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David Murdoch

Dean of the University of Otago, Christchurch

MB ChB, MD (Otago), MSc (Lond), DTM&H (Liv), FRACP, FRCPA, FFSc(RCPA)

Email david.murdoch@otago.ac.nz 

Current roles

Professor David Murdoch is Dean of the University of Otago, Christchurch.

He is the co-leader of The Infection Group, the co-director of One Health Aotearoa, a Senior Associate in the Department of International Health at Johns Hopkins School of Public Health, and a clinical microbiologist at Canterbury Health Laboratories.

Research interests

David’s main research interests are the epidemiology, diagnosis and prevention of respiratory tract infections, pneumococcal disease, legionellosis, bloodstream infections, and the role of vitamin D in infectious diseases.

He has a particular interest in the microbial aetiology of pneumonia, and is the Laboratory Director of the Pneumonia Etiology Research for Child Health (PERCH) project which is focused on determining the causes of severe pneumonia in young children from developing countries. David has ongoing projects based in nine countries in Africa and Asia.

In the media

Professors David Murdoch and Steve Chambers were interviewed for Radio New Zealand's Our Changing World series in March 2014.

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Publications

Mohammadi, A., Chambers, S. T., Slow, S., Anderson, T., Williman, J., Scott, P., Murdoch, D., & Scott-Thomas, A. (2021). Presence of Legionella Longbeachae in pine but not composted green waste used in manufacture of potting soils in New Zealand. Journal of Applied & Environmental Microbiology, 9(1), 1-4. doi: 10.12691/jaem-9-1-1

Murdoch, D. R., Crengle, S., Frame, B., French, N. P., & Priest, P. C. (2021). "We have been warned": Preparing now to prevent the next pandemic. New Zealand Medical Journal, 134(1536), 8-11. Retrieved from https://www.nzma.org.nz/journal

Brueggemann, A. B., Jansen van Rensburg, M. J., Shaw, D., Jolley, K. A., McCarthy, N. D., Maiden, M. C. J., … Murdoch, D. R., … Zhou, F. (2021). Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: A prospective analysis of surveillance data. Lancet Digital Health, 3(6), e360-e370. doi: 10.1016/S2589-7500(21)00077-7

Geoghegan, J. L., Douglas, J., Ren, X., Storey, M., Hadfield, J., Silander, O. K., … Baker, M. G., Murdoch, D. R., … de Ligt, J. (2021). Use of genomics to track Coronavirus disease outbreaks, New Zealand. Emerging Infectious Diseases, 27(5), 1317-1322. doi: 10.3201/eid2705.204579

Park, D. E., Higdon, M. M., Prosperi, C., Baggett, H. C., Brooks, W. A., Feikin, D. R., … Murdoch, D. R., … Knoll, M. D. (2021). Upper respiratory tract co-detection of human endemic coronaviruses and high-density pneumococcus associated with increased severity among HIV-uninfected children under 5 years old in the PERCH study. Pediatric Infectious Disease Journal, 40(6), 503-512. doi: 10.1097/inf.0000000000003139

Pollard, A. J., & Murdoch, D. R. (2007). Bergmedizin: Höhenbedingte erkrankungen und gesundheitsgefahren bei bergsteigern (3rd ed.). Bern, Switzerland: Hans Huber, 240p.

Authored Book - Research

Pollard, A. J., & Murdoch, D. R. (2003). The high altitude medicine handbook (3rd ed.). Oxon, UK: Radcliffe Medical Press, 193p.

Authored Book - Other

Pollard, A. J., & Murdoch, D. R. (2001). Travel Medicine. Oxford: Health Press, 152p.

Authored Book - Other

Pollard, A. J., & Murdoch, D. R. (1998). The High Altitude Medicine Handbook (2 ed.). Abingdon: Radcliffe Medical Press, 165p.

Authored Book - Other

Begg, E., Barclay, M., Vella-Brincat, J., Gardiner, S. J., Doogue, M., McDermott, L., … Chambers, S., & Murdoch, D. (Eds.). (2004). Preferred Medicines List (8th ed.). Christchurch: The Caxton Press, 172p.

