi: 10.1302/0301-620X.104B6.BJJ-2021-1744.R1

Journal - Research Article

Taylor, S. C., Kieser, D. C., Hammer, N., Ondruschka, B., Kranioti, E., Pullen, A., & Hooper, G. (2022). Viability of Bos taurus scapulae as a flat bone proxy for ballistic testing. BMJ Military Health, 168, 196-199. doi: 10.1136/bmjmilitary-2019-001369

Journal - Research Article

Taylor, S. C., Ondruschka, B., Kieser, D. C., Hammer, N., Lee, M., Hooper, G. J., & Kranioti, E. (2022). Ballistic trauma caused by military rifles: Experimental study based on synthetic skull proxies. Forensic Science, Medicine, & Pathology. Advance online publication. doi: 10.1007/s12024-021-00432-7

Journal - Research Article

Wyatt, M. C., Kieser, D. C., Frampton, C. M. A., Woodfield, T., & Hooper, G. J. (2022). How do 3D-printed primary uncemented acetabular components compare with established uncemented acetabular cups? The experience of the New Zealand National Joint Registry. HIP International, 32(1), 73-79. doi: 10.1177/1120700020918233

Journal - Research Article

Alcala-Orozco, C. R., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2021). Converging functionality: Strategies for 3D hybrid-construct biofabrication and the role of composite biomaterials for skeletal regeneration. Acta Biomaterialia, 132, 188-216. doi: 10.1016/j.actbio.2021.03.008

Journal - Research Article

Aldrich, E. D., Cui, X., Murphy, C. A., Lim, K. S., Hooper, G. J., McIlwraith, C. W., & Woodfield, T. B. F. (2021). Allogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities. Stem Cells Translational Medicine, 10(11), 1500-1515. doi: 10.1002/sctm.20-0552

Journal - Research Article

Baer, K., Kieser, S., Schon, B., Rajendran, K., ten Harkel, T., Ramyar, M., … Bateman, C., Butler, A., Raja, A. Y., Hooper, G., Anderson, N., & Woodfield, T. (2021). Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioengineering, 5(2), 026101. doi: 10.1063/5.0035312

Journal - Research Article

Baxter-Parker, G., Roffe, L., Moltchanova, E., Jefferies, J., Raajasekar, S., Hooper, G., & Gieseg, S. P. (2021). Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. PLoS ONE, 16(8), e0256072. doi: 10.1371/journal.pone.0256072

Journal - Research Article

Hudson, B., Williman, J. A., Stamp, L. K., Alchin, J. S., Hooper, G. J., Mangin, D., Lennox Thompson, B. F., & Toop, L. (2021). Nortriptyline for pain in knee osteoarthritis in general practice: A double blind randomised controlled trial. British Journal of General Practice, 71(708), e538-e546. doi: 10.3399/bjgp.2020.0797

Journal - Research Article

Lindberg, G. C. J., Cui, X., Durham, M., Veenendaal, L., Schon, B. S., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2021). Probing multicellular tissue fusion of cocultured spheroids: A 3D-bioassembly model. Advanced Science, 8(22), 2103320. doi: 10.1002/advs.202103320

Journal - Research Article

Lindberg, G. C. J., Lim, K. S., Soliman, B. G., Nguyen, A., Hooper, G. J., Narayan, R. J., & Woodfield, T. B. F. (2021). Biological function following radical photo-polymerization of biomedical polymers and surrounding tissues: Design considerations and cellular risk factors. Applied Physics Reviews, 8(1), 011301. doi: 10.1063/5.0015093

Journal - Research Article

Longoni, A., Li, J., Lindberg, G. C. J., Rnjak-Kovacina, J., Wise, L. M., Hooper, G. J., Woodfield, T. B. F., Kieser, D. C., & Lim, K. S. (2021). Strategies for inclusion of growth factors into 3D printed bone grafts. Essays in Biochemistry, 65(3), 569-585. doi: 10.1042/ebc20200130

Journal - Research Article

Nugent, M., Young, S. W., Frampton, C. M., & Hooper, G. J. (2021). The lifetime risk of revision following total hip arthroplasty: A New Zealand joint registry study. Bone & Joint Journal, 103-B(3), 479-485. doi: 10.1302/0301-620x.103b3.Bjj-2020-0562.R2

Journal - Research Article

Pullen, A. E., Kieser, D. C., Hooper, G., & Plummer, T. C. H. (2021). A study into the viability of Synbone® as a proxy for Sus scrofa (domesticus) ribs for use with 7.62 × 51 mm Full Metal Jacket ammunition in ballistic testing. Forensic Science, Medicine, & Pathology, 17(4), 665-669. doi: 10.1007/s12024-021-00426-5

Journal - Research Article

Pullen, A., Kieser, D. C., & Hooper, G. (2021). A study into the viability of Synbone® as a proxy for Sus scrofa (domesticus) ribs for use with 5.56-mm open tip match ammunition in ballistic testing. International Journal of Legal Medicine, 135, 521-526. doi: 10.1007/s00414-020-02416-8

Journal - Research Article

Silman, A., Combescure, C., Ferguson, R. J., Graves, S. E., Paxton, E. W., Frampton, C., … Hooper, G., … Rolfson, O. (2021). International variation in distribution of ASA class in patients undergoing total hip arthroplasty and its influence on mortality: Data from an international consortium of arthroplasty registries. Acta Orthopaedica, 92(3), 304-310. doi: 10.1080/17453674.2021.1892267

