Fronius, M. (2012). Mechanical forces impair alveolar ion transport processes: A putative mechanism contributing to the formation of pulmonary edema. In E. M. Irusen (Ed.), Lung diseases: Selected state of the art reviews. (pp. 561-578). Rijeka, Croatia: InTech.

Chapter in Book - Research

Munasinghe, P. E., Saw, E. L., Reily-Bell, M., Tonkin, D., Kakinuma, Y., Fronius, M., & Katare, R. (2023). Non-neuronal cholinergic system delays cardiac remodelling in type 1 diabetes. Heliyon, 9, e17434. doi: 10.1016/j.heliyon.2023.e17434

Journal - Research Article

Brown, E. F., Fronius, M., & Brown, C. H. (2022). Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels? Molecular & Cellular Endocrinology, 558, 111764. doi: 10.1016/j.mce.2022.111764

Journal - Research Article

Paudel, P., van Hout, I., Bunton, R. W., Parry, D. J., Coffey, S., McDonald, F. J., & Fronius, M. (2022). Epithelial sodium channel δ subunit is expressed in human arteries and has potential association with hypertension. Hypertension, 79(7), 1385-1394. doi: 10.1161/hypertensionaha.122.18924

Journal - Research Article

Barth, D., Knoepp, F., & Fronius, M. (2021). Enhanced shear force responsiveness of epithelial Na+ channel’s (ENaC) δ subunit following the insertion of N-glycosylation motifs relies on the extracellular matrix. International Journal of Molecular Sciences, 22(5), 2500. doi: 10.3390/ijms22052500

Journal - Research Article

Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140

Journal - Research Article

Saw, E. L., Pearson, J. T., Schwenke, D. O., Munasinghe, P. E., Tsuchimochi, H., Rawal, S., Coffey, S., … Bunton, R., Van Hout, I., … Williams, M. J. A., … Fronius, M., & Katare, R. (2021). Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular Diabetology, 20, 50. doi: 10.1186/s12933-021-01231-8

Journal - Research Article

Baldin, J.-P., Barth, D., & Fronius, M. (2020). Epithelial Na⁺ channel (ENaC) formed by one or two subunits forms functional channels that respond to shear force. Frontiers in Physiology, 11, 141. doi: 10.3389/fphys.2020.00141

Journal - Research Article

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na⁺ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Journal - Research Article

Kumar, P., Scholze, P., Fronius, M., Krasteva-Christ, G., & Hollenhorst, M. I. (2020). Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors. British Journal of Pharmacology, 177, 5595-5608. doi: 10.1111/bph.15270

Journal - Research Article

Barth, D., & Fronius, M. (2019). Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands. Scientific Reports, 9, 6781. doi: 10.1038/s41598-019-43097-7

Journal - Research Article

Ashley, Z., Mugloo, S., McDonald, F. J., & Fronius, M. (2018). Epithelial Na⁺ channel differentially contributes to shear stress-mediated vascular responsiveness in carotid and mesenteric arteries from mice. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1022-H1032. doi: 10.1152/ajpheart.00506.2017

Journal - Research Article

Knoepp, F., Bettmer, J., & Fronius, M. (2017). Gadolinium released by the linear gadolinium-based contrast-agent Gd-DTPA decreases the activity of human epithelial Na⁺ channels (ENaCs). Biochimica et Biophysica Acta: Biomembranes, 1859(5), 1040-1048. doi: 10.1016/j.bbamem.2017.02.019

Journal - Research Article

Richter, K., Mathes, V., Fronius, M., Althaus, M., Hecker, A., Krasteva-Christ, G., … Grau, V. (2016). Phosphocholine: An agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Scientific Reports, 6, 28660. doi: 10.1038/srep28660

Journal - Research Article

Dittrich, N. P., Kummer, W., Clauss, W. G., & Fronius, M. (2015). Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs. International Immunopharmacology, 29(1), 166-172. doi: 10.1016/j.intimp.2015.08.010

