Contact Details
University Links
- Position
- Emeritus Research Professor
- Department
- Department of Biochemistry
- Qualifications
- BSc (Cant) MSc PhD (Otago) FRSNZ
- Research summary
- Cancer Genetics, genomics and cancer biology
Research
Professor Tony Reeve has a notable career in cancer research. His work in the Cancer Genetics Laboratory is focussed on the molecular mechanisms of tumour suppressor genes, growth factors, and imprinted genes. He is internationally recognised for his work on Wilms tumour - a paediatric kidney tumour - demonstrating the importance of tumour suppressor genes, growth factor s such as insulin-like growth factor 2, and the disruption that occurs to the genomic imprinting mechanism of specific genes. He also has an interest in cancer genomics particularly as applied to colorectal cancer. By using high throughput gene expression his group showed that low cellular proliferation and an increased adaptive immune response are both hallmarks of poor prognosis for this disease. In addition to the Cancer Genetics Laboratory Professor Reeve also directs the Otago Genomics Facility which specialises in high throughput gene technologies. He played a lead role in establishing NZ Genome Ltd, an infrastructure which will provide a NZ wide network for genome technologies and biostatistical support.Professor Reeve is a board member of the Health Research Council (NZ) and chair of the Biomedical Research Committee. He is or has served on several editorial boards including Genes Chromosomes and Cancer, Journal of Pediatric Hematology/Oncology, Genomic Medicine, Genome Letters, NZ Medical Journal and The International DNA Methylation Society.
He was awarded the first medal for Health Research in NZ; the Sir Charles Hercus Medal. He is an Honorary member of the NZ Society of Paediatrics, a Fellow of the Royal Society of NZ and was appointed as an Officer of The NZ Order of Merit for services to medical sciences.
Publications
Mehta, S., Wright, D., Black, M. A., Merrie, A., Anjomshoaa, A., Munro, F., Reeve, A., McCall, J., & Print, C. (2022). Impact of clinical data veracity on cancer genomic research. JNCI Cancer Spectrum. doi: 10.1093/jncics/pkac070 Journal - Research Article
Blair, V. R., McLeod, M., Carneiro, F., Coit, D. G., D'Addario, J. L., van Dieren, J. M., … Paringatai, K., Bougen-Zhukov, N., Brew, T., … Godwin, T. D., … Nouri, Y., … Reeve, A. E., & Guilford, P. (2020). Hereditary diffuse gastric cancer: Updated clinical practice guidelines. Lancet Oncology, 21(8), e386-e397. doi: 10.1016/S1470-2045(20)30219-9 Journal - Research Other
Fukuzawa, R., Anaka, M. R., Morison, I. M., & Reeve, A. E. (2017). The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. PLoS ONE, 12(10), e0186333. doi: 10.1371/journal.pone.0186333 Journal - Research Article
McInnes, T., Zou, D., Rao, D. S., Munro, F. M., Phillips, V. L., McCall, J. L., Black, M. A., Reeve, A. E., & Guilford, P. J. (2017). Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer, 17, 228. doi: 10.1186/s12885-017-3226-4 Journal - Research Article
McInnes, T., Zou, D., Black, M. A., Reeve, A. E., & Guilford, P. J. (2015, August-September). Genome-wide methylation analysis identifies a core set of hypermethylated CpG islands in CIMP-H colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
2022
Journal - Research Article
Mehta, S., Wright, D., Black, M. A., Merrie, A., Anjomshoaa, A., Munro, F., Reeve, A., McCall, J., & Print, C. (2022). Impact of clinical data veracity on cancer genomic research. JNCI Cancer Spectrum. doi: 10.1093/jncics/pkac070
2020
Journal - Research Other
Blair, V. R., McLeod, M., Carneiro, F., Coit, D. G., D'Addario, J. L., van Dieren, J. M., … Paringatai, K., Bougen-Zhukov, N., Brew, T., … Godwin, T. D., … Nouri, Y., … Reeve, A. E., & Guilford, P. (2020). Hereditary diffuse gastric cancer: Updated clinical practice guidelines. Lancet Oncology, 21(8), e386-e397. doi: 10.1016/S1470-2045(20)30219-9
2017
Journal - Research Article
Fukuzawa, R., Anaka, M. R., Morison, I. M., & Reeve, A. E. (2017). The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. PLoS ONE, 12(10), e0186333. doi: 10.1371/journal.pone.0186333
