Dr Simran Maggo has a strong interest in drug-induced adverse drug reactions (ADRs) and is currently investigating the genetic basis of common and rare ADRs.
Kee, P. S., Karunanathie, H., Maggo, S. D. S., Kennedy, M. A., & Chua, E. W. (2023). Long-range polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods and protocols: Methods in molecular biology (Vol. 2967). (2nd ed.) (pp. 181-192). New York, NY: Humana. doi: 10.1007/978-1-0716-3358-8_15
Chapter in Book - Research
Kee, P. S., Maggo, S. D. S., Kennedy, M. A., & Chin, P. K. L. (2023). The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses [Brief research report]. Frontiers in Pharmacology, 14, 1080117. doi: 10.3389/fphar.2023.1080117
Journal - Research Article
Kee, P. S., Maggo, S. D. S., Kennedy, M. A., Barclay, M. L., Miller, A. L., Lehnert, K., … Chin, P. K. L. (2022). Omeprazole treatment failure in gastroesophageal reflux disease and genetic variation at the CYP2C locus [Brief research report]. Frontiers in Genetics, 13, 869160. doi: 10.3389/fgene.2022.869160
Journal - Research Other
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Frontiers in Genetics, 13, 1016416. doi: 10.3389/fgene.2022.1016416
Journal - Research Article
Hitchman, L. M., Faatoese, A., Merriman, T. R., Miller, A. L., Liau, Y., Graham, O. E. E., Kee, P. S., Pearson, J. F., … Cameron, V. A., Kennedy, M. A., & Maggo, S. D. S. (2022, August-September). Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples. Poster session presented at the 31st Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.
Conference Contribution - Poster Presentation (not in published proceedings)
Kee, P. S., Maggo, S., Kennedy, M. A., Barclay, M. L., Miller, A., Lehnert, K., … Faull, R. L. M., … Chin, P. K. L. (2022, August-September). Omeprazole treatment failure in gastro-oesophageal reflux disease and genetic variation at the CYP2C locus. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Liau, Y., Maggo, S., Lehnert, K., Doogue, M. P., Scull, A., Miller, A. L., Pearson, J. F., & Kennedy, M. A. (2022, August-September). Genomic analysis of angiotensin converting enzyme inhibitor-induced angioedema. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S., Kee, J., Hitchman, L., Chin, P., Doogue, M., Miller, A., … Kennedy, M. (2021). Assessing the pharmacogenomic landscape of adverse drug reactions in Aotearoa [Invited]. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go
Conference Contribution - Published proceedings: Abstract
Searchfield, G. D., Poppe, T. N. E. R., Durai, M., Jensen, M., Kennedy, M. A., Maggo, S., Miller, A. L., … Russell, B. R., … Wise, K. (2020). A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity. International Journal of Neuroscience, 130(7), 671-682. doi: 10.1080/00207454.2019.1702544
Journal - Research Article
Kee, P. S., Chin, P. K. L., Kennedy, M. A., & Maggo, S. D. S. (2020). Pharmacogenetics of statin-induced myotoxicity. Frontiers in Genetics, 11, 575678. doi: 10.3389/fgene.2020.575678
Journal - Research Other
Liau, Y., Cree, S. L., Maggo, S., Miller, A. L., Pearson, J. F., Gladding, P. A., & Kennedy, M. A. (2019). A multiplex pharmacogenetics assay using the MinION nanopore sequencing device. Pharmacogenetics & Genomics, 29(9), 207-215. doi: 10.1097/fpc.0000000000000385
Journal - Research Article
Liau, Y., Maggo, S., Miller, A. L., Pearson, J. F., Kennedy, M. A., & Cree, S. L. (2019). Nanopore sequencing of the pharmacogene CYP2D6 allows simultaneous haplotyping and detection of duplications. Pharmacogenomics, 20(14), 1033-1047. doi: 10.2217/pgs-2019-0080
Journal - Research Article
Maggo, S. D. S., Sycamore, K. L. V., Miller, A. L., & Kennedy, M. A. (2019). The three ps: Psychiatry, pharmacy, and pharmacogenomics, a brief report from New Zealand. Frontiers in Psychiatry, 10, 690. doi: 10.3389/fpsyt.2019.00690