Journal - Research Article

Hecker, A., Küllmar, M., Wilker, S., Richter, K., Zakrzewicz, A., Atanasova, S., … Fronius, M., … Grau, V. (2015). Phosphocholine-modified macromolecules and canonical nicotinic agonists inhibit ATP-induced IL-1β release. Journal of Immunology, 195, 2325-2334. doi: 10.4049/jimmunol.1400974

Journal - Research Article

Vitzthum, C., Clauss, W. G., & Fronius, M. (2015). Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress. Biochimica et Biophysica Acta: Biomembranes, 1848(11), 2942-2951. doi: 10.1016/j.bbamem.2015.09.009

Journal - Research Article

Ashry, O., Schnecko, A., Clauss, W. G., & Fronius, M. (2014). Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respiratory Physiology & Neurobiology, 195(1), 37-40. doi: 10.1016/j.resp.2014.02.001

Journal - Research Article

Deckmann, K., Filipski, K., Krasteva-Christ, G., Fronius, M., Althaus, M., Rafiq, A., … Kummer, W. (2014). Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. PNAS, 111(22), 8287-8292. doi: 10.1073/pnas.1402436111

Journal - Research Article

Richter, K., Kiefer, K. P., Grzesik, B. A., Clauss, W. G., & Fronius, M. (2014). Hydrostatic pressure activates ATP-sensitive K⁺ channels in lung epithelium by ATP release through pannexin and connexin hemichannels. FASEB Journal, 28(1), 45-55. doi: 10.1096/fj.13-229252

Journal - Research Article

Schönberger, M., Althaus, M., Fronius, M., Clauss, W., & Trauner, D. (2014). Controlling epithelial sodium channels with light using photoswitchable amilorides. Nature Chemistry, 6(8), 712-719. doi: 10.1038/nchem.2004

Journal - Research Article

Althaus, M., Urness, K. D., Clauss, W. G., Baines, D. L., & Fronius, M. (2012). The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells. British Journal of Pharmacology, 166(6), 1946-1963. doi: 10.1111/j.1476-5381.2012.01909.x

Journal - Research Article

Hollenhorst, M. I., Lips, K. S., Weitz, A., Krasteva, G., Kummer, W., & Fronius, M. (2012). Evidence for functional atypical nicotinic receptors that activate K⁺-dependent Cl^- secretion in mouse tracheal epithelium. American Journal of Respiratory Cell & Molecular Biology, 46(1), 106-114. doi: 10.1165/rcmb.2011-0171OC

Journal - Research Article

Hollenhorst, M. I., Lips, K. S., Wolff, M., Wess, J., Gerbig, S., Takats, Z., … Fronius, M. (2012). Luminal cholinergic signalling in airway lining fluid: A novel mechanism for activating chloride secretion via Ca ²⁺-dependent Cl^- and K⁺ channels. British Journal of Pharmacology, 166(4), 1388-1402. doi: 10.1111/j.1476-5381.2012.01883.x

Journal - Research Article

Krumm, P., Giraldez, T., Alvarez de la Rosa, D., Clauss, W. G., Fronius, M., & Althaus, M. (2012). Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). Bioorganic & Medicinal Chemistry, 20(13), 3979-3984. doi: 10.1016/j.bmc.2012.05.021

Journal - Research Article

Wesch, D., Althaus, M., Miranda, P., Cruz-Muros, I., Fronius, M., González-Hernández, T., … Giraldez, T. (2012). Differential N termini in epithelial Na⁺ channel δ-subunit isoforms modulate channel trafficking to the membrane. American Journal of Physiology: Cell Physiology, 302(6), C868-879. doi: 10.1152/ajpcell.00255.2011

Journal - Research Article

Althaus, M., Clauss, W. G., & Fronius, M. (2011). Amiloride-sensitive sodium channels and pulmonary edema. Pulmonary Medicine, 2011, 830320. doi: 10.1155/2011/830320