McInnes, T., Zou, D., Rao, D. S., Munro, F. M., Phillips, V. L., McCall, J. L., Black, M. A., Reeve, A. E., & Guilford, P. J. (2017). Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer. BMC Cancer, 17, 228. doi: 10.1186/s12885-017-3226-4
2015
Journal - Research Article
Michailidou, K., Beesley, J., Lindstrom, S., Canisius, S., Dennis, J., Lush, M. J., … kConFab, including George, P., Kidd, A., Reeve, T., Robinson, B., Walker, L., … Easton, D. F. (2015). Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nature Geoscience, 47, 373-380. doi: 10.1038/ng.3242
Kuchenbaecker, K. B., Ramus, S. J., Tyrer, J., Lee, A., Shen, H. C., Beesley, J., … kConFab, including George, P., Kidd, A., Reeve, T., Robinson, B., Walker, L., … for the Consortium of Investigators of Modifiers of BRCA1 and BRCA2. (2015). Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature Genetics, 47(2), 164-171. doi: 10.1038/ng.3185
Conference Contribution - Poster Presentation (not in published proceedings)
McInnes, T., Zou, D., Black, M. A., Reeve, A. E., & Guilford, P. J. (2015, August-September). Genome-wide methylation analysis identifies a core set of hypermethylated CpG islands in CIMP-H colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2014
Journal - Research Article
Perry, J. R. B., Day, F., Elks, C. E., Sulem, P., Thompson, D. J., Ferreira, T., … kConFab, including George, P., Kidd, A., Reeve, T., Robinson, B., Walker, L., … Ong, K. K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514, 92-97. doi: 10.1038/nature13545
2013
Journal - Research Article
Wu, M. K., Sabbaghian, N., Xu, B., Addidou-Kalucki, S., Bernard, C., Zou, D., Reeve, A. E., Eccles, M. R., … Foulkes, W. D. (2013). Biallelic DICER1 mutations occur in Wilms tumours. Journal of Pathology, 230(2), 154-164. doi: 10.1002/path.4196
Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017
Girardin, A., McCall, J., Black, M. A., Edwards, F., Phillips, V., Taylor, E. S., Reeve, A. E., & Kemp, R. A. (2013). Inflammatory and regulatory T cells contribute to a unique immune microenvironment in tumor tissue of colorectal cancer patients. International Journal of Cancer, 132(8), 1842-1850. doi: 10.1002/ijc.27855
2012
Conference Contribution - Poster Presentation (not in published proceedings)
Dasari, S., Black, M., McNoe, L., McCall, J., & Reeve, A. (2012, August). Determining the molecular mechanisms in triple negative colorectal cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Mehta, S., Lasham, A., Wright, D., Black, M. A., Reeve, A., Guilford, P., McCall, J., … Print, C. (2012, August). Towards improving clinical decisions for colon cancer patients: A step closer to personalised medicine. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2011
Journal - Research Article
Kemp, R. A., Black, M. A., McCall, J., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. E. (2011). T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 30, 78. doi: 10.1186/1756-9966-30-78
Conference Contribution - Published proceedings: Abstract
Black, M., Anjomshoaa, A., Print, C., McCall, J., & Reeve, A. (2011). Bioinformatic approaches in colorectal cancer. Proceedings of the Inaugural International Cancer Symposium. Retrieved from http://www.wnmeds.ac.nz/cancersymposium/programme.html
Intellectual Property
Anjomshoaa, A., Reeve, A. E., Lin, Y.-H., & Black, M. A. (2011). Proliferation signature and prognosis for gastrointestinal cancer. (562237).
2010
Journal - Research Article
Fukuzawa, R., Holman, S. K., Chow, C. W., Savarirayan, R., Reeve, A. E., & Robertson, S. P. (2010). WTX mutations can occur both early and late in the pathogenesis of Wilms tumour. Journal of Medical Genetics, 47, 791-794. doi: 10.1136/jmg.2010.080663
Nasri, S., Anjomshoaa, A., Song, S., Guilford, P., McNoe, L., Black, M., Phillips, V., Reeve, A., & Humar, B. (2010). Oligonucleotide array outperforms SNP array on formalin-fixed paraffin-embedded clinical samples. Cancer Genetics & Cytogenetics, 198(1), 1-6. doi: 10.1016/j.cancergencyto.2009.12.002
Conference Contribution - Poster Presentation (not in published proceedings)
Kemp, R., Girardin, A., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. (2010, August). The presence of Foxp3+ T cells in the lymph node as an indicator of patient outcome in colorectal cancer. Poster session presented at the 14th International Congress of Immunology, Kobe, Japan.
