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Nutrition in Medicine Research Group Research

The Nutrition in Medicine Research Group carries out translational nutrient-based clinical studies with the aim of having a positive impact on patient health outcomes and quality of life.

Critical illness and septic shock

ICU monitor screen image thumbWe have shown that critically ill patients, particularly those with septic shock, have severely depleted vitamin C status, despite recommended intakes. This indicates enhanced requirement for the vitamin during inflammatory and infectious conditions.

We are currently administering intravenous vitamin C to patients with septic shock to assess the effects on patient health outcomes as vitamin C has been shown to support the cardiovascular and other organ systems.

Published research

Review articles and commentaries

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Infectious diseases and immune function

Lungs illustration thumbVitamin C supports the immune system and has important roles to play in immune cell function. We are carrying out observational and interventional studies in patients with pneumonia, which is one of the major causes of sepsis. If we are able to attenuate the symptoms of pneumonia, this may decrease the likelihood of sepsis developing.

Published research

Review articles and book chapters

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Neurological disease and mental health

Brain illustration thumbThe brain and neuroendocrine glands contain the highest levels of vitamin C in the body indicating an important role for the vitamin in the nervous system. We are currently carrying out observational studies investigating the vitamin C status and biomarkers of inflammation and oxidative stress in patients with Parkinson’s disease and mood disorders.

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Metabolic health

Fingerprick test thumbIndividuals with diabetes mellitus are under enhanced inflammatory and oxidative stress. Our research shows that they have lower vitamin C status.

Published research

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Patient quality of life

Woman holding a model heart thumbAcute and chronic illnesses can dramatically impact on patients’ quality of life. Furthermore, various drugs, such as those used during cancer chemotherapy, can also impact negatively on quality of life.

We have carried out a number of case studies showing dramatic improvement in quality of life of oncology patients administered intravenous vitamin C. We are currently carrying out observational and interventional studies investigating the vitamin C status and the quality of life of myeloma patients undergoing conditioning chemotherapy and stem cell transplantation.

Published research

Review articles

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