Associate Professor Margaret Currie, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Principal Investigator

Associate Dean (Postgraduate Studies)

MSc(Hons)(Cant), PhD(Auck)

Email margaret.currie@otago.ac.nz
Tel +64 3 364 0544

Research interests

Associate Professor Margaret Currie is interested in how the tumour microenvironment affects tumour growth, tumour cell metastasis and tumour response to therapy.

The local tumour microenvironment is the milieu within which the tumour develops, and includes tumour blood vessels, other cells types (e.g. immune cells, fibroblasts, adipocytes), soluble growth factors and signalling molecules. All the various components of the tumour microenvironment can influence tumour growth and spread and, conversely, tumour cells can influence the local tumour microenvironment.

A further layer of complexity exists because the wider tumour microenvironment (i.e. the body within which the tumour develops) alters with age and health, and is affected by systemic changes in metabolism, hormones and immunity.

The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. Initially, their research focused on tumour blood vessel development and anti-angiogenic therapies. However, since 2009 Associate Professor Currie's interests have expanded to include the contribution to tumour progression made by tumour infiltrating immune cell populations, breast cancer stem cell-like populations, and obesity-related factors.

Current projects

Adipocytes in tumour stroma

In various human cancers, obesity is linked to invasive tumours that are resistant to therapy and have poor outcome. We are culturing human fat cells (adipocytes) and tumour cells together, to find out how adipocytes alter tumour cell phenotype and response to therapy. We are also studying tumour samples from normal weight and obese breast cancer patients to better understand the role adipocytes play in promoting aggressive tumour growth and spread, and identify patients likely to benefit from additional treatment during cancer therapy.

Circulating immune cell populations and tumour infiltrating immune cells in human cancers

Cutaneous squamous cell carcinomas (cSCC) are common in NZ, and most are simply treated. However, a small proportion (~5%) of these skin cancers grow aggressively, spread to other organs, and cause death. In patients who have had an organ transplant, we have identified blood vessel and immune characteristics that are correlated to cSCC aggressiveness. We are currently investigating whether these characteristics also account for the aggressiveness of cSCCs in non-transplant patients. A greater understanding of the biology of these tumours may help clinicians identify at-risk patients who could benefit from additional treatment and close surveillance. In addition, the specific immune and blood vessel factors identified are potential targets for developing novel cancer treatments.

Student: Jessika Wise
Degree: PhD (in progress)
Thesis title: 3D breast tumour models for drug discovery
Supervisors: PE Phillips, K Lim, T Woodfield, M Currie

Student: Ifran Yunianto
Degree: PhD (in progress)
Thesis title: The role of inflammation in ovarian cancer
Supervisors: P Sykes, K Chitcholtan, M Currie

Student: Ben Topham
Degree: BBiomedSc(Hons) (in progress)
Thesis title: Investigating the Relationship Between Ascorbate and the Differentiation of Monocytes in an In-Vitro Melanoma Model
Supervisors: M Currie

2021

Student: Dr Annika Seddon
Degree: PhD
Thesis title: Neutrophils and cancer: regulation of cell death and epigenetic pathways
Supervisors: M Hampton, A Stevens, M Currie, A Kettle

2020

Student: Dr Linda Buss
Degree: PhD
Thesis title: The immune system: A common link mediating exercise effects on the tumour microenvironment and skeletal muscle mitochondria?
Supervisors: G Dachs, M Currie, B Hock, A Ang, B Robinson

Student: Rebekah Crake
Degree: PhD
Thesis title: Local and systemic effects of adipocyte-secreted factors in breast cancer
Supervisors: M Currie, E Phillips, M Strother, B Robinson

2017

Student: Dr Vanessa Lattimore
Degree: PhD
Thesis title: Evaluating BRCA1 and BRCA2 sequence variants that modulate isoform expression
Supervisors: L Walker, M Currie, B Robinson

2015

Student: Dr Anthony Rahman
Degree: PhD
Thesis title: Venous Thromboembolism (VTE) in cancer patients commencing chemotherapy
Supervisors: B Robinson, M Smith, M Currie, S Gunningham