Conference Contribution - Verbal presentation and other Conference outputs
Girardin, A., Phillips, V., Anjomshoaa, A., McCall, J., Dunbar, P. R., Reeve, A., Yoon, H.-S., & Kemp, R. (2010, May). T cell mediated immune responses in colorectal cancer patients. Verbal presentation at the New Zealand Society for Oncology (NZSO) Annual Meeting, Auckland, New Zealand.
2009
Journal - Research Article
Hueber, P.-A., Fukuzawa, R., Elkares, R., Chu, L., Blumentkrantz, M., He, S.-J., Anaka, M. R., Reeve, A. E., Eccles, M. R., … Goodyer, P. R. (2009). PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype. Pediatric & Developmental Pathology, 12(5), 347-354. doi: 10.2350/08-05-0466.1
Lu, A.-T. T., Salpeter, S. R., Reeve, A. E., Eschrich, S., Johnston, P. G., Barrier, A. J., … Lin, A. Y. (2009). Gene expression profiles as predictors of poor outcomes in stage II colorectal cancer: A systematic review and meta-analysis. Clinical Colorectal Cancer, 8(4), 207-214. doi: 10.3816/CCC.2009.n.035
Anjomshoaa, A., Nasri, S., Humar, B., McCall, J. L., Chatterjee, A., Yoon, H.-S., McNoe, L., Black, M. A., & Reeve, A. E. (2009). Slow proliferation as a biological feature of colorectal cancer metastasis. British Journal of Cancer, 101(5), 822-828. doi: 10.1038/sj.bjc.6605229
Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455
Conference Contribution - Published proceedings: Abstract
Kemp, R. A., Yoon, H.-S., Anjomshoaa, A., & Reeve, A. E. (2009). Using T cell responses in the lymph node to predict patient outcome in colorectal cancer. Journal of Immunology. 182(Meeting Abstracts 1). [Abstract]
van Kogelenberg, M., Jenkins, Z. A., Morgan, T., Holman, S., Jeffs, A., Fukuzawa, R., … Reeve, A. E., Robertson, S. P., the OSCS Study Group. (2009). Germline mutations in the tumour suppressor WTX cause a sclerosing bone dysplasia but do not predispose to Wilms tumour. Proceedings of the American Society of Human Genetics 59th Annual Meeting. (pp. 734). Retrieved from http://www.ashg.org/2009meeting/pdf/poster_4up.pdf
Kemp, R. A., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. E. (2009). Using T cell responses in the lymph node to predict patient outcome in colorectal cancer. Proceedings of the Australasian Society for Immunology 39th Annual Scientific Meeting. ASI. Retrieved from http://www.asi2009.org/
Intellectual Property
Reeve, A. E., Black, M. A., McCall, J. L., Nekarda, H., Rosenberg, R., Friederichs, J., … Lin, Y.-H., & Pollock, R. C. (2009). Prognosis prediction for colorectal cancer. (544432).
2008
Journal - Research Article
Humar, B., McNoe, L., Dunbier, A., Heathcott, R., Braithwaite, A. W., & Reeve, A. E. (2008). Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics, 2(2), 329-337.
