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Professor Madhav Bhatia

Madhav BhatiaGroup Leader, Inflammation Research Group
Co-ordinator, BBiomedSc(Hons) Programme

BSc(Hons), MSc, PhD (All India Institute of Medical Sciences)

Email madhav.bhatia@otago.ac.nz 
Tel 64 3 378 6238

Research interests

Professor Madhav Bhatia’s research focuses on inflammation. He leads an active research programme on the molecular pharmacology and molecular pathology of inflammatory conditions, such as acute pancreatitis, polymicrobial sepsis, burns, and arthritis.

Professor Bhatia’s research has shown hydrogen sulfide and substance P as mediators of inflammation and potential therapeutic targets for inflammatory diseases. He is interested in defining the mechanism by which hydrogen sulfide and substance P contribute to inflammation. His research has also shown a key role of chemokines in inflammatory diseases, and of pancreatic acinar cell apoptosis in acute pancreatitis.

The long term goal of this research is to translate this knowledge to the clinic, and early results in this direction have been promising.

Funding

The Inflammation Research Group is supported by:

  • Lottery Health
  • Canterbury Medical Research Foundation
  • Arthritis New Zealand
  • University of Otago Research Grant
  • Maurice & Phyllis Paykel Trust 
  • Health Reseach Council of New Zealand Singapore Networking Grant
  • Royal Scoiety of New Zealand's Catalyst: Leaders New Zealand-China Scientist Exchange Programme

Prior to moving to Christchurch, Professor Bhatia's research was supported by research grants from Biomedical Research Council, Singapore, National Medical Research Council, Singapore, Academic Research Fund, National University of Singapore, Singapore, and Defence Science and Technology Agency-National University of Singapore Joint Applied R&D Co-operation Programme, Singapore.

Major review articles

  1. Pan LL, Li J, Shamoon M, Bhatia M, and Sun J. Recent advances on nutrition in treatment of acute pancreatitis. Front Immunol. 2017; 8: 762.
  2. Shamoon M, Chen Y, Bhatia M, and Sun J. Therapeutic implications of innate immune system in acute pancreatitis. Expert Opin Ther Targets. 2016; 20: 73-87.
  3. Bhatia M. H2S and inflammation - an overview. Handb Exp Pharmacol. 2015; 230: 165-180.
  4. Bhatia M. H2S and substance P in inflammation. Meth Enzymol. 2015; 555: 195-205.
  5. Bhatia M, Zemans RL, and Jeyaseelan S. Role of chemokines in the pathogenesis of acute lung injury. Amer J Resp Cell Mol Biol. 2012; 46: 566-572.
  6. Rivers J, Badiei A, and Bhatia M. Hydrogen sulfide as a therapeutic target for inflammation. Expert Opin Ther Targets. 2012; 16: 439-449.
  7. Bhatia M. Hydrogen sulfide and substance P in inflammation. Antioxid Redox Signal. 2010; 12: 1191-1202.
  8. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, and Chevali L. Pathophysiology of acute pancreatitis. Pancreatology. 2005; 5:132-144.
  9. Bhatia M. Hydrogen sulfide as a vasodilator. IUBMB Life. 2005; 57: 603-606.
  10. Puneet, P, Moochhala, S, and Bhatia, M. Chemokines in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2005; 288: L3-L15.
  11. Bhatia M. Inflammatory response on the pancreatic acinar cell injury. Scand J Surg. 2005; 94: 97-102.
  12. Bhatia M, and Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Path. 2004; 202: 145-156.
  13. Bhatia M. Apoptosis versus necrosis in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2004; 286: G189-196.
  14. Moore PK, Bhatia M, and Moochhala, S. Hydrogen sulphide: from the smell of the past to the mediator of the future? Trends Pharmacol Sci. 2003; 24: 609-611.
  15. Bhatia M, Brady M, Shokuhi S, Christmas SE, Neoptolemos JP, and Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol. 2000; 190: 117-125.

