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Associate Professor Tim Woodfield

Tim WoodfieldResearch Associate Professor

Rutherford Discovery Fellow 2012-2017

BE(Hons)(Cant) MASc(Tor) PhD(Twente)

Email tim.woodfield@otago.ac.nz

Tel +64 3 378 6114
Fax +64 3 364 0909

@Tim_WoodfieldNZ

Associate Professor Woodfield leads the Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group in the Department of Orthopaedic Surgery and Centre for Bioengineering & Nanomedicine at the University of Otago, Christchurch, New Zealand.

His CReaTE group is investigating stem cell and biomaterial-based strategies for musculoskeletal tissue regeneration and their application in the clinical translation of orthopaedic medical devices & cell-based therapies. His research technology platform involves 3D Bioprinting and additive manufacturing of biomaterial scaffolds/devices applied to regenerative medicine of cartilage and bone, including bio-ink development, advanced 3D tissue culture models and high throughput screening.

Tim was awarded a Rutherford Discovery Fellowship by the Royal Society of New Zealand in 2012 focussing on Regenerative Medicine of cartilage and bone, and is a Principal Investigator within the New Zealand Medical Technology Centre of Research Excellence (CoRE). He also holds an adjunct Associate Professor position at the Institute of Health & Biomedical Innovation, Queensland University of Technology, Australia.

Tim has published 49 articles in peer reviewed international journals and book chapters. He has attracted over NZ$19.3 million in competitive research funding as a PI or co-PI from Ministry of Business Innovation & Employment, Royal Society of New Zealand, Health Research Council, MedTech CoRE, and acts as coordinator of the European Commission skelGEN consortia project.

He is the outgoing President of the Australasian Society for Biomaterials & Tissue Engineering (ASBTE) having served as President, Executive Officer and Executive Committee member roles since 2008. He is Secretary and Executive Board member of the International Society for Biofabrication. He sits on the editorial board for the journals Biofabrication, Biomaterials & Biomedical Engineering, and Frontiers in Bioengineering & Biotechnology.

Roles

  • Principal Investigator, Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group
  • Theme Leader, Regenerative Medicine – University of Otago Centre for Bioengineering & Nanomedicine
  • Adjunct Associate Professor, Institute of Health & Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, Australia
  • Adjunct Senior Fellow, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
  • Principal Investigator, Centre of Research Excellence in Medical Technologies
  • Associate Investigator, MacDiarmid Institute for Advanced Materials & Nanotechnology
  • Associate Investigator, Maurice Wilkins Centre for Molecular Diversity

Professional affiliations

Professional interests

Orthopaedic Tissue Engineering and Regenerative Medicine

  • Stem cell and scaffold-based regeneration of cartilage and bone
  • Bio-fabrication and advanced scaffold design
  • Orthopaedic medical device development

Christchurch Regenerative Medicine and Tissue Engineering (CReATE) Group website
Regenerative Medicine website - Centre for Bioengineering & Nanomedicine

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Publications

Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467

Klotz, B. J., Lim, K. S., Chang, Y. X., Soliman, B. G., Pennings, I., Melchels, F. P. W., Woodfield, T. B. F., … Gawlitta, D. (2018). Engineers of a complex bone tissue model with endothelialised channels and capillary-like networks. European Cells & Materials, 35, 335-349. doi: 10.22203/eCM.v035a23

Chapter in Book - Research

Woodfield, T., Lim, K., Morouço, P., Levato, R., Malda, J., & Melchels, F. (2017). Biofabrication in tissue engineering. In P. Ducheyne, D. W. Grainger, K. E. Healy, D. W. Hutmacher & C. J. Kirkpatrick (Eds.), Comprehensive biomaterials II: (Vol. 5) Tissue Engineering and regenerative medicine: Fundamentals. (2nd ed.) (pp. 236-266). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-803581-8.10221-8

Hutmacher, D. W., Woodfield, T. B. F., & Dalton, P. D. (2015). Scaffold design and fabrication. In C. A. van Blitterswijk & J. de Boer (Eds.), Tissue engineering. (2nd ed.) (pp. 311-346). London, UK: Academic Press. doi: 10.1016/B978-0-12-420145-3.00010-9

Melchels, F., Malda, J., Fedorovich, N., Alblas, J., & Woodfield, T. (2011). Organ printing. In P. Ducheyne, K. E. Healy, D. W. Hutmacher, D. W. Grainger & C. J. Kirkpatrick (Eds.), Comprehensive biomaterials (vol. 5). (pp. 587-606). Elsevier Science.

Hutmacher, D., Woodfield, T., Dalton, P., & Lewis, J. (2008). Scaffold design and fabrication. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 403-454). London, UK: Academic Press.

Malda, J., Radisic, M., Levenberg, S., Woodfield, T., Bomens, C., Baaijens, F., … Vunjak-Novakovic, G. (2008). Cell nutrition. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 327-362). London, UK: Academic Press.

Habibovic, P., Woodfield, T., de Groot, K., & van Blitterswijk, C. (2006). Predictive value of in vitro and in vivo assays in bone and cartilage repair: What do they really tell us about the clinical performance? In J. P. Fisher (Ed.), Advances in Experimental Medicine & Biology: Tissue engineering (Vol. 585). (pp. 327-360). New York: Springer. doi: 10.1007/978-0-387-34133-0_22

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Journal - Research Article

Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020

Klotz, B. J., Lim, K. S., Chang, Y. X., Soliman, B. G., Pennings, I., Melchels, F. P. W., Woodfield, T. B. F., … Gawlitta, D. (2018). Engineers of a complex bone tissue model with endothelialised channels and capillary-like networks. European Cells & Materials, 35, 335-349. doi: 10.22203/eCM.v035a23

Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Roffe, L., FitzPatrick, A. J., Rodgers, G. W., Woodfield, T. B. F., & Hooper, G. J. (2017). Squeaking in ceramic-on-ceramic hips: No evidence of contribution from the trunnion morse taper. Journal of Orthopaedic Research, 35(8), 1793-1798. doi: 10.1002/jor.23458

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404

Brown, G. C. J., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. F. (2017). Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels. Macromolecular Bioscience, 17(12), 1700158. doi: 10.1002/mabi.201700158

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2017). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication. Advance online publication. doi: 10.1088/1758-5090/aa9ef1

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

FitzPatrick, A. J., Rodgers, G. W., Hooper, G. J., & Woodfield, T. B. F. (2017). Development and validation of an acoustic emission device to measure wear in total hip replacements in-vitro and in-vivo. Biomedical Signal Processing & Control, 33, 281-288. doi: 10.1016/j.bspc.2016.12.011

Rodgers, G. W., Welsh, R., King, L. J., FitzPatrick, A. J., Woodfield, T. B. F., & Hooper, G. J. (2017). Signal processing and event detection of hip implant acoustic emissions. Control Engineering Practice, 58, 287-297. doi: 10.1016/j.conengprac.2016.09.013

Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2017). Modular tissue assembly strategies for biofabrication of engineered cartilage. Annals of Biomedical Engineering, 45(1), 100-114. doi: 10.1007/s10439-016-1609-3

Moroni, L., Boland, T., Burdick, J. A., De Maria, C., Derby, B., Forgacs, G., … Woodfield, T. B. F., … Vozzi, G. (2017). Biofabrication: A guide to technology and terminology. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2017.10.015

Chen, F., Hochleitner, G., Woodfield, T., Groll, J., Dalton, P. D., & Amsdem, B. G. (2016). Additive manufacturing of a photo-cross-linkable polymer via direct melt electrospinning writing for producing high strength structures. Biomacromolecules, 17(1), 208-214. doi: 10.1021/acs.biomac.5b01316

