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Paul Chin

Senior Lecturer

MB ChB PhD

Email paulchinnz@gmail.com

Paul Chin is a clinical pharmacologist, employed as a Senior Lecturer at the University of Otago, Christchurch and Senior Medical Officer at Canterbury District Health Board, New Zealand. He is also a qualified general physician, and completed a PhD in pharmacokinetic aspects of gentamicin and dabigatran in 2014. Research interests include therapeutic drug monitoring (including continuing work with anticoagulants and antimicrobials), quality use of medicines, electronic prescribing, and clinical decision support and estimation of renal function.

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Publications

Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal

Wallenburg, E., Brüggemann, R. J. M., Roberts, J. A., Jager, N. G. L., Ulldemolins, M., Wilkes, S., … Chin, P. K. L., & ter Heine, R. (2021). A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients. Clinical Microbiology & Infection. Advance online publication. doi: 10.1016/j.cmi.2021.06.039

McNeill, R., Hanger, H. C., Chieng, J., & Chin, P. (2021). Polypharmacy in palliative care: Two deprescribing tools compared with a clinical review. Journal of Palliative Medicine, 24(5), 661-667. doi: 10.1089/jpm.2020.0225

Thomas, P. W. A., Chin, P. K. L., & Barclay, M. L. (2021). A nationwide survey on therapeutic drug monitoring of anti-tumour necrosis factor agents for inflammatory bowel disease. Internal Medicine Journal, 51(3), 341-347. doi: 10.1111/imj.14778

McNeill, R., Hanger, H. C., Chieng, J., & Chin, P. (2021). Polypharmacy in palliative care: Two deprescribing tools compared with a clinical review. Journal of Palliative Medicine, 24(5), 661-667. doi: 10.1089/jpm.2020.0225

Journal - Research Article

Thomas, P. W. A., Chin, P. K. L., & Barclay, M. L. (2021). A nationwide survey on therapeutic drug monitoring of anti-tumour necrosis factor agents for inflammatory bowel disease. Internal Medicine Journal, 51(3), 341-347. doi: 10.1111/imj.14778

Journal - Research Article

Wallenburg, E., Brüggemann, R. J. M., Roberts, J. A., Jager, N. G. L., Ulldemolins, M., Wilkes, S., … Chin, P. K. L., & ter Heine, R. (2021). A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients. Clinical Microbiology & Infection. Advance online publication. doi: 10.1016/j.cmi.2021.06.039

Journal - Research Article

Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972

Journal - Research Article

Chin, P. K. L., Chuah, Q., Crawford, A. M., Clendon, O. R., Drennan, P. G., Dalrymple, J. M., Barclay, M. L., & Doogue, M. P. (2020). Clinical decision support in a hospital electronic prescribing system informed by local data: Experience at a tertiary New Zealand centre. Internal Medicine Journal, 50, 1225-1232. doi: 10.1111/imj.14706

Journal - Research Article

Chin, P. K. L., McNeill, R., Lee, H. K., Zhang, M., Jensen, B., Smith, M., & Doogue, M. P. (2020). Routine therapeutic drug monitoring of dabigatran: Experience at a tertiary center. Therapeutic Drug Monitoring, 42(3), 468-472. doi: 10.1097/ftd.0000000000000713

Journal - Research Article

Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Zhang, M., Moore, G. A., & Chin, P. K. L. (2020). Simultaneous determination of dabigatran, rivaroxaban, and apixaban in human plasma by liquid chromatography/tandem mass spectrometry. Therapeutic Drug Monitoring, 42(3), 473-480. doi: 10.1097/ftd.0000000000000744

Journal - Research Article

Brett, O. F., Brett, C. N., & Chin, P. K. L. (2019). The effect of routine preoperative interruption of dabigatran therapy on coagulation parameters and dabigatran plasma levels in a mixed surgical population. Anaesthesia & Intensive Care, 47(2), 183-188. doi: 10.1177/0310057x19841009

