Professor Chris Pemberton

Research Professor

Christchurch Heart Institute
Department of Medicine
University of Otago, Christchurch
PO Box 4345
Christchurch 8140
New Zealand

Current roles

Director, Translational Biodiscovery Laboratory, Christchurch Heart Institute
Named Investigator on the current Christchurch Heart Institute HRC Programme grant.
Principal Investigator on HRC, MBIE and WADA funded signal peptide projects
Research Professor, Department of Medicine, Christchurch

Research interests

Novel protein/peptide biomarker identification and measurement
Cardioendocrine signalling in the circulation and heart tissue
Ex vivo study of novel cardiovascular diagnostic and therapeutic agents
Commercialisation of biomedical technologies

Awards and professional memberships

2012- Research Commercialisation – Strategic and Implementation Committee, Division of Health Sciences.
2012- Corresponding Member, Canterbury, NZ Society of Endocrinology
2011 Health Research Council of New Zealand Liley Medal
2011- European Society for Cardiology, Working Group on Cellular Biology of the Heart
2010- American Association of Clinical Chemistry
2007-11 Health Research Council of New Zealand Sir Charles Hercus Fellowship
2006-2009 Treasurer, Executive Committee Member, NZ Society of Endocrinology

Publications

Lim, E. T. A., Jardine, D., Pemberton, C. J., Frampton, C., Troughton, R., & Khanafer, A. (2026). Rapid responses of catecholamines, natriuretic peptides and inflammatory markers to acute type B Aortic Dissection (NOMAD Study). JVS Vascular Science. Advance online publication. doi: 10.1016/j.jvssci.2026.100422 Journal - Research Article

Kavsak, P. A., Pickering, J. W., Strauß, B., Greenslade, J. H., Thießen, N., Haller, P. M., … Pemberton, C., Troughton, R., Richards, A. M., … Than, M. (2026). External validation of a universal laboratory pathway for early risk-stratification of myocardial infarction in the emergency setting. Canadian Journal of Cardiology. Advance online publication. doi: 10.1016/j.cjca.2026.04.023 Journal - Research Article

Vicencio, D. P., Doudesis, D., Thurston, A. J. F., Chenevier-Gobeaux, C., Claessens, Y.-E., Lopez-Ayala, P., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2026). Machine learning to optimize the diagnostic performance of natriuretic peptides for acute heart failure across age groups. ESC Heart Failure, 13(1), xvzf006. doi: 10.1093/eschf/xvaf006 Journal - Research Article

Keys, T., Greer, C., Adamson, P. D., Pickering, J. W., Pilbrow, A. P., Frampton, C., … Troughton, R. W., … Richards, A. M., Pemberton, C. J., & Chew-Harris, J. (2025). Soluble urokinase plasminogen activator receptor for risk stratification from undifferentiated acute chest pain through to convalescence after acute coronary syndromes. European Heart Journal Open, 5(5), oeaf097. doi: 10.1093/ehjopen/oeaf097 Journal - Research Article

Montecillo, J., Troughton, R. W., Richards, A. M., Pemberton, C. J., & Chew-Harris, J. (2025). Influence of protein glycosylation on the measurement of soluble urokinase plasminogen activator receptor. Journal of Applied Laboratory Medicine, 10(6), 1564-1579. doi: 10.1093/jalm/jfaf147 Journal - Research Article

2026

Journal - Research Article

2025

Journal - Research Article

Pickering, J. W., Joyce, L., Devlin, G., Pemberton, C., Troughton, R., Richards, A. M., & Than, M. P. (2025). Improving Care with the First measurement of high-sensitivity troponin T (ICare-FirsT) to enable early rule out and reduce length of stay: A diagnostic and observational study. Emergency Medicine Journal, 42(9), 579-584. doi: 10.1136/emermed-2024-214754

Pearson, A. G., Pearson, J. F., Lewis, L. K., Fa'atoese, A., Poppe, K. K., Pemberton, C., … Richards, A. M., Troughton, R., & Doughty, R. N. (2025). Lower NT-proBNP plasma concentrations in Pacific peoples with heart failure. ESC Heart Failure, 12(4), 2976-2984. doi: 10.1002/ehf2.15314

Lee, J. A., Wise, J., Raudsepp, S. D., Paton, L. N., Powell, J., Jina, K., Aldous, S., Troughton, R. W., Adamson, P. D., Richards, A. M., … Than, M. P., Pickering, J. W., & Pemberton, C. J. (2025). Insulin-like growth factor binding protein-3 (IGFBP-3): A biomarker of coronary artery disease induced myocardial ischaemia. European Heart Journal Open, 5, oeaf028. doi: 10.1093/ehjopen/oeaf028

Thießen, N., Pickering, J. W., Kellner, C., Haller, P. M., Lehmacher, J., Toprak, B., … Pemberton, C., Troughton, R., Richards, A. M., … Than, M., … Neumann, J. T. (2025). A common algorithm for cardiac troponin to rule out and rule in acute myocardial infarction. Canadian Journal of Cardiology, 41(7), 1351-1360. doi: 10.1016/j.cjca.2025.02.029

Lim, E. T. A., Jardine, D., Frampton, C., Pemberton, C. J., Troughton, R., Roake, J., & Khanafer, A. (2025). Sympathetic nerve activity following acute type B aortic dissection: A pilot study. Journal of Vascular Research, 62(2), 88-95. doi: 10.1159/000543340

Journal - Research Other

Ocariza, M. G. C., Paton, L. N., Templeton, E. M., Pemberton, C. J., Pilbrow, A. P., & Appleby, S. (2025). CNDP2: An enzyme linking metabolism and cardiovascular diseases? Journal of Cardiovascular Translational Research, 18, 48-57. doi: 10.1007/s12265-024-10560-4

2024

Chapter in Book - Research

Montecillo, J., Pirker, T., Pemberton, C., & Chew-Harris, J. (2024). suPAR in cardiovascular disease. In G. S. Makowski (Ed.), Advances in clinical chemistry (Vol. 121). (pp. 89-131). London, UK: Elsevier. doi: 10.1016/bs.acc.2024.04.005

Journal - Research Article

Paterson, M. A., Pilbrow, A. P., Frampton, C. M. A., Cameron, V. A., Troughton, R. W., Pemberton, C. J., … Richards, A. M., … Palmer, B. R. (2024). Plasma soluble fms-like tyrosine kinase-1, placental growth factor, and vascular endothelial growth factor system gene variants as predictors of survival in heart failure. European Journal of Heart Failure, 26, 1804-1813. doi: 10.1002/ejhf.3368

Pickering, J. W., Kavsak, P., Christenson, R. H., Troughton, R. W., Pemberton, C. J., Richards, A. M., Joyce, L., & Than, M. P. (2024). Determination of clinically acceptable analytical variation of cardiac troponin at decision thresholds. Clinical Chemistry, 70(7), 967-977. doi: 10.1093/clinchem/hvae059

Greer, C. E., Chew-Harris, J., Adamson, P. D., Pemberton, C. J., Pickering, J. W., Pilbrow, A. P., Frampton, C. M., Troughton, R. W., Doughty, R. N., & Richards, A. M. (2024). Convalescent growth differentiation factor-15 and long-term outcomes after an acute coronary syndrome. Journal of Applied Laboratory Medicine, 09(04), 672-683. doi: 10.1093/jalm/jfae032

