The cellular and molecular basis of the mechanisms and regulation of epithelial transport and the effect of representative diseases on these processes.
Epithelia form remarkable barrier structures that regulate the entry and exit of substances into and out of the body. Control of these transport processes needs to be exquisite to avoid severe pathophysiology. Lecture modules will be based around pressing physiological problems, such as: How does too little chloride secretion cause cystic fibrosis? How does too much sodium uptake cause high blood pressure? What is the new dogma around glucose absorption in the intestine? To develop treatment for these conditions understanding of the alterations at the cell and tissue level is essential.
|Paper title||Cellular and Epithelial Physiology|
|Teaching period||Second Semester|
|Domestic Tuition Fees (NZD)||$1,059.15|
|International Tuition Fees (NZD)||$4,914.00|
- PHSL 233
- Schedule C
- One of five 300-level papers for Physiology majors.
Essential paper for Functional Human Biology majors.
Optional paper for Drugs and Human Health, Infection and Immunity, Molecular Basis of Health and Disease and Nutrition and Metabolism in Human Health majors.
- More information link
- Teaching staff
Course Convener: Associate Professor Fiona McDonald
Lecturers: Associate Professor Grant Butt, Associate Professor Fiona McDonald
Note: The teaching staff list may be updated. See the 'more information' link above for details.
- Paper Structure
The paper will be taught as several modules, each including both lecture and laboratory sessions. Lecture topics include:
- Recent advances in our understanding of the cellular and molecular basis of absorption and secretion of fluid and electrolytes by epithelia
- Protein trafficking in epithelial cells
- Cell biology and physiology of diseases such as cystic fibrosis, Liddle's Syndrome, Nephrogenic Diabetes Insipidus and gout
In the laboratory course you will design, perform, interpret and present your own experiment in a guided process over the entire semester.
Assessment consists of internal assessment (including the presentation of a research poster and a written research proposal) and a 3-hour final exam. A mark of at least 45% in the final exam must be attained to pass the paper as a whole.
For further detail please refer to the undergraduate handbooks BSc PHSL or BBiomedSc FUHB, available to download.
- Teaching Arrangements
- You will attend two lectures each week and two 4-hour laboratory sessions every second week (alternating with PHSL 344).
- Original research articles.
- Graduate Attributes Emphasised
- Lifelong learning, Scholarship, Communication, Critical thinking, Ethics, Research,
View more information about Otago's graduate attributes.
- Learning Outcomes
- Acquired deep knowledge and understanding of the physiology of epithelial body systems in normal and dysfunctional situations
- Developed skills in a variety of physiological techniques
- Developed oral and written scientific communication skills