Schuurman, W., Harimulyo, E. B., Gawlitta, D., Woodfield, T. B. F., Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2016). Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics. Journal of Tissue Engineering & Regenerative Medicine, 10(4), 315-324. doi: 10.1002/term.1726

Groll, J., Boland, T., Blunk, T., Burdick, J. A., Cho, D.-W., Dalton, P. D., … Woodfield, T. B. F., … Malda, J. (2016). Biofabrication: Reappraising the definition of an evolving field [Perspective]. Biofabrication, 8(1), 013001. doi: 10.1088/1758-5090/8/1/013001

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2016). Return to work for severely injured survivors of the Christchurch earthquake: Influences in the first 2 years. Disability & Rehabilitation, 38(10), 987-993. doi: 10.3109/09638288.2015.1070299

Lim, K. S., Schon, B. S., Mekhileri, N. V., Brown, G. C. J., Chia, C. M., Prabakar, S., Hooper, G. J., & Woodfield, T. B. F. (2016). New visible-light photoinitiating system for improved print fidelity in gelatin-based bioinks. ACS Biomaterials Science & Engineering, 2, 1752-1762. doi: 10.1021/acsbiomaterials.6b00149

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2015). Participation and quality of life outcomes among individuals with earthquake-related physical disability: A systematic review. Journal of Rehabilitation Medicine, 47, 385-393. doi: 10.2340/16501977-1965

Selvarajah, E., Hooper, G., Grabowski, K., Frampton, C., Woodfield, T. B. F., & Inglis, G. (2015). The rates of wear of X3 highly cross-linked polyethylene at five years when coupled with a 36 mm diameter ceramic femoral head in young patients. Bone & Joint Journal, 97-B(11), 1470-1474. doi: 10.1302/0301-620x.97b11.35736

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002

Schrobback, K., Klein, T. J., & Woodfield, T. B. F. (2015). The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. Tissue Engineering Part A, 21(11-12), 1785-1794. doi: 10.1089/ten.tea.2014.0691

Walker, J., Shadanbaz, S., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). Magnesium biomaterials for orthopedic application: A review from a biological perspective. Journal of Biomedical Materials Research Part B, 102(6), 1316-1331. doi: 10.1002/jbm.b.33113

Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015

Shadanbaz, S., Walker, J., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). Monetite and brushite coated magnesium: In vivo and in vitro models for degradation analysis. Journal of Materials Science: Materials in Medicine, 25(1), 173-183. doi: 10.1007/s10856-013-5059-2

Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005

Walker, J., Shadanbaz, S., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). The in vitro and in vivo evaluation of the biocompatibility of Mg alloys. Biomedical Materials, 9, 015006. doi: 10.1088/1748-6041/9/1/015006

Schrobback, K., Wrobel, J., Hutmacher, D. W., Woodfield, T. B. F., & Klein, T. J. (2013). Stage-specific embryonic antigen-4 is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells. Tissue Engineering Part A, 19(11-12), 1316-1326. doi: 10.1089/ten.tea.2012.0496

Selvarajah, E., Hooper, G. J., Woodfield, T. B. F., Inglis, G., & Frampton, C. (2013). Measurement of early wear rates with X3 polyethylene and 36-mm femoral heads in young patients: A prospective study. Current Orthopaedic Practice, 24(6), 641-646. doi: 10.1097/BCO.0b013e31829cc4c9

Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., … Kuijer, R. (2013). Tissue-engineered constructs: The effect of scaffold architecture in osteochondral repair. Journal of Tissue Engineering & Regenerative Medicine, 7(9), 751-756. doi: 10.1002/term.1477

Waterman, J., Birbilis, N., Dias, G. J., Woodfield, T. B. F., & Staiger, M. P. (2012). Improving in vitro corrosion resistance of biomimetic calcium phosphate coatings for Mg substrates using calcium hydroxide layer. Corrosion Engineering, Science & Technology, 47(5), 340-345. doi: 10.1179/1743278212y.0000000018

Nguyen, T. L., Blanquet, A., Staiger, M. P., Dias, G. J., & Woodfield, T. B. F. (2012). On the role of surface roughness in the corrosion of pure magnesium in vitro. Journal of Biomedical Materials Research Part B, 100 B(5), 1310-1318.