Journal - Research Article
Liau, Y., Chua, I., Kennedy, M. A., & Maggo, S. (2019). Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema. Clinical & Experimental Allergy, 49, 142-154. doi: 10.1111/cea.13326
Journal - Research Other
Maggo, S., Kennedy, M. A., Barczyk, Z. A., Miller, A. L., Rucklidge, J. J., Mulder, R. T., & Foulds, J. A. (2019). Common CYP2D6, CYP2C9, and CYP2C19 gene variants, health anxiety, and neuroticism are not associated with self-reported antidepressant side effects [Brief report]. Frontiers in Genetics, 10, 1199. doi: 10.3389/fgene.2019.01199
Journal - Research Other
Liu, W., Liau, Y., Maggo, S., Doogue, M., & Kennedy, M. (2019). Exploring combinatorial genetic contributions to a serious adverse drug reaction. Proceedings of the MapNet Meeting. (pp. 28). Retrieved from http://mapnet2019.nz/
Conference Contribution - Published proceedings: Abstract
Maggo, S., Kennedy, M., Barczyk, Z., Miller, A., Rucklidge, J., Mulder, R., & Foulds, J. (2019). Pharmacogenetic variants and psychological factors do not explain self-reported antidepressant side effects. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) and the Population Approach Group of Australia & New Zealand (PAGANZ) Joint Scientific Meeting: Shared Horizons: Optimizing Drug Response to Improve Patient Outcomes. (pp. 66). Retrieved from https://www.asceptasm.com
Conference Contribution - Published proceedings: Abstract
Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2018). Genetic polymorphism of CYP2C9 and VKORC1 in the Nigerian population: Significance for warfarin therapy in the population. Polish Annals of Medicine, 25(2), 180-183. doi: 10.29089/2017.17.00041
Journal - Research Article
Maggo, S., & Ashton, J. C. (2018). Effect of cannabinoid receptor agonists on isolated rat atria. Journal of Cardiovascular Pharmacology, 72(4), 191-194. doi: 10.1097/fjc.0000000000000613
Journal - Research Article
Maggo, S., Liau, Y., Doogue, M., & Kennedy, M. (2018). Understanding drug reactions using genome sequencing (UDRUGS) study: A New Zealand initiative to investigate the genetics of ADRs. Basic & Clinical Pharmacology & Toxicology, 123(Suppl. 1), (pp. 3). doi: 10.1111/bcpt.13020
Conference Contribution - Published proceedings: Abstract
Chua, E. W., Maggo, S., & Kennedy, M. A. (2017). Long fragment polymerase chain reaction. In L. Domingues (Ed.), PCR: Methods in molecular biology (Vol. 1620). (pp. 65-74). New York, NY: Springer. doi: 10.1007/978-1-4939-7060-5_3
Chapter in Book - Research
Adehin, A., Bolaji, O. O., Maggo, S., & Kennedy, M. A. (2017). Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population. Drug Metabolism & Personalized Therapy, 32(1), 39-47. doi: 10.1515/dmpt-2016-0041
Journal - Research Article
Maggo, S. D. S., Chua, E. W., Chin, P., Cree, S., Pearson, J., Doogue, M., & Kennedy, M. A. (2017). A New Zealand platform to enable genetic investigation of adverse drug reactions. New Zealand Medical Journal, 130(1466), 62-69. Retrieved from http://www.nzma.org.nz/journal
Journal - Research Article
Cree, S., Maggo, S., Slow, S., Ton, K., de Jong, L., Anderson, T., Pearson, J., Miller, A., Walker, L., Murdoch, D., & Kennedy, M. (2017). Long read nanopore sequencing in the laboratory. Proceedings of the MapNet Conference. Retrieved from http://scienceevents.co.nz/mapnet/
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Maggo, S. D. S., Foulds, J., Luty, S., Chua, E. W., Cree, S., Ton, K., Liau, Y., Miller, A. L., Chin, P., … Doogue, M. (2017). DNA banking and genetic analysis of adverse drug reactions in the New Zealand healthcare setting. Proceedings of the American Society of Human Genetics (ASHG) Annual Meeting. 2123. Retrieved from http://www.ashg.org/2017meeting/
Conference Contribution - Published proceedings: Abstract
