Dr Cushla McKinney
| Position | Research Fellow |
|---|---|
| Department | Department of Pathology (Dunedin) |
| Qualifications | PhD MBHL |
| Research summary | p53 isoforms, cancer and drug resistance |
| Memberships | CRISPR Hub co-convenor |
Research
I have a background in molecular biology and genetics, with twenty years of research experience. My initial research involved the genetics of complex diseases, with a focus on RA and gout. Most recently I have been using CRISPR / Cas9 and Nanopore technology to study genes involved in cancer development and the development of drug resistance.
Additional details
I have a strong interest in the ethical and legal issues surrounding new technologies and, in addition to my PhD in Biochemistry I also hold a Master’s degree in Bioethics and Health Law. Outside of my professional roles I am a member of the Council of the Friends of the Otago Museum, and a book reviewer for the ODT and Landfall on line.
Publications
McKinney, C. (2021). Mental capacity in anorexia nervosa. In P. Westmorland (Ed.), Tipping the scales: Ethical and legal dilemmas in managing severe eating disorders. (pp. 55-74). Washington, DC: American Psychiatric Association.
Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472
Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315
Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y
McKinney, C. (2021). Mental capacity in anorexia nervosa. In P. Westmorland (Ed.), Tipping the scales: Ethical and legal dilemmas in managing severe eating disorders. (pp. 55-74). Washington, DC: American Psychiatric Association.
Chapter in Book - Research
Merriman, T. R., & McKinney, C. (2013). An update on the genetic causes of hyperuricemia and gout. In N. Dalbeth, F. Perez-Ruiz & N. Schlesinger (Eds.), Gout. (pp. 54-69). London, UK: Future Medicine. doi: 10.2217/ebo.12.256
Chapter in Book - Research
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472
Journal - Research Article
Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473
Journal - Research Article
Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315
Journal - Research Article
Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C., Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20, 179. doi: 10.1186/s13075-018-1668-y
Journal - Research Article
Rasheed, H., McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R., … Merriman, T. R. (2016). The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample sets. PLoS ONE, 11(1), e0147939. doi: 10.1371/journal.pone.0147939
Journal - Research Article
Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176
Journal - Research Article
McKinney, C., Stamp, L. K., Dalbeth, N., Topless, R. K., Day, R. O., Kannangara, D. R. W., … Merriman, T. R. (2015). Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout. Arthritis Research & Therapy, 17, 288. doi: 10.1186/s13075-015-0802-3
Journal - Research Article
Teruel, M., McKinney, C., Balsa, A., Pascual-Salcedo, D., Rodriguez-Rodriguez, L., Ortiz, A. M., … Merriman, T., … Martin, J. (2013). Association of CD247 polymorphisms with rheumatoid arthritis: A replication study and a meta-analysis. PLoS ONE, 8(7), e68295. doi: 10.1371/journal.pone.0068295
Journal - Research Article
Chen-Xu, M., Topless, R., McKinney, C., Merriman, M. E., Phipps-Green, A., Dalbeth, N., … Harrison, A. A., Highton, J., … van Rij, A., Jones, G. T., … Stamp, L. K., … Merriman, T. R. (2012). Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Annals of the Rheumatic Diseases, 71(1), 155-157. doi: 10.1136/annrheumdis-2011-200591
Journal - Research Article
McKinney, C., & Merriman, T. R. (2012). Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes. Human Molecular Genetics, 21(10), 2370-2376. doi: 10.1093/hmg/dds039
Journal - Research Article
McKinney, C., Broen, J. C. A., Vonk, M. C., Beretta, L., Hesselstrand, R., Hunzelmann, N., … Merriman, T. R. (2012). Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis. Genes & Immunity, 13(6), 458-460. doi: 10.1038/gene.2012.15
Journal - Research Article
Hook, S. M., Phipps-Green, A. J., Faiz, F., McNoe, L., McKinney, C., Hollis-Moffatt, J. E., & Merriman, T. R. (2011). Smad2: A candidate gene for the murine autoimmune diabetes locus Idd21.1. Journal of Clinical Endocrinology & Metabolism, 96(12), E2072-E2077. doi: 10.1210/jc.2011-0463
Journal - Research Article
Bentley, R. W., Pearson, J., Gearry, R. B., Barclay, M. L., McKinney, C., Merriman, T. R., & Roberts, R. L. (2010). Association of higher DEFB4 genomic copy number with Crohn's disease. American Journal of Gastroenterology, 105(2), 354-359. doi: 10.1038/ajg.2009.582
Journal - Research Article
McKinney, C., Fanciulli, M., Merriman, M. E., Phipps-Green, A., Alizadeh, B. Z., Koeleman, B. P. C., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2010). Association of variation in Fcγ receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Annals of the Rheumatic Diseases, 69, 1711-1716. doi: 10.1136/ard.2009.123588
Journal - Research Article
McKinney, C., Merriman, M. E., Chapman, P. T., Gow, P. J., Harrison, A. A., Highton, J., … O'Donnell, J. L., … Stamp, L. K., Willis, J., … Merriman, T. R. (2008). Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases, 67, 409-413. doi: 10.1136/ard.2007.075028
Journal - Research Article
Nasri, S., More, H., Graziano, F., Ruzzo, A., Wilson, E., Dunbier, A., McKinney, C., Merriman, T., Guilford, P., … Humar, B. (2008). A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer, 8, 138. doi: 10.1186/1471-2407-8-138
Journal - Research Article
Gil, M., McKinney, C., Lee, M. K., Eells, J. B., Phyillaier, M. A., & Nikodem, V. M. (2007). Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo. Journal of Neurochemistry, 101, 142-150.
Journal - Research Article
McKinney, C., & Merriman, T. R. (2007). The human genome and understanding of common disease: Present and future technologies. Cellular & Molecular Life Sciences, 64(7-8), 961-978.
Journal - Research Article
Irvine, J., Horsfield, J. A., McKinney, C. Z., & Tate, W. P. (1998). A novel strategy to interfere with human immunodeficiency virus type 1 propagation. New Zealand Medical Journal, 111, 222-224.
Journal - Research Article
McKinney, C. (2015). Is resistance (n)ever futile? A response to "Futility in chronic anorexia nervosa: A concept whose time has not yet come" by Cynthia Geppert. American Journal of Bioethics, 15(7), 53-54. doi: 10.1080/15265161.2015.1042991
Journal - Research Other
Phipps-Green, A., McKinney, C., Rossol, M., Merriman, M. E., Topless, R., Hollis-Moffatt, J. E., Wan Taib, W. R., … Harrison, A. A., Highton, J., … Stamp, L. K., … Merriman, T. R. (2011). Analysis of association of DNASE2 promoter variation with rheumatoid arthritis in European Caucasians [Letter]. Annals of the Rheumatic Diseases, 70(8), 1512-1514. doi: 10.1136/ard.2010.138727
Journal - Research Other
McKinney, C. (2010). [Review of the book Artscience: Creativity in the post-Google generation]. Junctures, 13, 93-94.
Journal - Research Other
