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Dr Judith McKenzie

Judy McKenzieHaematology Research Group Leader

MSc(Oxon) PhD(Otago)

Email judy.mckenzie@otago.ac.nz

Tel 64 3 364 0579

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Publications

Tang, J. S., Bozonet, S. M., McKenzie, J. L., Anderson, R. F., Melton, L. D., & Vissers, M. C. M. (2019). Physiological concentrations of blueberry-derived phenolic acids reduce monocyte adhesion to human endothelial cells. Molecular Nutrition & Food Research. Advance online publication. doi: 10.1002/mnfr.201900478

Hock, B. D., Smith, S. M., McEntyre, C. J., McKenzie, J. L., Sies, C., & Keating, P. E. (2019). Development of a competitive binding homogeneous mobility shift assay for the quantification of adalimumab levels in patient serum. Journal of Immunological Methods, 474, 112672. doi: 10.1016/j.jim.2019.112672

Greer, A. W., McKenzie, J. L., McAnulty, R. W., Huntley, J. F., & McNeilly, T. N. (2018). Immune development and performance characteristics of Romney sheep selected for either resistance or resilience to gastrointestinal nematodes. Veterinary Parasitology, 250, 60-67. doi: 10.1016/j.vetpar.2017.12.013

Hock, B. D., McKenzie, J. L., Goddard, L., Smith, S. M., McEntyre, C. J., & Keating, P. E. (2018). Discrimination of anti-drug antibodies with neutralizing capacity in infliximab-and adalimumab-treated patients: Comparison of the homogeneous mobility shift assay and the affinity capture and elution assay. Therapeutic Drug Monitoring, 40(6), 705-715. doi: 10.1097/FTD.0000000000000553

Hock, B. D., Mulholland, K. S., Ganly, P., McKenzie, J. L., Pearson, J. F., & Macpherson, S. A. (2018). Impact of increased access to novel agents on the survival of multiple myeloma patients treated at a single New Zealand centre. Internal Medicine Journal. Advance online publication. doi: 10.1111/imj.14155

Journal - Research Article

Tang, J. S., Bozonet, S. M., McKenzie, J. L., Anderson, R. F., Melton, L. D., & Vissers, M. C. M. (2019). Physiological concentrations of blueberry-derived phenolic acids reduce monocyte adhesion to human endothelial cells. Molecular Nutrition & Food Research. Advance online publication. doi: 10.1002/mnfr.201900478

Hock, B. D., Smith, S. M., McEntyre, C. J., McKenzie, J. L., Sies, C., & Keating, P. E. (2019). Development of a competitive binding homogeneous mobility shift assay for the quantification of adalimumab levels in patient serum. Journal of Immunological Methods, 474, 112672. doi: 10.1016/j.jim.2019.112672

Greer, A. W., McKenzie, J. L., McAnulty, R. W., Huntley, J. F., & McNeilly, T. N. (2018). Immune development and performance characteristics of Romney sheep selected for either resistance or resilience to gastrointestinal nematodes. Veterinary Parasitology, 250, 60-67. doi: 10.1016/j.vetpar.2017.12.013

Hock, B. D., Mulholland, K. S., Ganly, P., McKenzie, J. L., Pearson, J. F., & Macpherson, S. A. (2018). Impact of increased access to novel agents on the survival of multiple myeloma patients treated at a single New Zealand centre. Internal Medicine Journal. Advance online publication. doi: 10.1111/imj.14155

Hock, B. D., McKenzie, J. L., Goddard, L., Smith, S. M., McEntyre, C. J., & Keating, P. E. (2018). Discrimination of anti-drug antibodies with neutralizing capacity in infliximab-and adalimumab-treated patients: Comparison of the homogeneous mobility shift assay and the affinity capture and elution assay. Therapeutic Drug Monitoring, 40(6), 705-715. doi: 10.1097/FTD.0000000000000553

Hock, B. D., Macpherson, S. A., & McKenzie, J. L. (2017). Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLoS ONE, 12(3), e0172858. doi: 10.1371/journal.pone.0172858

Seddon, A., Hock, B., Miller, A., Frei, L., Pearson, J., McKenzie, J., Simcock, J., & Currie, M. (2016). Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells. Journal of Dermatological Science, 83(2), 124-130. doi: 10.1016/j.jdermsci.2016.04.013

Hock, B. D., McIntosh, N. D., McKenzie, J. L., Pearson, J. F., Simcock, J. W., & Macpherson, S. A. (2016). Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients. Internal Medicine Journal, 46(12), 1414-1421. doi: 10.1111/imj.13261

Hock, B. D., McKenzie, J. L., Cross, N. B., & Currie, M. J. (2015). Dynamic changes in myeloid derived suppressor cell subsets following renal transplant: A prospective study. Transplant Immunology, 32(3), 164-171. doi: 10.1016/j.trim.2015.05.001

