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Free radicals and antioxidants

  • Green JN, Chapman ALP, Bishop CJ, Winterbourn CC, Kettle AJ. Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogenperoxide. Free Radic Biol Med. 2017 Oct 18;113:363-371. doi: 10.1016/j.freeradbiomed.2017.10.343. [Epub ahead of print]
  • Dickerhof N, Pearson JF, Hoskin TS, Berry LJ, Turner R, Sly PD, Kettle AJ; AREST CF. Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathionedeficiency. Free Radic Biol Med. 2017 Oct 2;113:236-243. doi: 10.1016/j.freeradbiomed.2017.09.028. [Epub ahead of print]
  • Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. J Biol Chem. 2017 Jul 6. pii: jbc.M117.793745. doi: 10.1074/jbc.M117.793745. [Epub ahead of print]
  • Pullar JM, Carr AC, Bozonet SM, Rosengrave P, Kettle, AJ and Vissers MC. Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men. Andrology [In press]
  • Peskin AV, Winterbourn C. Assay of superoxide dismutase activity in a plate assay using WST-1.  Free Radical Biology and Medicine. 103():188–191, Feb 2017

Nutrients and optimal health

  • Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton E, Carr A.Inadequate vitamin C status in prediabetes and type 2 diabetes mellitus: associations with glycaemic control, obesity and smoking. To be published in the Nutrients special edition on Vitamin C in health and disease
  • Pearson JF, Pullar JM, Wilson R, Spittlehouse JK, Vissers MCM, Skidmore PML, Willis J, Cameron VA, Carr A. Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study. Nutrients 2017, 9(8), 831; doi:10.3390/nu9080831
  • Bayer S, Gearry R, Drummond L. Putative mechanisms of kiwifruit on maintenance of normal gastrointestinal function. Critical Reviews in Food Science and Nutrition.
  • Carr A.C. and McCall C. The role of vitamin C in the treatment of pain: new insights. J Transl Med, 2017. In Press, Hot Topics series.
  • Conner TS, Brookie KL, Carr AC, Mainvil LA, Vissers MCM. Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomized controlled trial. PLOS ONE 12(2): e0171206. doi: 10.1371/journal.pone.0171206
  • Brookie KL, Mainvil LA, Carr AC, Vissers MC, Conner TS. The development and effectiveness of an ecological momentary intervention to increase daily fruit and vegetable consumption in low-consuming young adults. Appetite. 2017 Jan 1;108:32-41. doi: 10.1016/j.appet.2016.09.015.


Free radicals and antioxidants

  • Bayer SB, Low FM, Hampton MB, Winterbourn CC. Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radic Res. 2016 Dec;50(12):1329-1339. PMID:27677384
  • Winterbourn CC. Revisiting the reactions of superoxide with glutathione and other thiols. Arch Biochem Biophys. 2016 Apr 1;595:68-71. doi: 10.1016/ PMID:27095219
  • Winterbourn CC, Peskin AV. Kinetic Approaches to Measuring Peroxiredoxin Reactivity. Mol Cells. 2016 Jan;39(1):26-30. doi: 10.14348/molcells.2016.2325. Review. PMID:26813658
  • Poynton RA, Peskin AV, Haynes AC, Lowther WT, Hampton MB, Winterbourn CC. Kinetic analysis of structural influences on the susceptibility of peroxiredoxins 2 and 3 to hyperoxidation. Biochem J. 2016 Feb 15;473(4):411-21. doi: 10.1042/BJ20150572. PMID:26614766
  • Peskin AV, Pace PE, Behring JB, Paton LN, Soethoudt M, Bachschmid MM, Winterbourn CC. Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin. J Biol Chem. 2016 Feb 5;291(6):3053-62. doi: 10.1074/jbc.M115.692798. PMID:26601956
  • Bolaños JP, Cadenas E, Duchen MR, Hampton MB, Mann GE, Murphy MP. Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease. Free Radic Biol Med. 2016 Aug 5. pii: S0891-5849(16)30377-X. doi: 10.1016/j.freeradbiomed.2016.08.004. [Epub ahead of print] No abstract available. PMID:27502830
  • Yewdall NA, Venugopal H, Desfosses A, Abrishami V, Yosaatmadja Y, Hampton MB, Gerrard JA, Goldstone DC, Mitra AK, Radjainia M. Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State. Structure. 2016 Jul 6;24(7):1120-9. doi: 10.1016/j.str.2016.04.013. PMID:27238969
  • Hampton MB, O'Connor KM. Peroxiredoxins and the Regulation of Cell Death. Mol Cells. 2016 Jan;39(1):72-6. doi: 10.14348/molcells.2016.2351. Review. PMID:26810076


  • Winterbourn CC, Kettle AJ, Hampton MB. Reactive Oxygen Species and Neutrophil Function. Annu Rev Biochem. 2016 Jun 2;85:765-92. doi: 10.1146/annurev-biochem-060815-014442. PMID:27050287
  • Bekeschus S, Winterbourn CC, Kolata J, Masur K, Hasse S, Bröker BM, Parker HA. Neutrophil extracellular trap formation is elicited in response to cold physical plasma. J Leukoc Biol. 2016 Oct;100(4):791-799. PMID:26992432
  • Dickerhof N, Turner R, Khalilova I, Fantino E, Sly PD, Kettle AJ; AREST CF. Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease. J Cyst Fibros. 2016 Nov 24. pii: S1569-1993(16)30647-6. doi: 10.1016/j.jcf.2016.10.012. [Epub ahead of print] PMID:27889352
  • Kato Y, Oki K, Suga N, Ono S, Ishisaka A, Miura Y, Kanazawa S, Naito M, Kitamoto N, Kettle AJ. A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis. Free Radic Biol Med. 2016 Nov 14. pii: S0891-5849(16)31047-4. doi: 10.1016/j.freeradbiomed.2016.11.023. [Epub ahead of print] PMID:27856348


  • Campbell EJ, Vissers MC, Dachs GU. Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice. Hypoxia (Auckl). 2016 Apr 8;4:41-52. PMID:27800507
  • Campbell EJ, Vissers MC, Wohlrab C, Hicks KO, Strother RM, Bozonet SM, Robinson BA, Dachs GU. Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radic Biol Med. 2016 Oct;99:451-462. doi: 10.1016/j.freeradbiomed.2016.08.027. PMID:27567539
  • Cuddihy SL, Drake S, Harwood DT, Selwood AI, McNabb PS, Hampton MB. The marine cytotoxin portimine is a potent and selective inducer of apoptosis. Apoptosis. 2016 Dec;21(12):1447-1452. PMID:27738771

Nutrients & Optimal Health

  • Carr AC, Pullar JM, Bozonet SM, Vissers MC. Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation. Nutrients. 2016 Jun 3;8(6). pii: E341. doi: 10.3390/nu8060341. PMID:27271663
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