Professor Antony Braithwaite

2026

Journal - Research Article

Wang, S., Shafaei Pishabad, Z., Sarkar, D., Arun Bhandarkar, A., Sarwar, M., Jeffs, A., Reid, G., Braithwaite, A., & Mehta, S. (2026). YBX1 expression marks proliferative tumour states with context-dependent genomic instability: A pan-cancer analysis. International Journal of Molecular Sciences, 27(10), 4340. doi: 10.3390/ijms27104340

2025

Journal - Research Article

Bhandarkar, A. A., Kelly-Foleni, N. E., Sarkar, D., Jeffs, A., Slatter, T., Braithwaite, A., & Mehta, S. (2025). TP53 splice mutations have tumour-independent effects on genomic stability and prognosis: An in silico study. International Journal of Molecular Sciences, 26, 12080. doi: 10.3390/ijms262412080

Polwatta Lekamlage, S., Boix De Jesus, A. N., Machado Saraiva, A., Drummond, C., Dolan, H., March de Ribot, F., Royds, J. A., Mehta, S., Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2025). Δ133p53 isoform enhances TLR4 function to promote tumour growth. Carcinogenesis, 46(4), bgaf051. doi: 10.1093/carcin/bgaf051

Conference Contribution - Published proceedings: Abstract

Bhandarkar, A. A., Sarkar, D., Jeffs, A., Kelly-Foleni, N. E., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Role of the TP53 splice mutations in cancer progression. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Shafaei Pishabad, Z., Sarkar, D., Jeffs, A., Samaratunga, H., Rhodes, J., Costello, R., Highton, A., Wright, D., Pattison, S., Kemp, R., Delahunt, B., Braithwaite, A., Slatter, T., & Mehta, S. (2025). Development of a prognostic tool for identifying high-risk prostate cancer patients. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2024

Journal - Research Other

Hossain, S. M., Ly, K., Braithwaite, A., & Li, K. (2024). Immune checkpoint inhibitor therapy for metastatic melanoma: What should we focus on to improve the clinical outcomes? International Journal of Molecular Sciences, 25, 10120. doi: 10.3390/ijms251810120

Ray Das, S., Delahunt, B., Lasham, A., Li, K., Wright, D., Print, C., Slatter, T., Braithwaite, A., & Mehta, S. (2024). Combining TP53 mutation and isoform has the potential to improve clinical practice. Pathology, 56(4), 473-483. doi: 10.1016/j.pathol.2024.02.003

Conference Contribution - Verbal presentation and other Conference outputs

Sarkar, D., Gyanwali, G., Li, K., Sarwar, M., Braithwaite, A., & Mehta, S. (2024, August-September). Can YB-1 expression levels be used to classify immunotherapy responses of chromosomal instable tumours based on cGAS-STING activity? Verbal presentation at the Queenstown Research Week (QRW) Cancer Meeting, Queenstown, New Zealand.

Sarkar, D., Gyanwali, G. C., Patel, J., Shevchuk, P., Woolley, A., Siddiqui, H., Ratajska, M., Sarwar, M., Drummond, C. J., McKinney, C., Antony, J., McCormick, S. P., Braithwaite, A., & Mehta, S. (2024, August-September). Role of H179 p53 mutation in driving aggressive tumours in patients. Verbal presentation at the Queenstown Research Week (QRW) Cancer Meeting, Queenstown, New Zealand.

2023

Journal - Research Article

Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8

Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267

2022

Journal - Research Article

Reinhardt, L. S., Zhang, X., Groen, K., Morten, B. C., De Iuliis, G. N., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage. Cell Death & Disease, 13, 907. doi: 10.1038/s41419-022-05349-9

Zhang, X., Groen, K., Morten, B. C., Reinhardt, L. S., Campbell, H. G., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). The effect of p53 and its N-terminally truncated isoform, Δ40p53, on breast cancer migration and invasion. Molecular Oncology, 16, 447-465. doi: 10.1002/1878-0261.13118

Journal - Research Other

Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394

Conference Contribution - Verbal presentation and other Conference outputs

Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2

Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays. Cancers, 13(7), 1531. doi: 10.3390/cancers13071531

Journal - Research Other

Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085

2020

Journal - Research Article

Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405

Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3

Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital PCR to specifically detect and quantitate individual TP53 transcripts. Cancers, 12(3), 769. doi: 10.3390/cancers12030769

Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G₂ phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315

2019

Journal - Research Article

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., … Braithwaite, A. W., … Timpson, P. (2019). CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, 3637. doi: 10.1038/s41467-019-10968-6

Trevarton, A. J., Zhou, Y., Yang, D., Rewcastle, G. W., Flanagan, J. U., Braithwaite, A., … Lasham, A. (2019). Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1. Acta Pharmaceutica Sinica B, 9(5), 997-1007. doi: 10.1016/j.apsb.2018.12.011

Conference Contribution - Published proceedings: Abstract

Li, K., Wilson, M., Parker, K., Wiles, A., Schultz, M., Slatter, T., Baird, M., & Braithwaite, A. (2019). An Δ133p53-like isoform drives exaggerated immune responses to promote chronic inflammation. European Journal of Immunology, 49(Suppl. 3), (pp. 782). doi: 10.1002/eji.201970400

2018

Journal - Research Article

Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2

Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0

Conference Contribution - Published proceedings: Abstract

Zeng, J., Thomson, M., Broadbent, J., Foster Page, L., Shalev, I., Moffitt, T., Caspi, A., Williams, S., Braithwaite, A., Robertson, S., & Poulton, R. (2018). Examining the association between telomere length and periodontal attachment loss in the Dunedin Study. Proceedings of the Australasian Applied Statistics (AASC) Conference. (pp. 32). Retrieved from https://www.aasc.nz/

Munro, F., Gimenez, G., Shepherd, P., Braithwaite, A., McCall, J., & Fleming, N. (2018). A common variation in the IL6 promoter predicts time to metastasis for colorectal cancer and may indicate the mechanisms involved. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Hibma, M., Zhang, T., Gimenez, G., Ly, K., Burn, C., Young, K., Wilson, M., … Tschirley, A., Braithwaite, A., & Baird, M. (2018). Human papillomavirus regulation of Langerhans cell function in the skin. European Journal of Immunology, 48(Suppl. 1), (pp. 96-97). doi: 10.1002/eji.201871000

Conference Contribution - Poster Presentation (not in published proceedings)

Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., Braithwaite, A. W., & Slatter, T. L. (2018, August). Investigating p53 isoforms in HPV positive cervical cancers and in the placenta. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Ray, S., McKinney, C., Roth, L., Heinzel, S., Hodgkin, P., Mehta, S., Slatter, T. L., & Braithwaite, A. W. (2018, August). p53 does not cause growth arrest or death in normal B cells but only affects division rate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Mehta, S., Algie, M., Al Jabri, T., McKinney, C., Verma, C., Weini, M., … Henderson, L., Gould, M., Parker, K., Bhatia, P., Harfoot, R., Kleffmann, T., … Woolley, A., & Braithwaite, A. (2018, August). RSK mediated YB-1 phosphorylation: A key event required for completion of cytokinesis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Henderson, L., Mehta, S., Fleming, N., Eccles, M., Chatterjee, A., Print, C., … Braithwaite, A. (2018, August). p63 promotes proliferation in melanoma cell lines via regulation of AQP3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Braithwaite, A. W. (2018, August). Can the wild type p53 tumour suppressor cause cancer? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Munro, F. M., Gimenez, G., Shepherd, P. R., Braithwaite, A. W., McCall, J. L., & Fleming, N. I. (2018, August). Regulation of IL-6 is pivotal to outcome in colorectal cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Journal - Research Article

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Leroy, B., Ballinger, M. L., Baran-Marszak, F., Bond, G. L., Braithwaite, A., Concin, N., … Soussi, T. (2017). Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice. Cancer Research, 77(6), 1250-1260. doi: 10.1158/0008-5472.can-16-2179

Conference Contribution - Published proceedings: Abstract

Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio

Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio

Wiles, A., Kazantseva, M., Li, K., Williams, M., Bowie, S., Jo, S., Millier, M., Hessian, P., Stamp, L., Baird, M. A., Slatter, T., & Braithwaite, A. (2017). The presence of Δ133p53β in the autoimmune disease rheumatoid arthritis. Proceedings of the 3rd International p53 Isoform Conference. P10. Retrieved from http://www.uib.no/en/ccbio

