Professor Anthony Butler

Position	Head of Department and Professor
Department	Department of Radiology (Christchurch)
Qualifications	MB ChB PhD GradDipSc FRANZCR
Research summary	Radiology

Research

Anthony Butler's research is at the interface of clinical medicine and the technical sciences of physics and computing. His current focus is the development of MARS imaging and its translation from high energy physics to clinical medicine. The MARS technique provides 3D colour (spectral) X-ray images of biological tissue. These images provide significantly more clinical information than those modalities currently used in hospitals and laboratories. This enables researchers and clinicians to study diseases in new ways. Currently he and his collaborators are applying MARS to problems in heart disease, cancer, drug development, and bone health. MARS technology research spans particle detector development, design of imaging equipment, medical mathematics, and data visualisation. In addition, his other interests include the using mobile computing and virtual reality within hospitals.

Publications

Dahal, S., Raja, A. Y., Searle, E., Colgan, F. E., Crighton, J. S., Roake, J., … Gieseg, S., & Butler, A. P. H. (2022). Components of carotid atherosclerotic plaque in spectral photon-counting CT with histopathologic comparison. European Radiology. Advance online publication. doi: 10.1007/s00330-022-09155-x

Ostadhossein, F., Moitra, P., Gunaseelan, N., Nelappana, M., Lowe, C., Moghiseh, M., Butler, A., de Ruiter, N., … Pan, D. (2022). Hitchhiking probiotic vectors to deliver ultra-small hafnia nanoparticles for 'color' gastrointestinal tract photon counting X-ray imaging. Nanoscale Horizons. Advance online publication. doi: 10.1039/d1nh00626f

Saba, L., Nardi, V., Cau, R., Gupta, A., Kamel, H., Suri, J. S., … Butler, A. P. H., Gieseg, S., … Lanzino, G. (2022). Carotid artery plaque calcifications: Lessons from histopathology to diagnostic imaging. Stroke, 53, 290-297. doi: 10.1161/STROKEAHA.121.035692

Wu, W., Hu, D., Niu, C., Vanden Broeke, L., Butler, A. P. H., Cao, P., … Wang, G. (2021). Deep learning based spectral CT imaging. Neural Networks, 144, 342-358. doi: 10.1016/j.neunet.2021.08.026

Lowe, C., Ortega-Gil, A., Moghiseh, M., Anderson, N. G., Muñoz-Barrutia, A., Vaquero, J. J., Raja, A. Y., Matanaghi, A., … Dapamede, T., Adebileje, S. A., … Amma, M. R., … Asghariomabad, F., … Baer, K., … Butler, P. H., Carbonez, P., … Chapagain, K., … Crighton, J. S., Dahal, S., Damet, J., de Ruiter, N. J. A., … Gieseg, S. P., … Gurney, S., … Marfo, E., … Panta, R. K., … Schleich, N., … Butler, A. P. H. (2021). Molecular imaging of pulmonary tuberculosis in an ex-vivo mouse model using spectral photon-counting computed tomography and micro-CT. IEEE Access, 9, 67201-67208. doi: 10.1109/ACCESS.2021.3076432

Raja, A., Gieseg, S. P., Adebileje, S. A., Alexander, S. D., Amma, M. R., Asghariomabad, F., … Bamford, B., … Butler, A. P. H., Butler, P. H., Carbonez, P., … Dahal, S., Damet, J., de Ruiter, N. J. A., … Lowe, C., … Marfo, E., Matanaghi, A., Moghiseh, M., Panta, R. K., … Schleich, N., … Sheeja, J. S., … Wijesooriya, M. (2020). Spectral CT imaging using MARS scanners. In K. Taguchi, I. Blevis & K. Iniewski (Eds.), Spectral, photon counting computed tomography: Technology and applications. (pp. 117-138). Boca Raton, FL: CRC Press.

