Dr Paul Chin

2024

Journal - Research Article

Keating, P. E., Hock, B. D., Chin, P. K. L., O'Donnell, J. L., & Barclay, M. L. (2024). Evaluation of the homogenous mobility shift assay for infliximab and adalimumab anti-drug antibody detection in the clinical laboratory. Therapeutic Drug Monitoring. Advance online publication. doi: 10.1097/ftd.0000000000001200

Sundermann, M., Clendon, O., McNeill, R., Doogue, M., & Chin, P. K. L. (2024). Optimising interruptive clinical decision support alerts for antithrombotic duplicate prescribing in hospital. International Journal of Medical Informatics, 186, 104418. doi: 10.1016/j.ijmedinf.2024.105418

Conference Contribution - Published proceedings: Abstract

Sundermann, M., Every-Palmer, S., & Chin, P. K. L. (2024). A decision support alert for promoting prophylactic laxative use with clozapine. In J. Mantas, A. Hasman, G. Demiris, K. Saranto, M. Marschollek, T. Arvanitis, … E. Andrikopoulou (Eds.), Digital health and informatics innovations for sustainable health care systems: Proceedings of the Medical Informatics Europe Conference (MIE). (pp. 1748-1749). Amsterdam, Netherlands: IOS Press. doi: 10.3233/SHTI240766

Chin, P., Pairman, L., & Quayle, J. (2024). Electronic prescribing by medical students: Descriptive data and inferred clinical impact. In J. Mantas, A. Hasman, G. Demiris, K. Saranto, M. Marschollek, T. Arvanitis, … E. Andrikopoulou (Eds.), Digital health and informatics innovations for sustainable health care systems: Proceedings of the Medical Informatics Europe Conference (MIE). (pp. 1517-1518). Amsterdam, Netherlands: IOS Press. doi: 10.3233/shti240703

2023

Journal - Research Article

Chin, P. K. L., Charles, K., Murnion, B., McGuire, T. M., Hilmer, S. N., Martin, J., Reith, D., … Doogue, M., … O'Mara, D. (2023). Evaluation of the Prescribing Skills Assessment implementation, performance and medical student experience in Australia and New Zealand. British Journal of Clinical Pharmacology, 89, 3105-3115. doi: 10.1111/bcp.15814

Kee, P. S., Maggo, S. D. S., Kennedy, M. A., & Chin, P. K. L. (2023). The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses [Brief research report]. Frontiers in Pharmacology, 14, 1080117. doi: 10.3389/fphar.2023.1080117

Wang, M., Barclay, M. L., Chin, P. K. L., & Doogue, M. P. (2023). Changes in inpatient medicine prescribing during Covid-19 lockdown. Internal Medicine Journal, 53, 917-922. doi: 10.1111/imj.15996

Campbell, P. O., Chin, P. K. L., Dalton, S. C., Metcalf, S. C. L., Douglas, N. M., & Chambers, S. T. (2023). Frequency of pharmacological target attainment with flucloxacillin and cefazolin in invasive methicillin-susceptible Staphylococcus aureus infection: A prospective cohort study in hospitalized patients. International Journal of Antimicrobial Agents, 61, 106695. doi: 10.1016/j.ijantimicag.2022.106695

Journal - Research Other

Keating, P. E., Hock, B. D., Smith, S. M., Chin, P. K. L., O'Donnell, J. L., & Barclay, M. L. (2023). Four-year review of New Zealand laboratory infliximab and adalimumab concentration results indicating potential for improved dosing [Brief communication]. Internal Medicine Journal, 53(11), 2123-2127. doi: 10.1111/imj.16264

Chin, P. K. L., Than, M., & Chambers, S. (2023). One giant leap for cephalexin dosing, one small step for antimicrobial stewardship. Canadian Journal of Emergency Medicine, 25, 7-8. doi: 10.1007/s43678-022-00442-6

Conference Contribution - Published proceedings: Abstract

Morahan, M.-C., Yorkston, D., Knight, J., Borrie, T., Hastie, B., & Chin, P. (2023). The Covid-19 pandemic perspective from a New Zealand medicines information service. Pharmacy Education, 23(6), (pp. 176-177). doi: 10.46542/pe.2023.236.158191

Pairman, L., Chin, P., McNeill, R., & Doogue, M. (2023). The effect of compulsory indications in electronic hospital prescriptions on prescriber behaviour. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. 435. Retrieved from https://www.asceptasm.com

Barclay, M. L., Keating, P. E., Hock, B. D., Chin, P. K. L., & O'Donnell, J. L. (2023). Infliximab or adalimumab antidrug-antibody complex size has more clinical value than concentration. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. 235. Retrieved from https://www.asceptasm.com