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Publications

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Chapter in Book - Research

Lv, J., Bhatia, M., & Wang, X. (2017). Roles of mitochondrial DNA in energy metabolism. In H. Sun & X. Wang (Eds.), Mitochondrial DNA and diseases: Advances in experimental medicine and biology (Vol. 1038). (pp. 71-83). Singapore: Springer Nature. doi: 10.1007/978-981-10-6674-0_6

Bhatia, M. (2015). H2S and substance P in Inflammation. In E. Cadenas & L. Packer (Eds.), Methods in enzymology: Hydrogen sulfide in redox biology, Part B (Vol. 555). (pp. 195-205). Elsevier. doi: 10.1016/bs.mie.2014.11.024

Bhatia, M. (2015). H2S and inflammation: An overview. In P. K. Moore & M. Whiteman (Eds.), Chemistry, biochemistry and pharmacology of hydrogen sulfide (Handbook of experimental pharmacology, Vol. 230). (pp. 165-180). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-18144-8_8

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Journal - Research Article

Pan, L.-L., Li, J., Shamoon, M., Bhatia, M., & Sun, J. (2017). Recent advances on nutrition in treatment of acute pancreatitis. Frontiers in Immunology, 8, 762. doi: 10.3389/fimmu.2017.00762

Muniraj, N., Stamp, L. K., Badiei, A., Hegde, A., Cameron, V., & Bhatia, M. (2017). Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease. International Journal of Rheumatic Diseases, 20(2), 182-189. doi: 10.1111/1756-185x.12472

Gillies, N. A., Pendharkar, S. A., Singh, R. G., Windsor, J. A., Bhatia, M., & Petrov, M. S. (2017). Fasting levels of insulin and amylin after acute pancreatitis are associated with pro-inflammatory cytokines. Archives of Physiology & Biochemistry. Advance online publication. doi: 10.1080/13813455.2017.1308382

Singh, P. M., Reid, K., Gaddam, R., Bhatia, M., Smith, S., Jacob, A., & Chambers, P. (2017). Effect of choline chloride premedication on xylazine-induced hypoxaemia in sheep. Veterinary Anaesthesia & Analgesia, 44(5), 1149-1155. doi: 10.1016/j.vaa.2017.01.002

Gaddam, R. R., Chambers, S., Murdoch, D., Shaw, G., & Bhatia, M. (2017). Circulating levels of hydrogen sulfide and substance P in patients with sepsis. Journal of Infection, 75(4), 293-300. doi: 10.1016/j.jinf.2017.07.005

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Badiei, A., Chambers, S. T., Gaddam, R. R., & Bhatia, M. (2016). Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse. Journal of Biosciences, 41(1), 87-95. doi: 10.1007/s12038-016-9598-9

Deng, Y.-Y., Shamoon, M., He, Y., Bhatia, M., & Sun, J. (2016). Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice. Molecular Medicine Reports, 13(5), 3881-3885. doi: 10.3892/mmr.2016.5008

Dong, Z., Shang, H., Chen, Y. Q., Pan, L.-L., Bhatia, M., & Sun, J. (2016). Sulforaphane protects pancreatic acinar cell injury by modulating Nrf2-mediated oxidative stress and NLRP3 inflammatory pathway. Oxidative Medicine & Cellular Longevity, 2016, 7864150. doi: 10.1155/2016/7864150

Shamoon, M., Deng, Y., Chen, Y. Q., Bhatia, M., & Sun, J. (2016). Therapeutic implications of innate immune system in acute pancreatitis. Expert Opinion on Therapeutic Targets, 20(1), 73-87. doi: 10.1517/14728222.2015.1077227

Gaddam, R. R., Ang, A. D., Badiei, A., Chambers, S. T., & Bhatia, M. (2015). Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse. Pancreatology, 15(6), 647-653. doi: 10.1016/j.pan.2015.09.007

Badiei, A., Gieseg, S., Davies, S., Othman, M. I., & Bhatia, M. (2015). LPS up-regulates cystathionine γ-lyase gene expression in Primary human macrophages via NF-κB/ERK pathway. Inflammation & Allergy Drug Targets, 14(2), 99-104. doi: 10.2174/1871528114666151201201719

