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Gary HooperHead of Department

MBChB MD FRACS FRNZOA

Email gary.hooper@otago.ac.nz

Professional interests

  • Knee injuries and Joint Replacement
  • Rehabilitation following surgery
  • Impact of training on outcomes for patients
  • Regenerative medicine in Orthopaedics
  • Assessing outcomes following joint replacement

Research interests

Gary's research interests include clinical trials investigating improving outcomes after joint replacement and studies involving bone metabolism and musculoskeletal bioengineering.

Clinical outcomes include:

  • The wear of highly cross-linked polyethylene in hip replacement
  • Metal ion production in hard-on-hard bearing surfaces
  • Long term outcome of unicompartmental knee replacement
  • Acoustic monitoring of failing joint replacements
  • The use of larger femoral heads in hip replacement
  • The implications of increased BMI on the outcome
  • Bone density changes around implants
  • New Zealand Joint Registry outcomes

He also studies re-integration into society in multiple trauma patients with special emphasis on earthquake victims.

Gary's bone metabolism studies include bone density changes adjacent to uncemented hip and knee replacements and the implications this has for clinical practice.

He is also studying how to improve fracture healing rates following neck of femur and tibial shaft fracture.

Gary's biomechanical investigations include the building and production of cartilage scaffolds for the treatment of articular cartilage defects and developing titanium implants to fill bone deficits.

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Publications

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair. Bone, 154, 116198. doi: 10.1016/j.bone.2021.116198

Pullen, A., Kieser, D., & Hooper, G. (2021). Military thoracic gunshot wounds: A systematic review. Journal of Military Studies. Advance online publication. doi: 10.2478/jms-2021-0009

Aldrich, E. D., Cui, X., Murphy, C., Lim, K. S., Hooper, G. J., McIlwraith, C. W., & Woodfield, T. B. F. (2021). Allogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities. Stem Cells Translational Medicine. Advance online publication. doi: 10.1002/sctm.20-0552

Baxter-Parker, G., Roffe, L., Moltchanova, E., Jefferies, J., Raajasekar, S., Hooper, G., & Gieseg, S. P. (2021). Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. PLoS ONE, 16(8), e0256072. doi: 10.1371/journal.pone.0256072

Longoni, A., Li, J., Lindberg, G. C. J., Rnjak-Kovacina, J., Wise, L. M., Hooper, G. J., Woodfield, T. B. F., Kieser, D. C., & Lim, K. S. (2021). Strategies for inclusion of growth factors into 3D printed bone grafts. Essays in Biochemistry, EBC20200130. doi: 10.1042/ebc20200130

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

Chapter in Book - Research

Hooper, G. (2013). Orthopaedic Surgery and Musculoskeletal Medicine. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 38-40). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2022). Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair. Bone, 154, 116198. doi: 10.1016/j.bone.2021.116198

Journal - Research Article

Alcala-Orozco, C. R., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2021). Converging functionality: Strategies for 3D hybrid-construct biofabrication and the role of composite biomaterials for skeletal regeneration. Acta Biomaterialia. Advance online publication. doi: 10.1016/j.actbio.2021.03.008

Journal - Research Article

Aldrich, E. D., Cui, X., Murphy, C., Lim, K. S., Hooper, G. J., McIlwraith, C. W., & Woodfield, T. B. F. (2021). Allogeneic mesenchymal stromal cells for cartilage regeneration: A review of in vitro evaluation, clinical experience, and translational opportunities. Stem Cells Translational Medicine. Advance online publication. doi: 10.1002/sctm.20-0552

Journal - Research Article

Baer, K., Kieser, S., Schon, B., Rajendran, K., ten Harkel, T., Ramyar, M., … Bateman, C., Butler, A., Raja, A. Y., Hooper, G., Anderson, N., & Woodfield, T. (2021). Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioengineering, 5(2), 026101. doi: 10.1063/5.0035312

Journal - Research Article

Baxter-Parker, G., Roffe, L., Moltchanova, E., Jefferies, J., Raajasekar, S., Hooper, G., & Gieseg, S. P. (2021). Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. PLoS ONE, 16(8), e0256072. doi: 10.1371/journal.pone.0256072