Barclay, M. L., Keating, P. E., Hock, B. D., Smith, S. M., Chin, P. K. L., & O'Donnell, J. L. (2023). Four-year review of New Zealand laboratory infliximab and adalimumab concentration results indicating high potential for improved dosing. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. P513. Retrieved from https://www.asceptasm.com

Zhang, M., Moore, G., Chin, P. K. L., & Doogue, M. (2023). An efficient HILIC-MS/MS method for monitoring metformin in human plasma. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. P510. Retrieved from https://www.asceptasm.com

Chin, P. K. L., O'Mahoney, A., & Hiskett, I. (2023). Routine therapeutic drug monitoring of rivaroxaban: Experience at a tertiary center. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting: Transformational Pharmacology and Toxicology. P509. Retrieved from https://www.asceptasm.com

2022

Journal - Research Article

Wallenburg, E., Brüggemann, R. J. M., Roberts, J. A., Jager, N. G. L., Ulldemolins, M., Wilkes, S., … Chin, P. K. L., & ter Heine, R. (2022). A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients. Clinical Microbiology & Infection, 28, 446.e1-446.e7. doi: 10.1016/j.cmi.2021.06.039

Journal - Research Other

Kee, P. S., Maggo, S. D. S., Kennedy, M. A., Barclay, M. L., Miller, A. L., Lehnert, K., … Chin, P. K. L. (2022). Omeprazole treatment failure in gastroesophageal reflux disease and genetic variation at the CYP2C locus [Brief research report]. Frontiers in Genetics, 13, 869160. doi: 10.3389/fgene.2022.869160

Ng, J.-W., Tahir, N. A. M., Chin, P. K. L., Makmor-Bakry, M., & Mohd Saffian, S. (2022). A systematic review and meta-analysis of dabigatran peak and trough concentration in adults. British Journal of Clinical Pharmacology, 88, 4443-4459. doi: 10.1111/bcp.15431

Conference Contribution - Published proceedings: Abstract

Shaw, A. M., Chin, P. K., & Wright, D. F. B. (2022). Vancomycin AUC optimisation using minimal plasma concentration monitoring. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 555. Retrieved from https://www.asceptasm.com

Morahan, M.-C., Campbell, V., Selagan, N., Houghton, K., Gardiner, S., & Chin, P. (2022). Vanquish the vancomycin trough: The AUC strikes back. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 543. Retrieved from https://www.asceptasm.com

Pairman, L., McNeill, R., Chin, P., & Doogue, M. (2022). Using electronic prescription and laboratory data to assess prescribing practice. Proceedings of the Australasian Pharmaceutical Science Association (APSA) and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Conference. 111. Retrieved from https://www.asceptasm.com

Conference Contribution - Verbal presentation and other Conference outputs

Pairman, L., Chin, P., Gardiner, S., & Doogue, M. (2022, August-September). The effect of mandatory prescription indications for antibacterials. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

Kee, P. S., Maggo, S., Kennedy, M. A., Barclay, M. L., Miller, A., Lehnert, K., … Faull, R. L. M., … Chin, P. K. L. (2022, August-September). Omeprazole treatment failure in gastro-oesophageal reflux disease and genetic variation at the CYP2C locus. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

Morahan, M.-C., & Chin, P. (2022, August-September). Using Bayesian software to inform initial busulfan dose in adults receiving haematopoietic stem cell transplantation. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

2021

Journal - Research Article

McNeill, R., Hanger, H. C., Chieng, J., & Chin, P. (2021). Polypharmacy in palliative care: Two deprescribing tools compared with a clinical review. Journal of Palliative Medicine, 24(5), 661-667. doi: 10.1089/jpm.2020.0225

Thomas, P. W. A., Chin, P. K. L., & Barclay, M. L. (2021). A nationwide survey on therapeutic drug monitoring of anti-tumour necrosis factor agents for inflammatory bowel disease. Internal Medicine Journal, 51(3), 341-347. doi: 10.1111/imj.14778

Journal - Research Other

Gardiner, S. J., Duffy, E. J., Chambers, S. T., Thomas, M. G., Addidle, M., Arnold, B., … Balm, M. N. D., … Berger, S., … Birch, M., Blackmore, T. K., Bloomfield, M., … Bupha-Intr, O., … Campbell, C., Chin, P. K. L., Dalton, S. C., … Douglas, N. M., … Elvy, J., Everts, R., … Hudson, B., … Isenman, H., Issa, M., Kelly, M. J., Li, C., … Maze, M., Metcalf, S. C. L., McCall, C., Murdoch, D., … Pithie, A., Raymond, N., … Ussher, J. E., … Walls, T., & Yew, H. S. (2021). Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: Urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness. New Zealand Medical Journal, 134(1544), 113-128. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2020