Chapter in Book - Research

Kumar, P., Singh, B., Chaudhari, P., Jose, J., Butler, A., Prebble, H., Moghiseh, M., and the MARS Collaboration, including Schleich, N. C., & Woodfield, T. (2019). Preclinical non-invasive imaging in cancer research and drug discovery: An overview. In K. Bose & P. Chaudhari (Eds.), Unravelling cancer signaling pathways: A multidisciplinary approach. (pp. 419-469). Singapore: Springer Nature. doi: 10.1007/978-981-32-9816-3_17

Chapter in Book - Research

Walsh, M. F., Aamir, R., Panta, R. K., Rajendran, K., Anderson, N. G., Butler, A. P. H., & Butler, P. H. (2015). Spectral molecular CT with photon-counting detectors. In S. Awadalla (Ed.), Solid-state radiation detectors: Technology and applications. (pp. 195-219). Boca Raton, FL: CRC Press.

Chapter in Book - Research

Butler, A. (2013). Centre for Bioengineering. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 109-112). Christchurch, New Zealand: University of Otago.

Chapter in Book - Other

Journal - Research Article

Baer, K., Kieser, S., Schon, B., Rajendran, K., ten Harkel, T., Ramyar, M., … Bateman, C., Butler, A., Raja, A. Y., Hooper, G., Anderson, N., & Woodfield, T. (2021). Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioengineering, 5(2), 026101. doi: 10.1063/5.0035312

Journal - Research Article

Kanithi, P., de Ruiter, N. J. A., Amma, M. R., Lindeman, R. W., Butler, A. P. H., Butler, P. H., … Adebileje, S. A., … Asghariomabad, F., … Bamford, B., … Carbonez, P., … Clark, J. A., … Crighton, J. S., Dahal, S., Damet, J., … Gieseg, S. P., … Gurney, S., Healy, J. L., … Lowe, C., Marfo, E., Matanaghi, A., Moghiseh, M., … Panta, R. K., … Raja, A. Y., Renaud, P., … Schleich, N., … Sheeja, J. S., … Walker, E. P., … Younger, W. R. (2021). Interactive image segmentation of MARS datasets using bag of features. IEEE Transactions on Radiation & Plasma Medical Sciences, 5(4), 559-567. doi: 10.1109/TRPMS.2020.3030045

Journal - Research Article

Lau, L. C. M., Lee, W. Y. W., Butler, A. P. H., Chernoglazov, A. I., Chung, K. Y., Ho, K. K. W., … Butler, P. H., & Yung, P. S. H. (2021). Multi-energy spectral photon-counting computed tomography (MARS) for detection of arthroplasty implant failure. Scientific Reports, 11, 1554. doi: 10.1038/s41598-020-80463-2

Journal - Research Article

Marfo, E., Anderson, N. G., Butler, A. P. H., Schleich, N., Carbonez, P., Damet, J., Lowe, C., Healy, J., … Moghiseh, M., MARS Collaboration, & Raja, A. Y. (2021). Assessment of material identification errors, image quality, and radiation doses using small animal spectral photon-counting CT. IEEE Transactions on Radiation & Plasma Medical Sciences, 5(4), 578-587. doi: 10.1109/TRPMS.2020.3003260

Journal - Research Article

Ostadhossein, F., Tripathi, I., Benig, L., LoBato, D., Moghiseh, M., Lowe, C., Aamir, R., Butler, A., Panta, R., Anjomrouz, M., … Pan, D. (2020). Multi-"color" delineation of bone microdamages using ligand-directed sub-5 nm hafnia nanodots and photon counting CT imaging. Advanced Functional Materials, 30, 1904936. doi: 10.1002/adfm.201904936

Journal - Research Article

Simard, M., Kumar Panta, R., Bell, S. T., Butler, A. P. H., & Bouchard, H. (2020). Quantitative imaging performance of MARS spectral photon-counting CT for radiotherapy. Medical Physics, 47(8), 3423-3434. doi: 10.1002/mp.14204

Journal - Research Article

Anjomrouz, M., Shamshad, M., Panta, R. K., Vanden Broeke, L., Schleich, N., Atharifard, A., Raja, A., Bheesette, S., Walsh, M. F., Goulter, B. P., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2018). Beam profile assessment in spectral CT scanners. Journal of Applied Clinical Medical Physics, 19(2), 287-297. doi: 10.1002/acm2.12260

