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David Murdoch

Dean of the University of Otago, Christchurch

MB ChB, MD (Otago), MSc (Lond), DTM&H (Liv), FRACP, FRCPA, FFSc(RCPA)

Email david.murdoch@otago.ac.nz 

Current roles

Professor David Murdoch is Dean of the University of Otago, Christchurch.

He is the co-leader of The Infection Group, the co-director of One Health Aotearoa, a Senior Associate in the Department of International Health at Johns Hopkins School of Public Health, and a clinical microbiologist at Canterbury Health Laboratories.

Research interests

David’s main research interests are the epidemiology, diagnosis and prevention of respiratory tract infections, pneumococcal disease, legionellosis, bloodstream infections, and the role of vitamin D in infectious diseases.

He has a particular interest in the microbial aetiology of pneumonia, and is the Laboratory Director of the Pneumonia Etiology Research for Child Health (PERCH) project which is focused on determining the causes of severe pneumonia in young children from developing countries. David has ongoing projects based in nine countries in Africa and Asia.

In the media

Professors David Murdoch and Steve Chambers were interviewed for Radio New Zealand's Our Changing World series in March 2014.

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Publications

Carter, M. J., Gurung, P., Jones, C., Rajkarnikar, S., Kandasamy, R., Gurung, M., … Murdoch, D. R., … for the PneumoNepal Study Group. (2020). Assessment of an antibody-in-lymphocyte supernatant assay for the etiological diagnosis of pneumococcal pneumonia in children. Frontiers in Cellular & Infection Microbiology, 9, 459. doi: 10.3389/fcimb.2019.00459

Gallagher, K. E., Knoll, M. D., Prosperi, C., Baggett, H. C., Brooks, W. A., Feiken, D. R., … Murdoch, D. R., … for The PERCH Study Group. (2020). The predictive performance of a pneumonia severity score in Human Immunodeficiency Virus-negative children presenting to hospital in seven low- and middle-income countries. Clinical Infectious Diseases, 70, 1050-1057. doi: 10.1093/cid/ciz350

McCollum, E. D., Park, D. E., Watson, N. L., Fancourt, N. S. S., Focht, C., Baggett, H. C., … Murdoch, D. R., … Hammitt, L. L. (2020). Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children. Pediatric Pulmonology. Advance online publication. doi: 10.1002/ppul.25046

Hannaway, R. F., Wang, X., Schneider, M., Slow, S., Cowan, J., Brockway, B., Schofield, M. R., Morgan, X. C., Murdoch, D. R., & Ussher, J. E. (2020). Mucosal-associated invariant T cells and Vδ2+ γδ T cells in community acquired pneumonia: Association of abundance in sputum with clinical severity and outcome. Clinical & Experimental Immunology, 199(2), 201-215. doi: 10.1111/cei.13377

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Authored Book - Research

Pollard, A. J., & Murdoch, D. R. (2007). Bergmedizin: Höhenbedingte erkrankungen und gesundheitsgefahren bei bergsteigern (3rd ed.). Bern, Switzerland: Hans Huber, 240p.

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Authored Book - Other

Pollard, A. J., & Murdoch, D. R. (2003). The high altitude medicine handbook (3rd ed.). Oxon, UK: Radcliffe Medical Press, 193p.

Pollard, A. J., & Murdoch, D. R. (2001). Travel Medicine. Oxford: Health Press, 152p.

Pollard, A. J., & Murdoch, D. R. (1998). The High Altitude Medicine Handbook (2 ed.). Abingdon: Radcliffe Medical Press, 165p.

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Edited Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

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Chapter in Book - Research

Murdoch, D. R., Werno, A. M., & Jennings, L. C. (2019). Microbiological diagnosis of respiratory illness: Recent advances. In R. Wilmott, A. Bush, R. Deterding, F. Ratjen, P. Sly, H. Zar & H. Li (Eds.), Kendig's disorders of the respiratory tract in children. (9 ed.) (pp. 396-405.e3). Philadelphia, PA: Elsevier. doi: 10.1016/B978-0-323-44887-1.00022-5

Murdoch, D. R. (2005). Streptococcus pneumoniae. In J. Fuchs & M. Podda (Eds.), Encyclopedia of diagnostic genomics and proteomics. (pp. 1236-1240). New York: Marcel Dekker.

Murdoch, D. (2004). Altitude sickness. In Clinical Evidence 11. (pp. 1767-1773). BMJ Publishing Group. Retrieved from http://www.clinicalevidence.com/ceweb/conditions/index.jsp

Pollard, A. J., Litch, J. A., & Murdoch, D. R. (1998). Children at altitude. In H. Ohno, T. Kobayashi, S. Masuyama & M. Nakashima (Eds.), Progress in mountain medicine and high mountain physiology. (pp. 422-424). Japanese Society of Mountain Medicine.