Kennedy, M. A., Cree, S. L., Miller, A. L., Pearson, J., Maggo, S., Liau, Y., Ton, K., de Jong, L., & Walker, L. C. (2017, September). The MinION nanopore sequencer: Toy or tool? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Liau, Y., Cree, S. M., Maggo, S., Miller, A. L., Pearson, J., & Kennedy, M. A. (2017, September). A nanopore sequencing-based multiplex assay for pharmacogenetics of clopidogrel and warfarin. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S. D. S., Savage, R. L., & Kennedy, M. A. (2016). Impact of new genomic technologies on understanding adverse drug reactions. Clinical Pharmacokinetics, 55(4), 419-436. doi: 10.1007/s40262-015-0324-9
Journal - Research Article
Foulds, J. A., Maggo, S. D. S., & Kennedy, M. A. (2016). Personalised prescribing in psychiatry: Has pharmacogenomics delivered on its promise? Australian & New Zealand Journal of Psychiatry, 50(6), 509-510. doi: 10.1177/0004867416640099
Journal - Research Other
Maggo, S. D. S., Young, J., Lehnert, K., George, P., & Kennedy, M. A. (2016). Understanding adverse drug reactions using genome sequencing (UDRUGS): A focus on statin
induced myalgia. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. (pp. 44). Retrieved from http://www.queenstownresearchweek.org/index.php/ascept-nz/
Conference Contribution - Published proceedings: Abstract
Maggo, S., Young, J., Lehnert, K., George, P., & Kennedy, M. A. (2016). Statin induced myalgia, is there a genetic link? Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists and the Molecular Pharmacology of G Protein-Coupled Receptors (ASCEPT-MPGPCR) Joint Scientific Meeting. 334. Retrieved from http://www.asceptasm.com/
Conference Contribution - Published proceedings: Abstract
Maggo, S. D. S., & Ashton, J. C. (2015). Statins and the brain: Good, bad or both? In E. R. Travers (Ed.), Statins: Medical uses, mechanisms of action and clinical outcomes. (pp. 81-104). Nova Science.
Chapter in Book - Research
Cree, S. L., Miller, A. L., Chua, E. W., Maggo, S., & Kennedy, M. A. (2015, August). Long-read nanopore Sequencing for the detection of genetic polymorphisms in the CYP2D6 gene. Verbal presentation at the 7th Annual New Zealand Next Generation Sequencing (NGS) Conference, Palmerston North, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S. D. S., Foulds, J., Luty, S. E., Miller, A. L., Kennedy, H., Doogue, M., & Kennedy, M. A. (2015, September). Understanding adverse drug reactions using genome sequencing (UDRUGS): Recent cases on SSRIs and SNRIs. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S., & Ashton, J. C. (2014). Effects of HMG-CoA reductase inhibitors on learning and memory in the guinea pig. European Journal of Pharmacology, 723, 294-304. doi: 10.1016/j.ejphar.2013.11.018
Journal - Research Article
Maggo, S. (2014, November). Gentamicin ototoxicity, pharmacogenetic link? Verbal presentation at the 10th Annual Carney Pharmacogenomics Symposium, Christchurch, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Harrison-Woolrych, M., Härmark, L., Tan, M., Maggo, S., & van Grootheest, K. (2012). Epistaxis and other haemorrhagic events associated with the smoking cessation medicine varenicline: A case series from two national pharmacovigilance centres. European Journal of Clinical Pharmacology, 68, 1065-1072. doi: 10.1007/s00228-012-1220-y
Journal - Research Article
Harrison-Woolrych, M., Maggo, S., Tan, M., Savage, R., & Ashton, J. (2012). Cardiovascular events in patients taking varenicline: A case series from intensive postmarketing surveillance in New Zealand. Drug Safety, 35(1), 33-43. doi: 10.2165/11597690-000000000-00000
Journal - Research Article
Maggo, S., Clark, D., & Ashton, J. C. (2012). The effect of statins on performance in the Morris water maze in guinea pig. European Journal of Pharmacology, 674(2-3), 287-293. doi: 10.1016/j.ejphar.2011.11.006