Chew-Harris, J., Frampton, C., Greer, C., Appleby, S., Pickering, J. W., Kuan, W. S., … Adamson, P. D., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2024). Prognostic performance of soluble urokinase plasminogen activator receptor for heart failure or mortality in Western and Asian patients with acute breathlessness. International Journal of Cardiology, 406, 132071. doi: 10.1016/j.ijcard.2024.132071

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Verryt, T., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2024). Derivation and validation of thresholds using synthetic data methods for single-test screening of emergency department patients with possible acute myocardial infarction using a point-of-care troponin assay. Journal of Applied Laboratory Medicine, 9(3), 526-539. doi: 10.1093/jalm/jfae001

Appleby, S., Aitken-Buck, H. M., Holdaway, M. S., Byers, M. S., Frampton, C. M., Paton, L. N., Richards, A. M., Lamberts, R. R., & Pemberton, C. J. (2024). Cardiac effects of myoregulin in ischemia-reperfusion. Peptides, 174, 171156. doi: 10.1016/j.peptides.2024.171156

Conference Contribution - Published proceedings: Abstract

Ocariza, M. G. C., Paton, L. N., Tang, W. H. W., Templeton, E. M., Pilbrow, A. P., Pemberton, C. J., & Appleby, S. (2024). CNDP2 is a potential modulator of heart failure outcomes. Proceedings of the 17th GeneMappers Conference. Retrieved from https://www.genemappersconference.org

Pirker, T., Keys, T., Pham, T., Montecillo, J., Byers, M., Adamson, P., Richards, A. M., & Pemberton, C. (2024). The cardioprotective potential of soluble urokinase Plasminogen Activator Receptor (suPAR) in myocardial ischemia. European Heart Journal, 45(Suppl. 1), ehae666.3657. doi: 10.1093/eurheartj/ehae666.3657

Pemberton, C. J., Lee, J. A., Wise, J., Raudsepp, S. D., Paton, L., Powell, J., … Troughton, R. W., Adamson, P. D., Richards, A. M., … Than, M., & Pickering, J. W. (2024). Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) measurement in the detection of significant CAD in acute chest pain patients triaged using the No Objective Testing (NOT) rule. European Heart Journal, 45(Suppl. 1), ehae666.1572. doi: 10.1093/eurheartj/ehae666.1572

Pirker, T., Adamson, P., Pemberton, C., Pham, T., & Chew-Harris, J. (2024). Novel preservation of cardiac mitochondrial integrity by suPAR following anoxia-reoxygenation injury. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S69-S70). doi: 10.1016/j.hlc.2024.04.244

Montecillo, J., Troughton, R., Pemberton, C., & Chew-Harris, J. (2024). Removal of glycosylation improves performance of soluble urokinase plasminogen activator receptor (suPAR) levels for acute decompensated heart failure diagnosis. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S58). doi: 10.1016/j.hlc.2024.04.218

Pickering, J., Kavsak, P., Christenson, R., Troughton, R., Pemberton, C., Richards, M., Joyce, L., & Than, M. (2024). High-sensitivity troponin assays are safe to rule-out myocardial infarction even if they have high imprecision. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2024.04.259

Greer, G., Chew-Harris, J., Adamson, P., Pemberton, C., Pickering, J., Pilbrow, A., Troughton, R., Doughty, R., Richards, M., & Frampton, C. (2024). Convalescent GDF-15 and long-term outcomes after acute coronary syndrome. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S74-S75). doi: 10.1016/j.hlc.2024.04.256

Pearson, A., Lewis, L., Pemberton, C., Troughton, R., Richards, M., Devlin, G., … Fa'atoese, A. (2024). Lower levels of NT-proBNP in Pacific peoples with heart failure. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S80). doi: 10.1016/j.hlc.2024.04.269

Ocariza, M., Paton, L., Tang, W., Templeton, E., Pilbrow, A., Pemberton, C., & Appleby, S. (2024). Investigating the role of carnosine dipeptidase II (CNDP2) in heart disease. Heart, Lung & Circulation, 33(Suppl. 2), (pp. S62). doi: 10.1016/j.hlc.2024.04.228

2023

Journal - Research Article

Appleby, S., Frampton, C., Holdaway, M., Chew-Harris, J., Liew, O. W., Chong, J. P. C., Lewis, L., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2023). Circulating erythroferrone has diagnostic utility for acute decompensated heart failure in patients presenting with acute or worsening dyspnea. Frontiers in Cardiovascular Medicine, 10, 1195082. doi: 10.3389/fcvm.2023.1195082

Doudesis, D., Lee, K. K., Boeddinghaus, J., Bularga, A., Ferry, A. V., Tuck, C., … Pickering, J. W., Than, M. P., … CoDE-ACS Investigators, including Richards, A. M., Pemberton, C., Troughton, R. W., & Aldous, S. J. (2023). Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations. Nature Medicine, 29, 1201-1210. doi: 10.1038/s41591-023-02325-4

Neumann, J. T., Twerenbold, R., Ojeda, F., Aldous, S. J., Allen, B. R., Apple, F. S., … Pickering, J. W., Pemberton, C. J., … Richards, A. M., … Than, M. P., … Troughton, R. W., … the ARTEMIS study group. (2023). Personalized diagnosis in suspected myocardial infarction. Clinical Research in Cardiology, 112, 1288-1301. doi: 10.1007/s00392-023-02206-3

Koh, H. W. L., Pilbrow, A. P., Tan, S. H., Zhao, Q., Benke, P. I., Burla, B., … Pickering, J. W., Troughton, R., Pemberton, C., … Richards, A. M., & Chan, M. Y. (2023). An integrated signature of extracellular matrix proteins and a diastolic function imaging parameter predicts post-MI long-term outcomes. Frontiers in Cardiovascular Medicine, 10, 1123682. doi: 10.3389/fcvm.2023.1123682

Tan, E. S. J., Chan, S.-P., Choi, Y. C., Pemberton, C. J., Troughton, R., Poppe, K., … Richards, A. M. (2023). Regional handling and prognostic performance of circulating insulin-like growth factor binding protein-7 in heart failure. JACC: Heart Failure, 11(6), 662-674. doi: 10.1016/j.jchf.2023.01.016

Conference Contribution - Published proceedings: Abstract

Montecillo, J., Pirker, T., Richards, M., Pemberton, C., & Chew-Harris, J. (2023). Protein glycosylation influences soluble urokinase Plasminogen Activator Receptor (suPAR) measurements. Heart, Lung & Circulation, 32(Suppl. 2), P16. doi: 10.1016/j.hlc.2023.04.237

Pirker, T., Keys, T., Pham, T., Montecillo, J., Byers, M., Pemberton, C., Richards, M., & Chew-Harris, J. (2023). Soluble urokinase Plasminogen Activator Receptor (suPAR) promotes cardioprotective intracellular signalling in myocardial ischaemia. Heart, Lung & Circulation, 32(Suppl. 2), O02. doi: 10.1016/j.hlc.2023.04.208

Conference Contribution - Verbal presentation and other Conference outputs

Appleby, S., Sulit, A. K., Pemberton, C. J., Pearson, J. F., & Purcell, R. V. (2023, August). Circulating bacterial DNA as a prognostic marker for myocardial infarction. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.

