Professor Anthony Butler
| Position | Head of Department and Professor |
|---|---|
| Department | Department of Radiology (Christchurch) |
| Qualifications | MB ChB PhD GradDipSc FRANZCR |
| Research summary | Radiology |
Research
Anthony Butler's research is at the interface of clinical medicine and the technical sciences of physics and computing. His current focus is the development of MARS imaging and its translation from high energy physics to clinical medicine. The MARS technique provides 3D colour (spectral) X-ray images of biological tissue. These images provide significantly more clinical information than those modalities currently used in hospitals and laboratories. This enables researchers and clinicians to study diseases in new ways. Currently he and his collaborators are applying MARS to problems in heart disease, cancer, drug development, and bone health. MARS technology research spans particle detector development, design of imaging equipment, medical mathematics, and data visualisation. In addition, his other interests include the using mobile computing and virtual reality within hospitals.Publications
Kumar, P., Singh, B., Chaudhari, P., Jose, J., Butler, A., Prebble, H., Moghiseh, M., and the MARS Collaboration. (2019). Preclinical non-invasive imaging in cancer research and drug discovery: An overview. In K. Bose & P. Chaudhari (Eds.), Unravelling cancer signaling pathways: A multidisciplinary approach. (pp. 419-469). Singapore: Springer Nature. doi: 10.1007/978-981-32-9816-3_17
Ostadhossein, F., Tripathi, I., Benig, L., LoBato, D., Moghiseh, M., Lowe, C., Aamir, R., Butler, A., Panta, R., Anjomrouz, M., … Pan, D. (2019). Multi-"color" delineation of bone microdamages using ligand-directed sub-5 nm hafnia nanodots and photon counting CT imaging. Advanced Functional Materials, 1904936. Advance online publication. doi: 10.1002/adfm.201904936
Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020
Panta, R. K., Bell, S. T., Healy, J. L., Aamir, R., Bateman, C. J., Moghiseh, M., Butler, A. P. H., & Anderson, N. G. (2018). Element-specific spectral imaging of multiple contrast agents: A phantom study. Journal of Instrumentation, 13, T02001. doi: 10.1088/1748-0221/13/02/T02001
Anjomrouz, M., Shamshad, M., Panta, R. K., Vanden Broeke, L., Schleich, N., Atharifard, A., Raja, A., Bheesette, S., Walsh, M. F., Goulter, B. P., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2018). Beam profile assessment in spectral CT scanners. Journal of Applied Clinical Medical Physics, 19(2), 287-297. doi: 10.1002/acm2.12260
Chapter in Book - Research
Kumar, P., Singh, B., Chaudhari, P., Jose, J., Butler, A., Prebble, H., Moghiseh, M., and the MARS Collaboration. (2019). Preclinical non-invasive imaging in cancer research and drug discovery: An overview. In K. Bose & P. Chaudhari (Eds.), Unravelling cancer signaling pathways: A multidisciplinary approach. (pp. 419-469). Singapore: Springer Nature. doi: 10.1007/978-981-32-9816-3_17
Walsh, M. F., Aamir, R., Panta, R. K., Rajendran, K., Anderson, N. G., Butler, A. P. H., & Butler, P. H. (2015). Spectral molecular CT with photon-counting detectors. In S. Awadalla (Ed.), Solid-state radiation detectors: Technology and applications. (pp. 195-219). Boca Raton, FL: CRC Press.
Chapter in Book - Other
Butler, A. (2013). Centre for Bioengineering. In P. Joyce, G. Nicholls, K. Thomas & T. Wilkinson (Eds.), The Christchurch experience: 40 years of research and teaching. (pp. 109-112). Christchurch, New Zealand: University of Otago.