Journal - Research Article

Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020

Journal - Research Article

Mandalika, V. B. H., Chernoglazov, A. I., Billinghurst, M., Bartneck, C., Hurrell, M. A., de Ruiter, N., Butler, A. P. H., & Butler, P. H. (2018). A hybrid 2D/3D user interface for radiological diagnosis. Journal of Digital Imaging, 31(1), 56-73. doi: 10.1007/s10278-017-0002-6

Journal - Research Article

Moghiseh, M., Lowe, C., Lewis, J., Kumar, D., Butler, A., Anderson, N., & Raja, A. (2018). Spectral photon-counting molecular imaging for quantification of monoclonal antibody-conjugated gold nanoparticles targeted to lymphoma and breast cancer: An in vitro study. Contrast Media & Molecular Imaging, 2018, 2136840. doi: 10.1155/2018/2136840

Journal - Research Article

Panta, R. K., Bell, S. T., Healy, J. L., Aamir, R., Bateman, C. J., Moghiseh, M., Butler, A. P. H., & Anderson, N. G. (2018). Element-specific spectral imaging of multiple contrast agents: A phantom study. Journal of Instrumentation, 13, T02001. doi: 10.1088/1748-0221/13/02/T02001

Journal - Research Article

Prebble, H., Cross, S., Marks, E., Healy, J. L., Searle, E., Aamir, R., Butler, A., Roake, J., Hock, B., Anderson, N., & Gieseg, S. P. (2018). Induced macrophage activation in live excised atherosclerotic plaque. Immunobiology, 223(8-9), 526-535. doi: 10.1016/j.imbio.2018.03.002

Journal - Research Article

Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467

Journal - Research Article

Lu, G., Marsh, S., Damet, J., Carbonez, P., Laban, J., Bateman, C., Butler, A., & Butler, P. (2017). Dosimetry in MARS spectral CT: TOPAS Monte Carlo simulations and ion chamber measurements. Australasian Physical & Engineering Sciences in Medicine, 40(2), 297-303. doi: 10.1007/s13246-017-0532-8

Journal - Research Article

Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7

Journal - Research Article

Shamshad, M., Anjomrouz, M., Smithies, D. J., Largeau, A., Lu, G., Atharifard, A., … Aamir, R., Panta, R. K., Walsh, M. F., Goulter, B. P., Healy, J. L., Bheesette, S., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2017). Semi-analytic off-axis X-ray source model. Journal of Instrumentation, 12, P10013. doi: 10.1088/1748-0221/12/10/p10013

Journal - Research Article

Gregan, J., Balasingham, A., & Butler, A. (2016). Radiology in the Christchurch earthquake of 22 February 2011: Challenges, interim processes and clinical priorities. Journal of Medical Imaging & Radiation Oncology, 60(2), 172-181. doi: 10.1111/1754-9485.12315

Journal - Research Article

Moghiseh, M., Aamir, R., Panta, R. K., de Ruiter, N., Chernoglazov, A., Healy, J. L., Butler, A. P. H., & Anderson, N. G. (2016). Discrimination of multiple high-Z materials by multi-energy spectral CT: A phantom study. JSM Biomedical Imaging Data Papers, 3(1), 1007.

Journal - Research Article

Butler, A., Butler, P., Bell, S., Chelkov, G. A., Dedovich, D. V., Demichev, M. A., … Zhemchugov, A. S. (2015). Measurement of the energy resolution and calibration of hybrid pixel detectors with GaAs:Cr sensor and Timepix readout chip. Physics of Particles & Nuclei Letters, 12(1), 59-73. doi: 10.1134/S1547477115010021

Journal - Research Article

Foo, E., McDonald, R., Savage, E., Floyd, R., Butler, A., Rumball-Smith, A., & Connor, S. (2015). Mobile task management tool that improves workflow of an acute general surgical service. ANZ Journal of Surgery, 85(10), 760-765. doi: 10.1111/ans.12988