Journal - Research Article

Hudson, B., Williman, J. A., Stamp, L. K., Alchin, J. S., Hooper, G. J., Mangin, D., Lennox Thompson, B. F., & Toop, L. (2021). Nortriptyline for pain in knee osteoarthritis in general practice: A double blind randomised controlled trial. British Journal of General Practice. Advance online publication. doi: 10.3399/bjgp.2020.0797

Journal - Research Article

Lindberg, G. C. J., Lim, K. S., Soliman, B. G., Nguyen, A., Hooper, G. J., Narayan, R. J., & Woodfield, T. B. F. (2021). Biological function following radical photo-polymerization of biomedical polymers and surrounding tissues: Design considerations and cellular risk factors. Applied Physics Reviews, 8(1), 011301. doi: 10.1063/5.0015093

Journal - Research Article

Longoni, A., Li, J., Lindberg, G. C. J., Rnjak-Kovacina, J., Wise, L. M., Hooper, G. J., Woodfield, T. B. F., Kieser, D. C., & Lim, K. S. (2021). Strategies for inclusion of growth factors into 3D printed bone grafts. Essays in Biochemistry, EBC20200130. doi: 10.1042/ebc20200130

Journal - Research Article

Nugent, M., Young, S. W., Frampton, C. M., & Hooper, G. J. (2021). The lifetime risk of revision following total hip arthroplasty: A New Zealand joint registry study. Bone & Joint Journal, 103-B(3), 479-485. doi: 10.1302/0301-620x.103b3.Bjj-2020-0562.R2

Journal - Research Article

Pullen, A., Kieser, D. C., & Hooper, G. (2021). A study into the viability of Synbone® as a proxy for Sus scrofa (domesticus) ribs for use with 5.56-mm open tip match ammunition in ballistic testing. International Journal of Legal Medicine, 135, 521-526. doi: 10.1007/s00414-020-02416-8

Journal - Research Article

Silman, A., Combescure, C., Ferguson, R. J., Graves, S. E., Paxton, E. W., Frampton, C., … Hooper, G., … Rolfson, O. (2021). International variation in distribution of ASA class in patients undergoing total hip arthroplasty and its influence on mortality: Data from an international consortium of arthroplasty registries. Acta Orthopaedica. Advance online publication. doi: 10.1080/17453674.2021.1892267

Journal - Research Article

Snell, D. L., Dunn, J. A., Jerram, K. A. S., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2021). Associations between comorbidity and quality of life outcomes after total joint replacement. Quality of Life Research, 30, 137-144. doi: 10.1007/s11136-020-02610-6

Journal - Research Article

Stringer, M. R., Hooper, G. J., Frampton, C., & Kieser, D. C. (2021). Periprosthetic fractures of the femur in primary total hip arthroplasty: A New Zealand Joint Registry analysis. ANZ Journal of Surgery. Advance online publication. doi: 10.1111/ans.16611

Journal - Research Article

Alcala-Orozco, C. R., Mutreja, I., Cui, X., Kumar, D., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. Bioprinting, 18, e00073. doi: 10.1016/j.bprint.2019.e00073

Journal - Research Article

Atienza-Roca, P., Kieser, D., Cui, X., Bathish, B., Ramaswamy, Y., Hooper, G. J., Clarkson, A. N., … Wise, L. M., Woodfield, T. B. F., & Lim, K. S. (2020). Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors. Biomaterials Science, 8(18), 5005-5019. doi: 10.1039/D0BM00603C

Journal - Research Article

Chin, J., Blackett, J., Kieser, D. C., Frampton, C., & Hooper, G. (2020). The value of routine intravenous tranexamic acid in total hip arthroplasty: A preliminary study. Advances in Orthopedics, 2020, 2943827. doi: 10.1155/2020/2943827

Journal - Research Article

Cui, X., Li, J., Hartanto, Y., Durham, M., Tang, J., Zhang, H., Hooper, G., Lim, K., & Woodfield, T. (2020). Advances in extrusion 3D bioprinting: A focus on multicomponent hydrogel-based bioinks. Advanced Healthcare Materials, 9, 1901648. doi: 10.1002/adhm.201901648

Journal - Research Article

Deng, Y., Kieser, D., Wyatt, M., Stringer, M., Frampton, C., & Hooper, G. (2020). Risk factors for periprosthetic femoral fractures around total hip arthroplasty: A systematic review and meta-analysis. ANZ Journal of Surgery, 90, 441-447. doi: 10.1111/ans.15473

Journal - Research Article

Li, J., Cui, X., Hooper, G. J., Lim, K. S., & Woodfield, T. B. F. (2020). Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review. Journal of the Mechanical Behavior of Biomedical Materials, 105, 103671. doi: 10.1016/j.jmbbm.2020.103671

Journal - Research Article

Li, J., Mutreja, I., Hooper, G. J., Clinch, K., Lim, K., Evans, G., & Woodfield, T. B. F. (2020). Combined infection control and enhanced osteogenic differentiation capacity on additive manufactured Ti-6Al-4V are mediated via titania nanotube delivery of novel biofilm inhibitors. Advanced Materials Interfaces, 7, 1901963. doi: 10.1002/admi.201901963

Journal - Research Article

Li, J., Mutreja, I., Tredinnick, S., Jermy, M., Hooper, G. J., & Woodfield, T. B. F. (2020). Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. Materials Science & Engineering: C, 109, 110562. doi: 10.1016/j.msec.2019.110562

Journal - Research Article

Pullen, A., Kieser, D. C., & Hooper, G. (2020). Ballistic gelatin calibration standardisation. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2020-001430

Journal - Research Article

Snell, D. L., Jerram, K. A. S., Dunn, J. A., Hsieh, C. J., DeJong, G., & Hooper, G. J. (2020). Use of rehabilitation after hip and knee replacement in New Zealand: A national survey. New Zealand Medical Journal, 133(1510), 45-55. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Snell, D. L., Martin, R., Surgenor, L. J., Siegert, R. J., Hay-Smith, E. J. C., Melzer, T. R., Anderson, T. J., & Hooper, G. J. (2020). Wrestling with uncertainty after mild traumatic brain injury: A mixed methods study. Disability & Rehabilitation, 42(14), 1942-1953. doi: 10.1080/09638288.2018.1542461

Journal - Research Article

Soliman, B. G., Lindberg, G. C. J., Jungst, T., Hooper, G. J., Groll, J., Woodfield, T. B. F., & Lim, K. S. (2020). Stepwise control of crosslinking in a one-pot system for bioprinting of low-density bioinks. Advanced Healthcare Materials, 9, 1901544. doi: 10.1002/adhm.201901544

Journal - Research Article

Taylor, S. C., Kieser, D. C., Hammer, N., & Hooper, G. (2020). Microscopic and macroscopic comparisons of 0.223 soft point and full metal jacket ammunition with bos taurus scapulae as a proxy to human flat bones. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2020-001491

Journal - Research Article

Taylor, S. C., Kieser, D. C., Hammer, N., Ondruschka, B., Kranioti, E., Pullen, A., & Hooper, G. (2020). Viability of Bos taurus scapulae as a flat bone proxy for ballistic testing. BMJ Military Health. Advance online publication. doi: 10.1136/bmjmilitary-2019-001369

Journal - Research Article

Warhurst, S., Labbe-hubbard, S., Yi, M., Vella-Brincat, J., Sammon, T., Webb, J., … Hooper, G., & Gilchrist, N. L. (2020). Patient characteristics, treatment outcomes and rehabilitation practices for patients admitted with hip fractures using multiple data set analysis. New Zealand Medical Journal, 133(1526), 31-44. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Wyatt, M. C., Kieser, D. C., Frampton, C. M. A., Woodfield, T., & Hooper, G. J. (2020). How do 3D-printed primary uncemented acetabular components compare with established uncemented acetabular cups? The experience of the New Zealand National Joint Registry. HIP International. Advance online publication. doi: 10.1177/1120700020918233

Journal - Research Article

Wyatt, M. C., Poutawera, V., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). How do cemented short Exeter stems perform compared with standard-length Exeter stems? The experience of the New Zealand National Joint Registry. Arthroplasty Today, 6, 104-111. doi: 10.1016/j.artd.2020.01.003

Journal - Research Article

Wyatt, M. C., Whitehouse, M. R., Kieser, D. C., Frampton, C. M. A., & Hooper, G. J. (2020). Are lipped polyethylene liners associated with increased revision rates in patients with uncemented acetabular components? An observational cohort study. Clinical Orthopaedics & Related Research, 478, 581-589. doi: 10.1097/corr.0000000000001039

