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Paul Chin

Senior Lecturer

MB ChB PhD

Email paulchinnz@gmail.com

Paul Chin is a clinical pharmacologist, employed as a Senior Lecturer at the University of Otago, Christchurch and Senior Medical Officer at Canterbury District Health Board, New Zealand. He is also a qualified general physician, and completed a PhD in pharmacokinetic aspects of gentamicin and dabigatran in 2014. Research interests include therapeutic drug monitoring (including continuing work with anticoagulants and antimicrobials), quality use of medicines, electronic prescribing, and clinical decision support and estimation of renal function.

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Publications

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Brett, O. F., Brett, C. N., & Chin, P. K. L. (2019). The effect of routine preoperative interruption of dabigatran therapy on coagulation parameters and dabigatran plasma levels in a mixed surgical population. Anaesthesia & Intensive Care. Advance online publication. doi: 10.1177/0310057x19841009

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Zhang, M., Moore, G. A., Chin, P. K. L., Everts, R., & Begg, E. J. (2018). Simultaneous determination of Cefalexin, Cefazolin, Flucloxacillin and Probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Therapeutic Drug Monitoring. Advance online publication. doi: 10.1097/ftd.0000000000000555

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Journal - Research Article

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Brett, O. F., Brett, C. N., & Chin, P. K. L. (2019). The effect of routine preoperative interruption of dabigatran therapy on coagulation parameters and dabigatran plasma levels in a mixed surgical population. Anaesthesia & Intensive Care. Advance online publication. doi: 10.1177/0310057x19841009

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Zhang, M., Moore, G. A., Chin, P. K. L., Everts, R., & Begg, E. J. (2018). Simultaneous determination of Cefalexin, Cefazolin, Flucloxacillin and Probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Therapeutic Drug Monitoring. Advance online publication. doi: 10.1097/ftd.0000000000000555

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.13673

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Hernandez, I., Zhang, Y., Brooks, M. M., Chin, P. K. L., & Saba, S. (2017). Anticoagulation use and clinical outcomes after major bleeding on Dabigatran or Warfarin in atrial fibrillation. Stroke, 48(1), 159-166. doi: 10.1161/strokeaha.116.015150

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Saffian, S. M., Zhang, M., Chin, P. K. L., & Jensen, B. P. (2015). Quantification of dabigatran and indirect quantification of dabigatran acylglucuronides in human plasma by LC-MS/MS. Bioanalysis, 7(8), 957-966. doi: 10.4155/bio.15.32

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., Buffery, P. J., & Begg, E. J. (2015). Gentamicin and renal function: Lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin. Therapeutic Drug Monitoring, 37(1), 98-103. doi: 10.1097/FTD.0000000000000107

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Buffery, P. J., Allen, K. M., Chin, P. K. L., Moore, G. A., Barclay, M. L., & Begg, E. J. (2014). Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: Can the strategy be improved? Therapeutic Drug Monitoring, 36(1), 86-92. doi: 10.1097/FTD.0b013e31829dc940

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9

Van Egmond, R., Barclay, M. L., Chin, P. K. L., Sies, C. W., & Florkowski, C. M. (2013). Biological variation of thiopurine methyltransferase enzyme activity: When has a significant change taken place? Annals of Clinical Biochemistry, 50(5), 473-478. doi: 10.1177/0004563212473441

Chin, P. K. L., Vella-Brincat, J. W. A., Walker, S. L., Barclay, M. L., & Begg, E. J. (2013). Dosing of dabigatran etexilate in relation to renal function and drug interactions at a tertiary hospital. Internal Medicine Journal, 43(7), 778-783. doi: 10.1111/imj.12170

Wong, C., Kumar, S. S., Graham, G. G., Begg, E. J., Chin, P. K. L., Brett, J., … Day, R. O. (2013). Comparing dose prediction software used to manage gentamicin dosing. Internal Medicine Journal, 43(5), 519-525. doi: 10.1111/imj.12067