Journal - Research Article

Panta, R. K., Walsh, M. F., Bell, S. T., Anderson, N. G., Butler, A. P., & Butler, P. H. (2015). Energy calibration of the pixels of spectral X-ray detectors. IEEE Transactions on Medical Imaging, 34(3), 697-706. doi: 10.1109/TMI.2014.2337881

Journal - Research Article

Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005

Journal - Research Article

Anderson, N. G., & Butler, A. P. (2014). Clinical applications of spectral molecular imaging: Potential and challenges. Contrast Media & Molecular Imaging, 9(1), 3-12. doi: 10.1002/cmmi.1550

Journal - Research Article

Bennett, J. R., Opie, A. M. T., Xu, Q., Yu, H., Walsh, M., Butler, A., … Wang, G. (2014). Hybrid spectral micro-CT: System design, implementation and preliminary results. IEEE Transactions on Biomedical Engineering, 61(2), 246-253. doi: 10.1109/TBME.2013.2279673

Journal - Research Article

CMS Collaboration, including Butler, A. P. H. (2014). Measurement of the muon charge asymmetry in inclusive pp → W + X production at √s =7 TeV and an improved determination of light parton distribution functions. Physical Review D, 90, 032004. doi: 10.1103/PhysRevD.90.032004

Journal - Research Article

Opie, A. M. T., Bennett, J. R., Walsh, M., Rajendran, K., Yu, H., Xu, Q., Butler, A., … Wang, G. (2014). Study of scan protocol for exposure reduction in hybrid spectral micro-CT. Scanning, 36(4), 444-455. doi: 10.1002/sca.21140

Journal - Research Article

Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015

Journal - Research Article

He, P., Yu, H., Bennett, J., Ronaldson, P., Zainon, R., Butler, A., … Wang, G. (2013). Energy-discriminative performance of a spectral micro-CT system. Journal of X-Ray Science & Technology, 21(3), 335-345. doi: 10.3233/XST-130382

Journal - Research Article

Tappenden, R., Hegarty, J., Broughton, R., Butler, A., Coope, I., & Renaud, P. (2013). X-ray image enhancement via determinant based feature selection. Australasian Physical & Engineering Sciences in Medicine, 36(4), 449-455. doi: 10.1007/s13246-013-0221-1

Journal - Research Article

Walsh, M. F., Nik, S. J., Procz, S., Pichotka, M., Bell, S. T., Bateman, C. J., … De Ruiter, N., … Panta, R. K., Butler, A. P. H., & Butler, P. H. (2013). Spectral CT data acquisition with Medipix3.1. Journal of Instrumentation, 8, P10012. doi: 10.1088/1748-0221/8/10/P10012

Journal - Research Article

CMS Collaboration, including Butler, A. P. H. (2012). Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC. Physics Letters B, 716, 30-61. doi: 10.1016/j.physletb.2012.08.021

Journal - Research Article

He, P., Yu, H., Thayer, P., Jin, X., Xu, Q., Bennett, J., … Butler, A., … Wang, G. (2012). Preliminary experimental results from a MARS Micro-CT system. Journal of X-Ray Science & Technology, 20(2), 199-211. doi: 10.3233/xst-2012-0329

Journal - Research Article

Hurrell, M. A., Butler, A. P. H., Cook, N. J., Butler, P. H., Ronaldson, J. P., & Zainon, R. (2012). Spectral Hounsfield units: A new radiological concept. European Radiology, 22(5), 1008-1013. doi: 10.1007/s00330-011-2348-3

Journal - Research Article

Ronaldson, J. P., Zainon, R., Scott, N. J. A., Gieseg, S. P., Butler, A. P., Butler, P. H., & Anderson, N. G. (2012). Toward quantifying the composition of soft tissues by spectral CT with Medipix3. Medical Physics, 39(11), 6847-6857. doi: 10.1118/1.4760773

Journal - Research Article

Xu, Q., Yu, H., Bennett, J., He, P., Zainon, R., Doesburg, R., … Walsh, M., … Butler, A., … Wang, G. (2012). Image reconstruction for hybrid true-color micro-CT. IEEE Transactions on Biomedical Engineering, 59(6), 1711-1719. doi: 10.1109/tbme.2012.2192119