Journal - Research Article
Ostadhossein, F., Tripathi, I., Benig, L., LoBato, D., Moghiseh, M., Lowe, C., Aamir, R., Butler, A., Panta, R., Anjomrouz, M., … Pan, D. (2019). Multi-"color" delineation of bone microdamages using ligand-directed sub-5 nm hafnia nanodots and photon counting CT imaging. Advanced Functional Materials, 1904936. Advance online publication. doi: 10.1002/adfm.201904936
Bateman, C. J., Knight, D., Brandwacht, B., McMahon, J., Healy, J., Panta, R., Aamir, R., Rajendran, K., Moghiseh, M., Ramyar, M., … de Ruiter, N., … Shamshad, M., Anjomrouz, M., Atharifard, A., … Bheesette, S., … Anderson, N. G., Gieseg, S. P., Woodfield, T., Renaud, P. F., Butler, A. P. H., & Butler, P. H. (2018). MARS-MD: Rejection based image domain material decomposition. Journal of Instrumentation, 13, P05020. doi: 10.1088/1748-0221/13/05/p05020
Anjomrouz, M., Shamshad, M., Panta, R. K., Vanden Broeke, L., Schleich, N., Atharifard, A., Raja, A., Bheesette, S., Walsh, M. F., Goulter, B. P., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2018). Beam profile assessment in spectral CT scanners. Journal of Applied Clinical Medical Physics, 19(2), 287-297. doi: 10.1002/acm2.12260
Panta, R. K., Bell, S. T., Healy, J. L., Aamir, R., Bateman, C. J., Moghiseh, M., Butler, A. P. H., & Anderson, N. G. (2018). Element-specific spectral imaging of multiple contrast agents: A phantom study. Journal of Instrumentation, 13, T02001. doi: 10.1088/1748-0221/13/02/T02001
Prebble, H., Cross, S., Marks, E., Healy, J. L., Searle, E., Aamir, R., Butler, A., Roake, J., Hock, B., Anderson, N., & Gieseg, S. P. (2018). Induced macrophage activation in live excised atherosclerotic plaque. Immunobiology, 223(8-9), 526-535. doi: 10.1016/j.imbio.2018.03.002
Mandalika, V. B. H., Chernoglazov, A. I., Billinghurst, M., Bartneck, C., Hurrell, M. A., de Ruiter, N., Butler, A. P. H., & Butler, P. H. (2018). A hybrid 2D/3D user interface for radiological diagnosis. Journal of Digital Imaging, 31(1), 56-73. doi: 10.1007/s10278-017-0002-6
Moghiseh, M., Lowe, C., Lewis, J., Kumar, D., Butler, A., Anderson, N., & Raja, A. (2018). Spectral photon-counting molecular imaging for quantification of monoclonal antibody-conjugated gold nanoparticles targeted to lymphoma and breast cancer: An in vitro study. Contrast Media & Molecular Imaging, 2018, 2136840. doi: 10.1155/2018/2136840
Raja, A. Y., Moghiseh, M., Bateman, C. J., de Ruiter, N., Schon, B., Schleich, N., Woodfield, T. B. F., Butler, A. P. H., & Anderson, N. G. (2018). Measuring identification and quantification errors in spectral CT material decomposition. Applied Sciences, 8(3), 467. doi: 10.3390/app8030467
Lu, G., Marsh, S., Damet, J., Carbonez, P., Laban, J., Bateman, C., Butler, A., & Butler, P. (2017). Dosimetry in MARS spectral CT: TOPAS Monte Carlo simulations and ion chamber measurements. Australasian Physical & Engineering Sciences in Medicine, 40(2), 297-303. doi: 10.1007/s13246-017-0532-8
Shamshad, M., Anjomrouz, M., Smithies, D. J., Largeau, A., Lu, G., Atharifard, A., … Aamir, R., Panta, R. K., Walsh, M. F., Goulter, B. P., Healy, J. L., Bheesette, S., … Bateman, C. J., Butler, A. P. H., & Butler, P. H. (2017). Semi-analytic off-axis X-ray source model. Journal of Instrumentation, 12, P10013. doi: 10.1088/1748-0221/12/10/p10013
Rajendran, K., Löbker, C., Schon, B. S., Bateman, C. J., Younis, R. A., de Ruiter, N. J. A., … Ramyar, M., Hooper, G. J., Butler, A. P. H., Woodfield, T. B. F., & Anderson, N. G. (2017). Quantitative imaging of excised osteoarthritic cartilage using spectral CT. European Radiology, 27(1), 384-392. doi: 10.1007/s00330-016-4374-7
Moghiseh, M., Aamir, R., Panta, R. K., de Ruiter, N., Chernoglazov, A., Healy, J. L., Butler, A. P. H., & Anderson, N. G. (2016). Discrimination of multiple high-Z materials by multi-energy spectral CT: A phantom study. JSM Biomedical Imaging Data Papers, 3(1), 1007.
