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Gary HooperHead of Department

MBChB MD FRACS FRNZOA

Email gary.hooper@otago.ac.nz

Professional interests

  • Knee injuries and Joint Replacement
  • Rehabilitation following surgery
  • Impact of training on outcomes for patients
  • Regenerative medicine in Orthopaedics
  • Assessing outcomes following joint replacement

Research interests

Gary's research interests include clinical trials investigating improving outcomes after joint replacement and studies involving bone metabolism and musculoskeletal bioengineering.

Clinical outcomes include:

  • The wear of highly cross-linked polyethylene in hip replacement
  • Metal ion production in hard-on-hard bearing surfaces
  • Long term outcome of unicompartmental knee replacement
  • Acoustic monitoring of failing joint replacements
  • The use of larger femoral heads in hip replacement
  • The implications of increased BMI on the outcome
  • Bone density changes around implants
  • New Zealand Joint Registry outcomes

He also studies re-integration into society in multiple trauma patients with special emphasis on earthquake victims.

Gary's bone metabolism studies include bone density changes adjacent to uncemented hip and knee replacements and the implications this has for clinical practice.

He is also studying how to improve fracture healing rates following neck of femur and tibial shaft fracture.

Gary's biomechanical investigations include the building and production of cartilage scaffolds for the treatment of articular cartilage defects and developing titanium implants to fill bone deficits.

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Publications

Wyatt, M. C., Poutawera, V., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). How do cemented short Exeter stems perform compared with standard-length Exeter stems? The experience of the New Zealand National Joint Registry. Arthroplasty Today. Advance online publication. doi: 10.1016/j.artd.2020.01.003

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials. Advance online publication. doi: 10.1002/adhm.201901544

Li, J., Mutreja, I., Hooper, G. J., Clinch, K., Lim, K., Evans, G., & Woodfield, T. B. F. (2020). Combined infection control and enhanced osteogenic differentiation capacity on additive manufactured Ti-6Al-4V are mediated via titania nanotube delivery of novel biofilm inhibitors. Advanced Materials Interfaces. Advance online publication. doi: 10.1002/admi.201901963

Li, J., Mutreja, I., Tredinnick, S., Jermy, M., Hooper, G. J., & Woodfield, T. B. F. (2020). Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. Materials Science & Engineering: C, 109, 110562. doi: 10.1016/j.msec.2019.110562

Snell, D. L., Jerram, K. A. S., Dunn, J. A., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2020). Use of rehabilitation after hip and knee replacement in New Zealand: A national survey. New Zealand Medical Journal, 133(1510), 45-55. Retrieved from https://www.nzma.org.nz/journal

Chapter in Book - Research

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

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Chapter in Book - Other

Hooper, G. (2013). Orthopaedic Surgery and Musculoskeletal Medicine. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 38-40). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Wyatt, M. C., Poutawera, V., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). How do cemented short Exeter stems perform compared with standard-length Exeter stems? The experience of the New Zealand National Joint Registry. Arthroplasty Today. Advance online publication. doi: 10.1016/j.artd.2020.01.003

Snell, D. L., Jerram, K. A. S., Dunn, J. A., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2020). Use of rehabilitation after hip and knee replacement in New Zealand: A national survey. New Zealand Medical Journal, 133(1510), 45-55. Retrieved from https://www.nzma.org.nz/journal

Li, J., Mutreja, I., Tredinnick, S., Jermy, M., Hooper, G. J., & Woodfield, T. B. F. (2020). Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. Materials Science & Engineering: C, 109, 110562. doi: 10.1016/j.msec.2019.110562

Li, J., Mutreja, I., Hooper, G. J., Clinch, K., Lim, K., Evans, G., & Woodfield, T. B. F. (2020). Combined infection control and enhanced osteogenic differentiation capacity on additive manufactured Ti-6Al-4V are mediated via titania nanotube delivery of novel biofilm inhibitors. Advanced Materials Interfaces. Advance online publication. doi: 10.1002/admi.201901963

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials. Advance online publication. doi: 10.1002/adhm.201901544

Taylor, S. C., Kieser, D. C., Hammer, N., Ondruschka, B., Kranioti, E., Pullen, A., & Hooper, G. (2020). Viability of Bos taurus scapulae as a flat bone proxy for ballistic testing. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2019-001369

Chin, J., Blackett, J., Kieser, D. C., Frampton, C., & Hooper, G. (2020). The value of routine intravenous tranexamic acid in total hip arthroplasty: A preliminary study. Advances in Orthopedics, 2020, 2943827. doi: 10.1155/2020/2943827