Print, C., Lasham, A., Knowlton, N., Trevarton, A., Jebb, A., Blenkiron, C., … Harris, G., … Braithwaite, A., & Black, M. (2017). Bioinformatic prospecting for breast cancer drivers. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 60). Auckland, New Zealand: Auckland University of Technology. [Abstract]

Hale, T. K., Solomon, R., Bond, S. D., Mehta, S., Braithwaite, A., Wheeler, D., & Fitzsimons, H. (2017). Untethering the genome: Loss of HP1α enhances malignant cell invasion. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 40). Auckland, New Zealand: Auckland University of Technology. [Abstract]

Morten, B., Campbell, H., Braithwaite, A., Scott, R., & Avery-Kiejda, K. (2017). The Role of Δ 40P53 in the response to DNA damage in breast cancer cells. Asia-Pacific Journal of Clinical Oncology, 13(Suppl. 5), (pp. 19). doi: 10.1111/ajco.12813

Zhang, X., Morten, B., Campbell, H., Braithwaite, A., Thorne, R., Scott, R., & Avery-Kiejda, K. (2017). Δ40P53 inhibits migration/invasion in MCF-7 breast cancer cells. Asia-Pacific Journal of Clinical Oncology, 13(Suppl. 5), (pp. 19-20). doi: 10.1111/ajco.12813

Conference Contribution - Verbal presentation and other Conference outputs

Hibma, M., Zhang, J., Baird, M., & Braithwaite, A. (2017, July). Evaluating immune modulation of Langerhans cells by microparticles shed from human papillomavirus type 16-E7 expressing keratinocyctes. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand.

2016

Journal - Research Article

Mehta, S., Tsai, P., Lasham, A., Campbell, H., Reddel, R., Braithwaite, A., & Print, C. (2016). A study of TP53 RNA splicing illustrates pitfalls of RNA-seq methodology. Cancer Research, 76(24), 7151-7159. doi: 10.1158/0008-5472.can-16-1624

Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137

Dasgupta, T., Antony, J., Braithwaite, A. W., & Horsfield, J. A. (2016). HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting cohesin-dependent transcription in MCF7 cancer cells. Journal of Biological Chemistry, 291(24), 12761-12770. doi: 10.1074/jbc.M115.704627

Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., … Fleming, N. I., Braithwaite, A. W., & Baird, M. A. (2016). Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology, 5(3), e1112941. doi: 10.1080/2162402X.2015.1112941

Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45

Thomson, W. M., Zeng, J., Broadbent, J. M., Foster Page, L. A., Shalev, I., Moffitt, T. E., … Williams, S. M., Braithwaite, A. W., Robertson, S. P., & Poulton, R. (2016). Telomere length and periodontal attachment loss: A prospective cohort study. Journal of Clinical Periodontology, 43(2), 121-127. doi: 10.1111/jcpe.12499

Conference Contribution - Published proceedings: Abstract

Braithwaite, A., Slatter, T., Wilson, M., & Baird, M. (2016). D133p53 isoform: A novel adjuvant for tumour vaccination. European Journal of Immunology, 46(Suppl. 1), (pp. 1007). doi: 10.1002/eji.201670200

Zhang, T., Burn, C., Ly, K., Young, K., Wilson, M., Braithwaite, A., Baird, M., & Hibma, M. (2016). Immune modulation of Langerhans cells by microparticles from human papillomavirus type 16 E7 expressing keratinocytes. European Journal of Immunology, 46(Suppl. 1), (pp. 890-891). doi: 10.1002/eji.201670200

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia.

Fleming, N. I., Henderson, L. E., Campbell, H. G., Antony, J., Print, C. G., Baird, M., & Braithwaite, A. W. (2016, August-September). A common variation within the IL6 promoter may alter its control by the p53 protein family and influence cancer progression. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Mehta, S., Lasham, A., Woolley, A., Algie, M., Al Jabry, T., Ma, W., Fleming, N., Young, K., Parker, K., … Braithwaite, A. (2016, August-September). Role of YB-1 in cell cycle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Campbell, H., Fleming, N., Roth, I., Vennin, C., McCall, J., Mehta, S., Wiles, A., Williams, G., … Baird, M., & Braithwaite, A. W. (2016, August-September). IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the Δ133p53 isoform. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Sun, Y., Bell, J. L., Carter, D., Gherardi, S., Poulos, R. C., Milazzo, G., … Braithwaite, A., & Liu, T. (2015). WDR5 supports an N-Myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma. Cancer Research, 75(23), 5143-5154. doi: 10.1158/0008-5472.CAN-15-0423

Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149

Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270

Conference Contribution - Poster Presentation (not in published proceedings)

Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., … Fleming, N., Baird, M., & Braithwaite, A. (2015, October). Does a variant of the tumour suppressor P53 play a role in tumour metastasis? Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Kazantseva, M., Slatter, T., Hung, N., & Braithwaite, A. (2015, September). Altered regulation of Δ133p53 isoforms expression in prostate tumours. Verbal presentation at the 2nd International p53 Isoform Workshop, Aix-en-Provence, France.

Braithwaite, A. (2015, October). The gene that stops cancer. Verbal presentation at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.

Fleming, N., Henderson, L. E., Print, C. G., Baird, M. A., & Braithwaite, A. W. (2015, August). Tumour suppression mechanisms and pro-migratory signals. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Braithwaite, A. (2015, August). The p53 tumour supressor and human cancer. Invited presentation at the Inaugural Dunedin School of Medicine Symposium, Dunedin, New Zealand.

2014

Journal - Research Article

Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159

Shalev, I., Moffitt, T. E., Braithwaite, A. W., Danese, A., Fleming, N. I., Goldman-Mellor, S., … Poulton, R., Robertson, S. P., … Caspi, A. (2014). Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Molecular Psychiatry, 19, 1163-1170. doi: 10.1038/mp.2013.183

Conference Contribution - Published proceedings: Abstract

Thomson, W. M., Broadbent, J. M., Poulton, R., Moffitt, T. E., Braithwaite, A. W., & Zeng, J. (2014). Telomere erosion and periodontal attachment loss by age 38. Journal of Dental Research, 93(Spec Iss B), 988. Retrieved from http://www.iadr.org

Conference Contribution - Poster Presentation (not in published proceedings)

Roth, I., Rubio, C., Campbell, H., Fleming, N., Baird, M., & Braithwaite, A. (2014, September). The Δ133p53 isoform promotes secreted cytokine-dependent cell migration. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Braithwaite, A. (2014, August). Role of YB1 in cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2013

Journal - Research Article

Bildsoe, H., Loebel, D. A. F., Jones, V. J., Hor, A. C. C., Braithwaite, A. W., Chen, Y.-T., … Tam, P. P. L. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Developmental Biology, 374, 295-307. doi: 10.1016/j.ydbio.2012.12.004

Lasham, A., Print, C. G., Woolley, A. G., Dunn, S. E., & Braithwaite, A. W. (2013). YB-1: Oncoprotein, prognostic marker and therapeutic target? Biochemical Journal, 449, 11-23. doi: 10.1042/bj20121323

Campbell, H. G., Mehta, R., Neumann, A. A., Rubio, C., Baird, M., Slatter, T. L., & Braithwaite, A. W. (2013). Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene, 32(7), 827-836. doi: 10.1038/onc.2012.102

Journal - Professional & Other Non-Research Articles

Neilsen, P. M., Braithwaite, A. W., Gamell, C., Haupt, S., Janic, A., Strasser, A., … Haupt, Y. (2013). Stimulating p53 down-under: A report from the 1st Australian p53 Workshop. Cell Death & Differentiation, 20(12), 1753-1756. doi: 10.1038/cdd.2013.2

Conference Contribution - Published proceedings: Abstract

Harfoot, R., Fleming, S., Braithwaite, A., & Mercer, A. A. (2013). A retinoblastoma-associated protein (pRB) binding protein from orf virus. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/

Conference Contribution - Verbal presentation and other Conference outputs

Braithwaite, A. (2013, December). p53 in inflammatory diseases. Verbal presentation at the University of Otago Triple Theme Research Meeting: The Kidney in Health and Disease, Gut Health Network, Arthritis Research, Dunedin, New Zealand.

2012

Journal - Research Article

Huschtscha, L. I., Napier, C. E., Noble, J. R., Bower, K., Au, A. Y. M., Campbell, H. G., Braithwaite, A. W., & Reddell, R. R. (2012). Enhanced isolation of fibroblasts from human skin explants. Biotechniques, 53(4), 239-244. doi: 10.2144/0000113939

Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054

Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., … Woolley, A. G., … Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. (2012). YB-1, the E2F Pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute, 104(2), 133-146. doi: 10.1093/jnci/djr512

Conference Contribution - Poster Presentation (not in published proceedings)

Al Jabry, T. S., Cohen, S. B., & Braithwaite, A. W. (2012, August). Characterising the functions of YB-1 phosphorylation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Fitzgerald, S., Braithwaite, A., Shelling, A., Print, C., & Lasham, A. (2012, August). The role of YB-1 in resistance to chemotherapeutics in triple negative breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Campbell, H. G., Rubio, C., Slatter, T. L., Jeffs, A. R., Baird, M., & Braithwaite, A. W. (2012, August). The p53 isoform, Δ133p53 binds to and inhibits the p53 family members, p63 and p73. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Algie, M., Jeffs, A., Woolley, A., Kleffmann, T., & Braithwaite, A. (2012, August). Identification of binding partners of the oncoprotein Y-box binding protein (YBX1) in breast cancer cell-line. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Braithwaite, A. W., Baird, M. A., Campbell, H. G., Hung, N. A., Jeffs, A. R., Print, C. G., & Slatter, T. L. (2012, August). Isoforms of the p53 tumour suppressor, inflammation, and cancer. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737

Joshi, S., Braithwaite, A. W., Robinson, P. J., & Chircop, M. (2011). Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Molecular Cancer, 10, 78. doi: 10.1186/1476-4598-10-78

Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603

Li, C. G., Nyman, J. E., Braithwaite, A. W., & Eccles, M. R. (2011). PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene, 30, 4824-4834. doi: 10.1038/onc.2011.190

Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851

Conference Contribution - Published proceedings: Abstract

Royds, J. A., Al Nadaf, S., Ahn, A., Chen, Y.-J., Wiles, A., Jellinek, D., Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). Older patients with glioma have a high frequency of a rare CDKN2A P14/16 allele. Neuro-Oncology, 13(Suppl. 2), 50, (pp. ii10). doi: 10.1093/neuonc/nor144

Eccles, M. R., Li, C. G., Nyman, J. E., & Braithwaite, A. W. (2011). A role for PAX8 in promoting tumor cell type-specific proliferation through positively regulating E2F1 transcription and stabilizing RB protein. Proceedings of the American Association for Cancer Research (AACR) 102nd Annual Meeting. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

2010

Journal - Research Article

Heinlein, C., Deppert, W., Braithwaite, A. W., & Speidel, D. (2010). A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle, 9(17), 3584-3590. doi: 10.4161/cc.9.17.12831

Joshi, S., Perera, S., Gilbert, J., Smith, C. M., Mariana, A., Gordon, C. P., … Braithwaite, A. W., & Chircop, M. (2010). The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. doi: 10.1158/1535-7163.MCT-10-0161

Cohen, S. B., Ma, W., Valova, V. A., Algie, M., Harfoot, R., Woolley, A. G., … Braithwaite, A. W. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29, 403-410. doi: 10.1038/onc.2009.321

Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death & Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136

Conference Contribution - Published proceedings: Abstract

Joshi, S., Gaddipatti, S., Gilbert, J., . . ., Braithwaite, A. W., & Chircop, M. (2010). Dynamin inhibition: A new therapeutic approach for the treatment of cancer. Proceedings of the American Association for Cancer Research (AACR) 101st Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

2009

Journal - Research Article

Jiang, W.-Q., Zhong, Z.-H., Nguyen, A., Henson, J. D., Toouli, C. D., Braithwaite, A. W., & Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. Journal of Cell Biology, 185(5), 797-810. doi: 10.1083/jcb.200810084

Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., … Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z

Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016

Huschtscha, L., Moore, J. D., Noble, J. R., Campbell, H. G., Royds, J. A., Braithwaite, A. W., & Reddel, R. R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21^WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. doi: 10.1242/jcs.044107

Conference Contribution - Published proceedings: Abstract

Tang, C., Slatter, T., Wilson, M., Braithwaite, A., & Baird, M. (2009). Dendritic cells from mice lacking p53, in contrast to those from mutant p53 and wild type mice, fail to induce Th1 immune responses and do not suppress tumour growth. Proceedings of the Australasian Society for Immunology 39th Annual Scientific Meeting. ASI. Retrieved from http://www.asi2009.org/

Conference Contribution - Verbal presentation and other Conference outputs

Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Tang, C. W., Baird, M. A., & Braithwaite, A. W. (2009, June). New roles for p53-mediated apoptosis in B cell development and in dendritic cell function. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand.