Journal - Research Article

Snell, D. L., Dunn, J. A., Jerram, K. A. S., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2021). Associations between comorbidity and quality of life outcomes after total joint replacement. Quality of Life Research, 30, 137-144. doi: 10.1007/s11136-020-02610-6

Journal - Research Article

Stringer, M. R., Hooper, G. J., Frampton, C., & Kieser, D. C. (2021). Periprosthetic fractures of the femur in primary total hip arthroplasty: A New Zealand Joint Registry analysis. ANZ Journal of Surgery, 91, 404-408. doi: 10.1111/ans.16611

Journal - Research Article

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Journal - Research Article

Atienza-Roca, P., Kieser, D., Cui, X., Bathish, B., Ramaswamy, Y., Hooper, G. J., Clarkson, A. N., … Wise, L. M., Woodfield, T. B. F., & Lim, K. S. (2020). Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors. Biomaterials Science, 8(18), 5005-5019. doi: 10.1039/D0BM00603C

Journal - Research Article

Chin, J., Blackett, J., Kieser, D. C., Frampton, C., & Hooper, G. (2020). The value of routine intravenous tranexamic acid in total hip arthroplasty: A preliminary study. Advances in Orthopedics, 2020, 2943827. doi: 10.1155/2020/2943827

Journal - Research Article

Cui, X., Li, J., Hartanto, Y., Durham, M., Tang, J., Zhang, H., Hooper, G., Lim, K., & Woodfield, T. (2020). Advances in extrusion 3D bioprinting: A focus on multicomponent hydrogel-based bioinks. Advanced Healthcare Materials, 9, 1901648. doi: 10.1002/adhm.201901648

Journal - Research Article

Deng, Y., Kieser, D., Wyatt, M., Stringer, M., Frampton, C., & Hooper, G. (2020). Risk factors for periprosthetic femoral fractures around total hip arthroplasty: A systematic review and meta-analysis. ANZ Journal of Surgery, 90, 441-447. doi: 10.1111/ans.15473

Journal - Research Article

Li, J., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review. Journal of the Mechanical Behavior of Biomedical Materials, 105, 103671. doi: 10.1016/j.jmbbm.2020.103671

Journal - Research Article

Li, J., Mutreja, I., Hooper, G. J., Clinch, K., Lim, K., Evans, G., & Woodfield, T. B. F. (2020). Combined infection control and enhanced osteogenic differentiation capacity on additive manufactured Ti-6Al-4V are mediated via titania nanotube delivery of novel biofilm inhibitors. Advanced Materials Interfaces, 7, 1901963. doi: 10.1002/admi.201901963

Journal - Research Article

Li, J., Mutreja, I., Tredinnick, S., Jermy, M., Hooper, G. J., & Woodfield, T. B. F. (2020). Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. Materials Science & Engineering: C, 109, 110562. doi: 10.1016/j.msec.2019.110562

Journal - Research Article

Snell, D. L., Jerram, K. A. S., Dunn, J. A., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2020). Use of rehabilitation after hip and knee replacement in New Zealand: A national survey. New Zealand Medical Journal, 133(1510), 45-55. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation, 42(14), 1942-1953. doi: 10.1080/09638288.2018.1542461

Journal - Research Article

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials, 9, 1901544. doi: 10.1002/adhm.201901544

Journal - Research Article

Taylor, S. C., Kieser, D. C., Hammer, N., & Hooper, G. (2020). Microscopic and macroscopic comparisons of 0.223 soft point and full metal jacket ammunition with bos taurus scapulae as a proxy to human flat bones. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2020-001491

Journal - Research Article

Warhurst, S., Labbe-hubbard, S., Yi, M., Vella-Brincat, J., Sammon, T., Webb, J., … Hooper, G., & Gilchrist, N. L. (2020). Patient characteristics, treatment outcomes and rehabilitation practices for patients admitted with hip fractures using multiple data set analysis. New Zealand Medical Journal, 133(1526), 31-44. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Wyatt, M. C., Poutawera, V., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). How do cemented short Exeter stems perform compared with standard-length Exeter stems? The experience of the New Zealand National Joint Registry. Arthroplasty Today, 6, 104-111. doi: 10.1016/j.artd.2020.01.003

Journal - Research Article

Wyatt, M. C., Whitehouse, M. R., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). Are lipped polyethylene liners associated with increased revision rates in patients with uncemented acetabular components? An observational cohort study. Clinical Orthopaedics & Related Research, 478, 581-589. doi: 10.1097/corr.0000000000001039

Journal - Research Article

Baxter-Parker, G., Roffe, L., Cross, S., Frampton, C., Hooper, G. J., & Gieseg, S. (2019). Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin. Clinical Biochemistry, 63, 39-45. doi: 10.1016/j.clinbiochem.2018.11.002

Journal - Research Article

Dehn, G., Kieser, D., Maxwell, R., Hooper, G., Frampton, C., & Coates, M. (2019). Does the size of the femoral condyle contribute to the development of osteoarthritis of the knee? A retrospective randomised MRI study. Journal of Arthritis, 8(4), 284. Retrieved from https://www.iomcworld.org/arthritis.html

Journal - Research Article

Henzell, I. S., Zhou, L., Frampton, C., Hooper, G., Ackerman, I., & Young, S. W. (2019). Lifetime risk of primary total knee replacement surgery in New Zealand from 2000 to 2015. New Zealand Medical Journal, 132(1489), 48-56. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Journal - Research Article

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Journal - Research Article

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