Edited Book - Other

Murdoch, D. R., Werno, A. M., & Jennings, L. C. (2019). Microbiological diagnosis of respiratory illness: Recent advances. In R. Wilmott, A. Bush, R. Deterding, F. Ratjen, P. Sly, H. Zar & H. Li (Eds.), Kendig's disorders of the respiratory tract in children. (9 ed.) (pp. 396-405.e3). Philadelphia, PA: Elsevier. doi: 10.1016/B978-0-323-44887-1.00022-5

Chapter in Book - Research

Murdoch, D. R. (2005). Streptococcus pneumoniae. In J. Fuchs & M. Podda (Eds.), Encyclopedia of diagnostic genomics and proteomics. (pp. 1236-1240). New York: Marcel Dekker.

Chapter in Book - Research

Murdoch, D. (2004). Altitude sickness. In Clinical Evidence 11. (pp. 1767-1773). BMJ Publishing Group. Retrieved from http://www.clinicalevidence.com/ceweb/conditions/index.jsp

Chapter in Book - Research

Pollard, A. J., Litch, J. A., & Murdoch, D. R. (1998). Children at altitude. In H. Ohno, T. Kobayashi, S. Masuyama & M. Nakashima (Eds.), Progress in mountain medicine and high mountain physiology. (pp. 422-424). Japanese Society of Mountain Medicine.

Chapter in Book - Research

Murdoch, D. (2013). Pathology. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 45-49). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Brueggemann, A. B., Jansen van Rensburg, M. J., Shaw, D., Jolley, K. A., McCarthy, N. D., Maiden, M. C. J., … Murdoch, D. R., … Zhou, F. (2021). Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: A prospective analysis of surveillance data. Lancet Digital Health, 3(6), e360-e370. doi: 10.1016/S2589-7500(21)00077-7

Journal - Research Article

Geoghegan, J. L., Douglas, J., Ren, X., Storey, M., Hadfield, J., Silander, O. K., … Baker, M. G., Murdoch, D. R., … de Ligt, J. (2021). Use of genomics to track Coronavirus disease outbreaks, New Zealand. Emerging Infectious Diseases, 27(5), 1317-1322. doi: 10.3201/eid2705.204579

Journal - Research Article

Jolliffe, D. A., Camargo, Jr, C. A., Sluyter, J. D., Aglipay, M., Aloia, J. F., Ganmaa, D., … Murdoch, D. R., … Martineau, A. R. (2021). Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes & Endocrinology. Advance online publication. doi: 10.1016/S2213-8587(21)00051-6

Journal - Research Article

Mohammadi, A., Chambers, S. T., Slow, S., Anderson, T., Williman, J., Scott, P., Murdoch, D., & Scott-Thomas, A. (2021). Presence of Legionella Longbeachae in pine but not composted green waste used in manufacture of potting soils in New Zealand. Journal of Applied & Environmental Microbiology, 9(1), 1-4. doi: 10.12691/jaem-9-1-1

Journal - Research Article

Park, D. E., Higdon, M. M., Prosperi, C., Baggett, H. C., Brooks, W. A., Feikin, D. R., … Murdoch, D. R., … Knoll, M. D. (2021). Upper respiratory tract co-detection of human endemic coronaviruses and high-density pneumococcus associated with increased severity among HIV-uninfected children under 5 years old in the PERCH study. Pediatric Infectious Disease Journal, 40(6), 503-512. doi: 10.1097/inf.0000000000003139

Journal - Research Article

Pericàs, J. M., Llopis, J., Athan, E., Hernández-Meneses, M., Hannan, M. M., Murdoch, D. R., … on behalf of the International Collaboration on Endocarditis (ICE) Investigators. (2021). Prospective cohort study of infective endocarditis in people who inject drugs. Journal of the American College of Cardiology, 77(5), 544-555. doi: 10.1016/j.jacc.2020.11.062

Journal - Research Article

Carter, M. J., Gurung, P., Jones, C., Rajkarnikar, S., Kandasamy, R., Gurung, M., … Murdoch, D. R., … for the PneumoNepal Study Group. (2020). Assessment of an antibody-in-lymphocyte supernatant assay for the etiological diagnosis of pneumococcal pneumonia in children. Frontiers in Cellular & Infection Microbiology, 9, 459. doi: 10.3389/fcimb.2019.00459