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Wyatt, M. C., Whitehouse, M. R., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). Are lipped polyethylene liners associated with increased revision rates in patients with uncemented acetabular components? An observational cohort study. Clinical Orthopaedics & Related Research, 478, 581-589. doi: 10.1097/corr.0000000000001039

Pullen, A., Kieser, D. C., & Hooper, G. (2020). Ballistic gelatin calibration standardisation. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2020-001430

Cui, S., Li, J., Hartanto, Y., Durham, M., Tang, J., Zhang, H., Hooper, G., Lim, K., & Woodfield, T. (2020). Advances in extrusion 3D bioprinting: A focus on multicomponent hydrogel-based bioinks. Advanced Healthcare Materials. Advance online publication. doi: 10.1002/adhm.201901648

Wyatt, M. C., Kieser, D. C., Frampton, C. M. A., Woodfield, T., & Hooper, G. J. (2020). How do 3D-printed primary uncemented acetabular components compare with established uncemented acetabular cups? The experience of the New Zealand National Joint Registry. HIP International. Advance online publication. doi: 10.1177/1120700020918233

Li, J., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review. Journal of the Mechanical Behavior of Biomedical Materials. Advance online publication. doi: 10.1016/j.jmbbm.2020.103671

Baxter-Parker, G., Roffe, L., Cross, S., Frampton, C., Hooper, G. J., & Gieseg, S. (2019). Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin. Clinical Biochemistry, 63, 39-45. doi: 10.1016/j.clinbiochem.2018.11.002

Snell, D. L., Dunn, J. A., Sinnott, K. A., Hsieh, C. J., De Jong, G., & Hooper, G. J. (2019). Joint replacement rehabilitation and the role of funding source. Journal of Rehabilitation Medicine, 51(10), 770-778. doi: 10.2340/16501977-2600

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2019). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation. Advance online publication. doi: 10.1080/09638288.2018.1542461

Henzell, I. S., Zhou, L., Frampton, C., Hooper, G., Ackerman, I., & Young, S. W. (2019). Lifetime risk of primary total knee replacement surgery in New Zealand from 2000 to 2015. New Zealand Medical Journal, 132(1489), 48-56. Retrieved from https://www.nzma.org.nz/journal

Nugent, M., May, J. H., Parker, J. D., Kieser, D. C., Douglas, M., Pereira, R., Lim, K. S., & Hooper, G. J. (2019). Does tranexamic acid reduce knee swelling and improve early function following arthroscopic meniscectomy? A double-blind randomized controlled trial. Orthopaedic Journal of Sports Medicine, 7(8), 2325967119866122. doi: 10.1177/2325967119866122

Nugent, M., Wyatt, M. C., Frampton, C. M., & Hooper, G. J. (2019). Despite improved survivorship of uncemented fixation in total knee arthroplasty for osteoarthritis, cemented fixation remains the gold standard: An analysis of a National Joint Registry. Journal of Arthroplasty, 34, 1626-1633. doi: 10.1016/j.arth.2019.03.047

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Wyatt, M. C., Kieser, D. C., Kemp, M. A., McHugh, G., Frampton, C. M. A., & Hooper, G. J. (2019). Does the femoral offset affect replacements? The results from a National Joint Registry. HIP International, 29(3), 289-298. doi: 10.1177/1120700018780318

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Kieser, D. C., Ailabouni, R., Kieser, S. C. J., Wyatt, M. C., Armour, P. C., Coates, M. H., & Hooper, G. J. (2018). The use of an Ossis custom 3D-printed tri-flanged acetabular implant for major bone loss: Minimum 2-year follow-up. HIP International, 28(6), 668-674. doi: 10.1177/1120700018760817

Campi, S., Pandit, H., Hooper, G., Snell, D., Jenkins, C., Dodd, C. A. F., Maxwell, R., & Murray, D. W. (2018). Ten-year survival and seven-year functional results of cementless Oxford unicompartmental knee replacement: A prospective consecutive series of our first 1000 cases. Knee, 25(6), 1231-1237. doi: 10.1016/j.knee.2018.07.012

Snell, D. L., Hipango, J., Sinnott, K. A., Dunn, J. A., Rothwell, A., Hsieh, C. J., … Hooper, G. (2018). Rehabilitation after total joint replacement: A scoping study. Disability & Rehabilitation, 40(14), 1718-1731. doi: 10.1080/09638288.2017.1300947

Smith, J. O., Frampton, C. M. A., Hooper, G. J., & Young, S. W. (2018). The impact of patient and surgical factors on the rate of postoperative infection after total hip arthroplasty: A New Zealand Joint Registry Study. Journal of Arthroplasty, 33(6), 1884-1890. doi: 10.1016/j.arth.2018.01.021

