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Tony Kettle

Principal Investigator
Research Professor

BSc(Hons) PhD(Otago) MSc(SFU) FRSNZ

Email tony.kettle@otago.ac.nz
Tel +64 3 364 0577

Research interests

For the past 25 years, we have probed the enzymology of myeloperoxidase (MPO). This haem protein gives pus and phlegm their characteristic green tinge. MPO produces chlorine bleach from hydrogen peroxide and common salt.

The knowledge from this work has helped us understand how white blood cells called neutrophils use MPO to kill bacteria. It has also revealed that chlorine bleach and free radicals contribute to inflammation.

We have shown that chlorine bleach promotes inflammatory tissue damage in cystic fibrosis, asthma, rheumatoid arthritis, and cardiovascular disease. In collaboration with AstraZeneca, we have also developed specific inhibitors of MPO that are potential anti-inflammatory drugs.

Current research topics

 

Cystic Fibrosis

Cycstic fibrosis and oxidative stress

Heart Disease

Plaque developing inside a blood vessel

Neutrophils

Bacteria killing by neutrophils

Radical Reactions

Radical Reactions

Myeloperoxidase

Mechanisms of inhibition of myeloperoxidase

Biomarkers

Biomarkers of hypochlorous acid

Public Health Lectures



In the media

Professor Kettle was interviewed for Radio New Zealand's Our Changing World series in October 2014.

Affiliations

Publications

logo - Google Scholar

Inaugural Professorial Lectures

Tony Kettle delivers his Inaugural Professorial Lecture
Watch Prof. Kettle's Inaugural Professorial Lecture, Free Radicals spark the fires of inflammation, March 2013

A white blood cell hunting & phagocytosing E coli.

Publications

Blake, T. L., Sly, P. D., Anderson, I., Wainwright, C. E., Reid, D. W., Bell, S. C., Smith, B. R., Kettle, A. J., & Dickerhof, N. (2024). Changes in urinary glutathione sulfonamide (GSA) levels between admission and discharge of patients with cystic fibrosis. Journal of Cystic Fibrosis. Advance online publication. doi: 10.1016/j.jcf.2024.04.009 Journal - Research Other

Swaminathan, A., Borichevsky, G. M., Frampton, C. M., Day, A. S., Hampton, M. B., Kettle, A. J., & Gearry, R. B. (2024). Comparison of fecal calprotectin and myeloperoxidase in predicting outcomes in inflammatory bowel disease. Inflammatory Bowel Diseases. Advance online publication. doi: 10.1093/ibd/izae032 Journal - Research Article

Kettle, T., Dickerhof, N., Ford, D., Dilly, J. D., Ashby, L. V., Anderson, R. F., & Payne, R. J. (2023). Dioxygenation of tryptophan residues by superoxide and myeloperoxidase. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Flannery, M., McKenzie, J., Ashby, L., & Kettle, T. (2023). Interactions between superoxide and myeloperoxidase inside phagocytic neutrophils. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

Magon, N. J., Turner, R., Kettle, A. J., & Winterbourn, C. C. (2023). Cross-linking between cysteine and lysine, tryptophan or tyrosine in peptides and proteins treated with hypochlorous acid and other reactive halogens. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference Conference Contribution - Published proceedings: Abstract

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