Journal - Research Article

Gardiner, S. J., Basevi, A. B., Hamilton, N. L., Metcalf, S. C. L., Chambers, S. T., Withington, S. G., Chin, P. K., Freeman, J. T., Dalton, S. C., on behalf of the Canterbury District Health Board Antimicrobial Stewardship Committee. (2020). Point prevalence surveys of antimicrobial use in adult inpatients at Canterbury District Health Board hospitals. New Zealand Medical Journal, 133(1525), 18-33. Retrieved from https://www.nzma.org.nz/journal

Chambers, S. T., Long, M., Gardiner, S. J., Chin, P. K. L., Yi, M., Dalton, S. C., … Metcalf, S. C. L. (2020). Determinants of vancomycin nephrotoxicity when administered to outpatients as a continuous 24-hour infusion. International Journal of Antimicrobial Agents, 55, 105972. doi: 10.1016/j.ijantimicag.2020.105972

Zhang, M., Moore, G. A., & Chin, P. K. L. (2020). Simultaneous determination of dabigatran, rivaroxaban, and apixaban in human plasma by liquid chromatography/tandem mass spectrometry. Therapeutic Drug Monitoring, 42(3), 473-480. doi: 10.1097/ftd.0000000000000744

Chin, P. K. L., Chuah, Q., Crawford, A. M., Clendon, O. R., Drennan, P. G., Dalrymple, J. M., Barclay, M. L., & Doogue, M. P. (2020). Clinical decision support in a hospital electronic prescribing system informed by local data: Experience at a tertiary New Zealand centre. Internal Medicine Journal, 50, 1225-1232. doi: 10.1111/imj.14706

Chin, P. K. L., McNeill, R., Lee, H. K., Zhang, M., Jensen, B., Smith, M., & Doogue, M. P. (2020). Routine therapeutic drug monitoring of dabigatran: Experience at a tertiary center. Therapeutic Drug Monitoring, 42(3), 468-472. doi: 10.1097/ftd.0000000000000713

Journal - Research Other

Kee, P. S., Chin, P. K. L., Kennedy, M. A., & Maggo, S. D. S. (2020). Pharmacogenetics of statin-induced myotoxicity. Frontiers in Genetics, 11, 575678. doi: 10.3389/fgene.2020.575678

2019

Journal - Research Article

Brett, O. F., Brett, C. N., & Chin, P. K. L. (2019). The effect of routine preoperative interruption of dabigatran therapy on coagulation parameters and dabigatran plasma levels in a mixed surgical population. Anaesthesia & Intensive Care, 47(2), 183-188. doi: 10.1177/0310057x19841009

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2019). A randomised controlled trial of patient information leaflets as a medication counselling aid. Internal Medicine Journal, 49(3), 328-332. doi: 10.1111/imj.14038

Conference Contribution - Published proceedings: Abstract

McNeill, R., Hanger, C., Chieng, J., & Chin, P. (2019). Polypharmacy in palliative care: A retrospective comparison of two explicit deprescribing tools. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 22). Retrieved from https://www.asceptasm.com

Doogue, M. P., & Chin, P. K. L. (2019). Using patient simulation in the clinical learning environment. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia and New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 59). Retrieved from https://www.asceptasm.com

2018

Journal - Research Article

Slow, S., Epton, M., Storer, M., Thiessen, R., Lim, S., Wong, J., Chin, P., Tovaranonte, P., Pearson, J., Chambers, S. T., Murdoch, D. R., and VIDCAPS Group, including Jardine, D., & Pithie, A. (2018). Effect of adjunctive single high-dose vitamin D₃ on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial. Scientific Reports, 8(1), 13829. doi: 10.1038/s41598-018-32162-2

Zhang, M., Moore, G. A., Chin, P. K. L., Everts, R., & Begg, E. J. (2018). Simultaneous determination of Cefalexin, Cefazolin, Flucloxacillin and Probenecid by liquid chromatography-tandem mass spectrometry for total and unbound concentrations in human plasma. Therapeutic Drug Monitoring, 40(6), 682-692. doi: 10.1097/FTD.0000000000000555

Chin, P. K. L., Drennan, P. G., Gardiner, S. J., Zhang, M., Dalton, S. C., Chambers, S. T., & Begg, E. J. (2018). Total flucloxacillin plasma concentrations poorly reflect unbound concentrations in hospitalised patients with Staphylococcus aureus bacteraemia. British Journal of Clinical Pharmacology, 84(10), 2311-2316. doi: 10.1111/bcp.13673