Journal - Research Article

Althaus, M., Pichl, A., Clauss, W. G., Seeger, W., Fronius, M., & Morty, R. E. (2011). Nitric oxide inhibits highly selective sodium channels and the Na⁺/K⁺-ATPase in H441 cells. American Journal of Respiratory Cell & Molecular Biology, 44(1), 53-65. doi: 10.1165/2009-0335OC

Journal - Research Article

Berger, J., Richter, K., Clauss, W. G., & Fronius, M. (2011). Evidence for basolateral Cl^- channels as modulators of apical Cl^- secretion in pulmonary epithelia of Xenopus laevis. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 300(3), R616-R623. doi: 10.1152/ajpregu.00464.2010

Journal - Research Article

Hollenhorst, M. I., Richter, K., & Fronius, M. (2011). Ion transport by pulmonary epithelia. Journal of Biomedicine & Biotechnology, 2011, 174306. doi: 10.1155/2011/174306

Journal - Research Article

Kessler, S., Clauss, W. G., & Fronius, M. (2011). Laminar shear stress modulates the activity of heterologously expressed P2X4 receptors. Biochimica et Biophysica Acta: Biomembranes, 1808(10), 2488-2495. doi: 10.1016/j.bbamem.2011.07.010

Journal - Research Article

Kessler, S., Clauss, W. G., Günther, A., Kummer, W., & Fronius, M. (2011). Expression and functional characterization of P2X receptors in mouse alveolar macrophages. Pflügers Archiv: European Journal of Physiology, 462(3), 419-430. doi: 10.1007/s00424-011-0980-z

Journal - Research Article

Berger, J., Hardt, M., Clauss, W. G., & Fronius, M. (2010). Basolateral Cl^- uptake mechanisms in Xenopus laevis lung epithelium. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 299(1), R92-R100. doi: 10.1152/ajpregu.00749.2009

Journal - Research Article

Fronius, M., Bogdan, R., Althaus, M., Morty, R. E., & Clauss, W. G. (2010). Epithelial Na⁺ channels derived from human lung are activated by shear force. Respiratory Physiology & Neurobiology, 170(1), 113-119. doi: 10.1016/j.resp.2009.11.004

Journal - Research Article

Mikulski, Z., Hartmann, P., Jositsch, G., Zasłona, Z., Lips, K. S., Pfeil, U., … Fronius, M., & Kummer, W. (2010). Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration. Respiratory Research, 11, 133. doi: 10.1186/1465-9921-11-133

Journal - Research Article

Althaus, M., Fronius, M., Buchäckert, Y., Vadász, I., Clauss, W. G., Seeger, W., … Morty, R. E. (2009). Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. American Journal of Respiratory Cell & Molecular Biology, 41(6), 639-650. doi: 10.1165/rcmb.2008-0458OC

Journal - Research Article

Bogdan, R., Veith, C., Clauss, W., & Fronius, M. (2008). Impact of mechanical stress on ion transport in native lung epithelium (Xenopus laevis): Short-term activation of Na⁺, Cl^- and K⁺ channels. Pflügers Archiv: European Journal of Physiology, 456(6), 1109-1120. doi: 10.1007/s00424-008-0486-5

Journal - Research Article

Fronius, M., & Clauss, W. G. (2008). Mechano-sensitivity of ENaC: May the (shear) force be with you. Pflügers Archiv: European Journal of Physiology, 455(5), 775-785. doi: 10.1007/s00424-007-0332-1

Journal - Research Article

Althaus, M., Bogdan, R., Clauss, W. G., & Fronius, M. (2007). Mechano-sensitivity of epithelial sodium channels (ENaCs): Laminar shear stress increases ion channel open probability. FASEB Journal, 21(10), 2389-2399. doi: 10.1096/fj.06-7694com

Journal - Research Article

Schnizler, M. K., Bogdan, R., Bennert, A., Bury, N. R., Fronius, M., & Clauss, W. (2007). Short-term exposure to waterborne free silver has acute effects on membrane current of Xenopus oocytes. Biochimica et Biophysica Acta: Biomembranes, 1768(2), 317-323. doi: 10.1016/j.bbamem.2006.09.007

Journal - Research Article

Sommer, D., Bogdan, R., Berger, J., Peters, D. M., Morty, R. E., Clauss, W. G., & Fronius, M. (2007). CFTR-dependent Cl^- secretion in Xenopus laevis lung epithelium. Respiratory Physiology & Neurobiology, 158(1), 97-106. doi: 10.1016/j.resp.2007.03.016

Journal - Research Article

Krumm, S., Goebel-Lauth, S. G., Fronius, M., & Clauss, W. (2005). Transport of sodium and chloride across earthworm skin in vitro. Journal of Comparative Physiology B, 175, 601-608. doi: 10.1007/s00360-005-0023-1

Journal - Research Article

Berk, A., Fronius, M., Clauss, W., & Schnizler, M. (2004). Prostaglandin E2 induces upregulation of Na+ transport across Xenopus lung epithelium. Journal of Comparative Physiology B, 174, 83-89. doi: 10.1007/s00360-003-0391-3

Journal - Research Article

Fronius, M., Berk, A., Clauss, W., & Schnizler, M. (2004). Ion transport across Xenopus alveolar epithelium is regulated by extracellular ATP, UTP and adenosine. Respiratory Physiology & Neurobiology, 139, 133-144. doi: 10.1016/j.resp.2003.09.007

Journal - Research Article

Fronius, M., Clauss, W., & Schnizler, M. (2003). Stimulation of transepithelial Na⁺ current by extracellular Gd³⁺ in Xenopus laevis alveolar epithelium. Journal of Membrane Biology, 195(1), 43-51. doi: 10.1007/s00232-003-2043-7

Journal - Research Article

Fronius, M., Rehn, M., Eckstein-Ludwig, U., & Clauss, W. (2001). Inhibitory non-genomic effects of progesterone on Na⁺ absorption in epithelial cells from Xenopus kidney (A6). Journal of Comparative Physiology B, 171, 377-386. doi: 10.1007/s003600100186

Journal - Research Article

Brown, E. F., Mitaera, T., & Fronius, M. (2022). COVID-19 and liquid homeostasis in the lung: A perspective through the epithelial sodium channel (ENaC) lens. Cells, 11, 1801. doi: 10.3390/cells11111801

Journal - Research Other

Fronius, M. (2022). Epithelial Na⁺ channel and the glycocalyx: A sweet and salty relationship for arterial shear stress sensing. Current Opinion in Nephrology & Hypertension, 31(2), 142-150. doi: 10.1097/mnh.0000000000000779

Journal - Research Other

Paudel, P., McDonald, F. J., & Fronius, M. (2021). The δ subunit of epithelial sodium channel in humans: A potential player in vascular physiology. American Journal of Physiology: Heart & Circulatory Physiology, 320, H487-H493. doi: 10.1152/ajpheart.00800.2020

Journal - Research Other

Saw, E. L., Kakinuma, Y., Fronius, M., & Katare, R. (2018). The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of Molecular & Cellular Cardiology, 125, 129-139. doi: 10.1016/j.yjmcc.2018.10.013

Journal - Research Other

Fronius, M. (2013). Treatment of pulmonary edema by ENaC activators/stimulators. Current Molecular Pharmacology, 6(1), 13-27. doi: 10.2174/1874467211306010003

Journal - Research Other

Fronius, M., Clauss, W. G., & Althaus, M. (2012). Why do we have to move fluid to be able to breathe? Frontiers in Physiology, 3, 146. doi: 10.3389/fphys.2012.00146

Journal - Research Other

Hollenhorst, M. I., Clauss, W., & Fronius, M. (2012). Acetylcholin als non-neuronales Signalmolekül [The non-neuronal cholinergic system]. Biologie in unserer Zeit, 42(6), 390-395. doi: 10.1002/biuz.201210495

Journal - Research Other