2013

Student: Caroline Kuiper
Degree: PhD
Thesis title: The role of ascorbate in the regulation of HIF-1 in cancer cells
Supervisors: M Vissers, G Dachs, M Currie

2011

Student: Ekaterina Volkova
Degree: PhD
Thesis title: Obesity and colorectal cancer
Supervisors: M Currie, G Dachs, J Willis, B Robinson

2010

Student: Michelle Hunt
Degree: PhD
Thesis title: Vessel directed enzyme prodrug therapy for cancer
Supervisors: G Dachs, M Currie, A Patterson, B Robinson

Student: Kasia Mackenzie
Degree: PhD
Thesis title: Why are skin cancers more aggressive in renal transplant recipients?
Supervisors: M Currie, B Hock, J Simcock, B Robinson, J Roake

2007

Student: Sarah Gunningham
Degree: PhD
Thesis title: The role of VEGF faminly in breast and colorectal cancer
Supervisors: M Currie, V Cameron, B Robinson, S Fox

Student: So Young Moon
Degree: PhD
Thesis title: Identification of genetic aberrations in chronic lymphocytic leukaemia using array CGH
Supervisors: C Morris, P Ganly, M Currie

2017

Student: Leah Butt
Degree: BBiomedSc(Hons)
Thesis title: Measuring markers of immune response in patients treated with Nivolumab (Opdivo) or Pembrolizumab (Keytruda)
Supervisors: M Currie, B Hock, M Strother

2015

Student: Morgan Jones
Degree: BBiomedSc(Hons)
Thesis title: Does fat provide energy for breast cancer cell invasion and metastasis?
Supervisors: M Currie, E Phillips

Student: Rebekah Crake
Degree: BBiomedSc(Hons)
Thesis title: Obesity and breast cancer development
Supervisors: L Walker, M Currie, E Phillips

Student: Anishah Mandani
Degree: BBiomedSc(Hons)
Thesis title: Development of a breast cancer ApoE/ArKO mouse model
Supervisors: G Dachs, M Currie

2013

Student: Annika Seddon
Degree: BBiomedSc(Hons)
Thesis title: Immune Suppression and Squamous Cell Carcinoma Tumour Biology
Supervisors: M Currie, B Hock

2010

Student: Anna Van Pomeren
Degree: BBiomedSc(Hons)
Thesis title: Myeloid-derived suppressor cells and tumour angiogenesis
Supervisors: M Currie, B Hock

2020

Student: Mohini Puri
Degree: MMedSc
Thesis title: Role of cancer associated adipocytes (CAA) and tumour associated collagen structures (TACS) in breast cancer cell invasion and metastasis
Supervisors: M Currie, E Phillips

2014

Student: Lisa Brennan
Degree: MSc (Massey University)
Thesis title: Biomarkers as predictors of six month survival outcomes of patients presenting with solid tumours
Supervisors: M Currie, A Rahman, B Robinson, C Kendrick

2007

Student:Maiko Kano
Degree: BMedSc
Thesis title: Biology of cancer in Maori
Supervisors: G Dachs, M Currie, B Robinson

Funding

The Mackenzie Charitable Foundation
Cancer Society of New Zealand (& CSNZ Canterbury-West Coast Division)
University of Otago Christchurch Cancer Fellowship
New Zealand Breast Cancer Foundation
University of Otago

Selected Recent Publications

Seddon AR, Hock BD, Miller AP, Frei LP, Pearson JF, McKenzie JL, Simcock JW, Currie MJ. Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Advanced ePub. Journal of Dermatological Science (2016), DOI 10.1016/j.jdermsci.2016.04.013.
Slatter TL, Royds JA, Pilbrow AP, Ahn A, Morrin H, Frampton C, Russell A, Moravec CS, Sweet WE, Tang WH, Currie MJ, Hung NA. The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4A expression. Frontiers in Oncology; 5, 306, 2015. (Times cited=0).
BD Hock, JL McKenzie, NB Cross, MJ Currie. Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology; 32(3), 164-171. June 2015 (IF 1.8). (Times cited=0).
Richardson AK, Currie MJ, Robinson BA, Morrin H, Phung Y, Pearson JF, Anderson TP, Potter JD, Walker LC. Cytomegalovirus and Epstein-Barr virus in breast cancer. PLoS One. 2015, Feb 27; 10(2):e0118989. (IF 3.5). (Times cited=1).