Journal - Research Article

Ebruke, B. E., Knoll, M. D., Haddix, M., Zaman, S. M. A., Prosperi, C., Feikin, D. R., … Murdoch, D. R., … Howie, S. R. C. (2020). The aetiology of pneumonia from analysis of lung aspirate and pleural fluid samples: Findings from the PERCH study. Clinical Infectious Diseases. Advance online publication. doi: 10.1093/cid/ciaa1032

Journal - Research Article

Gallagher, K. E., Knoll, M. D., Prosperi, C., Baggett, H. C., Brooks, W. A., Feiken, D. R., … Murdoch, D. R., … for The PERCH Study Group. (2020). The predictive performance of a pneumonia severity score in Human Immunodeficiency Virus-negative children presenting to hospital in seven low- and middle-income countries. Clinical Infectious Diseases, 70, 1050-1057. doi: 10.1093/cid/ciz350

Journal - Research Article

Geoghegan, J. L., Ren, X., Storey, M., Hadfield, J., Jelley, L., Jefferies, S., … Baker, M. G., Murdoch, D. R., … de Ligt, J. (2020). Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand. Nature Communications, 11(1), 6351. doi: 10.1038/s41467-020-20235-8

Journal - Research Article

Hannaway, R. F., Wang, X., Schneider, M., Slow, S., Cowan, J., Brockway, B., Schofield, M. R., Morgan, X. C., Murdoch, D. R., & Ussher, J. E. (2020). Mucosal-associated invariant T cells and Vδ2+ γδ T cells in community acquired pneumonia: Association of abundance in sputum with clinical severity and outcome. Clinical & Experimental Immunology, 199(2), 201-215. doi: 10.1111/cei.13377

Journal - Research Article

McCollum, E. D., Park, D. E., Watson, N. L., Fancourt, N. S. S., Focht, C., Baggett, H. C., … Murdoch, D. R., … Hammitt, L. L. (2020). Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children. Pediatric Pulmonology, 55, 3197-3208. doi: 10.1002/ppul.25046

Journal - Research Article

Mohammadi, A., Chambers, S. T., Scott-Thomas, A., Lewis, J. G., Anderson, T., Podmore, R., Williman, J., Murdoch, D., & Slow, S. (2020). Enhancement of culture of Legionella longbeachae from respiratory samples using immunomagnetic separation and antimicrobial decontamination. Journal of Clinical Microbiology. Advance online publication. doi: 10.1128/jcm.01218-20

Journal - Research Article

Slow, S., Pearson, J. F., Florkowski, C. M., Elder, P. A., Lewis, J. G., Kennedy, M. A., & Murdoch, D. R. (2020). Effect of genetic factors on the response to vitamin D3 supplementation in the VIDARIS randomised controlled trial. Nutrition, 75-76, 110761. doi: 10.1016/j.nut.2020.110761

Journal - Research Article

Kandasamy, R., Gurung, M., Thorson, S., Yu, L.-M., Galal, U., Voysey, M., … Murdoch, D. R., … Pollard, A. J. (2019). Comparison of two schedules of two-dose priming with the ten-valent pneumococcal conjugate vaccine in Nepalese children: An open-label, randomised non-inferiority controlled trial. Lancet Infectious Diseases, 19, 156-164. doi: 10.1016/s1473-3099(18)30568-1

Journal - Research Article

Martineau, A. R., Jolliffe, D. A., Greenberg, L., Aloia, J. F., Bergman, P., Dubnoz-Raz, G., … Murdoch, D. R., … Hooper, R. L. (2019). Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis. Health Technology Assessment, 23(2). doi: 10.3310/hta23020

Journal - Research Article

Oo, K. M., Myat, T. O., Htike, W. W., Biswas, A., Hannaway, R. F., Murdoch, D. R., Crump, J. A., & Ussher, J. E. (2019). Molecular mechanisms of antimicrobial resistance and phylogenetic relationships of Salmonella enterica isolates from febrile patients in Yangon, Myanmar. Transactions of the Royal Society of Tropical Medicine & Hygiene, 113, 641-648. doi: 10.1093/trstmh/trz053

