Research Professor
Associate Dean of Research (University of Otago, Christchurch)
Co-Director, University of Otago Research Centre – Genetics Otago
Co-ordinator, New Zealand Familial Breast Cancer Study
Research interests
Professor Logan Walker's research is focused on understanding the impace of genetic changes on our health. Professor Walker leads the New Zealand Familial Breast Cancer Study, which has contributed to international consortia, including the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Consortium, and the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). He has led international multi-site studies to understand how DNA copy number variants contribute to cancer risk, particularly in breast, ovarian and endometrial cancer.
He is a member of multiple international groups tasked with adapting the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) framework for classifying variants in disease susceptibility genes. Professor Walker has also co-developed international guidelines to standardise RNA-based genetic testing, improving diagnostic accuracy and equity in genetic health.
Professional affiliations
- ClinGen Variant Classification Working Group
- ClinGen Sequence Splicing Working Group
- ClinGen Hereditary Breast, Ovarian and Pancreatic Cancer Variant Curation Expert Panel
- ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel
- BRCA Challenge Steering Group
- ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles) Consortium
- Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
- Endometrial Cancer Association Consortium (ECAC)
- Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)
News
Publications
Canson, D. M., Wiggins, G. A. R., Walker, L. C., & Spurdle, A. B. (2026). Correspondence on “Genome sequencing reveals the impact of pseudoexons in rare genetic disease” by Pitsava et al. Genetics in Medicine, 28(1), 101636. doi: 10.1016/j.gim.2025.101636 Journal - Research Other
Walker, L. (2025, March). Preparing for the future of genetic health. University of Otago, Christchurch, New Zealand. [Inaugural Professorial Lecture]. Other Research Output
Johnatty, S. E., Tudini, E., Parsons, M. T., Michailidou, K., Zanti, M., Canson, D. M., … Walker, L. C., … Spurdle, A. B. (2025). BRCA1-, BRCA2-, and PALB2-related Fanconi anemia: Scope to expand disease phenotypic features and predict breast cancer risk in heterozygotes. American Journal of Human Genetics. Advance online publication. doi: 10.1016/j.ajhg.2025.10.007 Journal - Research Article
Stylianou, C. E., Wiggins, G. A. R., Lau, V. L., Dennis, J., Shelling, A. N., Wilson, M., Sykes, P., … Pearson, J., & Walker, L. C. (2024). Germline copy number variants and endometrial cancer risk. Human Genetics, 143, 1481-1498. doi: 10.1007/s00439-024-02707-9 Journal - Research Article
Parsons, M. T., de la Hoya, M., Richardson, M. E., Tudini, E., Anderson, M., Berkofsky-Fessler, W., … Wiggins, G. A. R., … Walker, L. C., … Spurdle, A. B. (2024). Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel. American Journal of Human Genetics, 111(9), 2044-2058. doi: 10.1016/j.ajhg.2024.07.013 Journal - Research Article
Richardson, M. E., Holdren, M., Brannan, T., de la Hoya, M., Spurdle, A. B., Tavtigian, S. V., … Walker, L. C., … Couch, F. J. (2024). Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline ATM sequence variants. American Journal of Human Genetics, 111, 2411-2426. doi: 10.1016/j.ajhg.2024.08.022 Journal - Research Article
Davidson, A., Morley-Bunker, A., Wiggins, G., Walker, L., Harris, G., Mukundan, R., & kConFab Investigators. (2025). Deep learning segmentation of chromogenic dye RNAscope from breast cancer tissue. Journal of Imaging Informatics in Medicine, 38, 1704-1721. doi: 10.1007/s10278-024-01301-9 Journal - Research Article