2022

Journal - Research Article

Eggers, K. M., Hammarsten, O., Aldous, S. J., Cullen, L., Greenslade, J., Lindahl, B., … Pemberton, C. J., Pickering, J. W., Richards, A. M., Troughton, R. W., & Than, M. P. (2022). Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain. PLoS ONE, 17(11), e0276645. doi: 10.1371/journal.pone.0276645

Lewis, L. K., Raudsepp, S. D., Whitlow, J. C., Appleby, S., Pemberton, C. J., Yandle, T. G., & Richards, A. M. (2022). Assays specific for BNP1-32 and NT-proBNP exhibit a similar performance to two widely used assays in the diagnosis of heart failure. Clinical Chemistry, 68(10), 1292-1301. doi: 10.1093/clinchem/hvac126

Lee, K. K., Doudesis, D., Anwar, M., Astengo, A., Chenevier-Gobeaux, C., Claessens, Y.-E., … Pemberton, C., … Richards, A. M., … on behalf of the CoDE-HF investigators. (2022). Development and validation of a decision support tool for the diagnosis of acute heart failure: Systematic review, meta-analysis, and modelling study. BMJ, 377, e068424. doi: 10.1136/bmj-2021-068424

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Appleby, S., Frampton, C., Troughton, R., … Richards, A. M., & Pemberton, C. J. (2022). Comparative performances of soluble urokinase plasminogen activator receptor and Mid-regional proADM to predict composite death and new heart failure rehospitalisation in acutely breathless patients. European Heart Journal, 43(Suppl. 2), (pp. 1087). doi: 10.1093/eurheartj/ehac544.1087

Keys, T., Chew-Harris, J., Pemberton, C., Adamson, P., Troughton, R., Doughty, R., & Richards, A. M. (2022). Soluble urokinase plasminogen activator receptor predicts mortality and adverse cardiovascular outcomes following acute coronary syndrome. Heart, Lung & Circulation, 31(Suppl. 2), (pp. S28-S29). doi: 10.1016/j.hlc.2022.05.020

Lewis, L., Raudsepp, S., Whitlow, J., Appleby, S., Pemberton, C., & Richards, A. M. (2022). Do more specific assays for B-type natriuretic peptides better predict heart failure in breathless patients than the currently used assays? European Heart Journal, 43(Suppl. 1), (pp. i76). doi: 10.1093/eurheartj/ehab849.060

Other Research Output

Pemberton, C. (2022, September). Caterpillars, coronaries and COVID: A career spent testing boundaries. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture].

2021

Journal - Research Article

Palmer, B. R., Paterson, M. A., Frampton, C. M., Pilbrow, A. P., Skelton, L., Pemberton, C. J., … Troughton, R. W., Richards, A. M., & Cameron, V. A. (2021). Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes. PLoS ONE, 16(7), e0254206. doi: 10.1371/journal.pone.0254206

Lassé, M., Pilbrow, A. P., Kleffmann, T., Andersson Överström, E., von Zychlinski, A., Frampton, C. M. A., … Troughton, R. W., Lewis, L. K., Prickett, T. C. R., Pemberton, C. J., Richards, A. M., & Cameron, V. A. (2021). Fibrinogen and hemoglobin predict near future cardiovascular events in asymptomatic individuals. Scientific Reports, 11(1), 4605. doi: 10.1038/s41598-021-84046-7

Poh, K. K., Shabbir, A., Ngiam, J. N., Lee, P. S. S., So, J., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2021). Plasma clearance of B-type natriuretic peptide (BNP) before and after bariatric durgery for morbid obesity. Clinical Chemistry, 67(4), 662-671. doi: 10.1093/clinchem/hvaa308

Journal - Research Other

Richards, A. M., & Pemberton, C. J. (2021). Progress in proteomic probing for pathogenic pathways in heart failure with preserved ejection fraction. European Journal of Heart Failure, 23, 1645-1647. doi: 10.1002/ejhf.2332

Richards, A. M., & Pemberton, C. J. (2021). Urinary peptides in heart failure: The need for care with pees and cues. European Journal of Heart Failure, 23, 1888-1890. doi: 10.1002/ejhf.2269

Conference Contribution - Published proceedings: Abstract

Holdaway, M., Lewis, L., Chew-Harris, J., Richards, M., Pemberton, C., & Appleby, S. (2021). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S76). doi: 10.1016/j.hlc.2021.05.044

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S85-S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Prognostic performance of soluble urokinase plasminogen activator receptor (suPAR) in predicting mortality in Asian and Western patients with acute breathlessness. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.070

Chew-Harris, J., Appleby, S., Adamson, P., Troughton, R., Richards, A. M., & Pemberton, C. (2021). Soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in patients with acute chest pain. Heart, Lung & Circulation, 30(Suppl. 2), (pp. S86). doi: 10.1016/j.hlc.2021.05.069

2020

Journal - Research Article

Chan, M. Y., Efthymios, M., Tan, S. H., Pickering, J. W., Troughton, R., Pemberton, C., … Pilbrow, A., & Richards, A. M. (2020). Prioritizing candidates of post-myocardial infarction heart failure using plasma proteomics and single-cell transcriptomics. Circulation, 142, 1408-1421. doi: 10.1161/circulationaha.119.045158

Harris, S. L., Troughton, R., Lewis, L., Austin, N., & Pemberton, C. (2020). Circulating forms of B-type natriuretic peptide in very preterm infants. Journal of Applied Laboratory Medicine, 5(3), 506-515. doi: 10.1093/jalm/jfaa003

Pickering, J. W., Young, J. M., George, P. M., Pemberton, C. J., Watson, A., Aldous, S. J., … Troughton, R. W., Richards, A. M., … Than, M. P. (2020). Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. Clinica Chimica Acta, 505, 15-25. doi: 10.1016/j.cca.2020.02.009

Appleby, S., Chew-Harris, J., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Analytical and biological assessment of circulating human erythroferrone. Clinical Biochemistry, 79, 41-47. doi: 10.1016/j.clinbiochem.2020.02.001

Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., Liew, O. W., Frampton, C., Troughton, R., Pemberton, C. J., … Richards, A. M. (2020). Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure in the presence of atrial fibrillation. European Journal of Heart Failure, 22, 692-700. doi: 10.1002/ejhf.1660

Mbikou, P., Rademaker, M. T., Charles, C. J., Richards, M. A., & Pemberton, C. J. (2020). Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts. Peptides, 124, 170192. doi: 10.1016/j.peptides.2019.170192

Journal - Research Other

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Pemberton, C. J., & Richards, A. M. (2020). ProBNP processing is decreased by obesity in patients with heart failure. Annals of Translational Medicine, 8(4), 135. doi: 10.21037/atm.2019.12.81

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) can predict long-term mortality in patients with acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1695). doi: 10.1093/ehjci/ehaa946.1695

Chew-Harris, J., Appleby, S., Kuan, W. S., Ibrahim, I., Chan, S. P., Li, Z., … Frampton, C., Troughton, R. W., … Richards, A. M., & Pemberton, C. J. (2020). Prognostic performance of soluble urokinase plasminogen activator receptor for 1-year mortality in Asian and Western patients with acute breathlessness. European Heart Journal, 41(Suppl. 2), (pp. 1202). doi: 10.1093/ehjci/ehaa946.1202

Chew-Harris, J., Appleby, S., Troughton, R. W., Richards, A. M., & Pemberton, C. J. (2020). Soluble urokinase plasminogen activator receptor (suPAR) predicts 2-year cardiovascular events in patients after acute chest pain. European Heart Journal, 41(Suppl. 2), (pp. 1696). doi: 10.1093/ehjci/ehaa946.1696

