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Tim WoodfieldResearch Associate Professor

Rutherford Discovery Fellow 2012-2017

BE(Hons)(Cant) MASc(Tor) PhD(Twente)

Email tim.woodfield@otago.ac.nz

Tel +64 3 378 6114
Fax +64 3 364 0909

@Tim_WoodfieldNZ

Associate Professor Woodfield leads the Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group which is associated with the University of Otago’s Department of Orthopaedic Surgery and its Centre for Bioengineering & Nanomedicine. The Department’s location at the Christchurch hospital campus helps him maintain strong connections with the city’s medical and surgical staff, and the Centre draws upon talent across several disciplines based out of the University’s Dunedin, Christchurch, and Wellington locations in New Zealand.

His CReaTE Group is pursuing stem cell and biomaterial-based strategies for musculoskeletal tissue regeneration, and is primarily investigating their application in the clinical translation of orthopaedic medical devices & cell-based therapies.

The Group’s research technology platform includes complex 3D Biofabrication and Additive Manufacturing of biomaterial scaffolds and medical devices applied to regenerative medicine of cartilage and bone, including: novel bio-ink/bio-resin development, advanced 3D tissue culture models, and high throughput screening.

Tim is a Principal Investigator within the New Zealand Medical Technology Centre of Research Excellence (CoRE), and he is an adjunct Associate Professor in the Institute of Health & Biomedical Innovation, Queensland University of Technology, in Australia, as well as for the Auckland Bioegineering Institute, in the University of Auckland, New Zealand.

He has published over 100 peer reviewed journal articles, book chapters and proceedings (h-index: 25), and has acted as coordinator of the recent European Commission ‘skelGEN’ consortia project.

He has attracted over NZ$23 million in competitive research funding as Principal or Named Investigator through grants from the Royal Society of New Zealand, MBIE, HRC, AO Foundation.
Tim holds a prestigious Rutherford Discovery Fellowship, awarded to him by the Royal Society of New Zealand.

He serves the International Society for Biofabrication (ISBF) as its Vice President and Executive Board Member, and is the former President of the Australasian Society for Biomaterials & Tissue Engineering (ASBTE). He also sits on the Asia Pacific Council for the Tissue Engineering and Regenerative Medicine International Society (TERMIS), and is an Editorial Board Member for Biofabrication, APL Bioengineering, and Frontiers in Bioengineering & Biotechnology.

Roles

  • Principal Investigator, Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group
  • Theme Leader, Regenerative Medicine – University of Otago Centre for Bioengineering & Nanomedicine
  • Adjunct Associate Professor, Institute of Health & Biomedical Innovation (IHBI), Queensland University of Technology, Brisbane, Australia
  • Adjunct Senior Fellow, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand
  • Principal Investigator, Centre of Research Excellence in Medical Technologies
  • Associate Investigator, MacDiarmid Institute for Advanced Materials & Nanotechnology
  • Associate Investigator, Maurice Wilkins Centre for Molecular Diversity

Professional affiliations

Professional interests

Orthopaedic Tissue Engineering and Regenerative Medicine

  • Stem cell and scaffold-based regeneration of cartilage and bone
  • Bio-fabrication and advanced scaffold design
  • Orthopaedic medical device development

Christchurch Regenerative Medicine and Tissue Engineering (CReATE) Group website
Regenerative Medicine website - Centre for Bioengineering & Nanomedicine

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Publications

Parrish, J., Lim, K., Zhang, B., Radisic, M., & Woodfield, T. B. F. (2019). New frontiers for biofabrication and bioreactor design in microphysiological system development. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2019.04.009

Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141

Lim, K. S., Baptista, M., Moon, S., Woodfield, T. B. F., & Rnjak-Kovacina, J. (2019). Microchannels in development, survival, and vascularisation of tissue analogues for regenerative medicine. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2019.04.004

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Page, M., Baer, K., Schon, B., Mekhileri, N., Woodfield, T., & Puttlitz, C. (2019). Biaxial mechanics of 3D fiber deposited ply-laminate scaffolds for soft tissue engineering part I: Experimental evaluation. Journal of the Mechanical Behavior of Biomedical Materials. Advance online publication. doi: 10.1016/j.jmbbm.2019.06.029

Chapter in Book - Research

Atienza Roca, P., Cui, X., Hooper, G. J., Woodfield, T. B. F., Lim, K. S., & Khang, G. (2018). Growth factor delivery systems for tissue engineering and regenerative medicine. In H. J. Chun, C. H. Park & I. K. Kwon (Eds.), Advances in experimental medicine and biology: (Vol. 1078) Cutting-edge enabling technologies for regenerative medicine. (pp. 245-269). Singapore: Springer. doi: 10.1007/978-981-13-0950-2_13