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Chapter in Book - Other

Murdoch, D. (2013). Pathology. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 45-49). Christchurch, New Zealand: University of Otago.

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Journal - Research Article

Carter, M. J., Gurung, P., Jones, C., Rajkarnikar, S., Kandasamy, R., Gurung, M., … Murdoch, D. R., … for the PneumoNepal Study Group. (2020). Assessment of an antibody-in-lymphocyte supernatant assay for the etiological diagnosis of pneumococcal pneumonia in children. Frontiers in Cellular & Infection Microbiology, 9, 459. doi: 10.3389/fcimb.2019.00459

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Hannaway, R. F., Wang, X., Schneider, M., Slow, S., Cowan, J., Brockway, B., Schofield, M. R., Morgan, X. C., Murdoch, D. R., & Ussher, J. E. (2020). Mucosal-associated invariant T cells and Vδ2+ γδ T cells in community acquired pneumonia: Association of abundance in sputum with clinical severity and outcome. Clinical & Experimental Immunology, 199(2), 201-215. doi: 10.1111/cei.13377

McCollum, E. D., Park, D. E., Watson, N. L., Fancourt, N. S. S., Focht, C., Baggett, H. C., … Murdoch, D. R., … Hammitt, L. L. (2020). Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children. Pediatric Pulmonology. Advance online publication. doi: 10.1002/ppul.25046

Gallagher, K. E., Knoll, M. D., Prosperi, C., Baggett, H. C., Brooks, W. A., Feiken, D. R., … Murdoch, D. R., … for The PERCH Study Group. (2020). The predictive performance of a pneumonia severity score in Human Immunodeficiency Virus-negative children presenting to hospital in seven low- and middle-income countries. Clinical Infectious Diseases, 70, 1050-1057. doi: 10.1093/cid/ciz350

Mohammadi, A., Chambers, S. T., Scott-Thomas, A., Lewis, J. G., Anderson, T., Podmore, R., Williman, J., Murdoch, D., & Slow, S. (2020). Enhancement of culture of Legionella longbeachae from respiratory samples using immunomagnetic separation and antimicrobial decontamination. Journal of Clinical Microbiology. Advance online publication. doi: 10.1128/jcm.01218-20

Ebruke, B. E., Knoll, M. D., Haddix, M., Zaman, S. M. A., Prosperi, C., Feikin, D. R., … Murdoch, D. R., … Howie, S. R. C. (2020). The aetiology of pneumonia from analysis of lung aspirate and pleural fluid samples: Findings from the PERCH study. Clinical Infectious Diseases. Advance online publication. doi: 10.1093/cid/ciaa1032

Priest, P. C., Slow, S., Chambers, S. T., Cameron, C. M., Balm, M. N., Beale, M. W., Blackmore, T. K., … Ussher, J. E., van der Linden, A. J., … Murdoch, D. R. (2019). The burden of Legionnaires' disease in New Zealand (LegiNZ): A national surveillance study. Lancet Infectious Diseases, 19, 770-777. doi: 10.1016/S1473-3099(19)30113-6

Oo, K. M., Myat, T. O., Htike, W. W., Biswas, A., Hannaway, R. F., Murdoch, D. R., Crump, J. A., & Ussher, J. E. (2019). Molecular mechanisms of antimicrobial resistance and phylogenetic relationships of Salmonella enterica isolates from febrile patients in Yangon, Myanmar. Transactions of the Royal Society of Tropical Medicine & Hygiene, 113, 641-648. doi: 10.1093/trstmh/trz053

The Pneumonia Etiology Research for Child Health (PERCH) Study Group, including Murdoch, D. R., & Anderson, T. P. (2019). Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: The PERCH multi-country case-control study. Lancet, 394(10200), 757-779. doi: 10.1016/S0140-6736(19)30721-4

Oo, W. T., Myat, T. O., Htike, W. W., Ussher, J. E., Murdoch, D. R., Lwin, K. T., … Maze, M. J., … Crump, J. A. (2019). Incidence of typhoid and paratyphoid fevers among adolescents and adults in Yangon, Myanmar. Clinical Infectious Diseases, 68(Suppl. 2), S124-S129. doi: 10.1093/cid/ciy1109