Stewart, R., Kieser, D. C., Scholze, M., Hammer, N., Stone, B., & Hooper, G. (2018). Preliminary biomechanical results of a novel pin configuration for external fixation of vertical shear pelvic fractures. ANZ Journal of Surgery, 88(10), 1051-1055. doi: 10.1111/ans.14822

Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018). A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models. Lab on a Chip, (18), 2757-2775. doi: 10.1039/c8lc00485d

Kieser, D. C., Wyatt, M. C., Beswick, A., Kunutsor, S., & Hooper, G. J. (2018). Does the type of surgical drape (disposable versus non-disposable) affect the risk of subsequent surgical site infection? Journal of Orthopaedics, 15(2), 566-570. doi: 10.1016/j.jor.2018.05.015

Snell, D. L., Martin, R., Macleod, A. D., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T., Hooper, G. J., & Anderson, T. (2018). Untangling chronic pain and post-concussion symptoms: The significance of depression. Brain Injury, 32(5), 583-592. doi: 10.1080/02699052.2018.1432894

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Storey, R., Frampton, C., Kieser, D., & Hooper, G. (2018). Does orthopaedic training compromise the outcome in knee joint arthroplasty? Journal of Surgical Education, 75(5), 1292-1298. doi: 10.1016/j.jsurg.2018.02.011

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404

Vadei, L., Kieser, D. C., Frampton, C., & Hooper, G. (2017). Survivorship of total hip joint replacements following isolated liner exchange for wear. Journal of Arthroplasty, 32(11), 3484-3487. doi: 10.1016/j.arth.2017.05.055

Gilchrist, N., Dalzell, K., Pearson, S., Hooper, G., Hoeben, K., Hickling, J., McKie, J., … Gutenstein, M. (2017). Enhanced hip fracture management: Use of statistical methods and dataset to evaluate a fractured neck of femur fast track pathway: Pilot study. New Zealand Medical Journal, 130(1455), 91-101. Retrieved from https://www.nzma.org.nz/journal

Roffe, L., FitzPatrick, A. J., Rodgers, G. W., Woodfield, T. B. F., & Hooper, G. J. (2017). Squeaking in ceramic-on-ceramic hips: No evidence of contribution from the trunnion morse taper. Journal of Orthopaedic Research, 35(8), 1793-1798. doi: 10.1002/jor.23458

Brown, G. C. J., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. F. (2017). Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels. Macromolecular Bioscience, 17(12), 1700158. doi: 10.1002/mabi.201700158

Halasi, T., Kieser, D., Frampton, C. M. A., & Hooper, G. J. (2017). Midterm analysis of the seleXys cup with ceramic inlay. Arthroplasty Today, 3, 171-175. doi: 10.1016/j.artd.2016.10.003

Inglis, T., Armour, P., Inglis, G., & Hooper, G. (2017). Rationing of hip and knee referrals in the public hospital: The true unmet need. New Zealand Medical Journal, 130(1452), 39-48. Retrieved from https://www.nzma.org.nz/journal

Stamp, L. K., Haslett, J., Chapman, P., O'Donnell, J., Raja, R., Rothwell, A., Frampton, C., & Hooper, G. (2017). Rates of joint replacement surgery in New Zealand, 1999-2015: A comparison of rheumatoid arthritis and osteoarthritis. Journal of Rheumatology, 44(12), 1823-1827. doi: 10.3899/jrheum.170551

Schouten, R., Malone, A. A., Frampton, C. M., Tiffen, C., & Hooper, G. (2017). Five-year follow-up of a prospective randomised trial comparing ceramic-on-metal and metal-on-metal bearing surfaces in total hip arthroplasty. Bone & Joint Journal, 99-B(10), 1298-1303. doi: 10.1302/0301-620x.99b10.bjj-2016-0905.r1

FitzPatrick, A. J., Rodgers, G. W., Hooper, G. J., & Woodfield, T. B. F. (2017). Development and validation of an acoustic emission device to measure wear in total hip replacements in-vitro and in-vivo. Biomedical Signal Processing & Control, 33, 281-288. doi: 10.1016/j.bspc.2016.12.011

Rodgers, G. W., Welsh, R., King, L. J., FitzPatrick, A. J., Woodfield, T. B. F., & Hooper, G. J. (2017). Signal processing and event detection of hip implant acoustic emissions. Control Engineering Practice, 58, 287-297. doi: 10.1016/j.conengprac.2016.09.013

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2017). Modular tissue assembly strategies for biofabrication of engineered cartilage. Annals of Biomedical Engineering, 45(1), 100-114. doi: 10.1007/s10439-016-1609-3

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2016). Return to work for severely injured survivors of the Christchurch earthquake: Influences in the first 2 years. Disability & Rehabilitation, 38(10), 987-993. doi: 10.3109/09638288.2015.1070299

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