Jackie Ludgate

Contact Details
- Phone
- +64 3 470 3455
- jackie.ludgate@otago.ac.nz
University Links
- Position
- Research Fellow
- Department
- Department of Pathology (Dunedin)
- Qualifications
- BSc(Hons)
- Research summary
- Genetic/Epigenetic origins of childhood leukaemia
Research
Providing laboratory support to a wide range of research projects undertaken in the Epigenetics Group.
- Investigating candidate genes for involvement in childhood acute lymphoblastic leukaemia
- Using a range of methods including: transgenic mice, yeast two-hybrid, methylation (epigenetic) analysis
Publications
Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1
Ludgate, J. L., Weeks, R. J., & Morison, I. M. (2021). Aberrant immunoglobulin kappa locus rearrangement in a patient with CARD11-related B cell lymphocytosis. Journal of Clinical Immunology, 41, 1943-1945. doi: 10.1007/s10875-021-01114-3
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics, 13(12), 1154-1173. doi: 10.1080/15592294.2018.1549462
Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open, 7, bio034884. doi: 10.1242/bio.034884
Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1
Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Journal - Research Article
Gamage, T. K. J. B., Schierding, W., Hurley, D., Tsai, P., Ludgate, J. L., Bhoothpur, C., … Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). The role of DNA methylation in human trophoblast differentiation. Epigenetics, 13(12), 1154-1173. doi: 10.1080/15592294.2018.1549462
Journal - Research Article
Gamage, T. K. J. B., Schierding, W., Tsai, P., Ludgate, J. L., Chamley, L. W., Weeks, R. J., Macaulay, E. C., & James, J. L. (2018). Human trophoblasts are primarily distinguished from somatic cells by differences in the pattern rather than the degree of global CpG methylation. Biology Open, 7, bio034884. doi: 10.1242/bio.034884
Journal - Research Article
Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399
Journal - Research Article
Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176
Journal - Research Article
Ludgate, J. L., Wright, J., Stockwell, P. A., Morison, I. M., Eccles, M. R., & Chatterjee, A. (2017). A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 10, 54. doi: 10.1186/s12920-017-0290-1
Journal - Research Article
Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341
Journal - Research Article
Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017
Journal - Research Article
Miller, J. C., Thomson, C. D., Williams, S. M., van Havre, N., Wilkins, G. T., Morison, I. M., Ludgate, J. L., & Skeaff, C. M. (2012). Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: A randomized controlled trial. American Journal of Clinical Nutrition, 96, 923-931. doi: 10.3945/ajcn.112.043125
Journal - Research Article
Oliver, V. F., Miles, H. L., Cutfield, W. S., Hofman, P. L., Ludgate, J. L., & Morison, I. M. (2012). Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population. Fertility & Sterility, 97(1), 147-153.e7. doi: 10.1016/j.fertnstert.2011.10.027
Journal - Research Article
Hare, J. R., Holmes, K. M., Wilson, J. L., & Cree, A. (2009). Modelling exposure to selected temperature during pregnancy: The limitations of squamate viviparity in a cool-climate environment. Biological Journal of the Linnean Society, 96(3), 541-552. doi: 10.1111/j.1095-8312.2008.01151.x
Journal - Research Article
Wilson, J., & Cree, A. (2003). Extended gestation with late-autumn births in a cool-climate viviparous gecko from southern New Zealand (Reptilia: Naultinus gemmeus). Austral Ecology, 28, 339-348.
Journal - Research Article
Ludgate, J. L., Weeks, R. J., & Morison, I. M. (2021). Aberrant immunoglobulin kappa locus rearrangement in a patient with CARD11-related B cell lymphocytosis. Journal of Clinical Immunology, 41, 1943-1945. doi: 10.1007/s10875-021-01114-3
Journal - Research Other
Wilson, J. L., & Morison, I. M. (2005). No evidence for preferential maternal origin of duplicated chromosome 14 in hyperdiploid ALL. Blood, 105(4), 1837-1838. doi: 10.1182/blood-2004-09-3804
Journal - Research Other