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Publications

Rajesh, A., Saito, M., Morrin, H., Tschirley, A., Simcock, J., Currie, M., & Hibma, M. (2022). Characterisation of the immune microenvironment of cutaneous squamous cell carcinoma in immunosuppression. Experimental Dermatology. Advance online publication. doi: 10.1111/exd.14650

Allan, J., Buss, L. A., Draper, N., & Currie, M. J. (2022). Exercise in people with cancer: A spotlight on energy regulation and cachexia. Frontiers in Physiology, 13, 836804. doi: 10.3389/fphys.2022.836804

Buss, L. A., Hock, B., Merry, T. L., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer. PLoS ONE, 16(10), e0258831. doi: 10.1371/journal.pone.0258831

Buss, L. A., Williams, T., Hock, B., Ang, A. D., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2021). Effects of exercise and anti-PD-1 on the tumour microenvironment. Immunology Letters, 239, 60-71. doi: 10.1016/j.imlet.2021.08.005

Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765

Journal - Research Article

Ang, A. D., Vissers, M. C. M., Burgess, E. R., Currie, M. J., & Dachs, G. U. (2021). Gene and protein expression is altered by ascorbate availability in murine macrophages cultured under tumour-like conditions. Antioxidants, 10(3), 430. doi: 10.3390/antiox10030430

Journal - Research Article

Crake, R. L. I., Strother, M. R., Phillips, E., Doogue, M. P., Zhang, M., Frampton, C. M. A., Robinson, B. A., & Currie, M. J. (2021). Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: A patient feasibility study. Scientific Reports, 11(1), 5648. doi: 10.1038/s41598-021-85048-1

Journal - Research Article

Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202

Journal - Research Article

Buss, L. A., Ang, A. D., Hock, B., Robinson, B. A., Currie, M. J., & Dachs, G. U. (2020). Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice. PLoS ONE, 15(3), e0229290. doi: 10.1371/journal.pone.0229290

Journal - Research Article

Hock, B. D., McKenzie, J. L., Strother, M., Goddard, L., Butt, L., & Currie, M. J. (2020). Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies. Cancer Immunology, Immunotherapy, 69(12), 2453-2464. doi: 10.1007/s00262-020-02636-2

Journal - Research Article

Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1

Journal - Research Article

Crake, R. L. I., Phillips, E., Kleffmann, T., & Currie, M. J. (2019). Co-culture with human breast adipocytes differentially regulates protein abundance in breast cancer cells. Cancer Geonomics & Proteomics, 16(5), 319-332. doi: 10.21873/cgp.20137

Journal - Research Article

Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693

Journal - Research Article

Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675

Journal - Research Article

Buss, L. A., Mandani, A., Phillips, E., Scott, N. J. A., Currie, M. J., & Dachs, G. U. (2018). Characterisation of a mouse model of breast cancer with metabolic syndrome. In Vivo, 32(5), 1071-1080. doi: 10.21873/invivo.11348

Journal - Research Article

Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140

Journal - Research Article

Robinson, B., Currie, M., Phillips, E., Dachs, G., Strother, M., Morrin, H., Davey, V., & Frampton, C. (2017). Body mass index (BMI): Association with clinicopathological factors and outcome of women with newly diagnosed breast cancer in New Zealand. New Zealand Medical Journal, 130(1451), 46-56. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334

Journal - Research Article

Royds, J. A., Pilbrow, A. P., Morrin, H. R., Frampton, C., Russell, I. A., Moravec, C. S., … Currie, M. J., Hung, N. A., & Slatter, T. L. (2016). The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16^INK4a expression. Frontiers in Oncology, 5, 306. doi: 10.3389/fonc.2015.00306

Journal - Research Article

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

Journal - Research Article

Dachs, G. U., Phillips, E., Phung, Y., Dyer, A., Willis, J. A., Currie, M. J., & Robinson, B. A. (2015). Tumour growth in mice resistant to diet-induced obesity. Journal of Molecular Biochemistry, 4(2), 42-49.