Gregan, J., Balasingham, A., & Butler, A. (2016). Radiology in the Christchurch earthquake of 22 February 2011: Challenges, interim processes and clinical priorities. Journal of Medical Imaging & Radiation Oncology, 60(2), 172-181. doi: 10.1111/1754-9485.12315
Foo, E., McDonald, R., Savage, E., Floyd, R., Butler, A., Rumball-Smith, A., & Connor, S. (2015). Mobile task management tool that improves workflow of an acute general surgical service. ANZ Journal of Surgery, 85(10), 760-765. doi: 10.1111/ans.12988
Butler, A., Butler, P., Bell, S., Chelkov, G. A., Dedovich, D. V., Demichev, M. A., … Zhemchugov, A. S. (2015). Measurement of the energy resolution and calibration of hybrid pixel detectors with GaAs:Cr sensor and Timepix readout chip. Physics of Particles & Nuclei Letters, 12(1), 59-73. doi: 10.1134/S1547477115010021
Panta, R. K., Walsh, M. F., Bell, S. T., Anderson, N. G., Butler, A. P., & Butler, P. H. (2015). Energy calibration of the pixels of spectral X-ray detectors. IEEE Transactions on Medical Imaging, 34(3), 697-706. doi: 10.1109/TMI.2014.2337881
Rajendran, K., Walsh, M. F., de Ruiter, N. J. A., Chernoglazov, A. I., Panta, R. K., Butler, A. P. H., … Anderson, N. G., Woodfield, T. B. F., Tredinnick, S. J., … Bateman, C. J., Aamir, R., … Smithies, D. J., Mohr, J. L., … Ronaldson, J. P., … Atharifard, A., … Schleich, N., & Billinghurst, M. (2014). Reducing beam hardening effects and metal artefacts in spectral CT using Medipix3RX. Journal of Instrumentation, 9, P03015. doi: 10.1088/1748-0221/9/03/P03015
Opie, A. M. T., Bennett, J. R., Walsh, M., Rajendran, K., Yu, H., Xu, Q., Butler, A., … Wang, G. (2014). Study of scan protocol for exposure reduction in hybrid spectral micro-CT. Scanning, 36(4), 444-455. doi: 10.1002/sca.21140
Aamir, R., Chernoglazov, A., Bateman, C. J., Butler, A. P. H., Butler, P. H., Anderson, N. G., … Panta, R. K., … Mohr, J. L., Rajendran, K., Walsh, M. F., de Ruiter, N., Gieseg, S. P., Woodfield, T., … Schleich, N., Scott, N., … Ronaldson, J. P., Cook, N. J., … Hodge, K. (2014). MARS spectral molecular imaging of lamb tissue: Data collection and image analysis. Journal of Instrumentation, 9, P02005. doi: 10.1088/1748-0221/9/02/P02005
Anderson, N. G., & Butler, A. P. (2014). Clinical applications of spectral molecular imaging: Potential and challenges. Contrast Media & Molecular Imaging, 9(1), 3-12. doi: 10.1002/cmmi.1550
Bennett, J. R., Opie, A. M. T., Xu, Q., Yu, H., Walsh, M., Butler, A., … Wang, G. (2014). Hybrid spectral micro-CT: System design, implementation and preliminary results. IEEE Transactions on Biomedical Engineering, 61(2), 246-253. doi: 10.1109/TBME.2013.2279673
CMS Collaboration, including Butler, A. P. H. (2014). Measurement of the muon charge asymmetry in inclusive pp → W + X production at √s =7 TeV and an improved determination of light parton distribution functions. Physical Review D, 90, 032004. doi: 10.1103/PhysRevD.90.032004
He, P., Yu, H., Bennett, J., Ronaldson, P., Zainon, R., Butler, A., … Wang, G. (2013). Energy-discriminative performance of a spectral micro-CT system. Journal of X-Ray Science & Technology, 21(3), 335-345. doi: 10.3233/XST-130382
Tappenden, R., Hegarty, J., Broughton, R., Butler, A., Coope, I., & Renaud, P. (2013). X-ray image enhancement via determinant based feature selection. Australasian Physical & Engineering Sciences in Medicine, 36(4), 449-455. doi: 10.1007/s13246-013-0221-1
Walsh, M. F., Nik, S. J., Procz, S., Pichotka, M., Bell, S. T., Bateman, C. J., … De Ruiter, N., … Panta, R. K., Butler, A. P. H., & Butler, P. H. (2013). Spectral CT data acquisition with Medipix3.1. Journal of Instrumentation, 8, P10012. doi: 10.1088/1748-0221/8/10/P10012
CMS Collaboration, including Butler, A. P. H. (2012). Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC. Physics Letters B, 716, 30-61. doi: 10.1016/j.physletb.2012.08.021
