Dr Nick Magon

2025

Journal - Research Article

Peskin, A. V., Magon, N. J., & Bozonet, S. M. (2025). High-dose vitamin C blocks HOCl production by myeloperoxidase: A potential therapeutic strategy. Biochemical & Biophysical Research Communications, 776, 152213. doi: 10.1016/j.bbrc.2025.152213

Brook, E. M., Helem, S. J., McDonald, C. C. M., Magon, N. J., Selwood, A. I., Harwood, D. T., … Hampton, M. B., & Dachs, G. U. (2025). Portimine A maintains bioactivity following exposure to liver microsomes and cell lysates: No evidence for significant metabolic inactivation. Medical Oncology, 42, 278. doi: 10.1007/s12032-025-02826-x

King-Hudson, T.-R. J., Pearson, A. G., Dunstan-Harrison, C., Powell, M. T., Magon, N. J., Edwards, T. S., Paton, L. N., … Kettle, A. J., Pearson, J. F., Kokaua, J., … Theodore, R., Ramrakha, S., Poulton, R., Moffitt, T. E., Ledgerwood, E. C., & Hampton, M. B. (2025). Biomarkers of oxidative and mitochondrial stress are associated with accelerated pace of aging at midlife in a birth cohort. Journals of Gerontology Series A, 80(7), glaf105. doi: 10.1093/gerona/glaf105

Peskin, A. V., Meotti, F. C., Magon, N. J., de Souza, L. F., Salvador, A., & Winterbourn, C. C. (2025). Mechanism of glutathionylation of the active site thiols of peroxiredoxin 2. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2025.108503

Smith-Díaz, C. C., Kumar, A., Das, A., Pace, P., Chitcholtan, K., Magon, N. J., Hossain, S. M., Eccles, M. R., Winterbourn, C. C., & Paumann-Page, M. (2025). Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma. Free Radical Biology & Medicine, 229, 427-440. doi: 10.1016/j.freeradbiomed.2025.01.007

Conference Contribution - Published proceedings: Abstract

Hitchman, L. M., Magon, N. J., Miller, A. L., Sheen, C. R., Dunn, E., Bozonet, S. M., Pearson, J. F., … Faatoese, A., Merriman, T. R., Kettle, A. J., & Kennedy, M. A. (2025). CYP2D6*71 is a poor metaboliser allele common in Polynesian and Māori people and absent from Europeans. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2024

Journal - Research Article

Heath, S. G., Naughton, J. D., Magon, N. J., Gray, S. G., Smith, B. R., Morris, V. K., & Göbl, C. (2024). Characterizing the amyloid core region of the tumor suppressor protein p16^INK4a using a limited proteolysis and peptide-based approach. Journal of Biological Chemistry, 300(8), 107590. doi: 10.1016/j.jbc.2024.107590

Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Naughton, J. D., … Göbl, C. (2024). Amyloid formation and depolymerization of tumor suppressor p16^INK4a are regulated by a thiol-dependent redox mechanism. Nature Communications, 15(1), 5535. doi: 10.1038/s41467-024-49581-7

Topham, B., de Vries, M., Nonis, M., van Berkel, R., Pullar, J. M., Magon, N. J., Vissers, M. C. M., Currie, M. J., Robinson, B. A., Gibbs, D., Ang, A., & Dachs, G. U. (2024). Blood vitamin C levels of patients receiving immunotherapy and relationship to monocyte subtype and epigenetic modification. Epigenomes, 8, 17. doi: 10.3390/epigenomes8020017

Conference Contribution - Verbal presentation and other Conference outputs

Dickerhof, N., Ashby, L. V., Magon, N. J., Dilly, J. J., Ford, D., Payne, R. J., … Kettle, A. J. (2024, November). Myeloperoxidase has a previously unrecognized dioxygenase activity. Verbal presentation at the 32nd Meeting of The Society for Redox Research Australasia (SFRRA) and 11th Joint Meeting with The Society for Free Radical Research Japan (SFRRJ), Canberra, Australia.