Journal - Research Article

Oo, W. T., Myat, T. O., Htike, W. W., Ussher, J. E., Murdoch, D. R., Lwin, K. T., … Maze, M. J., … Crump, J. A. (2019). Incidence of typhoid and paratyphoid fevers among adolescents and adults in Yangon, Myanmar. Clinical Infectious Diseases, 68(Suppl. 2), S124-S129. doi: 10.1093/cid/ciy1109

Journal - Research Article

Priest, P. C., Slow, S., Chambers, S. T., Cameron, C. M., Balm, M. N., Beale, M. W., Blackmore, T. K., … Ussher, J. E., van der Linden, A. J., … Murdoch, D. R. (2019). The burden of Legionnaires' disease in New Zealand (LegiNZ): A national surveillance study. Lancet Infectious Diseases, 19, 770-777. doi: 10.1016/S1473-3099(19)30113-6

Journal - Research Article

The Pneumonia Etiology Research for Child Health (PERCH) Study Group, including Murdoch, D. R., & Anderson, T. P. (2019). Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: The PERCH multi-country case-control study. Lancet, 394(10200), 757-779. doi: 10.1016/S0140-6736(19)30721-4

Journal - Research Article

Britto, C. D., Dyson, Z. A., Duchene, S., Carter, M. J., Gurung, M., Kelly, D. F., Murdoch, D. R., … Pollard, A. J. (2018). Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy. PLoS Neglected Tropical Diseases, 12(4), e0006408. doi: 10.1371/journal.pntd.0006408

Journal - Research Article

Coker, M. S., Forbes, L. V., Plowman-Holmes, M., Murdoch, D. R., Winterbourn, C. C., & Kettle, A. J. (2018). Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species. Archives of Biochemistry & Biophysics, 646, 80-89. doi: 10.1016/j.abb.2018.03.039

Journal - Research Article

Morpeth, S. C., Munywoki, P., Hammitt, L. L., Bett, A., Bottomley, C., Onyango, C. O., Murdoch, D. R., … Scott, J. A. G. (2018). Impact of viral upper respiratory tract infection on the concentration of nasopharyngeal pneumococcal carriage among Kenyan children. Scientific Reports, 8, 11030. doi: 10.1038/s41598-018-29119-w

Journal - Research Article

Scott, P., Priest, P. C., Chambers, S. T., Heijne, J. C. M., & Murdoch, D. R. (2018). Staphylococcus aureus carriage in a New Zealand primary school: A cohort study. Pediatric Infectious Disease Journal, 37(6), e172-e175. doi: 10.1097/inf.0000000000001796

Journal - Research Article

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Journal - Research Article

Baggett, H. C., Watson, N. L., Deloria Knoll, M., Brooks, W. A., Feikin, D. R., Hammitt, L. L., … Murdoch, D. R., … for the PERCH Study Group. (2017). Density of upper respiratory colonization with Streptococcus pneumoniae and its role in the diagnosis of pneumococcal pneumonia among children aged <5 years in the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S317-S327. doi: 10.1093/cid/cix100

Journal - Research Article

Barratt, K., Anderson, T. P., Fahey, J. A., Jennings, L. C., Werno, A. M., & Murdoch, D. R. (2017). Comparison of the fast track diagnostics respiratory 21 and Seegene Allplex multiplex polymerase chain reaction assays for the detection of respiratory viruses. British Journal of Biomedical Science, 74(2), 85-89. doi: 10.1080/09674845.2017.1278885

Journal - Research Article

DeLuca, A. N., Hammitt, L. L., Kim, J., Higdon, M. M., Baggett, H. C., Abdullah Brooks, W., … Murdoch, D. R., … for the PERCH Study Group. (2017). Safety of induced sputum collection in children hospitalized with severe or very severe pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S301-S308. doi: 10.1093/cid/cix078