Martineau, A. R., Jolliffe, D. A., Greenberg, L., Aloia, J. F., Bergman, P., Dubnoz-Raz, G., … Murdoch, D. R., … Hooper, R. L. (2019). Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis. Health Technology Assessment, 23(2). doi: 10.3310/hta23020

Kandasamy, R., Gurung, M., Thorson, S., Yu, L.-M., Galal, U., Voysey, M., … Murdoch, D. R., … Pollard, A. J. (2019). Comparison of two schedules of two-dose priming with the ten-valent pneumococcal conjugate vaccine in Nepalese children: An open-label, randomised non-inferiority controlled trial. Lancet Infectious Diseases, 19, 156-164. doi: 10.1016/s1473-3099(18)30568-1

Morpeth, S. C., Munywoki, P., Hammitt, L. L., Bett, A., Bottomley, C., Onyango, C. O., Murdoch, D. R., … Scott, J. A. G. (2018). Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children. Scientific Reports, 8, 11030. doi: 10.1038/s41598-018-29119-w

Britto, C. D., Dyson, Z. A., Duchene, S., Carter, M. J., Gurung, M., Kelly, D. F., Murdoch, D. R., … Pollard, A. J. (2018). Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy. PLoS Neglected Tropical Diseases, 12(4), e0006408. doi: 10.1371/journal.pntd.0006408

Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Scott, P., Priest, P. C., Chambers, S. T., Heijne, J. C. M., & Murdoch, D. R. (2018). Staphylococcus aureus carriage in a New Zealand primary school: A cohort study. Pediatric Infectious Disease Journal, 37(6), e172-e175. doi: 10.1097/inf.0000000000001796

Murdoch, D. R., Morpeth, S. C., Hammitt, L. L., Driscoll, A. J., Watson, N. L., Baggett, H. C., … for the PERCH Study Group. (2017). Microscopic analysis and quality assessment of induced sputum from children with pneumonia in the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S271-S279. doi: 10.1093/cid/cix083

Baggett, H. C., Watson, N. L., Deloria Knoll, M., Brooks, W. A., Feikin, D. R., Hammitt, L. L., … Murdoch, D. R., … for the PERCH Study Group. (2017). Density of upper respiratory colonization with Streptococcus pneumoniae and its role in the diagnosis of pneumococcal pneumonia among children aged <5 years in the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S317-S327. doi: 10.1093/cid/cix100

Shi, T., McAllister, D. A., O'Brien, K. L., Simoes, E. A. F., Madhi, S. A., Gessner, B. D., … for the RSV Global Epidemiology Network, including Murdoch, D. (2017). Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: A systematic review and modelling study. Lancet, 390, 946-958. doi: 10.1016/S0140-6736(17)30938-8

Slow, S., Anderson, T., Miller, J., Singh, S., Murdoch, D., & Biggs, P. J. (2017). Complete genome sequence of a Legionella longbeachae Serogroup 1 strain isolated from a patient with Legionnaires' disease. Genome Announcements, 5(24), e00564-17. doi: 10.1128/genomeA.00564-17

Kenagy, E., Priest, P. C., Cameron, C. M., Smith, D., Scott, P., Cho, V., … Murdoch, D. R. (2017). Risk factors for Legionella longbeachae Legionnaires' disease, New Zealand. Emerging Infectious Diseases, 23(7), 1148-1154. doi: 10.3201/eid2307.161429

Moore, D. P., Higdon, M. M., Hammitt, L. L., Prosperi, C., DeLuca, A. N., Da Silva, P., … Murdoch, D. R., … Madhi, S. A. (2017). The incremental value of repeated induced sputum and gastric aspirate samples for the diagnosis of pulmonary tuberculosis in young children with acute community-acquired pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S309-S316. doi: 10.1093/cid/cix099

Park, D. E., Baggett, H. C., Howie, S. R. C., Shi, Q., Watson, N. L., Brooks, W. A., … Murdoch, D. R., … for the PERCH Study Group. (2017). Colonization density of the upper respiratory tract as a predictor of pneumonia: Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Clinical Infectious Diseases, 64(Suppl. 3), S328-S336. doi: 10.1093/cid/cix104

Deloria Knoll, M., Fu, W., Shi, Q., Prosperi, C., Wu, Z., Hammitt, L. L., … Murdoch, D. R., … Zeger, S. L. (2017). Bayesian estimation of pneumonia etiology: Epidemiologic considerations and applications to the Pneumonia Etiology Research for Child Health Study. Clinical Infectious Diseases, 64(Suppl. 3), S213-S227. doi: 10.1093/cid/cix144

