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Contact Details

Phone
+64 3 364 0568
Email
nina.dickerhof@otago.ac.nz

University Links

Position
Senior Research Fellow
Department
Department of Pathology and Molecular Medicine (Christchurch)
Qualifications
MSc(Germany),PhD(Otago)
Research summary
Free Radical research

Research

Dr Nina Dickerhof's research is focused on neutrophil-derived oxidants and their role in health and disease. Her specialist expertise is mass spectrometry and its application to measuring oxidative modification of proteins, peptides and small molecules. She is interested in the development of biomarkers of neutrophil-derived oxidative stress in inflammatory and infectious disease with a particular focus on cystic fibrosis lung disease.

Dr Dickerhof is also studying the functional implications of oxidative modifications of proteins present at inflammatory sites, such as the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) and the neutrophil-resident antibacterial protein calprotectin.

More recently, she has become interested in understanding how bacteria protect themselves from oxidants produced by the immune system with a special interest in the role of bacterial low molecular weight thiols.

Publications

Dickerhof, N., Ashby, L. V., Ford, D., Dilly, J. J., Anderson, R. F., Payne, R. J., & Kettle, A. J. (2025). Dioxygenation of tryptophan residues by superoxide and myeloperoxidase. Journal of Biological Chemistry. Advance online publication. doi: 10.1016/j.jbc.2025.108402 Journal - Research Article

Shearer, H. L., Currie, M. J., Agnew, H. N., Trappetti, C., Stull, F., Pace, P. E., … Dobson, R. C. J., & Dickerhof, N. (2024). Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae. Journal of Biological Chemistry, 300(5), 107282. doi: 10.1016/j.jbc.2024.107282 Journal - Research Article

Blake, T. L., Sly, P. D., Anderson, I., Wainwright, C. E., Reid, D. W., Bell, S. C., Smith, B. R., Kettle, A. J., & Dickerhof, N. (2024). Changes in urinary glutathione sulfonamide (GSA) levels between admission and discharge of patients with cystic fibrosis. Journal of Cystic Fibrosis, 23, 1163-1166. doi: 10.1016/j.jcf.2024.04.009 Journal - Research Other

Shearer, H. L., Pace, P. E., Smith, L. M., Fineran, P. C., Matthews, A. J., Camilli, A., Dickerhof, N., & Hampton, M. B. (2023). Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. Journal of Bacteriology, 205(10). doi: 10.1128/jb.00208-23 Journal - Research Article

Shearer, H. L., Pace, P. E., Paton, J. C., Hampton, M. B., & Dickerhof, N. (2022). A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid. Journal of Biological Chemistry, 298(9), 102359. doi: 10.1016/j.jbc.2022.102359 Journal - Research Article

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