Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Health Sciences profile

Dr Laura Gumy

PositionSenior Lecturer
DepartmentDepartment of Anatomy
Research summaryImaging; neurobiology

Research

The main focus of my work is the microtubule cytoskeleton and microtubule-based vesicle transport in healthy and diseased/injured neurons. My research relies on combining high-resolution live cell imaging and quantitative analysis of cytoskeletal and transport dynamics, using advance microscopic assays and tools to visualise and manipulate proteins within cells. I also use different biochemical methods to characterise protein-protein interactions (pull-down assays and mass spectrometry-based protein identification). I employ primary neuronal cultures or non-neuronal cells to image live-tissue.

Publications

Mayo-Muñoz, D., Smith, L. M., Garcia-Doval, C., Malone, L. M., Harding, K. R., Jackson, S. A., Hampton, H. G., Fagerlund, R. D., Gumy, L. F., & Fineran, P. C. (2022). Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection. Molecular Cell. Advance online publication. doi: 10.1016/j.molcel.2022.10.028

Malone, L. M., Warring, S. L., Jackson, S. A., Warnecke, C., Gardner, P. P., Gumy, L. F., & Fineran, P. C. (2020). A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity. Nature Microbiology, 5, 48-55. doi: 10.1038/s41564-019-0612-5

Gumy, L. F., & Hoogenraad, C. C. (2018). Local mechanisms regulating selective cargo entry and long-range trafficking in axons. Current Opinion in Neurobiology, 51, 23-28. doi: 10.1016/j.conb.2018.02.007

Abil, Z., Gumy, L. F., Zhao, H., & Hoogenraad, C. C. (2017). Inducible control of mRNA transport using reprogrammable RNA-binding proteins. ACS Synthetic Biology, 6(6), 950-956. doi: 10.1021/acssynbio.7b00025

Gumy, L. F., Katrukha, E. A., Grigoriev, I., Jaarsma, D., Kapitein, L. C., Akhmanova, A., & Hoogenraad, C. C. (2017). MAP2 defines a pre-axonal filtering zone to regulate KIF1-versus KIF5-dependent cargo transport in sensory neurons. Neuron, 94(2), 347-362. doi: 10.1016/j.neuron.2017.03.046

Mayo-Muñoz, D., Smith, L. M., Garcia-Doval, C., Malone, L. M., Harding, K. R., Jackson, S. A., Hampton, H. G., Fagerlund, R. D., Gumy, L. F., & Fineran, P. C. (2022). Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection. Molecular Cell. Advance online publication. doi: 10.1016/j.molcel.2022.10.028

Journal - Research Article

Malone, L. M., Warring, S. L., Jackson, S. A., Warnecke, C., Gardner, P. P., Gumy, L. F., & Fineran, P. C. (2020). A jumbo phage that forms a nucleus-like structure evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity. Nature Microbiology, 5, 48-55. doi: 10.1038/s41564-019-0612-5

Journal - Research Article

Gumy, L. F., & Hoogenraad, C. C. (2018). Local mechanisms regulating selective cargo entry and long-range trafficking in axons. Current Opinion in Neurobiology, 51, 23-28. doi: 10.1016/j.conb.2018.02.007

Journal - Research Article

Abil, Z., Gumy, L. F., Zhao, H., & Hoogenraad, C. C. (2017). Inducible control of mRNA transport using reprogrammable RNA-binding proteins. ACS Synthetic Biology, 6(6), 950-956. doi: 10.1021/acssynbio.7b00025

Journal - Research Article

Gumy, L. F., Katrukha, E. A., Grigoriev, I., Jaarsma, D., Kapitein, L. C., Akhmanova, A., & Hoogenraad, C. C. (2017). MAP2 defines a pre-axonal filtering zone to regulate KIF1-versus KIF5-dependent cargo transport in sensory neurons. Neuron, 94(2), 347-362. doi: 10.1016/j.neuron.2017.03.046

Journal - Research Article

Ruane, P. T., Gumy, L. F., Bola, B., Anderson, B., Wozniak, M. J., Hoogenraad, C. C., & Allan, V. J. (2016). Tumour suppressor adenomatous polyposis coli (APC) localisation is regulated by both kinesin-1 and kinesin-2. Scientific Reports, 6, 27456 . doi: 10.1038/srep27456

Journal - Research Article

Gumy, L. F., Katrukha, E. A., Kapitein, L. C., & Hoogenraad, C. C. (2014). New insights into mRNA trafficking in axons. Developmental Neurobiology, 74(3), 233-244. doi: 10.1002/dneu.22121

Journal - Research Article

Schlager, M. A., Serra-Marques, A., Grigoriev, I., Gumy, L. F., Esteves da Silva, M., Wulf, P. S., … Hoogenraad, C. C. (2014). Bicaudal D family adaptor proteins control the velocity of dynein-based movements. Cell Reports, 8(5), 1248-1256. doi: 10.1016/j.celrep.2014.07.052

Journal - Research Article

Gumy, L. F., Chew, D. J., Tortosa, E., Katrukha, E. A., Kapitein, L. C., Tolkovsky, A. M., … Fawcett, J. W. (2013). The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration. Journal of Neuroscience, 33(28), 11329-11345. doi: 10.1523/JNEUROSCI.5221-12.2013

Journal - Research Article

van der Vaart, B., van Riel, W. E., Doodhi, H., Kevenaar, J. T., Katrukha, E. A., Gumy, L., … Akhmanova, A. (2013). CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor. Developmental Cell, 27(2), 145-160. doi: 10.1016/j.devcel.2013.09.010

Journal - Research Article

van Spronsen, M., van Battum, E. Y., Kuijpers, M., Vangoor, V. R., Rietman, M. L., Pothof, J., Gumy, L. F., … Hoogenraad, C. C. (2013). Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures. PLoS ONE, 8(10), e74907. doi: 10.1371/journal.pone.0074907

Journal - Research Article

Tan, C. L., Andrews, M. R., Kwok, J. C. F., Heintz, T. G. P., Gumy, L. F., Fässler, R., & Fawcett, J. W. (2012). Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration. Journal of Neuroscience, 32(21), 7325-7335. doi: 10.1523/JNEUROSCI.5472-11.2012

Journal - Research Article

Gumy, L. F., & Hoogenraad, C. C. (2013). Off the rails: Axonal cargoes on the road to nowhere. EMBO Journal, 32(10). [Review].

Journal - Research Other

More publications...