Heath, S. G., Gray, S. G., Hamzah, E. M., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Sethi, A., … Goebl, C. (2024, November). Amyloid formation and depolymerization of tumour suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Verbal presentation at the 32nd Meeting of The Society for Redox Research Australasia (SFRRA) and 11th Joint Meeting with The Society for Free Radical Research Japan (SFRRJ), Canberra, Australia.
Conference Contribution - Verbal presentation and other Conference outputs
Gray, S. G., Heath, S. G., Hamzah, E. M., Botha, A. D., O'Connor, K. M., Bozonet, S. M., … Göbl, C. (2024, September). Cancer-associated mutations of tumour suppressor p16INK4a increase the propensity for amyloid fibril formation. Verbal presentation at the Queenstown Research Week (QRW) Biomolecular Interactions Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
O'Connor, K. M., Botha, A. D., Heath, S. G., Morris, V. K., & Göbl, C. (2024, September). Functional amyloid formation of tumour suppressor p16 protein during S-phase of the cell cycle. Poster session presented at the 34th Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Schwartfeger, A. J., … Göbl, C., & Morris, V. K. (2024, September). Redox-controlled amyloid formation and disassembly of the tumour suppressor protein p16. Verbal presentation at the 34th Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Heath, S. G., Naughton, J. D., Magon, N. J., Gray, S. G., Smith, B. R., Morris, V. K., & Göbl, C. (2024). Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach. Journal of Biological Chemistry, 300(8), 107590. doi: 10.1016/j.jbc.2024.107590
Journal - Research Article
2024
Journal - Research Article
Heath, S. G., Naughton, J. D., Magon, N. J., Gray, S. G., Smith, B. R., Morris, V. K., & Göbl, C. (2024). Characterizing the amyloid core region of the tumor suppressor protein p16INK4a using a limited proteolysis and peptide-based approach. Journal of Biological Chemistry, 300(8), 107590. doi: 10.1016/j.jbc.2024.107590
Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Naughton, J. D., … Göbl, C. (2024). Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Nature Communications, 15(1), 5535. doi: 10.1038/s41467-024-49581-7
Conference Contribution - Poster Presentation (not in published proceedings)
O'Connor, K. M., Botha, A. D., Heath, S. G., Morris, V. K., & Göbl, C. (2024, September). Functional amyloid formation of tumour suppressor p16 protein during S-phase of the cell cycle. Poster session presented at the 34th Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Heath, S. G., Gray, S. G., Hamzah, E. M., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Sethi, A., … Goebl, C. (2024, November). Amyloid formation and depolymerization of tumour suppressor p16INK4a are regulated by a thiol-dependent redox mechanism. Verbal presentation at the 32nd Meeting of The Society for Redox Research Australasia (SFRRA) and 11th Joint Meeting with The Society for Free Radical Research Japan (SFRRJ), Canberra, Australia.
Gray, S. G., Heath, S. G., Hamzah, E. M., Botha, A. D., O'Connor, K. M., Bozonet, S. M., … Göbl, C. (2024, September). Cancer-associated mutations of tumour suppressor p16INK4a increase the propensity for amyloid fibril formation. Verbal presentation at the Queenstown Research Week (QRW) Biomolecular Interactions Meeting, Queenstown, New Zealand.
Heath, S. G., Gray, S. G., Hamzah, E., O'Connor, K. M., Bozonet, S. M., Botha, A. D., de Cordovez, P., Magon, N. J., Schwartfeger, A. J., … Göbl, C., & Morris, V. K. (2024, September). Redox-controlled amyloid formation and disassembly of the tumour suppressor protein p16. Verbal presentation at the 34th Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
2023
Journal - Research Article
Bozonet, S. M., Magon, N. J., Schwartfeger, A. J., Konigstorfer, A., Heath, S. G., Vissers, M. C. M., … Göbl, C., … Hampton, M. B. (2023). Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry, 299(6), 104792. doi: 10.1016/j.jbc.2023.104792
Conference Contribution - Verbal presentation and other Conference outputs
Goebl, C., Heath, S., O'Connor, K. M., Bozonet, S., Botha, A., Smith, B., Hamzah, E., … Sethi, A., & Morris, V. K. (2023, August). A novel amyloid formation mechanism: Oxidation-induced transition of the tumour suppressor protein p16 into amyloid fibrils. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
2022
Conference Contribution - Verbal presentation and other Conference outputs
Morris, V. K., Heath, S. G., O'Connor, K. M., Bozonnet, S., Gray, S. G., Naughton, J. D., Magon, N. J., Smith, B. R., Botha, A. D., … Göbl, C. (2022, August). The tumour suppressor protein p16 forms amyloid structures. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
2021
Journal - Research Article
Crowther, J. M., Gilmour, L. H., Porebski, B. T., Heath, S. G., Pattinson, N. R., Owen, M. C., … Göbl, C., & Dobson, R. C. J. (2021). Molecular basis of a redox switch: Molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen. Biochemical Journal, 478, 3319-3330. doi: 10.1042/bcj20210476
Conference Contribution - Published proceedings: Abstract
Heath, S. G., Magon, N. J., Winterbourn, C. C., Hampton, M., Morris, V. K., & Göbl, C. (2021). Oxidation induced amyloid formation of the tumour suppressor protein p16. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 33). Retrieved from https://www.faobmb2021.org
2017
Conference Contribution - Verbal presentation and other Conference outputs
O'Connor, K. M., Konigstorfer, A., Zawari, M., Betz, A., Heath, S., Hildebrand, J. M., … Hampton, M. (2017, September). MLKL-dependent disruption of mitochondrial function and redox homeostasis during the initiation of TNF-mediated necroptosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
PhD Candidate