Lewis, L., Raudsepp, S. D., Yandle, T. G., Frampton, C. M., Richards, A. M., Prickett, T. C. R., … Pemberton, C. J. (2020). ProBNP glycosylation of threonine 71 is increased with obesity in patients with heart failure. European Heart Journal, 41(Suppl. 1), ehz872.007. doi: 10.1093/ehjci/ehz872.007

2019

Journal - Research Article

Adamson, P. D., McAllister, D., Pilbrow, A., Pickering, J. W., Poppe, K., Shah, A., Whalley, G., … Pemberton, C., Troughton, R. W., … Richards, A. M. (2019). Convalescent troponin and cardiovascular death following acute coronary syndrome. Heart, 105, 1717-1724. doi: 10.1136/heartjnl-2019-315084

Chew-Harris, J., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Analytical, biochemical and clearance considerations of soluble urokinase plasminogen activator receptor (suPAR) in healthy individuals. Clinical Biochemistry, 69, 36-44. doi: 10.1016/j.clinbiochem.2019.05.010

Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., & Richards, A. M. (2019). ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure. Clinical Chemistry, 65(9), 1115-1124. doi: 10.1373/clinchem.2019.302547

Journal - Research Other

Richards, A. M., Pemberton, C., & Yandle, T. (2019). How does neprilysin inhibition in heart failure work? European Journal of Heart Failure, 21(5), 606-608. doi: 10.1002/ejhf.1454

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Lee, J. A., Aldous, S., Appleby, S., Chew-Harris, J., Than, M., Troughton, R. W., & Richards, A. M. (2019). The signal peptide of CNP is a novel predictor of MI, MACE and bleeding risk in chest pain patients. European Heart Journal, 40(Suppl. 1), (pp. 2029). doi: 10.1093/eurheartj/ehz745.0283

Chew-Harris, J. S., Appleby, S., Richards, A. M., Troughton, R. W., & Pemberton, C. J. (2019). Soluble urokinase plasminogen activator receptor (suPAR) predicts 1 year mortality in patients with acute breathlessness. European Heart Journal, 40(Suppl. 1), (pp. 1573). doi: 10.1093/eurheartj/ehz748.0939

Pemberton, C. J., Lee, J. A., Aldous, S., Skelton, L., Frampton, C. M., Than, M., Troughton, R. W., Adamson, P., & Richards, A. M. (2019). The protein APRIL predicts adverse outcomes in DAPT patients better than NT-proBNP and troponin. European Heart Journal, 40(Suppl. 1), (pp. 1052). doi: 10.1093/eurheartj/ehz748.0509

Aldous, S., Pickering, J., Young, J., George, P., Watson, A., Troughton, R., Pemberton, C., Richards, M., … Than, M. (2019). Rapid rule-out of myocardial infarction with a novel high precision point-of-care troponin assay appears safe and effective. European Heart Journal, 40(Suppl. 1), (pp. 1626). doi: 10.1093/eurheartj/ehz748.0992

2018

Journal - Research Article

Pickering, J. W., Young, J. M., George, P. M., Watson, A. S., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., … Than, M. P. (2018). Validity of a novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiology, 3(11), 1108-1112. doi: 10.1001/jamacardio.2018.3368

Marks, E. C. A., Wilkinson, T. M., Frampton, C. M., Skelton, L., Pilbrow, A. P., Yandle, T. G., Pemberton, C. J., … Whalley, G. A., … Troughton, R. W., … Cameron, V. A., Richards, A. M., Gieseg, S. P., & Palmer, B. R. (2018). Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes. BMC Cardiovascular Disorders, 18, 169. doi: 10.1186/s12872-018-0894-1

Than, M. P., Aldous, S. J., Troughton, R. W., Pemberton, C. J., Richards, A. M., Frampton, C. M. A., Florkowski, C. M., George, P. M., … Young, J. M., … Pickering, J. W. (2018). Detectable high-sensitivity cardiac troponin within the population reference interval conveys high 5-year cardiovascular risk: An observational study. Clinical Chemistry, 64(7), 1044-1053. doi: 10.1373/clinchem.2017.285700

van der Linden, N., Wildi, K., Twerenbold, R., Pickering, J. W., Than, M., Cullen, L., … Richards, A. M., Troughton, R., Pemberton, C., … Mueller, C. (2018). Combining high sensitivity cardiac troponin I and cardiac troponin T in the early diagnosis of acute myocardial infarction. Circulation, 138(10), 989-999. doi: 10.1161/circulationaha.117.032003

Harris, S. L., More, K., Dixon, B., Troughton, R., Pemberton, C., Horwood, J., Ellis, N., & Austin, N. (2018). Factors affecting N-terminal pro-B-type natriuretic peptide levels in preterm infants and use in determination of haemodynamic significance of patent ductus arteriosus. European Journal of Pediatrics, 177(4), 521-532. doi: 10.1007/s00431-018-3089-y

Arrigo, M., Vodovar, N., Nougué, H., Sadoune, M., Pemberton, C. J., Ballan, P., … Mebazaa, A. (2018). The heart regulates the endocrine response to heart failure: Cardiac contribution to circulating neprilysin. European Heart Journal, 39(20), 1794-1798. doi: 10.1093/eurheartj/ehx679

Pickering, J. W., Flaws, D., Smith, S. W., Greenslade, J., Cullen, L., Parsonage, W., … Richards, A. M., Troughton, R., Pemberton, C., George, P. M., & Than, M. P. (2018). A risk assessment score and initial high-sensitivity troponin combine to identify low risk of acute myocardial infarction in the emergency department. Academic Emergency Medicine, 25(4), 434-443. doi: 10.1111/acem.13343

Conference Contribution - Published proceedings: Abstract

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Circulation, 138(Suppl. 1), A11125. [Abstract]

Appleby, S., Chew-Harris, J., Troughton, R., Richards, M., & Pemberton, C. (2018). Erythroferrone can diagnose acute decompensated heart failure in patients presenting with breathlessness. Circulation, 138(Suppl. 1), A11094. [Abstract]

Pemberton, C. J., Lee, J. A., Jardine, R., Skelton, L., Frampton, C. M., Troughton, R. W., Richards, A. M., on behalf of Christchurch Heart Institute. (2018). The TNF receptor TACI is a novel inflammatory predictor of heart failure. European Heart Journal, 39(Suppl. 1), (pp. 576-577). doi: 10.1093/eurheartj/ehy565.P2791

Nanayakkara, S., Pemberton, C., Patel, H., Vizi, D., Mak, V., Richards, A. M., … Kaye, D. M. (2018). Mid regional atrial natriuretic peptide is an independent predictor of peak pulmonary capillary wedge pressure in patients with heart failure with preserved ejection fraction. European Heart Journal, 39(Suppl. 1), (pp. 222). doi: 10.1093/eurheartj/ehy565.1096

Conference Contribution - Poster Presentation (not in published proceedings)

Mbikou, P. P., Pemberton, C. J., Charles, C. J., & Rademaker, M. T. (2018, August). Characterising the role and the therapeutic potential of novel peptide DWORF in heart disease. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Chew-Harris, J., Appleby, S., Troughton, R., Richards, M., & Pemberton, C. (2018, August). Soluble urokinase plasminogen activator receptor is a strong prognostic indicator of mortality in acutely breathless patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Chapter in Book - Research

Pemberton, C. J., Charles, C. J., & Richards, A. M. (2017). Cardiac natriuretic peptides. In J. C. Schisler, C. H. Lang & M. S. Willis (Eds.), Endocrinology of the heart in health and disease. (pp. 3-39). Elsevier. doi: 10.1016/B978-0-12-803111-7.00001-4