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2013). The performances of the Cockcroft-Gault, Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Collaboration equations in predicting gentamicin clearance. Annals of Clinical Biochemistry, 50(6), 546-557. doi: 10.1177/0004563213492320

Jensen, B. P., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2012). Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin. British Journal of Clinical Pharmacology, 74(5), 797-805. doi: 10.1111/j.1365-2125.2012.04259.x

Ellis, E., Chin, P. K. L., Hunt, P. J., Lunt, H., Lewis, J. G., & Soule, S. G. (2012). Is late-night salivary cortisol a better screening test for possible cortisol excess than standard screening tests in obese patients with Type 2 diabetes? New Zealand Medical Journal, 125(1353). Retrieved from http://www.nzma.org.nz/journal

Van Egmond, R., Chin, P., Zhang, M., Sies, C. W., & Barclay, M. L. (2012). High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Alimentary Pharmacology & Therapeutics, 35(10), 1181-1189. doi: 10.1111/j.1365-2036.2012.05084.x

Vella-Brincat, J. W. A., Begg, E. J., Jensen, B. P., Chin, P. K. L., Roberts, R. L., Fairhall, M., … Reid, K. (2012). The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. Journal of Pain & Symptom Management, 43(3), 540-548. doi: 10.1016/j.jpainsymman.2011.04.022

Larsen, H. S., Chin, P. K. L., Begg, E. J., & Jensen, B. P. (2011). Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS. Bioanalysis, 3(8), 843-852. doi: 10.4155/bio.11.46

Jensen, B. P., Chin, P. K. L., & Begg, E. J. (2011). Quantification of total and free concentrations of R- and S-warfarin in human plasma by ultrafiltration and LC-MS/MS. Analytical & Bioanalytical Chemistry, 401(7), 2187-2193. doi: 10.1007/s00216-011-5303-x

Chin, P. K. L., Jensen, B. P., Larsen, H. S., & Begg, E. J. (2011). Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. British Journal of Clinical Pharmacology, 72(6), 985-989. doi: 10.1111/j.1365-2125.2011.04036.x

Chin, P. K. L., Beckert, L. E. L., Gunningham, S., Edwards, A. L., & Robinson, B. A. (2009). Audit of anticoagulant thromboprophylaxis in hospitalized oncology patients. Internal Medicine Journal, 39(12), 819-825. doi: 10.1111/j.1445-5994.2008.01828.x

Chin, P., Hurrell, M., McGregor, D., & Beckert, L. (2006). The role of CT pulmonary angiography in patients with suspected pulmonary embolism admitted to general medicine. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2052/content.pdf

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Journal - Research Other

Okamura-Kho, A., Chuah, Q., Chin, P., & Doogue, M. (2018). Rarely a triple whammy in general medicine. New Zealand Medical Journal, 1476(131), 92-95. Retrieved from https://www.nzma.org.nz/journal

Drennan, P., Doogue, M., van Hal, S. J., & Chin, P. (2018). Bayesian therapeutic drug monitoring software: Past, present and future. International Journal of Pharmacokinetics, 3(4), 109-114. doi: 10.4155/ipk-2018-0005

Chin, P. K. L., Fox, A. L., Marais, M., & Tiong, J. H. T. (2016). Screening coagulation tests are underutilised in patients on dabigatran presenting with thromboembolic or haemorrhagic events. Internal Medicine Journal, 46(2), 240-241. doi: 10.1111/imj.12970

Chin, P. K. L. (2015). Which patients may benefit from dose adjustment of non-vitamin K antagonist oral anticoagulants? Seminars in Thrombosis & Hemostasis, 41(2), 195-207. doi: 10.1055/s-0035-1546465

Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2014). Dabigatran in patients with mechanical heart valves. New England Journal of Medicine, 370, 382-383. doi: 10.1056/NEJMc1315004

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Chin, P. K. L., & Wright, D. F. B. (2014). [Letter by Chin et al regarding article, "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial analysis"]. Circulation, 130(22), e194. doi: 10.1161/circulationaha.114.010099