Walker, L. (2025, March). Using HTTCSTB: Experiences from researchers [Panel discussion: Strengthening the bridge: Genetic discoveries and the future of cancer research through He Taonga Tapu Cancer Society Tissue Bank (HTTCSTB)]. Verbal presentation at the Cancer Society of New Zealand Inaugural In Pursuit of Cancer Research and Innovation Conference, Ōtautahi Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Davidson, A., Morley-Bunker, A., Wiggins, G., Walker, L., Harris, G., Mukundan, R., & kConFab Investigators. (2024). Grey level texture features for segmentation of chromogenic dye RNAscope from breast cancer tissue. In R. Su, Y.-D. Zhang & A. F. Frangi (Eds.), International Conference on Medical Imaging and Computer-Aided Diagnosis (MICAD 2023): Lecture notes in electrical engineering (Vol. 1166). (pp. 72-82). Singapore: Springer. doi: 10.1007/978-981-97-1335-6_7 Conference Contribution - Published proceedings: Full paper
O'Mahony, D., Zanti, M., Parsons, M. T., Dennis, J., Fortuno, C., Vreeswijk, M., … Walker, L., … Breast Cancer Association Consortium. (2024). Large scale case-control analyses of rare variant data: Application to BRCA1 and BRCA2. European Journal of Human Genetics, 32(Suppl. 1), (pp. 53). doi: 10.1038/s41431-023-01480-z Conference Contribution - Published proceedings: Abstract
Walker, L. C., de la Hoya, M., Wiggins, G. A. R., Lindy, A., Vincent, L. M., Parsons, M. T., … & ClinGen Sequence Variant Interpretation Working Group. (2023). Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup. American Journal of Human Genetics, 110(7), 1046-1067. doi: 10.1016/j.ajhg.2023.06.002 Journal - Research Article
Jasiak, A., Koczkowska, M., Stukan, M., Wydra, D., Biernat, W., Izycka-Swieszewska, E., … Eccles, M. R., Walker, L., … Ratajska, M. (2023). Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer. Experimental & Molecular Pathology, 130(104856). doi: 10.1016/j.yexmp.2023.104856 Journal - Research Article
Holdren, M., Richardson, M., Ritter, D., Young, C., Brannan, T., Pesaran, T., … Walker, L., … Couch, F. (2023). ATM and PALB2 variant curation guidelines progress update: ClinGen Hereditary Breast, Ovarian, and Pancreatic Cancer Variant Curation Expert Panel. Genetics in Medicine Open, 1(1, Suppl.), (pp. 11). doi: 10.1016/j.gimo.2023.100080 Conference Contribution - Published proceedings: Abstract
Parsons, M., Anderson, M., Berkofsky-Fessler, W., Caputo, S., Chan, R., Cline, M., … Walker, L., … Spurdle, A. (2023). The ClinGen ENIGMA BRCA1/2 expert panel: A dynamic framework for evidence-based recommendations to improve classification criteria for variants in BRCA1/2. Genetics in Medicine Open, 1(1, Suppl.), (pp. 19). doi: 10.1016/j.gimo.2023.100095 Conference Contribution - Published proceedings: Abstract
Morley-Bunker, A., Currie, M., Pearson, J., Mukundan, R., Gavruskin, A., Hemmings, C., Eglinton, T., & Walker, L. (2023, August). Utilisation of digital pathology and AI methods for the detection of MSI status in colorectal cancer. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Hakkaart, C., Pearson, J. F., Marquart, L., Dennis, J., Wiggins, G. A. R., Barnes, D. R., Robinson, B. A., Mace, P. D., … Walker, L. C. (2022). Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers. Communications Biology, 5, 1061. doi: 10.1038/s42003-022-03978-6 Journal - Research Article
Thomassen, M., Mesman, R. L. S., Hansen, T. V. O., Menendez, M., Rossing, M., Esteban-Sánchez, A., … Walker, L. C., … Spurdle, A. B. (2022). Clinical, splicing and functional analysis to classify BRCA2 exon 3 variants: Application of a points-based ACMG/AMP approach. Human Mutation, 43, 1921-1944. doi: 10.1002/humu.24449 Journal - Research Article
Dennis, J., Tyrer, J. P., Walker, L. C., Michailidou, K., Dorling, L., Bolla, M. K., … Easton, D. F. (2022). Rare germline copy number variants (CNVs) and breast cancer risk. Communications Biology, 5(1), 65. doi: 10.1038/s42003-021-02990-6 Journal - Research Article
Morley-Bunker, A. E., Wiggins, G. A. R., Currie, M. J., Morrin, H. R., Whitehead, M. R., Eglinton, T., Pearson, J., & Walker, L. C. (2021). RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue. Acta Histochemica, 123, 151765. doi: 10.1016/j.acthis.2021.151765 Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Morley-Bunker, A. E., kConFab Investigators, Pearson, J. F., & Walker, L. C. (2021). Increased gene expression variability in BRCA1-associated and basal-like breast tumours. Breast Cancer Research & Treatment, 189, 363-375. doi: 10.1007/s10549-021-06328-y Journal - Research Article