Journal - Research Article

Pickering, J. W., Than, M. P., Cullen, L., Aldous, S., ter Avest, E., Body, R., … Florkowski, C. M., … George, P., … Pemberton, C., Richards, A. M., … Troughton, R., … Young, J. (2017). Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: A collaborative meta-analysis. Annals of Internal Medicine, 166(10), 715-724. doi: 10.7326/m16-2562

Liebetrau, C., Gaede, L., Wolter, J. S., Homann, J., Meyer, A., Dörr, O., … Richards, A. M., & Pemberton, C. J. (2017). Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction. Biomarkers, 22(3-4), 304-310. doi: 10.1080/1354750X.2016.1252965

Ibrihim, I., Kuan, W. S., Frampton, C., Troughton, R., Liew, O. W., Chong, J. P. C., … Pemberton, C. J., … Richards, A. M. (2017). Superior performance of N-terminal pro brain natriuretic peptide for diagnosis of acute decompensated heart failure in an Asian compared with a Western setting. European Journal of Heart Failure, 19(2), 209-217. doi: 10.1002/ejhf.612

Journal - Research Other

Laribi, S., Pemberton, C. J., Kirwan, L., Nouira, S., Turkdogan, K., Yilmaz, M. B., Troughton, R. W., … Richards, M., … on behalf of the GREAT (Global Research on Acute Conditions Team) Network. (2017). Mortality and acute exacerbation of COPD: A pilot study on the influence of myocardial injury. European Respiratory Journal, 49(6), 1700096. doi: 10.1183/13993003.00096-2017

Pemberton, C. (2017). Prognostic outcomes in patients with heart failure: A new SuPAR biomarker for risk prediction? JACC: Heart Failure, 5(4), 278-279. doi: 10.1016/j.jchf.2017.02.009

Conference Contribution - Poster Presentation (not in published proceedings)

Aitken-Buck, H. M., Appleby, S., Pemberton, C. J., & Lamberts, R. R. (2017, September). Myoregulin has no effect on contraction or relaxation of isolated rat hearts. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pilbrow, A. P., Runesson, A. S. D., Sommer, M. A. W., Jones, G. T., Frampton, C. M., Pemberton, C. J., Troughton, R. W., Richards, A. M., & Cameron, V. A. (2017, September). Using microRNAs to predict heart disease events in the general population. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2017). Biomarkers. [Marker reference: INSDx] (9,630,985). United States.

2016

Journal - Research Article

Pemberton, C. J., Frampton, C. M., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2016). B-type natriuretic peptide signal peptide (BNPsp) in patients presenting with chest pain. Clinical Biochemistry, 49, 645-650. doi: 10.1016/j.clinbiochem.2016.02.015

Cullen, L., Greenslade, J. H., Menzies, L., Leong, A., Than, M., Pemberton, C., Aldous, S., Pickering, J., … Parsonage, W. A. (2016). Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome. Emergency Medicine Journal, 33, 390-395. doi: 10.1136/emermed-2015-204978

Conference Contribution - Poster Presentation (not in published proceedings)

Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August-September). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Mbikou, P., Byers, M., Charles, C. J., Rademaker, M. T., & Pemberton, C. J. (2016, August). Role of B-type natriuretic signal peptide on AKT and ERK1/2 activity in myocardial rat ischemia. Poster session presented at the Medical Sciences Congress (MedSci), Nelson, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Charles, C. J., & Siriwardena, M. (2016). Cardiovascular therapeutics. [Marker reference: BNPTx] (2012 8 0050843.1). China.

2015

Journal - Research Article

Lee, J., Than, M., Aldous, S., Troughton, R., Richards, M., & Pemberton, C. J. (2015). CNP signal peptide in patients with cardiovascular disease. Frontiers in Cardiovascular Medicine, 2, 28. doi: 10.3389/fcvm.2015.00028

Liebetrau, C., Gaede, L., Dörr, O., Blumenstein, J., Rosenburg, S., Hoffmann, J., … Richards, A. M., & Pemberton, C. J. (2015). Reference values and release kinetics of B-type natriuretic peptide signal peptide in patients with acute myocardial infarction. Clinical Chemistry, 61(12), 1532-1539. doi: 10.1373/clinchem.2015.244327

Lee, J., Young, J., Frampton, C. M., Aldous, S., Troughton, R. W., Than, M., Richards, A. M., & Pemberton, C. J. (2015). A novel troponin T peptide in humans: Assay, biochemistry and preliminary findings in acute coronary syndromes. International Journal of Cardiology, 190, 68-74. doi: 10.1016/j.ijcard.2015.04.145

Meller, B., Cullen, L., Parsonage, W. A., Greenslade, J. H., Aldous, S., Reichlin, T., … Troughton, R., Pemberton, C. J., Richards, A. M., … Than, M., & Mueller, C. (2015). Accelerated diagnostic protocol using high-sensitivity cardiac troponin T in acute chest pain patients. International Journal of Cardiology, 184C, 208-215. doi: 10.1016/j.ijcard.2015.02.006

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Lee, J., Than, M., Pickering, J. W., Troughton, R. W., & Richards, M. (2015). Can copeptin assist the diagnosis of acute kidney injury in breathless patients? European Heart Journal, 36(Suppl. 1), (pp. 800). doi: 10.1093/eurheartj/ehv400

Liebetrau, C., Doerr, O. D., Gaede, L. G., Berkowitsch, A. B., Troidl, C. T., Hamm, C. H., … Richards, A. M., & Pemberton, C. J. (2015). Release kinetics of B-type natriuretic peptide signal peptide (BNPsp) in patients with acute myocardial infarction. European Heart Journal, 36(Suppl. 1), (pp. 71). doi: 10.1093/eurheartj/ehv398

Menzies, L., Cullen, L., Greenslade, J., Leong, A., Than, M., Pemberton, C., Aldous, S., Pickering, J., … Parsonage, W. (2015). The association of delay in presentation and 12-month health outcomes in emergency patients with symptoms of possible acute coronary syndromes. Heart, Lung & Circulation, 24(Suppl. 3), (pp. S167-S168). doi: 10.1016/j.hlc.2015.06.134

Fitzsimons, S., Troughton, R., Gamble, G., Pemberton, C., Devlin, G., Lund, M., Richards, M., & Doughty, R. (2015). High prevalence of iron deficiency in heart failure with preserved ejection fraction. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S78). doi: 10.1016/j.hlc.2015.04.070

Arshad, M., Richards, M., Pemberton, C., & Troughton, R. (2015). Routine measurement of NT-proBNP and post-discharge clinical outcomes: Initial findings from a randomised controlled trial. Heart, Lung & Circulation, 24(Suppl. 2), (pp. S94). doi: 10.1016/j.hlc.2015.04.109

2014

Journal - Research Article

Pemberton, C. J. (2014). Signal peptides: New markers in cardiovascular disease? Biomarkers in Medicine, 8(8), 1013-1019. doi: 10.2217/bmm.14.64

Pemberton, C. J., Siriwardena, M., Kleffmann, T., & Richards, A. M. (2014). C-type natriuretic peptide (CNP) signal peptide fragments are present in the human circulation. Biochemical & Biophysical Research Communications, 449, 301-306. doi: 10.1016/j.bbrc.2014.05.020

Mahagamasekera, P. G., Ruygrok, P. N., Palmer, S. C., Richards, A. M., Ansell, G. S., Nicholls, M. G., Pemberton, C. J., Lewis, L. K., & Yandle, T. G. (2014). B-type natriuretic peptide forms within the heart, coronary sinus, and peripheral circulation in humans: Evidence for degradation before secretion. Clinical Chemistry, 60(3), 549-558. doi: 10.1373/clinchem.2013.210435

Cullen, L., Aldous, S., Than, M., Greenslade, J. H., Tate, J. R., George, P. M., … Richards, A. M., Ungerer, J. P. J., Troughton, R. W., … Pemberton, C. J., Florkowski, C., … Parsonage, W. A. (2014). Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain. Clinical Biochemistry, 47(6), 321-326. doi: 10.1016/j.clinbiochem.2013.11.019

Conference Contribution - Verbal presentation and other Conference outputs

Pemberton, C. (2014, November). Hunting the Snark: New peptides to measure in the circulation. Verbal presentation at the HeartOtago First Australasian Symposium: Bench to Bedside and Back: New Advances in Cardiovascular Research, Dunedin, New Zealand.