Gardiner, S. J., Metcalf, S. C. L., Chin, P. K. L., Doogue, M. P., Dalton, S. C., & Chambers, S. T. (2018). Metronidazole stewardship initiative at Christchurch hospitals: Achievable with immediate benefits. New Zealand Medical Journal, 131(1473), 53-58. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Other

Drennan, P., Doogue, M., van Hal, S. J., & Chin, P. (2018). Bayesian therapeutic drug monitoring software: Past, present and future. International Journal of Pharmacokinetics, 3(4), 109-114. doi: 10.4155/ipk-2018-0005

Okamura-Kho, A., Chuah, Q., Chin, P., & Doogue, M. (2018). Rarely a triple whammy in general medicine. New Zealand Medical Journal, 1476(131), 92-95. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Doogue, M., Chin, P., Simpson, C., Frew, G., Hudson, B., & Heppenstall, C. (2018, August). Recording adverse drug reactions in New Zealand. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

Thomas, P. W. A., Chin, P. K. L., Doogue, M. P., & Barclay, M. L. (2018, August). A nationwide survey on therapeutic drug monitoring of anti-tumour necrosis factor agents for inflammatory bowel disease. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

Chin, P. K. L., Lee, M. H., Smith, M., & Doogue, M. P. (2018, August). Real-world dabigatran concentration monitoring: Christchurch experience. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

2017

Journal - Research Article

Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal

Hernandez, I., Zhang, Y., Brooks, M. M., Chin, P. K. L., & Saba, S. (2017). Anticoagulation use and clinical outcomes after major bleeding on Dabigatran or Warfarin in atrial fibrillation. Stroke, 48(1), 159-166. doi: 10.1161/strokeaha.116.015150

Journal - Professional & Other Non-Research Articles

Kamel, K. S., Chin, P. K. L., Doogue, M. P., & Barclay, M. L. (2017). Comment on: "Effect of age and renal function on idarucizumab pharmacokinetics and idarucizumab-mediated reversal of dabigatran anticoagulant activity in a randomized, double-blind, crossover phase Ib study>". Clinical Pharmacokinetics, 56(2), 207-208. doi: 10.1007/s40262-016-0481-5

Conference Contribution - Published proceedings: Abstract

Doogue, M., Morahan, M.-C., Coberger, E., & Chin, P. (2017). Severe cutaneous adverse reactions and the (in)accuracy of medicines information sources. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 50). Retrieved from http://www.asceptasm.com/

Doogue, M., McNeill, R., Young, M., Wilkinson, J., Pugh, S., Sylevych, V., … Chuah, Q., Hamilton, N., Chua, I., … Barclay, M., & Chin, P. (2017). Making adverse drug reactions visible. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 49). Retrieved from http://www.asceptasm.com/

Crawford, A., Chin, P., & Doogue, M. (2017). Antithrombotic drug-drug interaction alerts in MedChart™. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 48). Retrieved from http://www.asceptasm.com/

Hamilton, N., Chuah, Q., Chin, P., & Gardiner, S. (2017). Real-time review of electronic prescribing of restricted antimicrobials: A pilot of a new antimicrobial stewardship initiative for Christchurch Hospital. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 79). Retrieved from http://www.asceptasm.com/

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2017). A randomised controlled trial of patient information leaflets as a medication counselling tool. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 77). Retrieved from http://www.asceptasm.com/

Chin, P. K. L., Chuah, Q., & Doogue, M. P. (2017). Vignettes from hospital-level electronic prescribing data. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 58). Retrieved from http://www.asceptasm.com/

Chin, P., Crawford, A., Chuah, Q., & Doogue, M. (2017). Impact of locally customised "blodd thinner" alerts in MedChart™. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 50). Retrieved from http://www.hinz.org.nz/

Chuah, Q., Chin, P., Hamilton, N., Gardiner, S., Strother, M., Dalton, S., Metcalf, S., & Doogue, M. (2017). Using electronic prescribing data to direct antimicrobial stewardship. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 107). Retrieved from http://www.hinz.org.nz/

Kennedy, M. A., Maggo, S. D. S., Foulds, J., Luty, S., Chua, E. W., Cree, S., Ton, K., Liau, Y., Miller, A. L., Chin, P., … Doogue, M. (2017). DNA banking and genetic analysis of adverse drug reactions in the New Zealand healthcare setting. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 2123. Retrieved from http://www.ashg.org/2017meeting/

Doogue, M., Crawford, A., Miller, H., Drennan, P., Chuah, Q., Strowther, M., & Chin, P. (2017). Evidenced based drug-drug interaction alerts in an E-prescribing system. Clinical Therapeutics, 39(8, Suppl.), (pp. e18). doi: 10.1016/j.clinthera.2017.05.058

Conference Contribution - Verbal presentation and other Conference outputs

Chin, P. K. L., Chuah, Q., & Doogue, M. P. (2017, September). Vignettes from electronic prescribing data. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

McNeill, R., Chin, P., Coberger, E., & Doogue, M. (2017, September). Evaluation of patient information leaflets as a medication counselling tool. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

2016

Journal - Research Article

Chin, P. K. L., & Doogue, M. P. (2016). Long-term prescribing of new oral anticoagulants. Australian Prescriber, 39(6), 200-204. doi: 10.18773/austprescr.2016.068

Journal - Research Other

Chin, P. K. L., Fox, A. L., Marais, M., & Tiong, J. H. T. (2016). Screening coagulation tests are underutilised in patients on dabigatran presenting with thromboembolic or haemorrhagic events. Internal Medicine Journal, 46(2), 240-241. doi: 10.1111/imj.12970

Conference Contribution - Published proceedings: Abstract

Doogue, M., Chin, P., Strother, M., Dean, K., Lodge, C., & Hamilton, N. (2016). Evidence based clinical decision support for e-prescribing and administration to reduce alert fatigue. Proceedings of the Health Informatics New Zealand (HiNZ) Conference. (pp. 70-71). Retrieved from http://www.hinz.org.nz/

Zhang, M., Moore, G. A., & Chin, P. (2016). Simultaneous determination of dabigatran, rivaroxaban and apixaban in human plasma by liquid chromatography/tandem mass spectrometry. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 552. Retrieved from http://www.asceptasm.com/

Chuah, Q., Chin, P. K. L., Vella-Brincat, J., Strother, R. M., Lodge, C., Dean, K., & Doogue, M. P. (2016). Drug-drug interaction and brand-prescribing alerts in an electronic prescribing and administration (ePA) system. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 536. Retrieved from http://www.asceptasm.com/

Chuah, Q., Vella-Brincat, J., Chin, P., Barclay, M., & Doogue, M. (2016). Use of clinical decision support in ePrescribing to facilitate generic prescribing. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 20). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/

Wareing, T. R., Chin, P., Strother, R. M., Vella Brincat, J., Chuah, Q., & Doogue, M. P. (2016). Adverse drug reactions in an electronic prescribing and administration system. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 20). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/

Drennan, P., Chin, P., Strother, M., Lodge, C., Dean, K., & Doogue, M. P. (2016). Drug-drug interaction alerts in an electronic prescribing system. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 16). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/

Doogue, M. P., Chin, P., Strother, R. M., Lodge, C., Dean, K., & Hamilton, N. (2016). Clinical decision support in an electronic prescribing and administration system. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 14). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/

2015

Journal - Research Article

Chin, P. K. L., Chew-Harris, J. S. C., Florkowski, C. M., & Begg, E. J. (2015). The performance of contemporary cystatin C-based GFR equations in predicting gentamicin clearance. British Journal of Clinical Pharmacology, 79(2), 268-277. doi: 10.1111/bcp.12501

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P., & Endre, Z. (2015). Removal of body surface area normalisation improves raw-measured glomerular filtration rate estimation by the Chronic Kidney Disease Epidemiology Collaboration equation and drug dosing in the obese. Internal Medicine Journal, 45(7), 766-773. doi: 10.1111/imj.12791

Saffian, S. M., Zhang, M., Chin, P. K. L., & Jensen, B. P. (2015). Quantification of dabigatran and indirect quantification of dabigatran acylglucuronides in human plasma by LC-MS/MS. Bioanalysis, 7(8), 957-966. doi: 10.4155/bio.15.32

Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., Buffery, P. J., & Begg, E. J. (2015). Gentamicin and renal function: Lessons from 15 years' experience of a pharmacokinetic service for extended interval dosing of gentamicin. Therapeutic Drug Monitoring, 37(1), 98-103. doi: 10.1097/FTD.0000000000000107

Journal - Research Other

Chin, P. K. L. (2015). Which patients may benefit from dose adjustment of non-vitamin K antagonist oral anticoagulants? Seminars in Thrombosis & Hemostasis, 41(2), 195-207. doi: 10.1055/s-0035-1546465

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J. S. C., Chin, P. K. L., Florkowski, C. M., George, P. M., & Endre, Z. H. (2015). Accounting for individual body surface area does improve estimation of absolute GFR using the CKD-EPI equation. Pathology, 47(Suppl. 1), (pp. S82). doi: 10.1097/01.PAT.0000461557.00460.df

Chin, P. K. L., Drennan, P. G., Dalton, S. C., Zhang, M., & Begg, E. J. (2015). Flucloxacillin: Total concentrations poorly reflect unbound concentrations in hospitalised patients. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting: Drugs to Medicines: Up Close and Personal. 236. Retrieved from http://www.asceptasm.com/

Drennan, P., Chin, P., Strother, M., Lodge, C., Dean, K., & Doogue, M. (2015). Drug-drug interaction alerts in an electronic prescribing system. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting: Drugs to Medicines: Up Close and Personal. 164. Retrieved from http://www.asceptasm.com/

2014

Journal - Research Article

Chin, P. K. L., Wright, D. F. B., Patterson, D. M., Doogue, M. P., & Begg, E. J. (2014). A proposal for dose-adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time. British Journal of Clinical Pharmacology, 78(3), 599-609. doi: 10.1111/bcp.12364

Chin, P. K. L., Wright, D. F. B., Zhang, M., Wallace, M. C., Roberts, R. L., Patterson, D. M., Jensen, B. P., Barclay, M. L., & Begg, E. J. (2014). Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs in R&D, 14(2), 113-123. doi: 10.1007/s40268-014-0045-9

Chin, P. K. L., Patterson, D. M., Zhang, M., Jensen, B. P., Wright, D. F. B., Barclay, M. L., & Begg, E. J. (2014). Coagulation assays and plasma fibrinogen concentrations in real-world patients with atrial fibrillation treated with dabigatran. British Journal of Clinical Pharmacology, 78(3), 630-638. doi: 10.1111/bcp.12366

Buffery, P. J., Allen, K. M., Chin, P. K. L., Moore, G. A., Barclay, M. L., & Begg, E. J. (2014). Thirteen years' experience of pharmacokinetic monitoring and dosing of busulfan: Can the strategy be improved? Therapeutic Drug Monitoring, 36(1), 86-92. doi: 10.1097/FTD.0b013e31829dc940

Journal - Research Other

Chin, P. K. L., & Wright, D. F. B. (2014). [Letter by Chin et al regarding article, "Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial analysis"]. Circulation, 130(22), e194. doi: 10.1161/circulationaha.114.010099

Chin, P. K. L., Wright, D. F. B., Doogue, M. P., & Begg, E. J. (2014). Learning more from the dabigatran concentrations in RE-LY. JACC, 63(24), 2746-2747. doi: 10.1016/j.jacc.2013.11.069

Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2014). Dabigatran in patients with mechanical heart valves. New England Journal of Medicine, 370, 382-383. doi: 10.1056/NEJMc1315004

Conference Contribution - Verbal presentation and other Conference outputs

Chin, P. (2014, August). Application of a target trough dabigatran concentration range for atrial fibrillation. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

Awarded Doctoral Degree

Chin, P. K. L. (2014). Renal function in relation to gentamicin and dabigatran clearance and dosing (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/5020

2013

Journal - Research Article

Van Egmond, R., Barclay, M. L., Chin, P. K. L., Sies, C. W., & Florkowski, C. M. (2013). Biological variation of thiopurine methyltransferase enzyme activity: When has a significant change taken place? Annals of Clinical Biochemistry, 50(5), 473-478. doi: 10.1177/0004563212473441

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2013). The performances of the Cockcroft-Gault, Modification of Diet in Renal Disease Study and Chronic Kidney Disease Epidemiology Collaboration equations in predicting gentamicin clearance. Annals of Clinical Biochemistry, 50(6), 546-557. doi: 10.1177/0004563213492320

Wong, C., Kumar, S. S., Graham, G. G., Begg, E. J., Chin, P. K. L., Brett, J., … Day, R. O. (2013). Comparing dose prediction software used to manage gentamicin dosing. Internal Medicine Journal, 43(5), 519-525. doi: 10.1111/imj.12067

Chin, P. K. L., Vella-Brincat, J. W. A., Walker, S. L., Barclay, M. L., & Begg, E. J. (2013). Dosing of dabigatran etexilate in relation to renal function and drug interactions at a tertiary hospital. Internal Medicine Journal, 43(7), 778-783. doi: 10.1111/imj.12170

Journal - Research Other

Chin, P. K. L., Barclay, M. L., & Begg, E. J. (2013). Rifampicin and dabigatran etexilate: A place for laboratory coagulation monitoring. British Journal of Clinical Pharmacology, 75(2), 554-555. doi: 10.1111/j.1365-2125.2012.04408.x

Howey, O. K., & Chin, P. K. L. (2013). Usage of renal function equations to guide prescribing in general medicine. New Zealand Medical Journal, 126(1383). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Verbal presentation and other Conference outputs

Chin, P. K. L., Wright, D. F. B., & Begg, E. J. (2013, August). An in silico study of protein binding and clearance changes with adult ageing. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

Walter, C., Gow, C., Chin, P. K., & Barclay, M. L. (2013, August). All intensive care unit patients on phenytoin require measurement of free drug concentration due to reduced plasma protein binding. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.

2012

Journal - Research Article

Ellis, E., Chin, P. K. L., Hunt, P. J., Lunt, H., Lewis, J. G., & Soule, S. G. (2012). Is late-night salivary cortisol a better screening test for possible cortisol excess than standard screening tests in obese patients with Type 2 diabetes? New Zealand Medical Journal, 125(1353). Retrieved from http://www.nzma.org.nz/journal

Jensen, B. P., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2012). Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin. British Journal of Clinical Pharmacology, 74(5), 797-805. doi: 10.1111/j.1365-2125.2012.04259.x

Van Egmond, R., Chin, P., Zhang, M., Sies, C. W., & Barclay, M. L. (2012). High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Alimentary Pharmacology & Therapeutics, 35(10), 1181-1189. doi: 10.1111/j.1365-2036.2012.05084.x

Vella-Brincat, J. W. A., Begg, E. J., Jensen, B. P., Chin, P. K. L., Roberts, R. L., Fairhall, M., … Reid, K. (2012). The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. Journal of Pain & Symptom Management, 43(3), 540-548. doi: 10.1016/j.jpainsymman.2011.04.022

Journal - Research Other

Chin, P. K. L., Vella-Brincat, J. W. A., & Begg, E. J. (2012). Clarifying the American Society of Clinical Oncology Practice Guideline for Chemotherapy Dosing in Obese Adults. Journal of Clinical Oncology, 30(31), 3897. doi: 10.1200/JCO.2012.44.1626

Chin, P. K. L., Vella-Brincat, J. W. A., Barclay, M. L., & Begg, E. J. (2012). Perspective on dabigatran etexilate dosing: Why not follow standard pharmacological principles? British Journal of Clinical Pharmacology, 74(5), 734-740. doi: 10.1111/j.1365-2125.2012.04266.x

Begg, E. J., & Chin, P. K. L. (2012). A unified pharmacokinetic approach to individualized drug dosing. British Journal of Clinical Pharmacology, 73(3), 335-339. doi: 10.1111/j.1365-2125.2011.04089.x

Fairhall, M., Reid, K., Vella-Brincat, J. W. A., Walker, J., Chin, P. K. L., Jensen, B. P., … Begg, E. J. (2012). Exploring hospice patients' views about participating in research. Journal of Pain & Symptom Management, 43(3), e9-e11. doi: 10.1016/j.jpainsymman.2011.04.013

Conference Contribution - Published proceedings: Abstract

Kumar, S. S., Wong, C., Graham, G. G., Begg, E. J., Chin, P. K. L., Brett, J., … Day, R. (2012). Gentamicin directed therapy: Which program to use? Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Australasian Pharmaceutical Science Association (APSA) Joint Conference: Medication Safety. (pp. 56). Retrieved from http://www.ascept-apsa.com/

Chin, P. K. L., Florkowski, C. M., & Begg, E. J. (2012). The performance of the Cockcroft-Gault, MDRD and CKD-EPI equations in predicting gentamicin clearance. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Australasian Pharmaceutical Science Association (APSA) Joint Conference: Medication Safety. (pp. 43). Retrieved from http://www.ascept-apsa.com/

Chin, P. K. L., Barclay, M. L., & Begg, E. J. (2012). Dose individualisation of Dabigatrin. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Australasian Pharmaceutical Science Association (APSA) Joint Conference: Medication Safety. (pp. 33). Retrieved from http://www.ascept-apsa.com/

Vella-Brincat, J., Begg, E., & Chin, P. (2012). The use of plasma creatinine concentrations as a measure of drug induced kidney failure. Proceedings of the Medical Sciences Congress (MedSci). (pp. 53). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Buffery, P., Chin, P. K. L., & Begg, E. J. (2012). Gentamicin dosing: Musings from the higher end. Proceedings of the Medical Sciences Congress (MedSci). (pp. 41-42). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Begg, E. J., Chin, P. K. L., Allen, K., & Buffery, P. (2012). Economising on busulphan samples for concentration monitoring during intravenous therapy. Proceedings of the Medical Sciences Congress (MedSci). (pp. 41). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Chin, P. K. L., Barclay, M. L., & Begg, E. J. (2012, November). Dabigatrin oral availability: Role of P-glycoprotein. Verbal presentation at the 8th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.