Journal - Research Article

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Journal - Research Article

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673

Journal - Research Article

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Journal - Research Article

Zhang, M., Moore, G. A., Chin, P. K. L., Everts, R., & Begg, E. J. (2018). Simultaneous determination of Cefalexin, Cefazolin, Flucloxacillin and Probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Therapeutic Drug Monitoring, 40(6), 682-692. doi: 10.1097/FTD.0000000000000555

Journal - Research Article

Hernandez, I., Zhang, Y., Brooks, M. M., Chin, P. K. L., & Saba, S. (2017). Anticoagulation use and clinical outcomes after major bleeding on Dabigatran or Warfarin in atrial fibrillation. Stroke, 48(1), 159-166. doi: 10.1161/strokeaha.116.015150

Journal - Research Article

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Journal - Research Article

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Journal - Research Article

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Journal - Research Article

Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., Buffery, P. J., & Begg, E. J. (2015). Gentamicin and renal function: Lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin. Therapeutic Drug Monitoring, 37(1), 98-103. doi: 10.1097/FTD.0000000000000107

Journal - Research Article

Saffian, S. M., Zhang, M., Chin, P. K. L., & Jensen, B. P. (2015). Quantification of dabigatran and indirect quantification of dabigatran acylglucuronides in human plasma by LC-MS/MS. Bioanalysis, 7(8), 957-966. doi: 10.4155/bio.15.32

Journal - Research Article

Buffery, P. J., Allen, K. M., Chin, P. K. L., Moore, G. A., Barclay, M. L., & Begg, E. J. (2014). Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: Can the strategy be improved? Therapeutic Drug Monitoring, 36(1), 86-92. doi: 10.1097/FTD.0b013e31829dc940

Journal - Research Article

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9

Journal - Research Article

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2013). The performances of the Cockcroft-Gault, Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Collaboration equations in predicting gentamicin clearance. Annals of Clinical Biochemistry, 50(6), 546-557. doi: 10.1177/0004563213492320

Journal - Research Article

Chin, P. K. L., Vella-Brincat, J. W. A., Walker, S. L., Barclay, M. L., & Begg, E. J. (2013). Dosing of dabigatran etexilate in relation to renal function and drug interactions at a tertiary hospital. Internal Medicine Journal, 43(7), 778-783. doi: 10.1111/imj.12170

Journal - Research Article

Van Egmond, R., Barclay, M. L., Chin, P. K. L., Sies, C. W., & Florkowski, C. M. (2013). Biological variation of thiopurine methyltransferase enzyme activity: When has a significant change taken place? Annals of Clinical Biochemistry, 50(5), 473-478. doi: 10.1177/0004563212473441

Journal - Research Article

Wong, C., Kumar, S. S., Graham, G. G., Begg, E. J., Chin, P. K. L., Brett, J., … Day, R. O. (2013). Comparing dose prediction software used to manage gentamicin dosing. Internal Medicine Journal, 43(5), 519-525. doi: 10.1111/imj.12067

Journal - Research Article

Ellis, E., Chin, P. K. L., Hunt, P. J., Lunt, H., Lewis, J. G., & Soule, S. G. (2012). Is late-night salivary cortisol a better screening test for possible cortisol excess than standard screening tests in obese patients with Type 2 diabetes? New Zealand Medical Journal, 125(1353). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Article

Jensen, B. P., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2012). Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin. British Journal of Clinical Pharmacology, 74(5), 797-805. doi: 10.1111/j.1365-2125.2012.04259.x

Journal - Research Article

Van Egmond, R., Chin, P., Zhang, M., Sies, C. W., & Barclay, M. L. (2012). High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Alimentary Pharmacology & Therapeutics, 35(10), 1181-1189. doi: 10.1111/j.1365-2036.2012.05084.x

Journal - Research Article

Vella-Brincat, J. W. A., Begg, E. J., Jensen, B. P., Chin, P. K. L., Roberts, R. L., Fairhall, M., … Reid, K. (2012). The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. Journal of Pain & Symptom Management, 43(3), 540-548. doi: 10.1016/j.jpainsymman.2011.04.022