Ashby, L., Flannery, M., McKenzie, J., Magon, N., & Kettle, A. (2024, November). Fluorescent probes as markers of oxidative chemistry inside neutrophil phagosomes. Verbal presentation at the 32nd Meeting of The Society for Redox Research Australasia (SFRRA) and 11th Joint Meeting with The Society for Free Radical Research Japan (SFRRJ), Canberra, Australia.

Borichevsky, G. M., Magon, N. J., Tillett, Z., Allison, T. M., Ashby, L. V., Dobson, R. C. J., & Kettle, A. J. (2024, November). Calprotectin exhibits unique reactivity with chloramines. Verbal presentation at the 32nd Meeting of The Society for Redox Research Australasia (SFRRA) and 11th Joint Meeting with The Society for Free Radical Research Japan (SFRRJ), Canberra, Australia.

Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Schwartfeger, A. J., … Göbl, C., & Morris, V. K. (2024, September). Redox-controlled amyloid formation and disassembly of the tumour suppressor protein p16. Verbal presentation at the 34th Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.

Magon, N. (2024, November). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens [Papers of the year]. Verbal presentation at the Society for Redox Biology & Medicine (SfRBM) Conference, Savannah, USA.

2023

Journal - Research Article

Paumann-Page, M., Ashby, L. V., Khalilova, I., Magon, N. J., Hofbauer, S., Paton, L. N., … Kettle, A. J. (2023). Hypochlorous acid inactivates myeloperoxidase inside phagocytosing neutrophils. Redox Biochemistry & Chemistry, 5-6, 100008. doi: 10.1016/j.rbc.2023.100008

Major, G., Longoni, A., Simcock, J., Magon, N. J., Harte, J., Bathish, B., Kemp, R., Woodfield, T., & Lim, K. S. (2023). Clinical applicability of visible light-mediated cross-linking for structural soft tissue reconstruction. Advanced Science, 10, 2300538. doi: 10.1002/advs.202300538

Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 299(6), 104792. doi: 10.1016/j.jbc.2023.104792

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Redox Biochemistry & Chemistry, 1-2, 100002. doi: 10.1016/j.rbc.2023.100002

Conference Contribution - Published proceedings: Abstract

Smith-Diaz, C., Magon, N. J., McKenzie, J. L., Hore, T., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2023). Transcriptomics and epigenomics analysis of SKM-1 leukaemia response to Vitamin C. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Schwartfeger, A., Bozonet, S. M., Magon, N. J., Göbl, C., Morris, V. K., & Hampton, M. B. (2023). Oxidation triggered amyloid assembly of the cell death regulator caspase-8. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

2022

Journal - Research Article

Crake, R. L. I., Burgess, E. R., Wiggins, G. A. R., Magon, N. J., Das, A. B., Vissers, M. C. M., Morrin, H. R., Royds, J. A., Slatter, T. L., Robinson, B. A., Phillips, E., & Dachs, G. U. (2022). Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine. Scientific Reports, 12, 14845. doi: 10.1038/s41598-022-19032-8

Smyth, L. C. D., Murray, H. C., Hill, M., van Leeuwen, E., Highet, B., Magon, N. J., … Mathiesen, S. N., Mockett, B., … Clarkson, A. N., … Abraham, W. C., Hughes, S. M., … Kettle, A. J., … Hampton, M. B. (2022). Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease. Acta Neuropathologica Communications, 10, 38. doi: 10.1186/s40478-022-01347-2

Edwards, T. S., Dickerhof, N., Magon, N. J., Paton, L. N., Sly, P. D., & Kettle, A. J. (2022). Formation of calprotectin-derived peptides in the airways of children with cystic fibrosis. Journal of Immunology, 208, 979-990. doi: 10.4049/jimmunol.2001017

Conference Contribution - Verbal presentation and other Conference outputs

Morris, V. K., Heath, S. G., O'Connor, K. M., Bozonnet, S., Gray, S. G., Naughton, J. D., Magon, N. J., Smith, B. R., Botha, A. D., … Göbl, C. (2022, August). The tumour suppressor protein p16 forms amyloid structures. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukemia. Frontiers in Oncology, 11, 709543. doi: 10.3389/fonc.2021.709543

Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., … Eccles, M. R., & Winterbourn, C. C. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology, 46, 102090. doi: 10.1016/j.redox.2021.102090