Woodfield, T., Lim, K., Morouço, P., Levato, R., Malda, J., & Melchels, F. (2017). Biofabrication in tissue engineering. In P. Ducheyne, D. W. Grainger, K. E. Healy, D. W. Hutmacher & C. J. Kirkpatrick (Eds.), Comprehensive biomaterials II: (Vol. 5) Tissue Engineering and regenerative medicine: Fundamentals. (2nd ed.) (pp. 236-266). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-803581-8.10221-8

Hutmacher, D. W., Woodfield, T. B. F., & Dalton, P. D. (2015). Scaffold design and fabrication. In C. A. van Blitterswijk & J. de Boer (Eds.), Tissue engineering. (2nd ed.) (pp. 311-346). London, UK: Academic Press. doi: 10.1016/B978-0-12-420145-3.00010-9

Melchels, F., Malda, J., Fedorovich, N., Alblas, J., & Woodfield, T. (2011). Organ printing. In P. Ducheyne, K. E. Healy, D. W. Hutmacher, D. W. Grainger & C. J. Kirkpatrick (Eds.), Comprehensive biomaterials (vol. 5). (pp. 587-606). Elsevier Science.

Hutmacher, D., Woodfield, T., Dalton, P., & Lewis, J. (2008). Scaffold design and fabrication. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 403-454). London, UK: Academic Press.

Malda, J., Radisic, M., Levenberg, S., Woodfield, T., Bomens, C., Baaijens, F., … Vunjak-Novakovic, G. (2008). Cell nutrition. In C. van Blitterswijk (Ed.), Tissue engineering. (pp. 327-362). London, UK: Academic Press.

Habibovic, P., Woodfield, T., de Groot, K., & van Blitterswijk, C. (2006). Predictive value of in vitro and in vivo assays in bone and cartilage repair: What do they really tell us about the clinical performance? In J. P. Fisher (Ed.), Advances in experimental medicine & biology: (Vol. 5) Tissue engineering. (pp. 327-360). New York: Springer. doi: 10.1007/978-0-387-34133-0_22

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Journal - Research Article

Parrish, J., Lim, K., Zhang, B., Radisic, M., & Woodfield, T. B. F. (2019). New frontiers for biofabrication and bioreactor design in microphysiological system development. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2019.04.009

Page, M., Baer, K., Schon, B., Mekhileri, N., Woodfield, T., & Puttlitz, C. (2019). Biaxial mechanics of 3D fiber deposited ply-laminate scaffolds for soft tissue engineering part I: Experimental evaluation. Journal of the Mechanical Behavior of Biomedical Materials. Advance online publication. doi: 10.1016/j.jmbbm.2019.06.029

Lim, K. S., Klotz, B. J., Lindberg, G. C. J., Melchels, F. P. W., Hooper, G. J., Malda, J., … Woodfield, T. B. F. (2019). Visible light cross-linking of gelatin hydrogels offers an enhanced cell microenvironment with improved light penetration depth. Macromolecular Bioscience, 19(6), 1900098. doi: 10.1002/mabi.201900098

Lim, K. S., Baptista, M., Moon, S., Woodfield, T. B. F., & Rnjak-Kovacina, J. (2019). Microchannels in development, survival, and vascularisation of tissue analogues for regenerative medicine. Trends in Biotechnology. Advance online publication. doi: 10.1016/j.tibtech.2019.04.004

Mutreja, I., Warring, S. L., Lim, K. S., Swadi, T., Clinch, K., Mason, J. M., … Chambers, S. T., … Gerth, M. L., … Woodfield, T. B. F. (2019). Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. ACS Biomaterials Science & Engineering, 5(2), 748-758. doi: 10.1021/acsbiomaterials.8b01141

Klotz, B. J., Oosterhoff, L. A., Utomo, L., Lim, K. S., Vallmajo-Martin, Q., Clevers, H., Woodfield, T. B. F., … Gawlitta, D. (2019). A versatile biosynthetic hydrogel platform for engineering of tissue analogues. Advanced Healthcare Materials. Advance online publication. doi: 10.1002/adhm.201900979

Cidonio, G., Alcala-Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y.-H., … Woodfield, T. B. F., & Oreffo, R. O. C. (2019). Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks. Biofabrication, 11, 035027. doi: 10.1088/1758-5090/ab19fd

Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2019). Intact vitreous humor as a potential extracellular matrix hydrogel for cartilage tissue engineering applications. Acta Biomaterialia, 85, 117-130. doi: 10.1016/j.actbio.2018.12.022

Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020

Mekhileri, N. V., Lim, K. S., Brown, G. C. J., Mutreja, I., Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2018). Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. Biofabrication, 10(2). doi: 10.1088/1758-5090/aa9ef1

Klotz, B. J., Lim, K. S., Chang, Y. X., Soliman, B. G., Pennings, I., Melchels, F. P. W., Woodfield, T. B. F., … Gawlitta, D. (2018). Engineers of a complex bone tissue model with endothelialised channels and capillary-like networks. European Cells & Materials, 35, 335-349. doi: 10.22203/eCM.v035a23

Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018). A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models. Lab on a Chip, (18), 2757-2775. doi: 10.1039/c8lc00485d

Lim, K. S., Levato, R., Costa, P. F., Castilho, M. D., Alcala-Orozco, C. R., van Dorenmalen, K. M. A., … Hooper, G. J., … Woodfield, T. B. F. (2018). Bio-resin for high resolution lithography-based biofabrication of complex cell laden constructs. Biofabrication, 10, 034101. doi: 10.1088/1758-5090/aac00c

Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467

Parker, J. D., Lim, K. S., Kieser, D. C., Woodfield, T. B. F., & Hooper, G. J. (2018). Is tranexamic acid toxic to articular cartilage when administered topically? What is the safe dose? Bone & Joint Journal, 100-B(3), 404-412. doi: 10.1302/0301-620X.100B3.BJJ-2017-1135.R1

Moroni, L., Boland, T., Burdick, J. A., De Maria, C., Derby, B., Forgacs, G., … Woodfield, T. B. F., … Vozzi, G. (2018). Biofabrication: A guide to technology and terminology. Trends in Biotechnology, 36(4), 384-402. doi: 10.1016/j.tibtech.2017.10.015

Bertlein, S., Brown, G., Lim, K. S., Jungst, T., Boeck, T., Blunk, T., … Hooper, G. J., Woodfield, T. B. F., & Groll, J. (2017). Thiol-ene clickable gelatin: A platform bioink for multiple 3D biofabrication technologies. Advanced Materials, 29(44), 1703404. doi: 10.1002/adma.201703404

Roffe, L., FitzPatrick, A. J., Rodgers, G. W., Woodfield, T. B. F., & Hooper, G. J. (2017). Squeaking in ceramic-on-ceramic hips: No evidence of contribution from the trunnion morse taper. Journal of Orthopaedic Research, 35(8), 1793-1798. doi: 10.1002/jor.23458

Brown, G. C. J., Lim, K. S., Farrugia, B. L., Hooper, G. J., & Woodfield, T. B. F. (2017). Covalent incorporation of heparin improves chondrogenesis in photocurable gelatin-methacryloyl hydrogels. Macromolecular Bioscience, 17(12), 1700158. doi: 10.1002/mabi.201700158

FitzPatrick, A. J., Rodgers, G. W., Hooper, G. J., & Woodfield, T. B. F. (2017). Development and validation of an acoustic emission device to measure wear in total hip replacements in-vitro and in-vivo. Biomedical Signal Processing & Control, 33, 281-288. doi: 10.1016/j.bspc.2016.12.011

Rodgers, G. W., Welsh, R., King, L. J., FitzPatrick, A. J., Woodfield, T. B. F., & Hooper, G. J. (2017). Signal processing and event detection of hip implant acoustic emissions. Control Engineering Practice, 58, 287-297. doi: 10.1016/j.conengprac.2016.09.013

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

Schon, B. S., Hooper, G. J., & Woodfield, T. B. F. (2017). Modular tissue assembly strategies for biofabrication of engineered cartilage. Annals of Biomedical Engineering, 45(1), 100-114. doi: 10.1007/s10439-016-1609-3

Chen, F., Hochleitner, G., Woodfield, T., Groll, J., Dalton, P. D., & Amsdem, B. G. (2016). Additive manufacturing of a photo-cross-linkable polymer via direct melt electrospinning writing for producing high strength structures. Biomacromolecules, 17(1), 208-214. doi: 10.1021/acs.biomac.5b01316

Schuurman, W., Harimulyo, E. B., Gawlitta, D., Woodfield, T. B. F., Dhert, W. J. A., van Weeren, P. R., & Malda, J. (2016). Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics. Journal of Tissue Engineering & Regenerative Medicine, 10(4), 315-324. doi: 10.1002/term.1726

Groll, J., Boland, T., Blunk, T., Burdick, J. A., Cho, D.-W., Dalton, P. D., … Woodfield, T. B. F., … Malda, J. (2016). Biofabrication: Reappraising the definition of an evolving field [Perspective]. Biofabrication, 8(1), 013001. doi: 10.1088/1758-5090/8/1/013001