Journal - Research Article

Hock, B. D., McKenzie, J. L., Cross, N. B., & Currie, M. J. (2015). Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology, 32(3), 164-171. doi: 10.1016/j.trim.2015.05.001

Journal - Research Article

Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989

Journal - Research Article

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2014). Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response. Free Radical Biology & Medicine, 69, 308-317. doi: 10.1016/j.freeradbiomed.2014.01.033

Journal - Research Article

Kuiper, C., Dachs, G. U., Munn, D., Currie, M. J., Robinson, B. A., Pearson, J. F., & Vissers, M. C. M. (2014). Increased tumour ascorbate is associated with extended disease-free survival and decreased hypoxia-inducible factor-1 activation in human colorectal cancer. Frontiers in Oncology, 4, 10. doi: 10.3389/fonc.2014.00010

Journal - Research Article

Volkova, E., Robinson, B. A., Willis, J., Currie, M. J., & Dachs, G. U. (2014). Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells. Oncology Letters, 7(2), 311-320. doi: 10.3892/ol.2013.1710

Journal - Research Article

Currie, M. J., Beardsley, B. E., Harris, G. C., Gunningham, S. P., Dachs, G. U., Dijkstra, B., Morrin, H. R., Wells, J. E., & Robinson, B. A. (2013). Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: Relationships with markers of tumor hypoxia and microvascularity. Human Pathology, 44(3), 402-411. doi: 10.1016/j.humpath.2012.06.004

Journal - Research Article

Hock, B. D., Mackenzie, K. A., Cross, N. B., Taylor, K. G., Currie, M. J., Robinson, B. A., Simcock, J. W., & McKenzie, J. L. (2012). Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology Dialysis Transplantation, 27(1), 402-410. doi: 10.1093/ndt/gfr264

Journal - Research Article

Hunt, M. A., Li, D., Hay, M. P., Currie, M. J., Robinson, B. A., Patterson, A. V., & Dachs, G. U. (2012). Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro. Journal of Gene Medicine, 14(1), 62-74. doi: 10.1002/jgm.1635

Journal - Research Article

MacKenzie, K. A., Miller, A. P., Hock, B. D., Gardner, J., Simcock, J. W., Roake, J. A., Dachs, G. U., Robinson, B. A., & Currie, M. J. (2011). Angiogenesis and host immune response contribute to the aggressive character of non-melanoma skin cancers in renal transplant recipients. Histopathology, 58(6), 875-885. doi: 10.1111/j.1365-2559.2011.03845.x

Journal - Research Article

Pflüger, H.-J., Field, L. H., Nishino, H., & Currie, M. J. (2011). Neuromodulatory unpaired median neurons in the New Zealand tree weta, Hemideina femorata. Journal of Insect Physiology, 57(10), 1420-1430. doi: 10.1016/j.jinsphys.2011.07.010

Journal - Research Article

Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2011). Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. British Journal of Cancer, 104, 51-59. doi: 10.1038/sj.bjc.6606005

Journal - Research Article

Dachs, G. U., Kano, M., Volkova, E., Morrin, H. R., Davey, V. C. L., Harris, G. C., … Frampton, C., Currie, M. J., Wells, J. E., & Robinson, B. A. (2010). A profile of prognostic and molecular factors in European and Māori breast cancer patients. BMC Cancer, 10, 543. doi: 10.1186/1471-2407-10-543

Journal - Research Article

Hunt, M. A., Currie, M. J., Robinson, B. A., & Dachs, G. U. (2010). Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents. Journal of Biomolecular Techniques, 21, 66-72.