Howey, O. K., & Chin, P. K. L. (2013). Usage of renal function equations to guide prescribing in general medicine. New Zealand Medical Journal, 126(1383). Retrieved from http://www.nzma.org.nz/journal

Chin, P. K. L., Barclay, M. L., & Begg, E. J. (2013). Rifampicin and dabigatran etexilate: A place for laboratory coagulation monitoring. British Journal of Clinical Pharmacology, 75(2), 554-555. doi: 10.1111/j.1365-2125.2012.04408.x

Begg, E. J., & Chin, P. K. L. (2012). A unified pharmacokinetic approach to individualized drug dosing. British Journal of Clinical Pharmacology, 73(3), 335-339. doi: 10.1111/j.1365-2125.2011.04089.x

Chin, P. K. L., Vella-Brincat, J. W. A., Barclay, M. L., & Begg, E. J. (2012). Perspective on dabigatran etexilate dosing: Why not follow standard pharmacological principles? British Journal of Clinical Pharmacology, 74(5), 734-740. doi: 10.1111/j.1365-2125.2012.04266.x

Chin, P. K. L., Vella-Brincat, J. W. A., & Begg, E. J. (2012). Clarifying the American Society of Clinical Oncology Practice Guideline for Chemotherapy Dosing in Obese Adults. Journal of Clinical Oncology, 30(31), 3897. doi: 10.1200/JCO.2012.44.1626

Fairhall, M., Reid, K., Vella-Brincat, J. W. A., Walker, J., Chin, P. K. L., Jensen, B. P., … Begg, E. J. (2012). Exploring hospice patients' views about participating in research. Journal of Pain & Symptom Management, 43(3), e9-e11. doi: 10.1016/j.jpainsymman.2011.04.013

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Journal - Professional & Other Non-Research Articles

Kamel, K. S., Chin, P. K. L., Doogue, M. P., & Barclay, M. L. (2017). Comment on: "Effect of age and renal function on idarucizumab pharmacokinetics and idarucizumab-mediated reversal of dabigatran anticoagulant activity in a randomized, double-blind, crossover phase Ib study>". Clinical Pharmacokinetics, 56(2), 207-208. doi: 10.1007/s40262-016-0481-5

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Conference Contribution - Published proceedings: Abstract

Chin, P., Crawford, A., Chuah, Q., & Doogue, M. (2017). Impact of locally customised "blodd thinner" alerts in MedChart™. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 50). Retrieved from http://www.hinz.org.nz/

Chuah, Q., Chin, P., Hamilton, N., Gardiner, S., Strother, M., Dalton, S., Metcalf, S., & Doogue, M. (2017). Using electronic prescribing data to direct antimicrobial stewardship. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 107). Retrieved from http://www.hinz.org.nz/

Chin, P. K. L., Chuah, Q., & Doogue, M. P. (2017). Vignettes from hospital-level electronic prescribing data. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 58). Retrieved from http://www.asceptasm.com/

Doogue, M., Crawford, A., Miller, H., Drennan, P., Chuah, Q., Strowther, M., & Chin, P. (2017). Evidenced based drug-drug interaction alerts in an E-prescribing system. Clinical Therapeutics, 39(8, Suppl.), (pp. e18). doi: 10.1016/j.clinthera.2017.05.058

Doogue, M., Morahan, M.-C., Coberger, E., & Chin, P. (2017). Severe cutaneous adverse reactions and the (in)accuracy of medicines information sources. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 50). Retrieved from http://www.asceptasm.com/

Kennedy, M. A., Maggo, S. D. S., Foulds, J., Luty, S., Chua, E. W., Cree, S., Ton, K., Liau, Y., Miller, A. L., Chin, P., … Doogue, M. (2017). DNA banking and genetic analysis of adverse drug reactions in the New Zealand healthcare setting. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 2123. Retrieved from http://www.ashg.org/2017meeting/

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