2013

Chapter in Book - Other

Richards, M., Troughton, R., Espiner, E., Cameron, V., Ellmers, L., Pilbrow, A., Charles, C., Rademaker, M., Pemberton, C., & Yandle, T. (2013). Christchurch Heart Institute. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 68-74). Christchurch, New Zealand: University of Otago.

Journal - Research Article

Pemberton, C. J., & Kleffmann, T. (2013). Circulating signal peptides: More than just a bus ticket? Cardiovascular Endocrinology, 2(3), 41-45. doi: 10.1097/XCE.0b013e328362e44e

Greenslade, J. H., Cullen, L., Than, M., Aldous, S., Chu, K., Brown, A. F. T., Richards, A. M., Pemberton, C. J., George, P., & Parsonage, W. A. (2013). Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: A prospective cohort study. American Journal of Emergency Medicine, 31(7), 1103-1107. doi: 10.1016/j.ajem.2013.04.016

Cullen, L., Mueller, C., Parsonage, W. A., Wildi, K., Greenslade, J. H., Twerenbold, R., Aldous, S., … Troughton, R., … George, P., … Pemberton, C. J., Richards, A. M., … Florkowski, C., Deely, J. M., & Than, M. (2013). Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. JACC, 62(14), 1242-1249. doi: 10.1016/j.jacc.2013.02.078

Greenslade, J. H., Cullen, L., Kalinowski, L., Parsonage, W., Palmer, S., Aldous, S., Richards, M., … Troughton, R., Pemberton, C., & Than, M. (2013). Examining renal impairment as a risk factor for acute coronary syndrome: A prospective observational study. Annals of Emergency Medicine, 62(1), 38-46. doi: 10.1016/j.annemergmed.2013.01.011

Conference Contribution - Published proceedings: Abstract

Cullen, L., Parsonage, W., Greenslade, J., Aldous, S., George, P., Lamanna, A., … Richards, M., Pemberton, C. J., Than, M., on behalf of the Emergency Cardiology Group. (2013). Diagnostic accuracy of highly sensitive troponin I versus highly sensitive troponin T assays for acute myocardial infarction within two hours of emergency department presentation. European Heart Journal, 34(Suppl. 1), (pp. 86). doi: 10.1093/eurheartj/eht307.P484

Siriwardena, M., Charles, C. J., Byers, M., Richards, A. M., & Pemberton, C. J. (2013). BNP signal peptide is protective in ischaemia reperfusion injury. Heart, Lung & Circulation, 22(7), (pp. 578-579). doi: 10.1016/j.hlc.2013.04.074

Conference Contribution - Poster Presentation (not in published proceedings)

Byers, M. S., Bailey, M., Siriwardena, M., Lewis, L. K., Oliver, J., Troughton, R., Richards, A. M., & Pemberton, C. J. (2013, August). Plasma ghrelin signal peptide can exclude co-existent pneumonia in acute decompensated heart failure. Poster session presented at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Pemberton, C., Chase, G., & Willmott, G. (2013, June). Collaborating for Success: Point of care diagnostics. Verbal presentation at the Healthcare Congress: Future of Healthcare in New Zealand, Auckland, New Zealand.

Pemberton, C. J., Aldous, S., Bailey, M., Young, J., Troughton, R., Than, M., & Richards, M. (2013, August). BNP signal peptide in the diagnosis of acute coronary syndromes. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2013). Biomarkers. [Marker reference: GHRDx] (8,507,209). United States.

2012

Journal - Research Article

Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). High-sensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emergency Medicine Journal, 29(10), 805-810. doi: 10.1136/emermed-2011-200222

Pemberton, C. J., Siriwardena, M., Kleffmann, T., Ruygrok, P., Palmer, S. C., Yandle, T. G., & Richards, A. M. (2012). First identification of circulating Prepro-A-Type natriuretic peptide (PreproANP) signal peptide fragments in humans: Initial assessment as cardiovascular biomarkers. Clinical Chemistry, 58(4), 757-767. doi: 10.1373/clinchem.2011.176990

Journal - Research Other

Siriwardena, M., Campbell, V., Richards, A. M., & Pemberton, C. J. (2012). Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease. Clinical Chemistry, 58(10), 1492-1494. doi: 10.1373/clinchem.2012.187682

Aldous, S., Pemberton, C., Troughton, R., Than, M., & Richards, A. M. (2012). Heart fatty acid binding protein and myoglobin do not improve early rule out of acute myocardial infarction when highly sensitive troponin assays are used. Resuscitation, 83(2), e27-e28. doi: 10.1016/j.resuscitation.2011.09.031

Journal - Professional & Other Non-Research Articles

Aldous, S., Pemberton, C., Richards, A. M., Troughton, R., & Than, M. (2012). Authors' response. Emergency Medicine Journal, 29(7), 601-602. doi: 10.1136/emermed-2012-201216

Conference Contribution - Published proceedings: Abstract

Pemberton, C. (2012). Existing and new BNP peptides. New Zealand Journal of Medical Laboratory Science, 66(3), (pp. 93). [Abstract]

Pemberton, C. (2012). Endogenous peptides as therapeutic agents: Some new candidates. Proceedings of the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives. Retrieved from http://bioactives.otago.ac.nz/

Pemberton, C. J. (2012). Signal peptides: Time to leave the ER behind? Proceedings of the Medical Sciences Congress (MedSci). (pp. 38). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Byers, M. S., Siriwardena, M., Ruygrok, P., Yandle, T., Kleffmann, T., Richards, A. M., & Pemberton, C. J. (2012). Ghrelin signal peptide (GHRSP): Identification, immunoassay and circulating profile. Proceedings of the Medical Sciences Congress (MedSci). (pp. 18). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Pemberton, C. (2012, February). Endogenous peptides as therapeutic agents: Some new candidates. Invited presentation at the New Zealand Chapter of the Controlled Release Society 14th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

Pemberton, C. J. (2012, August). Signal peptides: Time to leave the ER behind? Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Intellectual Property

Pemberton, C. J., Richards, A. M., Nicholls, M. G., & Yandle, T. G. (2012). Methods of diagnosing acute cardiac disorders using BNP-SP. [Marker reference: BNPDx] (8,289,772). United States.