Journal - Research Article

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010). Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Research, 70(14), 5749-5758. doi: 10.1158/0008-5472.CAN-10-0263

Journal - Research Article

Mackenzie, K. A., Wells, J. E., Lynn, K. L., Simcock, J. W., Robinson, B. A., Roake, J. A., & Currie, M. J. (2010). First and subsequent nonmelanoma skin cancers: Incidence and predictors in a population of New Zealand renal transplant recipients. Nephrology Dialysis Transplantation, 25, 300-306. doi: 10.1093/ndt/gfp482

Journal - Research Article

Dachs, G. U., Currie, M. J., Mckenzie, F., Jeffreys, M., Cox, B., Foliaki, S., … Robinson, B. A. (2008). Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people. Lancet Oncology, 9(5), 473-484. doi: 10.1016/S1470-2045(08)70127-X

Journal - Research Article

Gunningham, S. P., Currie, M. J., Morrin, H. R., Tan, E. Y., Turley, H., Dachs, G. U., Watson, A. I., Frampton, C., Robinson, B. A., & Fox, S. B. (2007). The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is asociated with P-selectin expression in breast cancers. Journal of Pathology, 212, 335-344.

Journal - Research Article

Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007). Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radical Biology & Medicine, 42, 765-772.

Journal - Research Article

Dachs, G. U., Steele, A. J., Coralli, C., Kanthou, C., Brooks, A. C., Gunningham, S. P., Currie, M. J., Watson, A. I., Robinson, B. A., & Tozer, G. M. (2006). Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-I and gene expression. BMC Cancer, 6, 280. doi: 10.1186/1471-2407-6-280

Journal - Research Article

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Journal - Research Article

Currie, M. J., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Frampton, C., Han, C., Robinson, B. A., & Fox, S. B. (2005). Expression of HIF-1α in human tumours. Journal of Clinical Pathology, 58, 335-336.

Journal - Research Article

Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., & Robinson, B. (2005). The Christchurch Tissue Bank to support cancer research. New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1735/content.pdf

Journal - Research Article

Currie, M., Hanrahan, V., Gunningham, S. P., Morrin, H. R., Frampton, C., Han, C., Robinson, B. A., & Fox, S. B. (2004). Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1α) and the HIF-1α target gene DEC1, but not lymph node metastasis in primary human breast carcinomas. Journal of Clinical Pathology, 57, 829-834.

Journal - Research Article

Hanrahan, V., Currie, M., Gunningham, S. P., Morrin, H., Scott, P. A. E., Robinson, B. A., & Fox, S. B. (2003). The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. Journal of Pathology, 200(2), 183-194.

Journal - Research Article

Currie, M., Gunningham, S. P., Cheng, H., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2002). Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; Regulation by the von Hippel-Lindau gene and hypoxia. Journal of Pathology, 198, 502-510.

Journal - Research Article

Currie, M., Gunningham, S. P., Han, C., Scott, P. A. E., Robinson, B. A., Harris, A., & Fox, S. B. (2001). Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. Clinical Cancer Research, 7(4), 918-927.

Journal - Research Article

Gunningham, S. P., Currie, M. J., Han, C., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2001). VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis. Journal of Pathology, 193(3), 325-332.

Journal - Research Article

Gunningham, S. P., Currie, M. J., Han, C., Turner, K. S., Scott, P. A. E., Robinson, B. A., … Fox, S. B. (2001). Vascular endothelial growth factor-B and vascular endothelial growth factor-C expression in renal cell carcinomas: Regulation by the von Hippel-Lindau gene and hypoxia. Cancer Research, 61(7), 3206-3211.

Journal - Research Article

Gunningham, S. P., Currie, M. J., Han, C., Robinson, B. A., Scott, P. A. E., Harris, A. L., & Fox, S. B. (2000). The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factor C is related to lymph node metastasis in human breast cancers. Clinical Cancer Research, 6(11), 4278-4286.

Journal - Research Article

Bassett, N. S., Currie, M., Breier, B. H., Klempt, M., Min, S. H., McCutcheon, S. N., … Gluckman, P. (1997). The effects of ovine placental bitogen and bovine growth hormone on hepatic and mammary gene expression in lactating sheep. Growth Hormone & IGF Research, 8(6), 439-446.

Journal - Research Article

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