Kawanishi, H., Matsui, Y., Ito, M., Watanabe, J., Takahashi, T., Nishizawa, K., … Guilford, P., Reeve, A., … Ogawa, O. (2008). Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clinical Cancer Research, 14(9), 2579-2587. doi: 10.1158/1078-0432.CCR-07-1922
Fukuzawa, R., Anaka, M. R., Heathcott, R. W., McNoe, L. A., Morison, I. M., Perlman, E. J., & Reeve, A. E. (2008). Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes. Journal of Pathology, 215(4), 377-387. doi: 10.1002/path.2366
Anjomshoaa, A., Lin, Y.-H., Black, M. A., McCall, J. L., Humar, B., Song, S., Fukuzawa, R., Yoon, H.-S., … van Rij, A., Thompson-Fawcett, M., & Reeve, A. E. (2008). Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. British Journal of Cancer, 99, 966-973. doi: 10.1038/sj.bjc.6604560
Conference Contribution - Published proceedings: Abstract
Black, M. A., Song, S., Anjomshoaa, A., & Reeve, A. E. (2008). Gene set meta-analysis: Application to breast cancer microarray data. Proceedings of the American Association for Cancer Research (AACR) 99th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/
Conference Contribution - Poster Presentation (not in published proceedings)
Kemp, R., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. (2008, December). Using T cell responses in the lymph node to predict patient outcome in colorectal cancer. Poster session presented at the Australasian Society for Immunology 38th Annual Scientific Meeting, Canberra, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Kemp, R., Yoon, H.-S., Phillips, V., Anjomshoaa, A., & Reeve, A. (2008, December). Using T cell responses in the lymph node to predict patient outcome in colorectal cancer. Verbal presentation at the Australasian Society for Immunology 38th Annual Scientific Meeting, Canberra, Australia.
Intellectual Property
Reeve, A. E., Futschik, M. E., Sullivan, M. J., Kasabov, N. K., & Guilford, P. J. (2008). Medical applications of adaptive learning systems using gene expression data. (US 7,370,021).
2007
Journal - Research Article
Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D. P., Thompson, D., Ballinger, D. G., … McCredie, M., … and also Fleming, J., George, P., Reeve, T., & Robinson, B. (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, 1087-1095. doi: 10.1038/nature05887
Matsui, S., Ito, M., Nishiyama, H., Uno, H., Kotani, H., Watanabe, J., Guilford, P., Reeve, A., … Ogawa, O. (2007). Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models. Bioinformatics, 23(6), 732-738.
Ito, M., Nishiyama, H., Kawanishi, H., Matsui, S., Guilford, P., Reeve, A., & Ogawa, O. (2007). P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. Journal of Urology, 178, 1073-1079.
Fukuzawa, R., Heathcott, R. W., More, H. E., & Reeve, A. E. (2007). Sequential WT1 and CTNNB1 mutations and alterations of β-catenin localisation in intralobar nephrogenic rests and associated Wilms tumours: Two case studies. Journal of Clinical Pathology, 60, 1013-1016.
Fukuzawa, R., & Reeve, A. E. (2007). Molecular pathology and epidemiology of nephrogenic rests and Wilms tumors. Journal of Pediatric Hematology/Oncology, 29(9), 589-594.
Lin, H.-M., Chatterjee, A., Lin, Y.-H., Anjomshoaa, A., Fukuzawa, R., McCall, J. L., & Reeve, A. E. (2007). Genome wide expression profiling identifies genes associated with colorectal liver metastasis. Oncology Reports, 17(6), 1541-1549.
Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., … Reeve, A. E., … Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Research, 67(6), 2480-2489. doi: 10.1158/0008-5472.CAN-06-3021
Lin, Y.-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, V., Thompson-Fawcett, M., … van Rij, A., Yoon, H.-S., McCall, J. L., … Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clinical Cancer Research, 13(2), 498-507. doi: 10.1158/1078-0432.CCR-05-2734
Conference Contribution - Published proceedings: Abstract
Lin, Y.-H., Anjomshoaa, A., Song, S., Black, M. A., McCall, J. L., & Reeve, A. E. (2007). A proliferation gene signature can predict clinical outcome of multiple cancers. Proceedings of the American Association for Cancer Research (AACR) 98th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/
Elsworthy, J., Venn, B. J., Reeve, A. E., Morison, I. M., & Green, T. J. (2007). No effect of folic acid depletion or repletion on leukocyte DNA methylation overall or by MTHFR 677C→T genotype in healthy individuals. FASEB Journal, 21, 544.12. [Abstract]
2006
Journal - Research Article
Breslow, N. E., Beckwith, J. B., Perlman, E. J., & Reeve, A. E. (2006). Age distributions, birth weights, nephrogenic rests, and heterogeneity in the pathogenesis of Wilms Tumor. Pediatric Blood & Cancer, 47, 260-267.