Journal - Research Article

Deloria Knoll, M., Fu, W., Shi, Q., Prosperi, C., Wu, Z., Hammitt, L. L., … Murdoch, D. R., … Zeger, S. L. (2017). Bayesian estimation of pneumonia etiology: Epidemiologic considerations and applications to the Pneumonia Etiology Research for Child Health Study. Clinical Infectious Diseases, 64(Suppl. 3), S213-S227. doi: 10.1093/cid/cix144

Journal - Research Article

Deloria Knoll, M., Morpeth, S. C., Scott, J. A. G., Watson, N. L., Park, D. E., Baggett, H. C., … Murdoch, D., … for the PERCH Study Group. (2017). Evaluation of pneumococcal load in blood by polymerase chain reaction for the diagnosis of pneumococcal pneumonia in young children in the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S357-S367. doi: 10.1093/cid/cix149

Journal - Research Article

Driscoll, A. J., Deloria Knoll, M., Hammitt, L. L., Baggett, H. C., Brooks, W. A., Feikin, D. R., … Murdoch, D. R., for the PERCH Study Group. (2017). The effect of antibiotic exposure and specimen volume on the detection of bacterial pathogens in children with pneumonia. Clinical Infectious Diseases, 64(Suppl. 3), S368-S377. doi: 10.1093/cid/cix101

Journal - Research Article

Driscoll, A. J., Karron, R. A., Morpeth, S. C., Bhat, N., Levine, O. S., Baggett, H. C., … Murdoch, D. R. (2017). Standardization of laboratory methods for the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S245-S252. doi: 10.1093/cid/cix081

Journal - Research Article

Fancourt, N., Deloria Knoll, M., Baggett, H. C., Brooks, W. A., Feikin, D. R., Hammitt, L. L., … Murdoch, D. R., … for the PERCH Study Group. (2017). Chest radiograph findings in childhood pneumonia cases from the multisite PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S262-S270. doi: 10.1093/cid/cix089

Journal - Research Article

Feikin, D. R., Fu, W., Park, D. E., Shi, Q., Higdon, M. M., Baggett, H. C., … Murdoch, D. R., for the PERCH Study Group. (2017). Is higher viral load in the upper respiratory tract associated with severe pneumonia? Findings from the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S337-S346. doi: 10.1093/cid/cix148

Journal - Research Article

Feikin, D. R., Hammitt, L. L., Murdoch, D. R., O'Brien, K. L., & Scott, J. A. G. (2017). The enduring challenge of determining pneumonia etiology in children: Considerations for future research priorities. Clinical Infectious Diseases, 64(Suppl. 3), S188-S196. doi: 10.1093/cid/cix143

Journal - Research Article

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Journal - Research Article

Hammitt, L. L., Feikin, D. R., Scott, J. A. G., Zeger, S. L., Murdoch, D. R., O'Brien, K. L., & Deloria Knoll, M. (2017). Addressing the analytic challenges of cross-sectional pediatric pneumonia etiology data. Clinical Infectious Diseases, 64(Suppl. 3), S197-S204. doi: 10.1093/cid/cix147

Journal - Research Article

Higdon, M. M., Hammitt, L. L., Deloria Knoll, M., Baggett, H. C., Abdullah Brooks, W., Howie, S. R. C., … Murdoch, D. R., … for the PERCH Study Group. (2017). Should controls with respiratory symptoms be excluded from case-control studies of pneumonia etiology? Reflections from the PERCH Study. Clinical Infectious Diseases, 64(Suppl. 3), S205-S212. doi: 10.1093/cid/cix076

Journal - Research Article

Higdon, M. M., Le, T., O'Brien, K. L., Murdoch, D. R., Prosperi, C., Baggett, H. C., … for the PERCH Study Group. (2017). Association of C-reactive protein with bacterial and respiratory syncytial virus-associated pneumonia among children aged <5 years in the PERCH study. Clinical Infectious Diseases, 64(Suppl. 3), S378-S386. doi: 10.1093/cid/cix150

Journal - Research Article

Kenagy, E., Priest, P. C., Cameron, C. M., Smith, D., Scott, P., Cho, V., … Murdoch, D. R. (2017). Risk factors for Legionella longbeachae Legionnaires' disease, New Zealand. Emerging Infectious Diseases, 23(7), 1148-1154. doi: 10.3201/eid2307.161429

Journal - Research Article

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