Journal - Research Article

Baxter-Parker, G., Roffe, L., Cross, S., Frampton, C., Hooper, G. J., & Gieseg, S. (2019). Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin. Clinical Biochemistry, 63, 39-45. doi: 10.1016/j.clinbiochem.2018.11.002

Journal - Research Article

Dehn, G., Kieser, D., Maxwell, R., Hooper, G., Frampton, C., & Coates, M. (2019). Does the size of the femoral condyle contribute to the development of osteoarthritis of the knee? A retrospective randomised MRI study. Journal of Arthritis, 8(4), 284. Retrieved from https://www.iomcworld.org/arthritis.html

Journal - Research Article

Henzell, I. S., Zhou, L., Frampton, C., Hooper, G., Ackerman, I., & Young, S. W. (2019). Lifetime risk of primary total knee replacement surgery in New Zealand from 2000 to 2015. New Zealand Medical Journal, 132(1489), 48-56. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Journal - Research Article

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Journal - Research Article

Nugent, M., May, J. H., Parker, J. D., Kieser, D. C., Douglas, M., Pereira, R., Lim, K. S., & Hooper, G. J. (2019). Does tranexamic acid reduce knee swelling and improve early function following arthroscopic meniscectomy? A double-blind randomized controlled trial. Orthopaedic Journal of Sports Medicine, 7(8), 2325967119866122. doi: 10.1177/2325967119866122

Journal - Research Article

Nugent, M., Wyatt, M. C., Frampton, C. M., & Hooper, G. J. (2019). Despite improved survivorship of uncemented fixation in total knee arthroplasty for osteoarthritis, cemented fixation remains the gold standard: An analysis of a National Joint Registry. Journal of Arthroplasty, 34, 1626-1633. doi: 10.1016/j.arth.2019.03.047

Journal - Research Article

Snell, D. L., Dunn, J. A., Sinnott, K. A., Hsieh, C. J., De Jong, G., & Hooper, G. J. (2019). Joint replacement rehabilitation and the role of funding source. Journal of Rehabilitation Medicine, 51(10), 770-778. doi: 10.2340/16501977-2600

Journal - Research Article

Wyatt, M. C., Kieser, D. C., Kemp, M. A., McHugh, G., Frampton, C. M. A., & Hooper, G. J. (2019). Does the femoral offset affect replacements? The results from a National Joint Registry. HIP International, 29(3), 289-298. doi: 10.1177/1120700018780318

Journal - Research Article

Campi, S., Pandit, H., Hooper, G., Snell, D., Jenkins, C., Dodd, C. A. F., Maxwell, R., & Murray, D. W. (2018). Ten-year survival and seven-year functional results of cementless Oxford unicompartmental knee replacement: A prospective consecutive series of our first 1000 cases. Knee, 25(6), 1231-1237. doi: 10.1016/j.knee.2018.07.012

Journal - Research Article

Kieser, D. C., Ailabouni, R., Kieser, S. C. J., Wyatt, M. C., Armour, P. C., Coates, M. H., & Hooper, G. J. (2018). The use of an Ossis custom 3D-printed tri-flanged acetabular implant for major bone loss: Minimum 2-year follow-up. HIP International, 28(6), 668-674. doi: 10.1177/1120700018760817

Journal - Research Article

Kieser, D. C., Wyatt, M. C., Beswick, A., Kunutsor, S., & Hooper, G. J. (2018). Does the type of surgical drape (disposable versus non-disposable) affect the risk of subsequent surgical site infection? Journal of Orthopaedics, 15(2), 566-570. doi: 10.1016/j.jor.2018.05.015

Journal - Research Article

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Journal - Research Article

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Journal - Research Article

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Journal - Research Article

Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018). A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models. Lab on a Chip, (18), 2757-2775. doi: 10.1039/c8lc00485d

Journal - Research Article

Smith, J. O., Frampton, C. M. A., Hooper, G. J., & Young, S. W. (2018). The impact of patient and surgical factors on the rate of postoperative infection after total hip arthroplasty: A New Zealand Joint Registry Study. Journal of Arthroplasty, 33(6), 1884-1890. doi: 10.1016/j.arth.2018.01.021

Journal - Research Article

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