Wiggins, G. A. R., Black, M. A., Dunbier, A., Merriman, T. R., Pearson, J. F., & Walker, L. C. (2021). Variable expression quantitative trait loci analysis of breast cancer risk variants. Scientific Reports, 11(1), 7192. doi: 10.1038/s41598-021-86690-5 Journal - Research Article
McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320 Journal - Research Article
Stamp, L. K., Cameron, V. A., Woodfield, T. B. F., Walker, L., Currie, M., Templeton, E., Pilbrow, A. P., Tabakakis, K., Phillips, E., & Lim, K. S. (2021). Impact of COVID-19 on health research in New Zealand: A case study of a research-intensive campus. Journal of the Royal Society of New Zealand, 51(Suppl. 1), S75-S85. doi: 10.1080/03036758.2020.1867202 Journal - Research Article
Lattimore, V., Parsons, M. T., Spurdle, A. B., Pearson, J., Lehnert, K., Sullivan, J., … Morrin, H., Robinson, B., & Walker, L. (2021). Under-ascertainment of breast cancer susceptibility gene carriers in a cohort of New Zealand female breast cancer patients. Breast Cancer Research & Treatment, 185, 583-590. doi: 10.1007/s10549-020-05986-8 Journal - Research Article
Walker, L. C. (2021, November). Evaluation of copy number variants as modifiers of breast cancer risk for BRCA1 and BRCA2 pathogenic variant carriers. Verbal presentation at the New Zealand Breast Cancer Symposium (NZBCS), [Online]. Conference Contribution - Verbal presentation and other Conference outputs
Dennis, J., Walker, L., Tyrer, J., Michailidou, K., & Easton, D. F. (2021). Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation of z-scores improves detection and reliability. Genetic Epidemiology, 45, 237-248. doi: 10.1002/gepi.22367 Journal - Research Article
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-wide gene expression analyses of BRCA1- and BRCA2-associated breast and ovarian tumours. Cancers, 12(10), 3015. doi: 10.3390/cancers12103015 Journal - Research Other
Leman, R., Tubeuf, H., Raad, S., Tournier, I., Derambure, C., Lanos, R., … Walker, L. C., … Krieger, S. (2020). Assessment of branch point prediction tools to predict physiological branch points and their alteration by variants. BMC Genomics, 21, 86. doi: 10.1186/s12864-020-6484-5 Journal - Research Article
Wiggins, G., Pearson, J., Black, M., Dunbier, A., Merriman, T., & Walker, L. (2020). Variable expression quantitative trait loci analysis of breast cancer risk variants. New Zealand Medical Journal, 133(1524), (pp. 145). Retrieved from https://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract
Richardson, A. K., Walker, L. C., Cox, B., Rollag, H., Robinson, B. A., Morrin, H., Pearson, J. F., … Currie, M. J. (2020). Breast cancer and cytomegalovirus. Clinical & Translational Oncology, 22, 585-602. doi: 10.1007/s12094-019-02164-1 Journal - Research Article
Walker, L. C., Lattimore, V. L., Kvist, A., Kleiblova, P., Zemankova, P., de Jong, L., Wiggins, G. A. R., Hakkaart, C., Cree, S. L., … Kennedy, M. A., … de la Hoya, M. (2019). Comprehensive assessment of BARD1 messenger ribonucleic acid splicing with implications for variant classification. Frontiers in Genetics, 10, 1139. doi: 10.3389/fgene.2019.01139 Journal - Research Article
Spurdle, A. B., Greville-Heygate, S., Antoniou, A. C., Brown, M., Burke, L., de la Hoya, M., … Walker, L. C., … Eccles, D. M. (2019). Towards controlled terminology for reporting germline cancer susceptibility variants: An ENIGMA report. Journal of Medical Genetics, 56, 347-357. doi: 10.1136/jmedgenet-2018-105872 Journal - Research Other
Fischer, J., Walker, L. C., Robinson, B. A., Frizelle, F. A., Church, J. M., & Eglinton, T. W. (2019). Clinical implications of the genetics of sporadic colorectal cancer. ANZ Journal of Surgery, 89(10), 1224-1229. doi: 10.1111/ans.15074 Journal - Research Other
Lopez-Perolio, I., Leman, R., Behar, R., Lattimore, V., Pearson, J. F., Castéra, L., … Walker, L. C., … de la Hoya, M. (2019). Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: An ENIGMA report. Journal of Medical Genetics, 56, 453-460. doi: 10.1136/jmedgenet-2018-105834 Journal - Research Article