Hock, B. D., Macpherson, S. A., Fernyhough, L. J., & McKenzie, J. L. (2014). Chronic lymphocytic leukemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC. Leukemia Research, 38(10), 1217-1223. doi: 10.1016/j.leukres.2014.06.004

Hock, B. D., Fernyhough, L. J., Gough, S. M., & McKenzie, J. L. (2013). Clinical significance of plasma levels of soluble CD40 in patients with chronic lymphocytic leukemia. Open Journal of Blood Diseases, 3(1), 1-5. doi: 10.4236/ojbd.2013.31001

Hock, B. D., Taylor, K. G., Cross, N. B., Kettle, A. J., Hampton, M. B., & McKenzie, J. L. (2012). Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability. Immunology, 137(3), 249-258. doi: 10.1111/imm.12004

Hock, B. D., Mackenzie, K. A., Cross, N. B., Taylor, K. G., Currie, M. J., Robinson, B. A., Simcock, J. W., & McKenzie, J. L. (2012). Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology Dialysis Transplantation, 27(1), 402-410. doi: 10.1093/ndt/gfr264

Glubb, D. M., Gearry, R. B., Barclay, M. L., Roberts, R. L., Pearson, J., Keenan, J. I., McKenzie, J., & Bentley, R. W. (2011). NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease. World Journal of Gastroenterology, 17(23), 2829-2837. doi: 10.3748/wjg.v17.i23.2829

Geertsema, L., Lucas, S. J. E., Cotter, J. D., Hock, B., McKenzie, J., & Fernyhough, L. J. (2011). The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40, is lowered by ultra-endurance exercise in athletes. British Journal of Sports Medicine, 45(1), 42-45. doi: 10.1136/bjsm.2008.051896

Hock, B. D., McKenzie, J. L., McArthur, L., Tansley, S., Taylor, K. G., & Fernyhough, L. J. (2010). CD38 as a prognostic marker in chronic lymphocytic leukaemia at a single New Zealand centre: Patient survival in comparison to age and sex matched population data. Internal Medicine Journal, 40(12), 842-849. doi: 10.1111/j.1445-5994.2009.02135.x

Hock, B. D., Fernyhough, L. J., Gough, S. M., Steinkasserer, A., Cox, A. G., & McKenzie, J. L. (2009). Release and clinical significance of soluble CD83 in chronic lymphocytic leukemia. Leukemia Research, 33(8), 1089-1095. doi: 10.1016/j.leukres.2009.01.001

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Currie, M. J., McKenzie, J. L., Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2006). Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: Response to cytokines and natriuretic peptide receptor expression profiles. American Journal of Physiology: Heart & Circulatory Physiology, 291, H1952-H1958. doi: 10.1152/ajpheart.00764.2005

Hock, B. D., McKenzie, J. L., Patton, N. W., Drayson, M., Taylor, K., Wakeman, C., … Albitar, M. (2006). Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignancies. Cancer, 106(10), 2148-2157.

Hock, B. D., Drayson, M., Patton, W. N., Taylor, K., Kerr, L., McKenzie, J. L., & on behalf of the Working Party on Leukaemia in Adults. (2006). Circulating levels and clinical significance of soluble CD86 in myeloma patients. British Journal of Haematology, 133, 165-172.

Hock, B. D., O'Donnell, J. L., Taylor, K., Steinkasserer, A., McKenzie, J. L., Rothwell, A. G., & Summers, K. L. (2006). Levels of the soluble forms of CD80, CD86, and CD83 are elevated in the synovial fluid of rheumatoid arthritis patients. Tissue Antigens, 67(1), 57-60. doi: 10.1111/j.1399-0039.2005.00524.x

Hock, B. D., Roberts, G., McKenzie, J. L., Gokhale, P., Salm, N., McLellan, A. D., Patton, N. W., & Roake, J. A. (2005). Exposure to the electrofusion process can increase the immunogenicity of human cells. Cancer Immunology, Immunotherapy, 54, 880-890.

Hock, B. D., Haring, L. F., Steinkasserer, A., Taylor, K. G., Patton, W. N., & McKenzie, J. L. (2004). The soluble form of CD83 is present at elevated levels in a number of hematological malignancies. Leukemia Research, 28, 237-241.

Hock, B. D., Starling, G. C., Patton, W. N., Salm, N., Bond, K., McArthur, L. T., & McKenzie, J. L. (2004). Identification of a circulating soluble form of CD80: Levels in patients with hematological malignancies. Leukemia & Lymphoma, 45(10), 2111-2118. doi: 10.1080/10428190410001712199

Hock, B. D., McKenzie, J., Patton, W. N., Haring, L., Yang, Y., Shen, Y., … Albitar, M. (2003). The clinical significance of soluble CD86 levels in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer, 98, 1681-1688.