Conference Contribution - Published proceedings: Abstract
Brown, K. M., Reeve, A. E., Hampton, M. B., & Winterbourn, C. (2006). Sensitivity of methionine adenosyltransferase to oxidation: A critical enzyme for DNA methylation. Free Radical Research, 40(Suppl. 1), P15-6, (pp. S131). [Abstract]
Anjomshoaa, A., Lin, Y., Chatterjee, A., Lin, H., McCall, J., Black, M., & Reeve, A. E. (2006). Low proliferation is an indicator of poor outcome in colorectal cancer. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf
Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., Reeve, A., … Guilford, P. (2006). The early development of diffuse gastric cancer. Differentiation. 74(8), (pp. 455). [Abstract]
2005
Journal - Research Article
Li, W., Kessler, P., Yeger, H., Alami, J., Reeve, A. E., Heathcott, R., … Williams, B. R. G. (2005). A gene expression signature for relapse of primary Wilms tumors. Cancer Research, 65(7), 2592-2601.
Fukuzawa, R., Heathcott, R. W., Morison, I. M., & Reeve, A. E. (2005). Imprinting, expression, and localisation of DLK1 in Wilms tumours. Journal of Clinical Pathology, 58, 145-150.
Journal - Research Other
Fukuzawa, R., Reeve, A. E., & Morison, I. M. (2005). Correct usage of ″Loss of imprinting″ [Correspondence]. American Journal of Medical Genetics Part A, 138A, 412.
Conference Contribution - Poster Presentation (not in published proceedings)
Lin, H.-M., Chatterjee, A., Fukuzawa, R., Lin, Y.-H., McCall, J., Yoon, H.-S., & Reeve, A. E. (2005, August). Genes involved in cell interactions including the chemokine CXCL12 are upregulated in liver metastasis of colorectal cancer. Poster session presented at the 15th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Heathcott, R. W., Fukuzawa, R., Dunbier, A. K., McNoe, L., & Reeve, A. E. (2005, August). Myogenesis in Wilms tumors is associated with the WNT signalling pathway. Poster session presented at the 15th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.
Intellectual Property
Kasabov, N. K., Futschik, M. E., Sullivan, M. J., & Reeve, A. E. (2005). Medical decision support systems utilizing gene expression and clinical information and method for use. (23910).
2004
Journal - Research Article
Fukuzawa, R., Heathcott, R. W., Sano, M., Morison, I. M., Yun, K., & Reeve, A. E. (2004). Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway. Pediatric & Developmental Pathology, 7, 125-137.
Kawakami, T., Zhang, C., Taniguchi, T., Kim, C. J., Okada, Y., Sugihara, H., … Reeve, A. E., … Okamoto, K. (2004). Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells. Oncogene, 23, 6163-6169.
Fukuzawa, R., Breslow, N. E., Morison, I. M., Dwyer, P., Kusafuka, T., Kobayashi, Y., … Reeve, A. E. (2004). Epigenetic differences between Wilms' tumors in white and east-Asian children. Lancet, 363, 446-451.
Journal - Research Other
Kawakami, T., Okamoto, K., Sugihara, H., Hattori, T., Reeve, A. E., Ogawa, O., & Okada, Y. (2004). The MET proto-oncogene is not a major target for the gain of chromosome 7 in testicular germ-cell tumors of adolescents [Letter]. Virchows Archiv, 444, 480-481.
Fukuzawa, R., Heathcott, R. W., Morison, I. M., Reeve, A. E., & Sano, M. (2004). Reply to Dr. Sredni and colleagues. Pediatric & Developmental Pathology, 7, 670.
Conference Contribution - Poster Presentation (not in published proceedings)
Humar, B., Fukuzawa, R., Blair, V., More, H., Reeve, A., Charlton, A., … Guilford, P. (2004, June). A model for the development and progression of hereditary diffuse gastric cancer. Poster session presented at the World Congress on Gastrointestinal Cancer, Barcelona, Spain.
2003
Journal - Research Article
Futschik, M. E., Sullivan, M., Reeve, A., & Kasabov, N. (2003). Prediction of clinical behaviour and treatment for cancers. Applied Bioinformatics, 2(3, Suppl.), S53-S58.
Kawakami, T., Okamoto, K., Sugihara, H., Hattori, T., Reeve, A. E., Ogawa, O., & Okada, Y. (2003). The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. Journal of Urology, 169(4), 1546-1552.