2011

Journal - Research Article

Troughton, R. W., Lewis, L. K., Yandle, T. G., Pemberton, C. J., & Nicholls, M. G. (2011). B-type natriuretic peptides: Looking to the future. Annals of Medicine, 43(3), 188-197. doi: 10.3109/07853890.2010.526630

Journal - Research Other

Pemberton, C. J., Richards, A. M., Siriwardena, M., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Kleffmann, T., & Ruygrok, P. (2011). [Response to letter regarding article, B-Type natriuretic peptide signal peptide circulates in human blood: Evaluation as a potential biomarker of cardiac ischemia]. Circulation, 123(6), e234. doi: 10.1161/CIRCULATIONAHA.110.003574

Conference Contribution - Verbal presentation and other Conference outputs

Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Troughton, R. W., Yandle, T. G., & Richards, A. M. (2011, September). Cardiac biomarkers: Clinical utility for diagnosis, prognosis and guiding treatment of cardiovascular disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pemberton, C. (2011, March). Biomarkers: Searching for a new signal. Verbal presentation at the NZBIO Conference: Enabling Successful Bio Enterprise, Auckland, New Zealand.

2010

Journal - Research Article

Siriwardena, M., Kleffmann, T., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). B-type natriuretic peptide signal peptide circulates in human blood. Evaluation as a potential biomarker of cardiac ischemia. Circulation, 122, 255-264. doi: 10.1161/CIRCULATIONAHA.109.909937

Prosser, H. C., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2010). Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system. Peptides, 31, 1540-1545. doi: 10.1016/j.peptides.2010.05.009

Conference Contribution - Published proceedings: Abstract

Kleffmann, T., Siriwardena, M., Ruygrok, P., Cameron, V. A., Yandle, T. G., Nicholls, M. G., Richards, A. M., & Pemberton, C. J. (2010). Characterisation of unusual modifications of the circulating signal peptide of B-type naturetic peptide: A potential biomarker of cardiac ischemia. Proceedings of the 9th Human Proteome World Congress (HUPO): Launch of the Human Proteome Project. (pp. 106). Retrieved from http://www.hupo.org/congress/congress_2010/downloads/HUPO2010%20World%20Congress%20Abstract%20Book.pdf

Yandle, T. G., Mahagamasekera, P. M. G., Ruygrok, P., Palmer, S. C., Ansell, G., Nicholls, G., Pemberton, C. J., & Richards, M. (2010). Cardiac tissue, coronary sinus and circulating forms of B-type natriuretic peptide in in patients with and without heart failure. Endocrine Journal. 57(Suppl. 2), (pp. S325). [Abstract]

2009

Journal - Research Article

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Pemberton, C. J., & Zhang, M. (2009). Metformin increases plasma ghrelin in Type 2 diabetes. British Journal of Clinical Pharmacology, 68(6), 875-882. doi: 10.1111/j.1365-2125.2009.03372.x

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2009). Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Cardiovascular Research, 82(1), 40-50. doi: 10.1093/cvr/cvp003

2008

Journal - Research Article

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008). Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Peptides, 29(5), 770-777. doi: 10.1016/j.peptides.2007.08.013

Pemberton, C. J., & Richards, A. M. (2008). Biochemistry of ghrelin precursor peptides. Vitamins & Hormones, 77, 13-30. doi: 10.1016/S0083-6729(06)77002-9

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. J. (2008). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clinical Science, 114(4), 293-304. doi: 10.1042/CS20070229

Journal - Research Other

Pemberton, C. J. (2008). Leptin-induced cardiac hypertrophy: RhoAing a lipid raft down a protective p38 MAPK signalling stream? [Editorial]. Cardiovascular Research, 77(1), 4-5. doi: 10.1093/cvr/cvm053

Conference Contribution - Published proceedings: Abstract

Siriwardena, M., Nicholls, M. G., Yandle, T. G., Frampton, C. M., Richards, A. M., & Pemberton, C. J. (2008). Immunoreactive BNP-signal peptide: A potential early biomarker of AMI. Heart, Lung & Circulation, 17(Suppl. 3), (pp. S104). doi: 10.1016/j.hlc.2008.05.250

Pemberton, C. J., Rothwell, S. E., & Richards, A. M. (2008). The novel adipocytokine resistin worsens cardiac ischaemia-reperfusion injury. European Heart Journal. 29(Suppl. 1), (pp. 629). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2008, November). Cardiac chymase activity converts proangiotensin-12 (PA12) to angiotensin II: Effects of PA12 upon cardiac haemodynamics. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Piuhola, J., Kerkelä, R., Keenan, J. I., Hampton, M. B., Richards, A. M., & Pemberton, C. (2008, November). Direct cardiac actions of erythropoietin (EPO): Effects on cardiac contractility, BNP secretion and ischemia-reperfusion injury. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

Pemberton, C. (2008, October). Biomarkers: Searching for a signal. Verbal presentation at the New Zealand-Singapore Heart Failure Research Symposium, Christchurch, New Zealand.

Mahagamasekera, M. G. P., Ruygrok, P. N., Palmer, S., Ansell, G., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (2008, November). B-type natriuretic peptide and its degradation products in the heart and circulation in end-stage heart failure. Verbal presentation at the Medical Sciences Congress, Queenstown, New Zealand.

2007

Journal - Research Article

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. JACC, 49(4), 461-471.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597.

Bang, A. S., Soule, S. G., Yandle, T. G., Richards, A. M., & Pemberton, C. J. (2007). Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology, 192, 313-323.

Journal - Research Other

Pemberton, C. J. (2007). Hypertension, cardiotrophin-1 and gp130: Three points to heart failure? [Editorial comment]. Journal of Hypertension, 25(10), 2008-2010. doi: 10.1097/HJH.0b013e3282ef5632

Conference Contribution - Published proceedings: Abstract

Prosser, H. C. G., Forster, M. E., Richards, A. M., & Pemberton, C. J. (2007). Direct effects of proangiotensin-12 on the isolated rat heart. European Heart Journal. 28(Abstract Suppl.), (pp. 365). [Abstract]

2006

Journal - Research Article

Prosser, H. C. G., Leprince, J., Vaudry, H., Richards, A. M., Forster, M. E., & Pemberton, C. J. (2006). Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts. Peptides, 27, 3261-3268.

Rothwell, S. E., Richards, A. M., & Pemberton, C. J. (2006). Resistin worsens cardiac ischaemia-reperfusion injury. Biochemical & Biophysical Research Communications, 349, 400-407.

Conference Contribution - Published proceedings: Abstract

Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., Richards, A. M., on behalf of Christchurch Cardioendocrine Research Group. (2006). Urocortin 2 infusion in humans with mild heart failure: Haemodynamics, neurohormonal and renal responses. European Heart Journal, 27(Suppl. 1), (pp. 488). [Abstract]

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, M. (2006). Urocortin 2 infusion in healthy humans induces marked hemodynamic, neurohormonal, and renal responses. Journal of the American College of Cardiology. 47(4, Suppl. A), (pp. 310A). [Abstract]

2005

Journal - Research Article

Pemberton, C. J., Raudsepp, S. D., Yandle, T. G., Cameron, V. A., & Richards, A. M. (2005). Plasma cardiotrophin-1 is elevated in human hypertension and stimulated by ventricular stretch. Cardiovascular Research, 68(1), 109-117.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2005). Effect of urocortin I infusion in humans with stable congestive cardiac failure. Clinical Science, 109(4), 381-388. doi: 10.1042/CS20050079

Soule, S., Pemberton, C., Hunt, P., Cole, D., Raudsepp, S., & Inder, W. (2005). Prandial regulation of ghrelin secretion in humans: Does glucagon contribute to the preprandial increase in circulating ghrelin? Clinical Endocrinology, 63(4), 412-417. doi: 10.1111/j.1365-2265.2005.02357.x