He, P., Yu, H., Thayer, P., Jin, X., Xu, Q., Bennett, J., … Butler, A., … Wang, G. (2012). Preliminary experimental results from a MARS Micro-CT system. Journal of X-Ray Science & Technology, 20(2), 199-211. doi: 10.3233/xst-2012-0329
Hurrell, M. A., Butler, A. P. H., Cook, N. J., Butler, P. H., Ronaldson, J. P., & Zainon, R. (2012). Spectral Hounsfield units: A new radiological concept. European Radiology, 22(5), 1008-1013. doi: 10.1007/s00330-011-2348-3
Zainon, R., Ronaldson, J. P., Janmale, T., Scott, N. J., Buckenham, T. M., Butler, A. P. H., … Gieseg, S. P., Roake, J. A., & Anderson, N. G. (2012). Spectral CT of carotid atherosclerotic plaque: Comparison with histology. European Radiology, 22(12), 2581-2588. doi: 10.1007/s00330-012-2538-7
Xu, Q., Yu, H., Bennett, J., He, P., Zainon, R., Doesburg, R., … Walsh, M., … Butler, A., … Wang, G. (2012). Image reconstruction for hybrid true-color micro-CT. IEEE Transactions on Biomedical Engineering, 59(6), 1711-1719. doi: 10.1109/tbme.2012.2192119
Ronaldson, J. P., Zainon, R., Scott, N. J. A., Gieseg, S. P., Butler, A. P., Butler, P. H., & Anderson, N. G. (2012). Toward quantifying the composition of soft tissues by spectral CT with Medipix3. Medical Physics, 39(11), 6847-6857. doi: 10.1118/1.4760773
Ball, A., Bell, A., Butler, A., Butler, P., Hall-Wilton, R., Hegeman, J., … Vykydal, Z. (2011). Design, implementation and first measurements with the Medipix2-MXR detector at the Compact Muon Solenoid experiment. Journal of Instrumentation, 6, P08005. doi: 10.1088/1748-0221/6/08/P08005
Butler, A. P. H., Butzer, J., Schleich, N., Cook, N. J., Anderson, N. G., Scott, N., de Ruiter, N., … Butler, P. H. (2011). Processing of spectral X-ray data with principal components analysis. Nuclear Instruments & Methods in Physics Research Section A, 633(Suppl. 1), S140-S142. doi: 10.1016/j.nima.2010.06.149
Zainon, R., Butler, A. P. H., Cook, N. J., Butzer, J. S., Schleich, N., de Ruiter, N., … Butler, P. H. (2010). Construction and operation of the MARS-CT scanner. Internetworking Indonesia Journal, 2(1). Retrieved from http://www.internetworkingindonesia.org/Issues/Vol2-No1-Spring2010/iij_vol2_no1_2010_zainon.pdf
Anderson, N. G., Butler, A. P., Scott, N. J. A., Cook, N. J., Butzer, J. S., Schleich, N., … de Ruiter, N., … Butler, P. H. (2010). Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE. European Radiology, 20, 2126-2134. doi: 10.1007/s00330-010-1768-9
Butler, A., Bones, P., & Hurrell, M. (2008). Prototype system for enhancement of frontal chest radiographs using eigenimage processing. Journal of Medical Imaging & Radiation Oncology, 52, 244-253.
Butler, A. P. H., Anderson, N. G., Tipples, R., Cook, N., Watts, R., Meyer, J., … Melzer, T. R., & Butler, P. H. (2008). Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments & Methods in Physics Research Section A, 591(1), 141-146. doi: 10.1016/j.nima.2008.03.039
Melzer, T. R., Cook, N. J., Butler, A. P., Watts, R., Anderson, N., Tipples, R., & Butler, P. H. (2008). Spectroscopic biomedical imaging with the Medipix2 detector. Australasian Physical & Engineering Sciences in Medicine, 31(4), 300-306.
Journal - Research Other
Yu, H., Xu, Q., He, P., Bennett, J., Aamir, R., Dobbs, B., … Butler, A., … Wang, G. (2012). Medipix-based spectral micro-CT. Computerized Tomography Theory & Applications, 21(4), 583-596.
Fornaro, J., Leschka, S., Hibbeln, D., Butler, A., Anderson, N., Pache, G., … Stolzmann, P. (2011). Dual- and multi-energy CT: Approach to functional imaging [Review]. Insights into Imaging, 2(2), 149-159. doi: 10.1007/s13244-010-0057-0
Butler, A. (2009). The increasing role of bioengineering and medical physics in the practice of medicine [Editorial]. New Zealand Medical Journal, 122(1297). Retrieved from http://journal.nzma.org.nz/journal/122-1297/3658/content.pdf