Fukuzawa, R., Hata, J.-I., Hayashi, Y., Ikeda, H., & Reeve, A. E. (2003). Beckwith-Wiedemann syndrome-associated hepatoblastoma: Wnt signal activation occurs later in tumorigenesis in patients with 11p15.5 uniparental disomy. Pediatric & Developmental Pathology, 6, 299-306.
Kawakami, T., Okamoto, K., Kataoka, A., Koizumi, S., Iwaki, H., Sugihara, H., Reeve, A. E., … Okada, Y. (2003). Multipoint methylation analysis indicates a distinctive epigenetic phenotype among testicular germ cell tumors and testicular malignant lymphomas. Genes Chromosomes & Cancer, 38, 97-101.
Futschik, M. E., Reeve, A. E., & Kasabov, N. K. (2003). Evolving connectionist systems for knowledge discovery from gene expression data of cancer tissue. Artificial Intelligence in Medicine, 28, 165-189.
Conference Contribution - Published proceedings: Full paper
Futschik, M. E., Sullivan, M., Reeve, A., & Kasabov, N. (2003). Modular decision system and information integration for improved disease outcome prediction. Proceedings of the ECCB Conference. (pp. 13-15). ECCB. [Full Paper]
2002
Journal - Research Article
Kerr, N. J., Chun, Y.-H., Yun, K., Heathcott, R. W., Reeve, A. E., & Sullivan, M. J. (2002). Pancreatoblastoma is associated with chromosome 11p loss of heterozygosity and IGF2 overexpression. Medical & Pediatric Oncology, 39, 52-54.
Delahunt, B., Kittelson, J. M., McCredie, M. R. E., Reeve, A. E., Stewart, J. H., & Bilous, A. M. (2002). Prognostic importance of tumor size for localized conventional (clear cell) renal cell carcinoma: Assessment of TNM T1 and T2 tumor categories and comparison with other prognostic parameters. Cancer, 94(3), 658-664.
Futschik, M., Jeffs, A., Pattison, S., Kasabov, N., Sullivan, M., Merrie, A., & Reeve, A. (2002). Gene expression profiling of metastatic and nonmetastatic colorectal cancer cell lines. Genome Letters, 1(1), 26-34. doi: 10.1166/gl.2002.005
Mitsumori, K., Kittelson, J. M., Itoh, N., Delahunt, B., Heathcott, R., Stewart, J. H., McCredie, M. R. E., & Reeve, A. E. (2002). Chromosome 14q LOH in localized clear cell renal cell carcinoma. Journal of Pathology, 198, 110-114.
Heathcott, R. W., Morison, I. M., Gubler, M. C., Corbett, R., & Reeve, A. E. (2002). A review of the phenotypic variation due to the Denys-Drash Syndrome-associated germline WT1 mutation R362X. Human Mutation, 19(4), 462.
Morison, I. M., Ellis, L., Teague, L. R., & Reeve, A. E. (2002). Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia. Blood, 99(1), 375-377.
Reeve, A. E., Becroft, D. M. O., Morison, I. M., & Fukuzawa, R. (2002). IGF2 imprinting in cancer. Lancet, 359, 2050-2051.
Journal - Research Other
Kerr, N. J., Fukazawa, R., Reeve, A. E., & Sullivan, M. J. (2002). Beckwith-Wiedemann syndrome' pancreatoblastoma, and the Wnt signaling pathway [Letter to the editor]. American Journal of Pathology, 160(4), 1541.
Journal - Professional & Other Non-Research Articles
Morison, I. M., Becroft, D. M. O., & Reeve, A. E. (2002). Re: Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms Tumor. Journal of the National Cancer Institute, 94(23), 1809-1810.
2001
Journal - Research Article
Pattison, S. T., & Reeve, A. E. (2001). From molecule to malady. The future of high speed molecular biology in medicine. New Zealand Medical Journal, 114, 70-72.
Conference Contribution - Published proceedings: Abstract
Jeffs, A., Pattison, S., Xu, J., & Reeve, A. (2001). Microarray analysis of colorectal cancer cell lines. Nature Genetics, 27, (pp. 62). doi: 10.1038/87138
2000
Journal - Research Article
Itoh, N., Becroft, D. M. O., Reeve, A. E., & Morison, I. M. (2000). Proportion of cells with paternal 11p15 uniparental disomy correlates with organ enlargement in Wiedemann-Beckwith Syndrome. American Journal of Medical Genetics, 92, 111-116.
Morison, I. M., Eccles, M. R., & Reeve, A. E. (2000). Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis. Blood, 96(9), 3023-3028.
Rapley, E. A., Barfoot, R., Bonaite-Pellie, C., Chompret, A., Foulkes, W., Perusinghe, N., Reeve, A., … Rahman, N. (2000). Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2. British Journal of Cancer, 83(2), 177-183. doi: 10.1054/bjoc.2000.1283
Conference Contribution - Verbal presentation and other Conference outputs
Reeve, A. E., Kerr, N., & Sullivan, M. J. (2000). Pancreatoblastoma: Another embryonal tumour with 11p15.5 LOH and over expression of IGF2. Verbal presentation at the International Society of Paediatric Oncology and International Society of Paediatric Surgical Oncology, Amsterdam.
Morison, I. M., Ellis, L. M., Teague, L. R., & Reeve, A. E. (2000). Evidence for germ-line origin of childhood acute leukaemia. Verbal presentation at the Haematology Society of Australia and New Zealand Congress
Morison, I. M., Ellis, L. M., Mudford, J., & Reeve, A. E. (2000). Clinical and epidemiological implications of molecular genetics studies in childhood acute lymphoblastic leukaemia. Verbal presentation at the New Zealand Society for Oncology Annual Scientific Meeting
1999
Journal - Research Article
Benjes, S. M., Millow, L. J., Jeffs, A. R., Sowerby, S. J., Reeve, A. E., & Morris, C. M. (1999). 3' BCR recombines with IGL locus in BCR-ABL-positive Philadelphia-negative chronic myeloid leukaemia. Genes Chromosomes & Cancer, 26(4), 366-371.
Frevel, M. A. E., Hornberg, J. J., & Reeve, A. E. (1999). A potential imprint control element: identification of a conserved 42 bp sequence upstream of H19. Trends in Genetics, 15(6), 216-218.
Gardner, R. J. M., Gaff, C. L., Macrae, F. A., St John, D. J. B., Hopkins, J., Guilford, P. J., & Reeve, A. E. (1999). E-cadherin unlikely to be a common "low penetrance" gene for colorectal cancer. American Journal of Medical Genetics, 84(2), 169-171.
Shinmura, K., Kohno, T., Takahashi, M., Sasaki, A., Ochiai, A., Guilford, P., Hunter, A. K., Reeve, A. E., … Yokota, J. (1999). Familial gastric cancer: Clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. Carcinogenesis, 20(6), 1127-1131. doi: 10.1093/carcin/20.6.1127
Frevel, M. A. E., Sowerby, S. J., Petersen, G. B., & Reeve, A. E. (1999). Methylation sequencing analysis refines the region of H19 epimutation in Wilms Tumor. Journal of Biological Chemistry, 274(41), 29331-29340.
Yun, K., Soejima, H., Gunn, J., Merrie, A. E. H., McCall, J. L., & Reeve, A. E. (1999). Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific PCR. Journal of Pathology, 187, 518-522.
Guilford, P. J., Hopkins, J. B. W., Grady, W. M., Markowitz, S. D., Willis, J., Lynch, H., … Toro, T. T., … Shaw, D. P., Findlay, M. P. N., & Reeve, A. E. (1999). E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Human Mutation, 14(3), 249-255. doi: 10.1002/(SICI)1098-1004
Sullivan, M. J., Taniguchi, T., Jhee, A., Kerr, N., & Reeve, A. E. (1999). Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation. Oncogene, 18, 7527-7534.
1998
Journal - Research Article
Guilford, P., Hopkins, J. B. W., Harraway, J., McLeod, M., McLeod, N., Harawira, P., … Miller, A., & Reeve, A. E. (1998). E-cadherin germline mutations in familial gastric cancer. Nature, 392(6674), 402-405. doi: 10.1038/32918
Journal - Research Other
Morison, I. M., & Reeve, A. E. (1998). Insulin-like growth factor 2 and overgrowth: Molecular biology and clinical implications. Molecular Medicine Today, 4(3), 110-115. doi: 10.1016/S1357-4310(97)01197-0
Morison, I. M., & Reeve, A. E. (1998). A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Human Molecular Genetics, 7(10), 1599-1609. doi: 10.1093/hmg/7.10.1599
Journal - Professional & Other Non-Research Articles
Okamoto, K., Morison, I. M., Reeve, A. E., Tommerup, N., Wiedemann, H. R., & Friedrich, U. (1998). Is p57KIP2 mutation a common mechanism for Beckwith-Wiedemann syndrome or somatic overgrowth? Journal of Medical Genetics, 35(1), 86.