Lattimore, V. L., Pearson, J. F., Morley-Bunker, A. E., kConFab Investigators, Spurdle, A. B., Robinson, B. A., Currie, M. J., & Walker, L. C. (2019). Quantifying BRCA1 and BRCA2 mRNA isoform expression levels in single cells. International Journal of Molecular Sciences, 20(3), 693. doi: 10.3390/ijms20030693 Journal - Research Article
Morley-Bunker, A., Pearson, J., Currie, M. J., Morrin, H., Whitehead, M. R., Eglinton, T., & Walker, L. C. (2019). Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation. Oncotarget, 10(14), 1425-1439. doi: 10.18632/oncotarget.26675 Journal - Research Article
Brandão, R. D., Mensaert, K., López-Perolio, I., Tserpelis, D., Xenakis, M., Lattimore, V., Walker, L. C., … Blok, M. J. (2019). Targeted RNA-seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes. International Journal of Cancer, 145, 401-414. doi: 10.1002/ijc.32114 Journal - Research Article
Cline, M. S., Liao, R. G., Parsons, M. T., Paten, B., Alquaddoomi, F., Antoniou, A., … BRCA Challenge Authors, including Walker, L., … Spurdle, A. B. (2018). BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. PLoS Genetics, 14(12), e1007752. doi: 10.1371/journal.pgen.1007752 Journal - Research Other
Lattimore, V. L., Pearson, J. F., Currie, M. J., Spurdle, A. B., kConFab Investigators, Robinson, B. A., & Walker, L. C. (2018). Investigation of experimental factors that underlie BRCA1/2 mRNA isoform expression variation: Recommendations for utilising targeted RNA sequencing to evaluate potential spliceogenic variants. Frontiers in Oncology, 8, 140. doi: 10.3389/fonc.2018.00140 Journal - Research Article
Lattimore, V., Lehnert, K., Lintott, C., Sullivan, J., Morrin, H., Robinson, B., & Walker, L. (2018). Evaluating variants in breast cancer associated genes identified by panel sequencing of New Zealand breast cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/ Conference Contribution - Published proceedings: Abstract
de Jong, L. C., Cree, S., Lattimore, V., Wiggins, G. A. R., Spurdle, A. B., kConFab Investigators, Miller, A., Kennedy, M. A., & Walker, L. C. (2017). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-occurrence of known exon skipping events. Breast Cancer Research, 19, 127. doi: 10.1186/s13058-017-0919-1 Journal - Research Article
Walker, L. C., Marquart, L., Pearson, J. F., Wiggins, G. A. R., O'Mara, T. A., Parsons, M. T., … Spurdle, A. B. (2017). Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers. European Journal of Human Genetics, 25, 432-438. doi: 10.1038/ejhg.2016.203 Journal - Research Article
Walker, L. C., Pearson, J. F., Wiggins, G. A. R., Giles, G. G., Hopper, J. L., & Southey, M. C. (2017). Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry. Breast Cancer Research, 19, 30. doi: 10.1186/s13058-017-0825-6 Journal - Research Article
Shimelis, H., Mesman, R. L. S., Von Nicolai, C., Ehlen, A., Guidugli, L., Martin, C., … Walker, L., … Couch, F. J. (2017). BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Research, 77(11), 2789-2799. doi: 10.1158/0008-5472.can-16-2568 Journal - Research Article
de la Hoya, M., Soukarieh, O., López-Perolio, I., Vega, A., Walker, L. C., van Ierland, Y., … Lattimore, V., … Spurdle, A. B. (2016). Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms. Human Molecular Genetics, 25(11), 2256-2268. doi: 10.1093/hmg/ddw094 Journal - Research Article
Fackenthal, J. D., Yoshimatsu, T., Zhang, B., de Garibay, G. R., Colombo, M., De Vecchi, G., … Walker, L. C., … de la Hoya, M. (2016). Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. Journal of Medical Genetics, 53, 548-558. doi: 10.1136/jmedgenet-2015-103570 Journal - Research Article
Walker, L. C., Nones, K., Patch, A.-M., & Waddell, N. (2016). Studying genomic and epigenetic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417.pub2 Chapter in Book - Research
Morley-Bunker, A., Walker, L. C., Currie, M. J., Pearson, J., & Eglinton, T. (2016). Translating colorectal cancer genetics into clinically useful biomarkers. Colorectal Disease, 18(8), 749-762. doi: 10.1111/codi.13334 Journal - Research Article