Braithwaite, A. (2009, August). Cancer prediposition in mice expressing an isoform of the p53 tumour suppressor. Verbal presentation at the International MDM2 Workshop V, Ghent, Belgium.

2008

Journal - Research Article

Humar, B., McNoe, L., Dunbier, A., Heathcott, R., Braithwaite, A. W., & Reeve, A. E. (2008). Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics, 2(2), 329-337.

Chen, Y.-J., Campbell, H. G., Wiles, A. K., Eccles, M. R., Reddel, R. R., Braithwaite, A. W., & Royds, J. A. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. doi: 10.1158/0008-5472.CAN-08-0058

2007

Conference Contribution - Poster Presentation (not in published proceedings)

Chen, Y.-J., Wiles, A., Braithwaite, A., Eccles, M., Baguley, B., & Royds, J. A. (2007, August). PAX provides molecular clues to gliomagenesis. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Li, C., Jeffs, A., He, S., Marshall, E., Baguley, B., Braithwaite, A., & Eccles, M. (2007, August). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Wiles, A., Hibma, M., Russell, A., Braithwaite, A., & Royds, J. A. (2007, December). Factors affecting efficiency of Onco-viral therapy involving the adenovirus ONYX-015. Verbal presentation at the 4th Australian Virology Group Meeting, Fraser Island, Australia.

2006

Journal - Research Article

Braithwaite, A. W., Del Sal, G., & Lu, X. (2006). Some p53-binding proteins that can function as arbiters of life and death. Cell Death & Differentiation, 13, 984-993.

Braithwaite, A. W., & Prives, C. L. (2006). p53: More research and more questions. Cell Death & Differentiation, 13, 877-880.

Chen, Y.-J., Hakin-Smith, V., Teo, M., Xinarianos, G. E., Jellinek, D. A., Carroll, T., … Braithwaite, A. W., … Royds, J. A. (2006). Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Research, 66(13), 6473-6476.

Royds, J. A., Hibma, M., Dix, B. R., Hananeia, L., Russell, I. A., Wiles, A., … Braithwaite, A. W. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25, 1509-1520.

Conference Contribution - Published proceedings: Abstract

Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Fetal oncoproteins, PAX2 and PAX8, activate telomerase in glioma. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf

Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Upregulation of PAX2, 5, and 8 in glioma and their novel function in telomerase activation. Proceedings of the Centro Nacional de Investigaciones Oncológicas Cancer Conference. (pp. 52). Madrid, Spain: CNIO. [Abstract]

Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006). Silencing of PAX8 transcription factor reduced the viability of glioma cells. European Journal of Cancer Supplements, 4(12), (pp. 104-105). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Yang, C.-Y. O., Sheffield, .., Braithwaite, A. W., & Royds, J. A. (2006, August - September). Molecular features of ALT glioblastoma associated with lower invasiveness and favourable prognosis. Poster session presented at the Queenstown Molecular Biology Conference, Queenstown, New Zealand.

Huschtscha, L. I., Moore, J., Noble, J., Royds, J., Campbell, H., Braithwaite, A., & Reddel, R. (2006, February). Paradoxical interaction of tumour supressor genes p53 and p16 in human mammary epithelial cells. Poster session presented at the 18th Lorne Cancer Conference, Lorne, Australia.

Huschtscha, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., & Reddel, R. (2006, May). Paradoxical interaction of tumor supressor genes p53 and p16 in human mammary epithelial cells. Poster session presented at the 13th International p53 Workshop, New York.

Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006, May). p53 modulates the survival factor pax in gliomas. Poster session presented at the 13th International p53 Workshop, New York.

2005

Journal - Research Article

Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html

He, S.-J., Stevens, G., Braithwaite, A. W., & Eccles, M. R. (2005). Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity. Molecular Cancer Therapeutics, 4(6), 996-1003.

Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., … Braithwaite, A., Poulton, R., & Craig, I. W. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57(10), 1117-1127.

Journal - Research Other

Braithwaite, A. W., Royds, J. A., & Jackson, P. (2005). The p53 story: Layers of complexity. Carcinogenesis, 26(7), 1161-1169.

2004

Chapter in Book - Research

Russell, A., Royds, J. A., & Braithwaite, A. W. (2004). Exploitation of cell cycle and cell death controls by Adenoviruses: The road to a productive infection. In C. Alonso (Ed.), Progress in molecular and subcellular biology: Viruses and apoptosis. (pp. 207-243). Berlin: Springer.

Conference Contribution - Poster Presentation (not in published proceedings)

Tong, S., Inglis, E., Nooijen, A., Wynford-Thomas, D., Braithwaite, A., & Hibma, M. (2004, February). Evasion of host immunity by human papillomavirus mediated Fas (CD95) down-regulation. Poster session presented at the 21st International Papillomavirus Conference and Clinical Workshop, Mexico City.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., He, S. J., Braithwaite, A., Royds, J., & Baguley, B. (2004, June). A 'from the ground up' approach to the development of novel strategic genetic targets and methodologies for cancer gene therapy. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

2003

Chapter in Book - Research

Braithwaite, A. W., & Edwards, S. J. (2003). The p53 pathway, cancer and aging. In S. C. Kaul & R. Wadhwa (Eds.), Aging of cells in and outside the body. (pp. 121-149). UK: Kluwer Academic.

Journal - Research Article

Lasham, A., Moloney, S., Hale, T., Homer, C., Zhang, Y. F., Murison, J. G., Braithwaite, A. W., & Watson, J. (2003). The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor. Journal of Biological Chemistry, 278(37), 35516-35523.

Edwards, S. J., Hananeia, L., Eccles, M. R., Zhang, Y.-F., & Braithwaite, A. (2003). The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions. Oncogene, 22(29), 4517-4523.

Hall, R. J., Merriman, M. E., Green, R. A., Markham, V. H., Smyth, D. J., Heward, J. M., … Braithwaite, A., … Darlow, B. A., … Harrison, A. A., Highton, J., Hunt, P. J., Manning, P. J., … Scott, R. S., Taylor, B. J., Willis, J., … Merriman, T. R. (2003). The Deleted in Colorectal Carcinoma (DCC) gene 201 R → G polymorphism: No evidence for genetic association with autoimmune disease. European Journal of Human Genetics, 11, 840-844.

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. doi: 10.1126/science.1083968

Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357

Conference Contribution - Poster Presentation (not in published proceedings)

Tyers, N., Royds, J. A., & Braithwaite, A. (2003, February). Effect of thrombospondin on angiogenesis (relationship between P53 and TSP-1). Poster session presented at the 15th Lorne Cancer Conference, Lorne, Australia.

2002

Journal - Research Article

Mill, J. S., Caspi, A., McClay, J., Sugden, K., Purcell, S., Asherson, P., … Braithwaite, A., Poulton, R., & Moffitt, T. E. (2002). The dopamine D4 receptor and the hyperactivity phenotype: A developmental-epidemiological study. Molecular Psychiatry, 7(4), 383-391. doi: 10.1038/sj.mp.4000984

Edwards, S. J., Dix, B. R., Myers, C. J., Dobson-Le, D., Huschtscha, L., Hibma, M., Royds, J., & Braithwaite, A. W. (2002). Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14^ARF tumor suppressor genes. Journal of Virology, 76(24), 12483-12490. doi: 10.1128/JVI.76.24.12483-12490.2002

2001

Journal - Research Article

Dix, B. R., Edwards, S. J., & Braithwaite, A. W. (2001). Does the anti-tumour adenovirus, ONYX-015/dl1520 selectively target cells defective in the p53 pathway? Journal of Virology, 75(12), 5443-5447. doi: 10.1128/JVI.75.12.5443-5447.2001

Thomson, W. M., Edwards, S. J., Dobson-Le, D. P., Tompkins, G. R., Poulton, R., Knight, D. A., … Braithwaite, A. W. (2001). IL-1 genotype and adult periodontitis among young New Zealanders. Journal of Dental Research, 80, 1700-1703.

Braithwaite, A. W., & Russell, I. A. (2001). Induction of cell death by adenoviruses. Apoptosis, 6, 359-370.

Hibma, M., & Braithwaite, A. (2001). Viruses to the rescue: p53-based therapies in the fight against cancer. New Zealand Medical Journal, 114(1133), 266-269.