Conference Contribution - Published proceedings: Abstract
Sullivan, M. J., Kerr, N. J., Taniguchi, T., & Reeve, A. E. (1998). DNA methylation and relaxation of IGF2 imprinting in Wilms' tumours. Genomic Imprinting Symposium of the National Institutes of Environmental and Health Sciences. Durham, USA: Duke University. Retrieved from http://www.geneimprint.com/meetings/1998durham/
Reeve, A. E. (1998). Role of IGF-II in Wilms tumourigenesis and overgrowth disorders. International Congress Series, 1151. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Morison, I. M., & Reeve, A. E. (1998, April). IGF2 overexpression and imprinting in overgrowth syndromes. Verbal presentation at the Eli Lilly Global Medical Conference on Pediatric Endocrinology, Indianapolis, USA.
1997
Journal - Research Article
Taniguchi, T., Okamoto, K., & Reeve, A. E. (1997). Human p57KIP2 defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour. Oncogene, 14(10), 1201-1206.
Okamoto, K., Morison, I. M., Taniguchi, T., & Reeve, A. E. (1997). Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis. PNAS, 94(10), 5367-5371.
Conference Contribution - Poster Presentation (not in published proceedings)
Morison, I. M., Becroft, D. M. O., Taniguchi, T., Okamoto, K., & Reeve, A. E. (1997). Constitutional relaxation of insulin-like growth factor II imprinting is associated with a braod spectrum of overgrowth manifestations. Poster session presented at the American Association for Cancer Research Annual Meeting.
Intellectual Property
Reeve, A. E., & Guilford, P. J. (1997). Method of Testing. number 328994. Cancer Genetics Laboratory Biochemistry Department.
1996
Journal - Research Article
Morison, I. M., Becroft, D. M., Taniguchi, T., Reeve, A. E., & Woods, C. G. (1996). Somatic overgrowth associated with overexpression of insulin—like growth factor II. Nature Medicine, 2, 311-316. doi: 10.1038/nm0396-311
Reeve, A. E. (1996). Role of genomic imprinting in Wilms' Tumour and overgrowth disorders. Medical & Pediatric Oncology, 27(5), 470-475.
Mishina, M., Ogawa, O., Kinoshita, H., Oka, H., Okumura, K., Mitsumori, K., … Reeve, A. E., & Yoshida, O. (1996). Equivalent parental distribution of frequently lost alleles and biallelic expression of the H19 gene in human testicular germ cell tumors. Japanese Journal of Cancer Research, 87(8), 816-823.
1995
Chapter in Book - Research
Reeve, A. E. (1995). Genomic imprinting in embryonal and overgrowth disorders. In R. Ohlsson, K. Hall & M. Ritzen (Eds.), Nobel Symposium: Parental Imprinting: Causes and Consequences. (pp. 209-223). Cambridge: Cambridge University Press.
Journal - Research Article
Taniguchi, T., Sullivan, M. J., Ogawa, O., & Reeve, A. E. (1995). Epigenetic changes encompassing the IGF/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor. PNAS, 92(6), 2159-2163.
Becroft, D. M. O., Mauger, D. C., Skeen, J. E., Ogawa, O., & Reeve, A. E. (1995). Good prognosis of cellular mesoblastic nephroma with hyperdiploidy and relaxation of imprinting of the maternal IGF2 gene. Pediatric Pathology & Laboratory Medicine, 15, 679-688.
Taniguchi, T., Schofield, A. E., Scarlett, J. L., Morison, I. M., Sullivan, M. J., & Reeve, A. E. (1995). Altered specificity of IGF2 promoter imprinting during fetal development and onset of Wilms tumour. Oncogene, 11, 751-756.
Simms, L. A., Reeve, A. E., & Smith, P. J. (1995). Genetic mosaicism at the Insulin locus in liver associated with childhood hepatoblastoma. Genes Chromosomes & Cancer, 13, 72-73.