Conference Contribution - Published proceedings: Abstract

Doogue, M. P., Begg, E. J., Moore, M. P., Lunt, H., Zhang, M., & Pemberton, C. (2005). Metformin pharmacokinetics and the effect on hormones involved in appetite regulation. Proceedings of the Joint Meeting of ASCEPT and APSA. ASCEPT: Melbourne, Australia. [Abstract]

Pemberton, C., Raudsepp, S. D., Cameron, V. A., Yandle, T. G., & Richards, A. M. (2005). Cardiotrophin-1: A complex cytokine stimulated by ventricular stretch. European Heart Journal, 26(Suppl. 1), (pp. 66). doi: 10.1093/eurheartj/26.suppl_1.1

Davis, M. E., Skinner, M. H., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Frampton, C. M., & Richards, A. M. (2005). First report of urocortin 2 infusion in normal humans. Heart, Lung & Circulation, 14(1, Suppl.), (pp. S111-S112). doi: 10.1016/j.hlc.2005.04.007

2004

Journal - Research Article

Pemberton, C. J., Tokola, H., Bagi, Z., Koller, A., Pöntinen, J., Ola, A., … Ruskoaho, H. (2004). Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion. American Journal of Physiology: Heart & Circulatory Physiology, 287, H1522-H1529.

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin-1 infusion in normal humans. Journal of Clinical Endocrinology & Metabolism, 89(3), 1402-1409.

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Rothwell, S. E., Yandle, T. G., & Richards, A. M. (2004). Ghrelin and resistin: Metabolic hormones influencing cardiac function. First Annual Canterbury Health Research Scientific Conference. (pp. 31). [Abstract]

Pemberton, C. J., Raudsepp, S., Yandle, T. G., & Richards, A. M. (2004). Cardiotrophin-1: Circulating levels, cardiac secretion and molecular forms in cardiovascular disease. New Zealand Medical Sciences Congress AGM. [Abstract]

Davis, M. E., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2004). Urocortin infusion in humans with stable congestive cardiac failure. Heart, Lung & Circulation, 13(Suppl. 2), (pp. S117-S118). doi: 10.1016/j.hlc.2004.05.001

Conference Contribution - Poster Presentation (not in published proceedings)

Piuhola, J., Pemberton, C., Hampton, M., & Richards, M. (2004, June). Multiple cardiac effects of erythropoietin. Poster session presented at the 14th European Meeting on Hypertension, Paris.

Conference Contribution - Verbal presentation and other Conference outputs

Rothwell, S. E., Pemberton, C. J., & Richards, A. M. (2004, November). Resistin: A link between metabolic syndrome and cardiovascular disease. Verbal presentation at the Medical Sciences Congress: Physiological Society of New Zealand, Queenstown, New Zealand.

2003

Journal - Research Article

Pemberton, C. J., Wimalasena, P., Yandle, T. G., Soule, S. G., & Richards, A. M. (2003). C-terminal pro-ghrelin peptides are present in the human circulation. Biochemical & Biophysical Research Communications, 310(2), 567-573.

Conference Contribution - Published proceedings: Abstract

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003). First report of urocortin infusion and actions in normal humans. Circulation, 108(17 Suppl. IV), (pp. 242). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, November). First report of urocortin infusion and actions in normal humans. Verbal presentation at the American Heart Association Conference 2003, Orlando, USA.

Davis, M., Pemberton, C. J., Yandle, T. G., Lainchbury, J. G., Rademaker, M. T., Nicholls, M. G., Frampton, C. M., & Richards, A. M. (2003, July). First report of urocortin infusion and actions in normal humans. Verbal presentation at the Christchurch Medical Research Conference 2003, Christchurch, NZ.

2002

Journal - Research Article

Pemberton, C. J., Yandle, T. G., & Espiner, E. A. (2002). Immunoreactive forms of natriuretic peptides in ovine brain: Response to heart failure. Peptides, 23(12), 2235-2244.

Conference Contribution - Published proceedings: Full paper

Pemberton, C. J., Tokola, H., Pontinen, J., Ola, A., Vuolteenaho, O., & Ruskoaho, H. (2002). Ghrelin has a coronary vasoconstrictor action: role of L-Type Ca²⁺ channels and PK-C. The Endocrine Society of Australia, Proceedings 2002. 45, (pp. 165). Adelaide, Australia: Endocrine Society of Australia. [Full Paper]

2000

Journal - Research Article

Rademaker, M. T., Cameron, V. A., Charles, C. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000). Neurohormones in an ovine model of compensated post-infarction left ventricular dysfunction. American Journal of Physiology: Heart & Circulatory Physiology, 278, H731-H740.

Pemberton, C. J., Johnson, M. L., Yandle, T. G., & Espiner, E. A. (2000). Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Hypertension, 36(3), 355-359.

Conference Contribution - Verbal presentation and other Conference outputs

Rademaker, M. T., Charles, C. J., Cooper, G. J. S., Coy, D. H., Espiner, E. A., Lewis, L. K., Nicholls, M. G., Pemberton, C. J., & Richards, A. M. (2000, October). Combined adrenomedullin administration and neutral endopeptidase inhibitor in heart failure. Verbal presentation at the 4th Annual Meeting of the Society for Cardiovascular Endocrinology and Metabolism, Australia.

1999

Journal - Research Article

Seidler, T., Pemberton, C. J., Yandle, T. G., Espiner, E. A., Nicholls, M. G., & Richards, A. M. (1999). The amino terminal regions of proBNP and proANP: Oligomerise through leucine zipper-like coiled-coil motifs. Biochemical & Biophysical Research Communications, 255, 495-501.

Conference Contribution - Published proceedings: Full paper

Pemberton, C. J., Johnson, M., Yandle, T. G., & Espiner, E. A. (1999). The in vivo Half-life of NT-ProBNP is 14-fold Longer Than Mature BNP in Ovine Plasma. In A. Zanchetti & G. Mancia (Eds.), Ninth European Meeting on Hypertension - Abstracts. 9, (pp. S55-S56). Hagerstown, United States of America: International Society of Hypertension. [Full Paper]

1998

Journal - Research Article

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1998). Amino-terminal proBNP in ovine plasma: evidence for enhanced secretion in response to cardiac overload. American Journal of Physiology: Heart & Circulatory Physiology, 275(4Pt2), H1200-H1208.

1997

Journal - Research Article

Pemberton, C. J., Yandle, T. G., Charles, C. J., Rademaker, M. T., Aitken, G. D., & Espiner, E. A. (1997). Ovine brain natriuretic peptide in cardiac tissues and plasma: effects of cardiac hypertrophy and heart failure on tissue concentration and molecular forms. Journal of Endocrinology, 155(3), 541-550.

Conference Contribution - Published proceedings: Abstract

Pemberton, C. J., Yandle, T. G., Rademaker, M. T., Charles, C. J., Aitken, G. D., & Espiner, E. A. (1997). The Amino Terminal Fragment of ProBNP Circulates In Ovine Plasma. Proceedings of the Endocrine Society of Australia. 40, (pp. 48). Melbourne, Australia: The Endocrine Society of Australia. [Abstract]

1996

Journal - Research Article

Charles, C. J., Kaaja, R. J., Espiner, E. A., Nicholls, M. G., Pemberton, C. J., Richards, A. M., & Yandle, T. G. (1996). Natriuretic peptides in sheep with pressure overload left venticular hypertrophy. Clinical & Experimental Hypertension, 18(8), 1051-1071.