Gerring, Z., Pearson, J. F., Morrin, H. R., Robinson, B. A., Harris, G. C., & Walker, L. C. (2015). Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients. Histopathology, 67(4), 538-547. doi: 10.1111/his.12678 Journal - Research Article
Walker, L. C., Wiggins, G. A. R., & Pearson, J. F. (2015). The role of constitutional copy number variants in breast cancer. Microarrays, 4(3), 407-423. doi: 10.3390/microarrays4030407 Journal - Research Article
Richardson, A. K., Currie, M. J., Robinson, B. A., Morrin, H., Phung, Y., Pearson, J. F., … Walker, L. C. (2015). Cytomegalovirus and Epstein-Barr Virus in breast cancer. PLoS ONE, 10(2), e0118989. doi: 10.1371/journal.pone.0118989 Journal - Research Article
Peterlongo, P., Chang-Claude, J., Moysich, K. B., Rudolph, A., Schmutzler, R. K., Simard, J., … Walker, L. C., … Friedman, E. (2015). Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiology, Biomarkers & Prevention, 24(1), 308-316. doi: 10.1158/1055-9965.epi-14-0532 Journal - Research Article
Lattimore, V., Currie, M., Lintott, C., Sullivan, J., Robinson, B. A., & Walker, L. C. (2015). Meeting the challenges of interpreting variants of unknown clinical significance in BRCA testing. New Zealand Medical Journal, 128(1419). Retrieved from http://www.nzma.org.nz/journal Journal - Research Other
Moir-Meyer, G. L., Pearson, J. F., Lose, F., The Australian National Endometrial Cancer Study Group, Scott, R. J., McEvoy, M., … Walker, L. C. (2015). Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition. Human Genetics, 134(3), 269-278. doi: 10.1007/s00439-014-1507-4 Journal - Research Article
Colombo, M., Blok, M. J., Whiley, P., Santamariña, M., Gutiérrez-Enríquez, S., Romero, A., … Walker, L., … de la Hoya, M. (2014). Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: A report from the ENIGMA consortium. Human Molecular Genetics, 23(14), 3666-3680. doi: 10.1093/hmg/ddu075 Journal - Research Article
Whiley, P. J., de la Hoya, M., Thomassen, M., Becker, A., Brandão, R., Sokilde Pedersen, I., … Lattimore, V., … Walker, L., … on behalf of the ENIGMA consortium. (2014). Comparison of mRNA splicing assay protocols across multiple laboratories: Recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60(2), 341-352. doi: 10.1373/clinchem.2013.210658 Journal - Research Article
Walker, L. C., Whiley, P. J., Houdayer, C., Hansen, T. V. O., Vega, A., Santamarina, M., … on behalf of the ENIGMA consortium. (2013). Evaluation of a 5-tier scheme proposed for classification of sequence variants using bioinformatic and splicing assay data: Inter-reviewer variability and promotion of minimum reporting guidelines. Human Mutation, 34(10), 1424-1431. doi: 10.1002/humu.22388 Journal - Research Article
Walker, L. C., McDonald, M., Wells, J. E., Harris, G. C., Robinson, B. A., & Morris, C. M. (2013). Dual-color fluorescence in situ hybridization reveals an association of chromosome 8q22 but not 8p21 imbalance with high grade invasive breast carcinoma. PLoS ONE, 8(7), e70790. doi: 10.1371/journal.pone.0070790 Journal - Research Article
Lattimore, V., Currie, M., Robinson, B., kConFab Investigators, Spurdle, A., & Walker, L. (2013, September). Elevating BRCA1 and BRCA2 sequence variants that modulate isoform expression. Poster session presented at the Division of Health Sciences Research Forum: Foundations for Health: Otago Health Research, Christchurch, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Walker, L. C., Krause, L., kConFab Investigators, Spurdle, A. B., & Waddell, N. (2012). Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours. Breast Cancer Research & Treatment, 134(3), 1005-1011. doi: 10.1007/s10549-012-2024-6 Journal - Research Article
Spurdle, A. B., Thompson, D. J., Ahmed, S., Ferguson, K., Healey, C. S., O'Mara, T., Walker, L. C., … The Australian National Endometrial Cancer Study Group, … National Study of Endometrial Cancer Genetics Group, … Easton, D. F. (2011). Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43(5), 451-454. doi: 10.1038/ng.812 Journal - Research Article
Whiley, P. J., Guidugli, L., Walker, L. C., Healey, S., Thompson, B. A., Lakhani, S. R., … Spurdle, A. B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32(6), 678-687. doi: 10.1002/humu.21495 Journal - Research Article