Conference Contribution - Published proceedings: Abstract

Wiles, A., Hibma, M. H., Wynford-Thomas, D., Royds, J. A., & Braithwaite, A. (2001). p53 co-operates with adenovirus early protein E1b 55k to induce cell death. Lorne Conference. [Abstract]

Dobson-Le, D. P., Edwards, S. J., Royds, J. A., & Braithwaite, A. (2001). SV40 Small T antigen and cell death. Lorne Conference. [Abstract]

Russell, A., Royds, J. A., & Braithwaite, A. (2001). Rad51 may be required for adenoviral infection. Lorne Conference. [Abstract]

Royds, J. A., Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). Adenovirus early proten -E1b 55k, p53 and cell death. Lorne Conference. [Abstract]

Tyers, N., & Braithwaite, A. (2001). The effects of thrombospondin on angiogeneses (relationship between p53 and TSP-1). Abstracts of the Australasian Society of Clinical and Experimental Pharmacology and Toxicology. 9, (pp. 27). Dunedin. [Abstract]

Mill, J., Caspi, A., McClay, J., Poulton, R., Braithwaite, A., Asherson, P., & Moffitt, T. E. (2001). The dopamine D4 receptor (DRD4) gene, behaviour, and psychopathology: A developmental-epidemiological study. In R. Todd, C. Paparozzi & L. E. DeLisi (Eds.), American Journal of Medical Genetics: Abstracts for the IXth World Congress of Psychiatric Genetics. 105(7), (pp. O47). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). The influence of p53 and E1b55k on cell cycle following adenovirus type 5 infection. Verbal presentation at the DNA Tumour Virus Meeting, UK.

2000

Journal - Research Article

Hale, T. K., Myers, C., Maitra, R., Kolzau, T., Nishizawa, M., & Braithwaite, A. W. (2000). Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death. Journal of Biological Chemistry, 275(24), 17991-17999.

O'Carroll, S. J., Hall, A. R., Myers, C. J., Braithwaite, A. W., & Dix, B. R. (2000). Quantifying adenoviral titers by spectrophotometry. Biotechniques, 28, 408-410.

Dix, B. R., O'Carroll, S. J., Myers, C. J., Edwards, S. J., & Braithwaite, A. W. (2000). Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53. Cancer Research, 60, 2666-2672.

1999

Journal - Research Article

Kolzau, T., Hansen, R. S., Zahra, D., Reddel, R. R., & Braithwaite, A. W. (1999). Inhibition of SV40 large T antigen induced apoptosis by small T antigen. Oncogene, 18(40), 5598-5603.

Hale, T. K., & Braithwaite, A. W. (1999). The adenovirus oncoprotein E1a stimulates binding of the transcription factor ETF to transcriptionally activate the p53 gene. Journal of Biological Chemistry, 274, 23777-23786. doi: 10.1074/jbc.274.34.23777

1998

Journal - Research Article

Hall, A. R., O'Carroll, S. J., Dix, B. R., & Braithwaite, A. W. (1998). p53 dependent cell death/apoptosis is required for a productive adenovirus infection. Nature Medicine, 4, 1068-1072.

1997

Journal - Research Article

Ridgway, P. J., Hall, A. R., Myers, C. J., & Braithwaite, A. W. (1997). p53/E1b58kDa complex regulates adenovirus replication. Virology, 237, 404-413.

Braithwaite, A., & Poulton, R. (1997). Relevance in health research funding: reality or myth? New Zealand Medical Journal, 110, 361-362.

Hall, A. R., & Braithwaite, A. W. (1997). From clinical significance to significance in the clinic? New Zealand Medical Journal, 110, 347-348.

1996

Journal - Research Article

Hansen, R. S., & Braithwaite, A. (1996). The growth inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and ras. Oncogene, 13(5), 995-1007.

Sedger, L., Ramshaw, I., Condie, A., Medvecsky, J., Braithwaite, A., & Ruby, J. (1996). Vaccinia virus replication is independent of cellular HSP72 expression which is induced during virus infection. Virology, 225(2), 423-427.

Hall, A. R., & Braithwaite, A. W. (1996). Culling cancer cells and completing the cell cycle with the tumour suppressor p53. New Zealand BioScience, 4(3), 41-48.