Badiei, A., Rivers-Auty, J., Ang, A. D., & Bhatia, M. (2013). Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Applied Microbiology & Biotechnology, 97(17), 7845-7852. doi: 10.1007/s00253-013-5080-x

Ang, A. D., Rivers-Auty, J., Hegde, A., Ishii, I., & Bhatia, M. (2013). The effect of CSE gene deletion in caerulein-induced acute pancreatitis in the mouse. American Journal of Physiology: Gastrointestinal & Liver Physiology, 305, G712-G721. doi: 10.1152/ajpgi.00044.2013

Rivers, J. R., Badiei, A., & Bhatia, M. (2012). Hydrogen sulfide as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets, 16(5), 439-449. doi: 10.1517/14728222.2012.673591

Ang, A. D., Konigstorfer, A., Giles, G. I., & Bhatia, M. (2012). Measuring free tissue sulfide. Advances in Biological Chemistry, 2(4), 360-365. doi: 10.4236/abc.2012.24044

Koh, Y.-H., Moochhala, S., Bian, J.-S., & Bhatia, M. (2012). Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 16(7), 1582-1592. doi: 10.1111/j.1582-4934.2011.01475.x

Bhatia, M., Zemans, R. L., & Jeyaseelan, S. (2012). Role of chemokines in the pathogenesis of acute lung injury. American Journal of Respiratory Cell & Molecular Biology, 46(5), 566-572. doi: 10.1165/rcmb.2011-0392TR

Sidhapuriwala, J. N., Hegde, A., Ang, A. D., Zhu, Y. Z., & Bhatia, M. (2012). Effects of S-Propargyl-Cysteine (SPRC) in caerulein-induced acute pancreatitis in mice. PLoS ONE, 7(3), e32574. doi: 10.1371/journal.pone.0032574

Koh, Y.-H., Moochhala, S., & Bhatia, M. (2011). The role of neutral endopeptidase in caerulein-induced acute pancreatitis. Journal of Immunology, 187, 5429-5439. doi: 10.4049/jimmunol.1102011

Ang, S.-F., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: Involvement of substance P and ERK-NF-κB signaling. PLoS ONE, 6(9), e24535. doi: 10.1371/journal.pone.0024535

Hegde, A., & Bhatia, M. (2011). Hydrogen sulfide in inflammation: Friend or foe? Inflammation & Allergy Drug Targets, 10(2), 118-122.

Ang, S.-F., Sio, S. W. S., Moochhala, S. M., MacAry, P. A., & Bhatia, M. (2011). Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. Journal of Immunology, 187(9), 4778-4787. doi: 10.4049/jimmunol.1101559

Koh, Y.-H., Tamizhselvi, R., Moochhala, S., Bian, J.-S., & Bhatia, M. (2011). Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cells. Journal of Cellular & Molecular Medicine, 15(10), 2139-2149. doi: 10.1111/j.1582-4934.2010.01205.x

Zhang, J., Sio, S. W. S., Moochhala, S., & Bhatia, M. (2010). Role of hydrogen sulfide in severe burn injury-induced inflammation in mice. Molecular Medicine, 16(9-10), 417-424. doi: 10.2119/molmed.2010.00027

Ang, S.-F., Moochhala, S. M., & Bhatia, M. (2010). Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis. Critical Care Medicine, 38(2), 619-628. doi: 10.1097/CCM.0b013e3181c0df00

Koh, Y.-H., Tamizhselvi, R., & Bhatia, M. (2010). Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-κB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 332(3), 940-948. doi: 10.1124/jpet.109.160416

Ramnath, R. D., Sun, J., & Bhatia, M. (2010). PKC δ mediates pro-inflammatory responses in a mouse model of caerulein-induced acute pancreatitis. Journal of Molecular Medicine, 88, 1055-1063. doi: 10.1007/s00109-010-0647-9

Sio, S. W. S., Moochhala, S., Lu, J., & Bhatia, M. (2010). Early protection from burn-induced acute lung injury by deletion of preprotachykinin-A gene. American Journal of Respiratory & Critical Care Medicine, 181(1), 36-46. doi: 10.1164/rccm.200907-1073OC