Journal - Research Article

Zainon, R., Ronaldson, J. P., Janmale, T., Scott, N. J., Buckenham, T. M., Butler, A. P. H., … Gieseg, S. P., Roake, J. A., & Anderson, N. G. (2012). Spectral CT of carotid atherosclerotic plaque: Comparison with histology. European Radiology, 22(12), 2581-2588. doi: 10.1007/s00330-012-2538-7

Journal - Research Article

Ball, A., Bell, A., Butler, A., Butler, P., Hall-Wilton, R., Hegeman, J., … Vykydal, Z. (2011). Design, implementation and first measurements with the Medipix2-MXR detector at the Compact Muon Solenoid experiment. Journal of Instrumentation, 6, P08005. doi: 10.1088/1748-0221/6/08/P08005

Journal - Research Article

Butler, A. P. H., Butzer, J., Schleich, N., Cook, N. J., Anderson, N. G., Scott, N., de Ruiter, N., … Butler, P. H. (2011). Processing of spectral X-ray data with principal components analysis. Nuclear Instruments & Methods in Physics Research Section A, 633(Suppl. 1), S140-S142. doi: 10.1016/j.nima.2010.06.149

Journal - Research Article

Anderson, N. G., Butler, A. P., Scott, N. J. A., Cook, N. J., Butzer, J. S., Schleich, N., … de Ruiter, N., … Butler, P. H. (2010). Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE. European Radiology, 20, 2126-2134. doi: 10.1007/s00330-010-1768-9

Journal - Research Article

Zainon, R., Butler, A. P. H., Cook, N. J., Butzer, J. S., Schleich, N., de Ruiter, N., … Butler, P. H. (2010). Construction and operation of the MARS-CT scanner. Internetworking Indonesia Journal, 2(1). Retrieved from http://www.internetworkingindonesia.org/Issues/Vol2-No1-Spring2010/iij_vol2_no1_2010_zainon.pdf

Journal - Research Article

Butler, A. P. H., Anderson, N. G., Tipples, R., Cook, N., Watts, R., Meyer, J., … Melzer, T. R., & Butler, P. H. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments & Methods in Physics Research Section A, 591(1), 141-146. doi: 10.1016/j.nima.2008.03.039

Journal - Research Article

Butler, A., Bones, P., & Hurrell, M. (2008). Prototype system for enhancement of frontal chest radiographs using eigenimage processing. Journal of Medical Imaging & Radiation Oncology, 52, 244-253.

Journal - Research Article

Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., & Butler, P. H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Sciences in Medicine, 31(4), 300-306.

Journal - Research Article

Journal - Research Other

Gongadze, A., Zhemchugov, A., Chelkov, G., Kozhevnikov, D., Potrap, I., Demichev, M., … Butler, A. P., … Bell, S. T. (2015). Alignment and resolution studies of a MARS CT scanner. Physics of Particles & Nuclei Letters, 12(5), 725-735. doi: 10.1134/S1547477115050064

Journal - Research Other

Wang, G., Butler, A., Yu, Y., & Campbell, M. (2015). Special issue on spectral CT. IEEE Transactions on Medical Imaging, 34(3), 693-696. doi: 10.1109/TMI.2015.2404591

Journal - Research Other

Yu, H., Xu, Q., He, P., Bennett, J., Aamir, R., Dobbs, B., … Butler, A., … Wang, G. (2012). Medipix-based spectral micro-CT. Computerized Tomography Theory & Applications, 21(4), 583-596.

Journal - Research Other

Fornaro, J., Leschka, S., Hibbeln, D., Butler, A., Anderson, N., Pache, G., … Stolzmann, P. (2011). Dual- and multi-energy CT: Approach to functional imaging [Review]. Insights into Imaging, 2(2), 149-159. doi: 10.1007/s13244-010-0057-0

Journal - Research Other

Butler, A. (2009). The increasing role of bioengineering and medical physics in the practice of medicine [Editorial]. New Zealand Medical Journal, 122(1297). Retrieved from http://journal.nzma.org.nz/journal/122-1297/3658/content.pdf

Journal - Research Other

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Professor Anthony Butler

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