Copland, M., Baird, M. A., Rades, T., McKenzie, J., Becker, B., Reck, F., … Davies, N. M. (2003). Liposomal delivery of antigen to human dendritic cells. Vaccine, 21, 883-890.

Summers, K. L., Hock, B. D., McKenzie, J. L., & Hart, D. N. J. (2001). Phenotypic characterization of five dendritic cell subsets in human tonsils. American Journal of Pathology, 159, 285-295.

Hock, B. D., Kato, M., McKenzie, J., & Hart, D. N. J. (2001). A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. International Immunology, 13(7), 959-967.

Mannering, S. I., McKenzie, J. L., Fearnley, D. B., & Hart, D. N. J. (1997). HLA-DR1-restricted BCR-ABL (B3A2)-specific CD4(+) T lymphocytes respond to dentritic cells pulsed with B3A2 peptide and antigen-presenting cells exposed to B3A2 containing cell lysates. Blood, 90(1), 290-297.

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Journal - Research Other

Hock, B. D., McKenzie, J. L., & Keenan, J. I. (2017). Helicobacter pylori outer membrane vesicles inhibit human T cell responses via induction of monocyte COX-2 expression [Short communication]. Pathogens & Disease, 75(4), ftx034. doi: 10.1093/femspd/ftx034

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Conference Contribution - Published proceedings: Abstract

Seddon, A. R., Hock, B. D., Miller, A. P., Frei, L. P., Pearson, J. F., McKenzie, J. L., Simcock, J. W., & Currie, M. J. (2015). Neutrophils in cutaneous squamous cell carcinoma: Potential prognostic markers? New Zealand Medical Journal, 128(1421). Retrieved from https://www.nzma.org.nz/journal

Wilkinson, T. J., Tweed, M. J., McKenzie, J., Ali, A., Rudland, J., & Egan, A. (2010). Conditional pass facilitates action on professionalism and aligns assessment to learning. Proceedings of the 14th Ottawa Conference: Assessment of Competence in Medicine and the Healthcare Professions. (pp. 189-190). Retrieved from http://www.ottawaconference.org/images/stories/Ottawa_Conference_2010_Abstracts.5.10_1.pdf

Marshall, C. J., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2009). Acute systemic and local neutrophil and monocyte degranulation prior to primary percutaneous coronary intervention in ST elevation myocardial infarction. JACC, 53(10, Suppl. 1), (pp. A307-A308). [Abstract]

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A. J., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. R. (2008). Increased neutrophil and monocyte degranulation with release of intracellular leucocyte elastase and myeloperoxidase in acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S2). doi: 10.1016/j.hlc.2008.03.003

Marshall, C., Mocatta, T., McKenzie, J., Kettle, A., Blake, J., Elliott, J., Smyth, D., Richards, M., & McClean, D. (2008). Increased systemic and local neutrophil and monocyte degranulation in patients undergoing primary percutaneous coronary intervention for acute ST elevation myocardial infarction. Heart, Lung & Circulation, 17S, (pp. S106). doi: 10.1016/j.hlc.2008.05.255

Moon, S., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2007). High-resolution genomic profiling of chronic lymphocytic leukaemia by array CGH. Chromosome Research. 15(Suppl. 1), (pp. 268). [Abstract]

Moon, S. Y., McKenzie, J., Walker, L., McDonald, M., Ganly, P., & Morris, C. M. (2006). High throughput screening of genomic copy number changes in chronic lymphocytic leukaemia using array comparative genomic hybridisation. In L. Griffiths (Ed.), Proceedings of the 11th International Congress of Human Genetics. (pp. 149). [Abstract]

Jarvis, M. D., Rademaker, M. T., Ellmers, L. J., Palmer, B. R., Frampton, C. M., Gunningham, S. P., Currie, M. J., McKenzie, J. L., … Cameron, V. A. (2004). Cytokine induced changes in cultured cardiac fibroblasts: Cell morphology and natriuretic peptide receptor expression. Proceedings of the 12th International Congress of Endocrinology. (pp. 145). [Abstract]

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Conference Contribution - Verbal presentation and other Conference outputs

Currie, M., Hock, B., McKenzie, J., Miller, A., Simcock, J., Mackenzie, K., Seddon, A., & Kennedy, B. (2017, July). Functional and prognostic significance of neutrophil subpopulations in cutaneous squamous cell carcinoma. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

Moon, S.-Y., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2008, August-September). Identification of novel CNVs in chronic lymphocytic leukaemia using array CGH. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Moon, S., McKenzie, J., Jewell, U., Ganly, P., & Morris, C. (2007, July). High-resolution genomic profiling of chronic lymphocytic leukaemia by array CGH. Verbal presentation at the 6th European Cytogenetics Conference (ECC), Istanbul, Turkey.

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