Tamizhselvi, R., Koh, Y.-H., Sun, J., Zhang, H., & Bhatia, M. (2010). Hydrogen sulfide-induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-κB and Src-family kinases pathway. Experimental Cell Research, 316, 1625-1636. doi: 10.1016/j.yexcr.2010.02.044

Bhatia, M. (2010). Hydrogen sulfide and substance P in inflammation. Antioxidants & Redox Signaling, 12(10), 1191-1202. doi: 10.1089/ars.2009.2927

Shrivastava, P., & Bhatia, M. (2010). Essential role of monocytes and macrophages in the progression of acute pancreatitis. World Journal of Gastroenterology, 16(32), 3995-4002. doi: 10.3748/wjg.v16.i32.3995

Sowmya, S., Swathi, Y., Yeo, A. L., Shoon, M. L., Moore, P. K., & Bhatia, M. (2010). Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vascular Pharmacology, 53, 138-143. doi: 10.1016/j.vph.2010.05.004

Hegde, A., Tamizhselvi, R., Manikandan, J., Melendez, A. J., Moochhala, S. M., & Bhatia, M. (2010). Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A-/- mice. Molecular Medicine, 16, 188-198. doi: 10.2119/molmed.2009.00166

Sio, S. W. S., Ang, S. F., Lu, J., Moochhala, S., & Bhatia, M. (2010). Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-κB in a mouse model of burn-induced remote acute lung injury. Journal of Immunology, 185(10), 6265-6276. doi: 10.4049/jimmunol.1001739

Hegde, A., Uttamchandani, M., Bhatia, M., & Moochhala, S. M. (2010). Plasma cytokine profiles in Preprotachykinin-A knockout mice subjected to polymicrobial sepsis. Molecular Medicine, 16(1-2), 45-52. doi: 10.2119/molmed.2009.00112

Ang, A. D., Adhikari, S., Ng, S. W., & Bhatia, M. (2009). Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury. Pancreatology, 9(1-2), 150-159. doi: 10.1159/000178886

Ynsa, M. D., Ren, M. Q., Rajendran, R., Sidhapuriwala, J. N., van Kan, J. A., Bhatia, M., & Watt, F. (2009). Zinc mapping and density imaging of rabbit pancreas endocrine tissue sections using nuclear microscopy. Microscopy & Microanalysis, 15, 345-352. doi: 10.1017/S1431927609090795

Zhang, H., & Bhatia, M. (2009). Role of hydrogen sulfide in acute lung injury and acute respiratory distress syndrome. Open Critical Care Medicine Journal, 2, 13-17. doi: 10.2174/1874828700902010013

Sun, J., Ramnath, R. D., Tamizhselvi, R., & Bhatia, M. (2009). Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages. FASEB Journal, 23, 997-1010. doi: 10.1096/fj.08-121756

Tamizhselvi, R., Sun, J., Koh, Y.-H., & Bhatia, M. (2009). Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. Journal of Pharmacology & Experimental Therapeutics, 329, 1166-1178. doi: 10.1124/jpet.109.150532

Sidhapuriwala, J. N., Ng, S. W., & Bhatia, M. (2009). Effects of hydrogen sulfide on inflammation in caerulein-induced acute pancreatitis. Journal of Inflammation, 6, 35. doi: 10.1186/1476-9255-6-35

Ramnath, R. D., Sun, J., & Bhatia, M. (2009). Involvement of Src family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. Journal of Pharmacology & Experimental Therapeutics, 329, 418-428. doi: 10.1124/jpet.108.148684

Ramnath, R. D., Ng, S. W., Guglielmotti, A., & Bhatia, M. (2008). Role of MCP-1 in endotoxemia and sepsis. International Immunopharmacology, 8(6), 810-818. doi: 10.1016/j.intimp.2008.01.033

Webb, G. D., Lim, L. H., Oh, V. M. S., Yeo, S. B., Cheong, Y. P., Ali, M. Y., … Bhatia, M., … Moore, P. K. (2008). Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. Journal of Pharmacology & Experimental Therapeutics, 324, 876-882. doi: 10.1124/jpet.107.133538

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