Nguyen, T., Waterman, J., Staiger, M., & Woodfield, T. (2012). Controlling in vitro corrosion rate of pure Mg with rough surface texture via biomimetic coating systems. Corrosion Engineering, Science & Technology, 47(5), 358-364. doi: 10.1179/1743278212y.0000000023

Hooper, G. J., Maxwell, A. R., Wilkinson, B., Mathew, J., Woodfield, T. B. F., Penny, I. D., Burn, P. J., & Frampton, C. (2012). The early radiological results of the uncemented Oxford medial compartment knee replacement. Journal of Bone & Joint Surgery (Br), 94(3), 334-338. doi: 10.1302/0301-620X.94B3.27407

Schon, B. S., Schrobback, K., van der Ven, M., Stroebel, S., Hooper, G. J., & Woodfield, T. B. F. (2012). Validation of a high-throughput microtissue fabrication process for 3D assembly of tissue engineered cartilage constructs. Cell & Tissue Research, 347(3), 629-642. doi: 10.1007/s00441-011-1311-6

Murray, L. M., Nock, V., Alkaisi, M. M., Lee, J. J. M., & Woodfield, T. B. F. (2012). Fabrication of polymeric substrates with micro- and nanoscale topography bioimprinted at progressive cell morphologies. Journal of Vacuum Science & Technology B: Microelectronics & Nanometer Structures, 30(6), 06F902. doi: 10.1116/1.4758759

Walker, J., Shadanbaz, S., Kirkland, N. T., Stace, E., Woodfield, T., Staiger, M. P., & Dias, G. J. (2012). Magnesium alloys: Predicting in vivo corrosion with in vitro immersion testing. Journal of Biomedical Materials Research Part B, 100B(4), 1134-1141. doi: 10.1002/jbm.b.32680

Kirkland, N. T., Waterman, J., Birbilis, N., Dias, G., Woodfield, T. B. F., Hartshorn, R. M., & Staiger, M. P. (2012). Buffer-regulated biocorrosion of pure magnesium. Journal of Materials Science: Materials in Medicine, 23, 283-291. doi: 10.1007/s10856-011-4517-y

Nguyen, T. L., Staiger, M. P., Dias, G. J., & Woodfield, T. B. F. (2011). A novel manufacturing route for fabrication of topologically-ordered porous magnesium scaffolds. Advanced Engineering Materials, 13(9), 872-881. doi: 10.1002/adem.201100029

Kirkland, N. T., Kolbeinsson, I., Woodfield, T., Dias, G. J., & Staiger, M. P. (2011). Synthesis and properties of topologically ordered porous magnesium. Materials Science & Engineering: B, 176(20), 1666-1672. doi: 10.1016/j.mseb.2011.04.006

Waterman, J., Pietak, A., Birbilis, N., Woodfield, T., Dias, G., & Staiger, M. P. (2011). Corrosion resistance of biomimetic calcium phosphate coatings on magnesium due to varying pretreatment time. Materials Science & Engineering: B, 176(20), 1756-1760. doi: 10.1016/j.mseb.2011.06.021

Staiger, M. P., Kolbeinsson, I., Kirkland, N. T., Nguyen, T., Dias, G., & Woodfield, T. B. F. (2010). Synthesis of topologically-ordered open-cell porous magnesium. Materials Letters, 64(23), 2572-2574. doi: 10.1016/j.matlet.2010.08.049

Staiger, M. P., Kolbeinsson, I., Newman, J., Woodfield, T., & Sato, T. (2010). Orientation imaging microscopy of polycrystalline sodium chloride. Materials Characterization, 61(4), 413-419. doi: 10.1016/j.matchar.2010.01.007

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