Feikin, D. R., Fu, W., Park, D. E., Shi, Q., Higdon, M. M., Baggett, H. C., … Murdoch, D. R., for the PERCH Study Group. (2017). Is higher viral load in the upper respiratory tract associated with severe pneumonia? Findings from the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S337-S346. doi: 10.1093/cid/cix148

Higdon, M. M., Le, T., O'Brien, K. L., Murdoch, D. R., Prosperi, C., Baggett, H. C., … for the PERCH Study Group. (2017). Association of C-reactive protein with bacterial and respiratory syncytial virus-associated pneumonia among children aged <5 years in the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S378-S386. doi: 10.1093/cid/cix150

Fancourt, N., Deloria Knoll, M., Baggett, H. C., Brooks, W. A., Feikin, D. R., Hammitt, L. L., … Murdoch, D. R., … for the PERCH Study Group. (2017). Chest radiograph findings in childhood pneumonia cases from the multisite PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S262-S270. doi: 10.1093/cid/cix089

Feikin, D. R., Hammitt, L. L., Murdoch, D. R., O'Brien, K. L., & Scott, J. A. G. (2017). The enduring challenge of determining pneumonia etiology in children: Considerations for future research priorities. Clinical Infectious Diseases, 64(Suppl. 3), S188-S196. doi: 10.1093/cid/cix143

Barratt, K., Anderson, T. P., Fahey, J. A., Jennings, L. C., Werno, A. M., & Murdoch, D. R. (2017). Comparison of the fast track diagnostics respiratory 21 and Seegene Allplex multiplex polymerase chain reaction assays for the detection of respiratory viruses. British Journal of Biomedical Science, 74(2), 85-89. doi: 10.1080/09674845.2017.1278885

O'Brien, K. L., Baggett, H. C., Brooks, W. A., Feikin, D. R., Hammitt, L. L., Howie, S. R. C., … Murdoch, D. R., … Zeger, S. L. (2017). Introduction to the epidemiologic considerations, analytic methods, and foundational results from the pneumonia etiology research for child health study. Clinical Infectious Diseases, 64(Suppl. 3), S179-S184. doi: 10.1093/cid/cix142

Watson, N. L., Prosperi, C., Driscoll, A. J., Higdon, M. M., Park, D. E., Sanza, M., … Murdoch, D. R., … Deloria Knoll, M. (2017). Data management and data quality in PERCH, a large international case-control study of severe childhood pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S238-S244. doi: 10.1093/cid/cix080

Murdoch, D. R., Morpeth, S. C., Hammitt, L. L., Driscoll, A. J., Watson, N. L., Baggett, H. C., … for the PERCH Study Group. (2017). The diagnostic utility of induced sputum microscopy and culture in childhood pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S280-S288. doi: 10.1093/cid/cix090

Deloria Knoll, M., Morpeth, S. C., Scott, J. A. G., Watson, N. L., Park, D. E., Baggett, H. C., … Murdoch, D., … for the PERCH Study Group. (2017). Evaluation of pneumococcal load in blood by polymerase chain reaction for the diagnosis of pneumococcal pneumonia in young children in the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S357-S367. doi: 10.1093/cid/cix149

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

DeLuca, A. N., Hammitt, L. L., Kim, J., Higdon, M. M., Baggett, H. C., Abdullah Brooks, W., … Murdoch, D. R., … for the PERCH Study Group. (2017). Safety of induced sputum collection in children hospitalized with severe or very severe pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S301-S308. doi: 10.1093/cid/cix078

Hammitt, L. L., Feikin, D. R., Scott, J. A. G., Zeger, S. L., Murdoch, D. R., O'Brien, K. L., & Deloria Knoll, M. (2017). Addressing the analytic challenges of cross-sectional pediatric pneumonia etiology data. Clinical Infectious Diseases, 64(Suppl. 3), S197-S204. doi: 10.1093/cid/cix147

Driscoll, A. J., Karron, R. A., Morpeth, S. C., Bhat, N., Levine, O. S., Baggett, H. C., … Murdoch, D. R. (2017). Standardization of laboratory methods for the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S245-S252. doi: 10.1093/cid/cix081

Thea, D. M., Seidenberg, P., Park, D. E., Mwananyanda, L., Fu, W., Shi, Q., … Murdoch, D. R., … for the PERCH Study Group. (2017). Limited utility of polymerase chain reaction in induced sputum specimens for determining the causes of childhood pneumonia in resource-poor settings: Findings from the Pneumonia Etiology Research for Child Health (PERCH) study. Clinical Infectious Diseases, 64(Suppl. 3), S289-S300. doi: 10.1093/cid/cix098

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