Walker, L. C., Thompson, B. A., Waddell, N., kConFab Investigators, Grimmond, S. M., & Spurdle, A. B. (2010). Use of DNA–damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. PLoS Genetics, 6(2), e1000850. doi: 10.1371/journal.pgen.1000850 Journal - Research Article
Walker, L. C., Whiley, P., Couch, F. J., Farrugia, D. J., Healey, S., Eccles, D. M., … kConFab Investigators, … Spurdle, A. B. (2010). Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: Implications for prediction of pathogenicity. Human Mutation, 31(6), E1484-E1505. doi: 10.1002/humu.21267 Journal - Research Article
Walker, L. C., Fredericksen, Z. S., Wang, X., Tarrell, R., Pankratz, V. S., Lindor, N. M., … Couch, F. J. (2010). Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research, 12(6), R102. doi: 10.1186/bcr2785 Journal - Research Article
Walker, L. C., & Spurdle, A. B. (2010). Prioritizing candidate genetic modifiers of BRCA1 and BRCA2 using a combinatorial analysis of global expression and polymorphism association studies of breast cancer. In M. Webb (Ed.), Cancer susceptibility: Methods and protocols (Methods in molecular biology, Vol. 653). (pp. 23-34). New York: Springer. doi: 10.1007/978-1-60761-759-4 Chapter in Book - Research
Walker, L. C., & Waddell, N. (2010). Studying genomic aberrations by microarray profiling. In Encyclopedia of Life Sciences. Chichester, UK: John Wiley & Sons. doi: 10.1002/9780470015902.a0022417 Chapter in Book - Research
Walker, L. C., Waddell, N., Ten Haaf, A., kConFab Investigators, Grimmond, S., & Spurdle, A. B. (2008). Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. Breast Cancer Research & Treatment, 112(2), 229-236. doi: 10.1007/s10549-007-9848-5 Journal - Research Article
Whiley, P., Pettigrew, C. A., Brewster, B. L., Walker, L. C., for kConFab Investigators, Spurdle, A. B., & Brown, M. A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11, 80. doi: 10.1186/1471-2350-11-80 Journal - Research Article
Walker, L. C. (2009). Toward understanding the molecular basis of ovarian cancer. Human Mutation, 30(12), v. doi: 10.1002/humu.21162 Journal - Research Other
Walker, L. C., Harris, G. C., Wells, J. E., Robinson, B. A., & Morris, C. M. (2008). Association of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes Chromosomes & Cancer, 47(5), 405-417. doi: 10.1002/gcc.20545 Journal - Research Article
Waddell, N., Ten Haaf, A., Marsh, A., Johnson, J., Walker, L. C., kConFab Investigators, … Spurdle, A. B. (2008). BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression. PLoS Genetics, 4(5), e1000080. doi: 10.1371/journal.pgen.1000080 Journal - Research Article
Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics & Cytogenetics, 178, 94-103. Journal - Research Article
Ganly, P. S., Walker, L. C., & Morris, C. M. (2004). Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia. Leukemia & Lymphoma, 45(1), 1-10. Journal - Research Article
Walker, L. C., Campbell, H. J., Corbett, R., Spearing, R. L., Heaton, D. C., Macdonald, D. H., Morris, C. M., & Ganly, P. S. (2002). A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia. British Journal of Haematology, 117(4), 878-881. doi: 10.1046/j.1365-2141.2002.03512.x Journal - Research Article
Walker, L. C., Morrison, M. J., Parfitt, R., & Crossen, P. E. (2001). Translocation (2;14) associated with complex rearrangements of the Ig heavy chain in non-Hodgkin lymphoma. Cancer Genetics & Cytogenetics, 128, 137-140. Journal - Research Article
Sin, F. T. Y., Mukherjee, U. K., Walker, L. C., & Sin, I. L. (1997). The application of gene transfer techniques to marine resource mangement: Recent advances, problems and future directions. Hydrobiologia, 352, 263-278. Journal - Research Article
Walker, L. (2017, October). Nanopore sequencing of full-length BRCA1 mRNA transcripts reveals co-currence of known exon skipping events. Poster session presented at the New Zealand Society for Oncology (NZSO) Conference, Auckland, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Walker, L. (2007). Genetic aberrations in breast cancer (PhD). University of Otago, Dunedin, New Zealand. 229p. Awarded Doctoral Degree