2011

Journal - Research Article

Jensen, B. P., Chin, P. K. L., & Begg, E. J. (2011). Quantification of total and free concentrations of R- and S-warfarin in human plasma by ultrafiltration and LC-MS/MS. Analytical & Bioanalytical Chemistry, 401(7), 2187-2193. doi: 10.1007/s00216-011-5303-x

Chin, P. K. L., Jensen, B. P., Larsen, H. S., & Begg, E. J. (2011). Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. British Journal of Clinical Pharmacology, 72(6), 985-989. doi: 10.1111/j.1365-2125.2011.04036.x

Larsen, H. S., Chin, P. K. L., Begg, E. J., & Jensen, B. P. (2011). Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS. Bioanalysis, 3(8), 843-852. doi: 10.4155/bio.11.46

Conference Contribution - Published proceedings: Abstract

Barclay, M. L., Van Egmond, R., Chin, P. K. L., & Mulder, C. J. J. (2011). High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 7.4. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf

Begg, E. J., Plajer, S. M., Chin, P. K. L., Vella-Brincat, J. W. A., & Buffery, P. (2011). Extended-interval gentamicin dosing in adult patients with impaired renal function: Should the dose interval be extended further? Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 2.5. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf

Chin, P. K. L., & Begg, E. J. (2011). The performance of GFR formulae for estimating gentamicin clearance. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 1.2. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf

Vella-Brincat, J. W. A., Begg, E. J., Jensen, B. P., Chin, P. K. L., Roberts, R. L., Fairhall, M., MacLeod, S. A. D., … Walker, J. (2011). The pharmacokinetics of the antiemetic cyclizine, and how it feels to be subjected to blood sample orientated research, in palliative care. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and Carney Symposium: New Zealand Annual Scientific Meeting. 4.3. Retrieved from http://www.otago.ac.nz/asceptnz/docs/programme.pdf

Jensen, B. P., Vella-Brincat, J. W. A., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2011). An LC-MS/MS assay for quantification of cyclizine and norcyclizine in a pharmacokinetic study of subcutaneous cyclizine in palliative care patients. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) - Australian Physiological Society (AuPS) - High Blood Pressure Research Council of Australia (HBPRCA) Joint Meeting. Retrieved from http://ascept2011.eproceedings.com.au/papers/p17.pdf

2010

Conference Contribution - Published proceedings: Abstract

Jensen, B. P., Chin, P. K. L., Roberts, R. L., & Begg, E. J. (2010). Total and free clearance of R- and S-warfarin in elderly people. Proceedings of the 44th Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Retrieved from http://ascept.eproceedings.com.au/papers/p76.pdf

Jensen, B. P., Chin, P., Roberts, R. R., Maddison, J., & Begg, E. J. (2010). Total and free clearance of R- and S-warfarin in elderly people. Basic & Clinical Pharmacology & Toxicology, 107(Suppl. 1), (pp. 354-355). doi: 10.1111/j.1742-7843.2010.00600.x

Patel, D., Vella-Brincat, J., Chin, P., Jensen, B., & Begg, E. (2010). Is frailty associated with impaired drug clearance in the elderly? Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/

Jensen, B. P., Chin, P., Roberts, R. L., & Begg, E. J. (2010). Total and free clearance of R- and S-warfarin in elderly people. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/

2009

Journal - Research Article

Chin, P. K. L., Beckert, L. E. L., Gunningham, S., Edwards, A. L., & Robinson, B. A. (2009). Audit of anticoagulant thromboprophylaxis in hospitalized oncology patients. Internal Medicine Journal, 39(12), 819-825. doi: 10.1111/j.1445-5994.2008.01828.x

Conference Contribution - Published proceedings: Abstract

Begg, E., Chin, P., Svensson, A., & Davis, N. (2009). From pharmacogenetics to drug interactions. Proceedings of the 5th Annual Carney Pharmacogenomics Symposium. Retrieved from http://www.otago.ac.nz/christchurch/otago019049.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Chin, P. K. L., & Begg, E. J. (2009, September). The use of gentamicin clearance to decsribe the relationship of GFR with age. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.

2006

Journal - Research Article

Chin, P., Hurrell, M., McGregor, D., & Beckert, L. (2006). The role of CT pulmonary angiography in patients with suspected pulmonary embolism admitted to general medicine. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2052/content.pdf