Conference Contribution - Published proceedings: Abstract

Smith-Díaz, C. C., Magon, N. J., McKenzie, J. L., Hampton, M. B., Vissers, M. C. M., & Das, A. B. (2021). Ascorbate inhibits proliferation and promotes myeloid differentiation in TP53-mutant leukaemia. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 183). Retrieved from https://www.faobmb2021.org

Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org

2020

Chapter in Book - Research

Magon, N. J., Parker, H. A., Ashby, L. V., Springer, R. J., & Hampton, M. B. (2020). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil: Methods and protocols: Methods in molecular biology (Vol. 2087). (3rd ed.) (pp. 149-164). New York, NY: Humana Press. doi: 10.1007/978-1-0716-0154-9_12

Journal - Research Article

Meng, Y., Sheen, C. R., Magon, N. J., Hampton, M. B., & Dobson, R. C. J. (2020). Structure-function analyses of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture. Journal of Biological Chemistry, 295(10), 2984-2999. doi: 10.1074/jbc.RA119.012226

Conference Contribution - Verbal presentation and other Conference outputs

Magon, N. (2020, December). Caspase inhibition by hypothiocyanous acid switches TNF-mediated cell death from apoptosis to necroptosis. Verbal presentation at the Society for Redox Research Australasia (SFRRA) Meeting, [Online].

2015

Journal - Research Article

Magon, N. J., Turner, R., Gearry, R. B., Hampton, M. B., Sly, P. D., & Kettle, A. J. (2015). Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis. Free Radical Biology & Medicine, 86, 133-144. doi: 10.1016/j.freeradbiomed.2015.05.022

Wilkie-Grantham, R. P., Magon, N. J., Harwood, D. T., Kettle, A. J., Vissers, M. C., Winterbourn, C. C., & Hampton, M. B. (2015). Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils. Journal of Biological Chemistry, 290(15), 9896-9905. doi: 10.1074/jbc.M114.613422

2014

Chapter in Book - Research

Parker, H. A., Magon, N. J., Green, J. N., Hampton, M. B., & Winterbourn, C. C. (2014). Analysis of neutrophil bactericidal activity. In M. T. Quinn & F. R. DeLeo (Eds.), Neutrophil methods and protocols: Methods in Molecular Biology (Vol. 1124). (2nd ed.) (pp. 291-306). New York, NY: Springer. doi: 10.1007/978-1-62703-845-4_19

Journal - Research Article

Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014). Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependant oxidation of epicatechins. Biochemical Journal, 462(2), 303-314. doi: 10.1042/BJ20140612

2013

Conference Contribution - Published proceedings: Abstract

Magon, N. J., Turner, R., Dickerhof, N., Gearry, R., Hampton, M., Sly, P., & Kettle, A. (2013). Oxidation of methionine in calprotectin by neutrophils in the airways of children with cystic fibrosis. Free Radical Biology & Medicine, 65(Suppl. 2), (pp. S62-S63). doi: 10.1016/j.freeradbiomed.2013.10.535

Conference Contribution - Poster Presentation (not in published proceedings)

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2013, August). Oxidised calprotectin as a biomarker for inflammatory disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Conference Contribution - Published proceedings: Abstract

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2012). Oxidised calprotectin as a biomarker for inflammatory disease. Proceedings of the Oxygen Theme Meeting. (pp. 8). Dunedin, New Zealand: University of Otago. Retrieved from https://www.otago.ac.nz/research/otago051864.pdf

2011

Journal - Research Article

Tidén, A.-K., Sjögren, T., Svensson, M., Bernlind, A., Senthilmohan, R., Auchère, F., … Forbes, L. V., Magon, N. J., Paton, L. N., Jameson, G. N. L., … Kettle, A. J. (2011). 2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation. Journal of Biological Chemistry, 286(43), 37578-37589. doi: 10.1074/jbc.M111.266981

2010

Conference Contribution - Published proceedings: Abstract

Magon, N. J., Gearry, R. B., Hampton, M. B., & Kettle, A. J. (2010). Oxidised calprotectin as a biomarker for inflammatory disease. Free Radical Biology and Medicine. 49(Suppl. 1), (pp. S169). doi: 10.1016/j.freeradbiomed.2010.10.479