Journal - Research Article

Chin, P. K. L., Jensen, B. P., Larsen, H. S., & Begg, E. J. (2011). Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. British Journal of Clinical Pharmacology, 72(6), 985-989. doi: 10.1111/j.1365-2125.2011.04036.x

Journal - Research Article

Jensen, B. P., Chin, P. K. L., & Begg, E. J. (2011). Quantification of total and free concentrations of R- and S-warfarin in human plasma by ultrafiltration and LC-MS/MS. Analytical & Bioanalytical Chemistry, 401(7), 2187-2193. doi: 10.1007/s00216-011-5303-x

Journal - Research Article

Larsen, H. S., Chin, P. K. L., Begg, E. J., & Jensen, B. P. (2011). Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS. Bioanalysis, 3(8), 843-852. doi: 10.4155/bio.11.46

Journal - Research Article

Chin, P. K. L., Beckert, L. E. L., Gunningham, S., Edwards, A. L., & Robinson, B. A. (2009). Audit of anticoagulant thromboprophylaxis in hospitalized oncology patients. Internal Medicine Journal, 39(12), 819-825. doi: 10.1111/j.1445-5994.2008.01828.x

Journal - Research Article

Chin, P., Hurrell, M., McGregor, D., & Beckert, L. (2006). The role of CT pulmonary angiography in patients with suspected pulmonary embolism admitted to general medicine. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2052/content.pdf

Journal - Research Article

Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Kee, P. S., Chin, P. K. L., Kennedy, M. A., & Maggo, S. D. S. (2020). Pharmacogenetics of statin-induced myotoxicity. Frontiers in Genetics, 11, 575678. doi: 10.3389/fgene.2020.575678

Journal - Research Other

Drennan, P., Doogue, M., van Hal, S. J., & Chin, P. (2018). Bayesian therapeutic drug monitoring software: Past, present and future. International Journal of Pharmacokinetics, 3(4), 109-114. doi: 10.4155/ipk-2018-0005

Journal - Research Other

Okamura-Kho, A., Chuah, Q., Chin, P., & Doogue, M. (2018). Rarely a triple whammy in general medicine. New Zealand Medical Journal, 1476(131), 92-95. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Chin, P. K. L., Fox, A. L., Marais, M., & Tiong, J. H. T. (2016). Screening coagulation tests are underutilised in patients on dabigatran presenting with thromboembolic or haemorrhagic events. Internal Medicine Journal, 46(2), 240-241. doi: 10.1111/imj.12970

Journal - Research Other

Chin, P. K. L. (2015). Which patients may benefit from dose adjustment of non-vitamin K antagonist oral anticoagulants? Seminars in Thrombosis & Hemostasis, 41(2), 195-207. doi: 10.1055/s-0035-1546465

Journal - Research Other

Chin, P. K. L., & Wright, D. F. B. (2014). [Letter by Chin et al regarding article, "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial analysis"]. Circulation, 130(22), e194. doi: 10.1161/circulationaha.114.010099

Journal - Research Other

Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2014). Dabigatran in patients with mechanical heart valves. New England Journal of Medicine, 370, 382-383. doi: 10.1056/NEJMc1315004

Journal - Research Other

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Journal - Research Other

Chin, P. K. L., Barclay, M. L., & Begg, E. J. (2013). Rifampicin and dabigatran etexilate: A place for laboratory coagulation monitoring. British Journal of Clinical Pharmacology, 75(2), 554-555. doi: 10.1111/j.1365-2125.2012.04408.x

Journal - Research Other

Howey, O. K., & Chin, P. K. L. (2013). Usage of renal function equations to guide prescribing in general medicine. New Zealand Medical Journal, 126(1383). Retrieved from http://www.nzma.org.nz/journal

Journal - Research Other

Begg, E. J., & Chin, P. K. L. (2012). A unified pharmacokinetic approach to individualized drug dosing. British Journal of Clinical Pharmacology, 73(3), 335-339. doi: 10.1111/j.1365-2125.2011.04089.x

Journal - Research Other

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