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2016). Return to work for severely injured survivors of the Christchurch earthquake: Influences in the first 2 years. Disability & Rehabilitation, 38(10), 987-993. doi: 10.3109/09638288.2015.1070299

Lim, K. S., Schon, B. S., Mekhileri, N. V., Brown, G. C. J., Chia, C. M., Prabakar, S., Hooper, G. J., & Woodfield, T. B. F. (2016). New visible-light photoinitiating system for improved print fidelity in gelatin-based bioinks. ACS Biomaterials Science & Engineering, 2, 1752-1762. doi: 10.1021/acsbiomaterials.6b00149

Nunnerley, J., Dunn, J., McPherson, K., Hooper, G., & Woodfield, T. (2015). Participation and quality of life outcomes among individuals with earthquake-related physical disability: A systematic review. Journal of Rehabilitation Medicine, 47, 385-393. doi: 10.2340/16501977-1965

Selvarajah, E., Hooper, G., Grabowski, K., Frampton, C., Woodfield, T. B. F., & Inglis, G. (2015). The rates of wear of X3 highly cross-linked polyethylene at five years when coupled with a 36 mm diameter ceramic femoral head in young patients. Bone & Joint Journal, 97-B(11), 1470-1474. doi: 10.1302/0301-620x.97b11.35736

Mutreja, I., Woodfield, T. B. F., Sperling, S., Nock, V., Evans, J. J., & Alkaisi, M. M. (2015). Positive and negative bioimprinted polymeric substrates: New platforms for cell culture. Biofabrication, 7, 025002. doi: 10.1088/1758-5090/7/2/025002

Schrobback, K., Klein, T. J., & Woodfield, T. B. F. (2015). The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. Tissue Engineering Part A, 21(11-12), 1785-1794. doi: 10.1089/ten.tea.2014.0691

Walker, J., Shadanbaz, S., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). Magnesium biomaterials for orthopedic application: A review from a biological perspective. Journal of Biomedical Materials Research Part B, 102(6), 1316-1331. doi: 10.1002/jbm.b.33113

Shadanbaz, S., Walker, J., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). Monetite and brushite coated magnesium: In vivo and in vitro models for degradation analysis. Journal of Materials Science: Materials in Medicine, 25(1), 173-183. doi: 10.1007/s10856-013-5059-2

Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015

Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005

Walker, J., Shadanbaz, S., Woodfield, T. B. F., Staiger, M. P., & Dias, G. J. (2014). The in vitro and in vivo evaluation of the biocompatibility of Mg alloys. Biomedical Materials, 9, 015006. doi: 10.1088/1748-6041/9/1/015006

Schrobback, K., Wrobel, J., Hutmacher, D. W., Woodfield, T. B. F., & Klein, T. J. (2013). Stage-specific embryonic antigen-4 is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells. Tissue Engineering Part A, 19(11-12), 1316-1326. doi: 10.1089/ten.tea.2012.0496

Selvarajah, E., Hooper, G. J., Woodfield, T. B. F., Inglis, G., & Frampton, C. (2013). Measurement of early wear rates with X3 polyethylene and 36-mm femoral heads in young patients: A prospective study. Current Orthopaedic Practice, 24(6), 641-646. doi: 10.1097/BCO.0b013e31829cc4c9

Emans, P. J., Jansen, E. J. P., van Iersel, D., Welting, T. J. M., Woodfield, T. B. F., Bulstra, S. K., … Kuijer, R. (2013). Tissue-engineered constructs: The effect of scaffold architecture in osteochondral repair. Journal of Tissue Engineering & Regenerative Medicine, 7(9), 751-756. doi: 10.1002/term.1477

Waterman, J., Birbilis, N., Dias, G. J., Woodfield, T. B. F., & Staiger, M. P. (2012). Improving in vitro corrosion resistance of biomimetic calcium phosphate coatings for Mg substrates using calcium hydroxide layer. Corrosion Engineering, Science & Technology, 47(5), 340-345. doi: 10.1179/1743278212y.0000000018

Nguyen, T., Waterman, J., Staiger, M., & Woodfield, T. (2012). Controlling in vitro corrosion rate of pure Mg with rough surface texture via biomimetic coating systems. Corrosion Engineering, Science & Technology, 47(5), 358-364. doi: 10.1179/1743278212y.0000000023

Nguyen, T. L., Blanquet, A., Staiger, M. P., Dias, G. J., & Woodfield, T. B. F. (2012). On the role of surface roughness in the corrosion of pure magnesium in vitro. Journal of Biomedical Materials Research Part B, 100 B(5), 1310-1318.

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