Journal - Research Article
Rivers, J. R., Maggo, S. D. S., & Ashton, J. C. (2012). Neuroprotective effect of hydroxypropyl-β-cyclodextrin in hypoxia-ischemia. NeuroReport, 23(3), 134-138. doi: 10.1097/WNR.0b013e32834ee47c
Journal - Research Article
Ashton, J. C., Mockett, B., & Maggo, S. D. S. (2012). Cholesterol lowering through HMG CoA reductase inhibitors (statins) impairs long term potentiation and induces anxiety in guinea pigs. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 78). Retrieved from http://www.ans.org.au/ans-annual-conference/
Conference Contribution - Published proceedings: Abstract
Maggo, S. D. S., Mockett, B. G., & Ashton, J. C. (2012). The effects of chronic statin administration: Assessment of hippocampal spatial memory and long term potentiation in area CA1. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research.30, (pp. 75). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Conference Contribution - Published proceedings: Abstract
Maggo, S. D. S., Mockett, B. G., & Ashton, J. C. (2012). The effects of chronic statin administration: Assessment of hippocampal spatial memory and long term potentiation in area CA1. Proceedings of the Medical Sciences Congress (MedSci). (pp. 24-25). Retrieved from http://www.medscinz.co.nz/QRW2012%20MedSci%20Abstracts.pdf
Conference Contribution - Published proceedings: Abstract
Maggo, S. D. S., Kennedy, M. A., & Clark, D. W. J. (2011). Clinical implications of pharmacogenetic variation on the effects of statins. Drug Safety, 34(1), 1-19. doi: 10.2165/11584380-000000000-00000
Journal - Research Article
Maggo, S. (2011). Research highlights: Highlights from the latest articles in statin pharmacogenomics. Pharmacogenomics, 12(6), 773-778. doi: 10.2217/pgs.11.57
Journal - Research Other
Maggo, S. D., Mockett, B. G., & Ashton, J. C. (2011). Cholesterol lowering through HMG CoA reductase inhibitors (statins) impairs long term potentiation and induces anxiety in guinea pigs. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main
Conference Contribution - Published proceedings: Abstract
Maggo, S., Mockett, B. G., & Ashton, J. C. (2011). Cholesterol lowering through HMG CoA reductase inhibitors (statins) impairs long term potentiation and induces anxiety in guinea pigs. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research.29, 4.8. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Conference Contribution - Published proceedings: Abstract
Maggo, S., Clark, D. W. J., & Ashton, J. (2010). Statin induced anxiety: What happens when you make guinea pigs swim. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting and the 6th Annual Carney Pharmacogenomics Symposium. ASCEPT. Retrieved from http://www.ascept.org.nz/
Conference Contribution - Published proceedings: Abstract
Lees, G., Dixon, C., Maggo, S., Clark, D., Tyndall, J., & Strandell, J. (2009, September). Modulation of ion channels by the antiviral drug efavirenz. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S. D. S., Ashton, J. C., Lees, G., & Clark, D. W. J. (2009, September). Lipid lowering drugs and psychiatric ADRS: An animal behavioural assessment. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Maggo, S., Savage, R., Ashton, J. A., & Clark, D. W. G. (2008). Retrospective analysis of psychiatric effects reported for HMG-COA reductase inhibitors (STATINS) at the NZPHVC. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Conference Contribution - Published proceedings: Abstract
Maggo, S., Strandell, J., & Clark, D. W. J. (2007, August). Are psychiatric effects reported for HMG-COA reductase inhibitors (statins) likely to be true adverse drug reactions? Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists (NZ) Annual Scientific Meeting, Auckland, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs