2024
Journal - Research Other
Ray Das, S., Delahunt, B., Lasham, A., Li, K., Wright, D., Print, C., Slatter, T., Braithwaite, A., & Mehta, S. (2024). Combining TP53 mutation and isoform has the potential to improve clinical practice. Pathology. Advance online publication. doi: 10.1016/j.pathol.2024.02.003
2023
Journal - Research Article
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
2022
Journal - Research Article
Mehta, S., Wright, D., Black, M. A., Merrie, A., Anjomshoaa, A., Munro, F., Reeve, A., McCall, J., & Print, C. (2022). Impact of clinical data veracity on cancer genomic research. JNCI Cancer Spectrum. doi: 10.1093/jncics/pkac070
Shields, N. J., Peyroux, E. M., Campbell, K., Mehta, S., Woolley, A. G., Counoupas, C., Neumann, S., & Young, S. L. (2022). Calpains released from necrotic tumor cells enhance antigen cross-presentation to activate CD8+ T cells in vitro. Journal of Immunology, 209(9), 1635-1651. doi: 10.4049/jimmunol.2100500
Journal - Research Other
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394
Conference Contribution - Published proceedings: Abstract
Henry, C., Paterson, E., Sarkar, D., Mehta, S., & Danielson, K. (2022). Investigating EV cargo in treatment resistant endometrial cancer. Proceedings of the ComBio Conference. (pp. 54). Retrieved from https://combio.org.au/combio2022/
Nezbedová, L., McGhie, T., Christensen, M., Heyes, J., Ahmed Nasef, N., & Mehta, S. (2022). Impact of processing on the phytochemical profile of NZ heritage apple cultivar 'Monty's Surprise' and their cancer management properties. Proceedings of the New Zealand Institute of Food Science & Technology (NZIFST) Conference: Collaboration: Building New Zealand Inc. S19. Retrieved from http://www.nzifst.org.nz
Conference Contribution - Verbal presentation and other Conference outputs
Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.
Other Research Output
Mehta, S. (2022, November). Cancer cell evolution: YB-1, chromosomal instability and uncharacterised TP53 mutations. UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].
2021
Journal - Research Article
McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540
Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2
Hong, C. R., Mehta, S. Y., Liyanage, H. D. S., McManaway, S. P., Lee, H. H., Jaiswal, J. K., … Hicks, K. O. (2021). Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug. Cancer Chemotherapy & Pharmacology, 88, 673-687. doi: 10.1007/s00280-021-04320-3
Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays. Cancers, 13(7), 1531. doi: 10.3390/cancers13071531
Ali, A., Mehta, S., Starck, C., Wong, M., O'Brien, W. J., Haswell, C., … Nasef, N. A. (2021). Effect of SunGold kiwifruit and vitamin C consumption on ameliorating exercise-induced stress response in women. Molecular Nutrition & Food Research, 65, 2001219. doi: 10.1002/mnfr.202001219
Journal - Research Other
Nezbedova, L., McGhie, T., Christensen, M., Heyes, J., Ahmed Nasef, N., & Mehta, S. (2021). Onco-preventive and chemo-protective effects of apple bioactive compounds. Nutrients, 13(11), 4025. doi: 10.3390/nu13114025
Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085
2020
Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472
Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital PCR to specifically detect and quantitate individual TP53 transcripts. Cancers, 12(3), 769. doi: 10.3390/cancers12030769
Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315
Lasham, A., Fitzgerald, S. J., Knowlton, N., Robb, T., Tsai, P., Black, M. A., … Mehta, S. Y., Harris, G., … Print, C. G. (2020). A predictor of early disease recurrence in patients with breast cancer using a cell-free RNA and protein liquid biopsy. Clinical Breast Cancer, 20(2), 108-116. doi: 10.1016/j.clbc.2019.07.003
Journal - Research Other
Ahmed Nasef, N., & Mehta, S. (2020). Role of inflammation in pathophysiology of colonic disease: An update. International Journal of Molecular Sciences, 21(13), 4748. doi: 10.3390/ijms21134748
2019
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1
Conference Contribution - Published proceedings: Full paper
Johnson, T. G., Schelch, K., Mehta, S., Burgess, A., & Reid, G. (2019). Why be one protein when you can affect many? The multiple roles of YB-1 in lung cancer and mesothelioma. Frontiers in Cell & Developmental Biology, 7, 221. doi: 10.3389/fcell.2019.00221
2018
Journal - Research Article
Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635
Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3
Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111
Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0
Conference Contribution - Poster Presentation (not in published proceedings)
Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Ray, S., McKinney, C., Roth, L., Heinzel, S., Hodgkin, P., Mehta, S., Slatter, T. L., & Braithwaite, A. W. (2018, August). p53 does not cause growth arrest or death in normal B cells but only affects division rate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Mehta, S., Algie, M., Al Jabri, T., McKinney, C., Verma, C., Weini, M., … Henderson, L., Gould, M., Parker, K., Bhatia, P., Harfoot, R., Kleffmann, T., … Woolley, A., & Braithwaite, A. (2018, August). RSK mediated YB-1 phosphorylation: A key event required for completion of cytokinesis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Henderson, L., Mehta, S., Fleming, N., Eccles, M., Chatterjee, A., Print, C., … Braithwaite, A. (2018, August). p63 promotes proliferation in melanoma cell lines via regulation of AQP3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2017
Journal - Research Article
Tercel, M., Lee, H. H., Mehta, S. Y., Tendoung, J.-J. Y., Bai, S. Y., Liyanage, H. D. S., & Pruijn, F. B. (2017). Influence of a basic side chain on the properties of hypoxia-selective nitro analogues of the duocarmycins: Demonstration of substantial anticancer activity in combination with irradiation or chemotherapy. Journal of Medicinal Chemistry, 60(13), 5834-5856. doi: 10.1021/acs.jmedchem.7b00563
Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6
Journal - Research Other
Nasef, N. A., Mehta, S., & Ferguson, L. R. (2017). Susceptibility to chronic inflammation: An update. Archives of Toxicology, 9(3), 1131-1141. doi: 10.1007/s00204-016-1914-5
Conference Contribution - Published proceedings: Abstract
Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio
Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio
Hale, T. K., Solomon, R., Bond, S. D., Mehta, S., Braithwaite, A., Wheeler, D., & Fitzsimons, H. (2017). Untethering the genome: Loss of HP1α enhances malignant cell invasion. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 40). Auckland, New Zealand: Auckland University of Technology. [Abstract]
2016
Journal - Research Article
Mehta, S., Tsai, P., Lasham, A., Campbell, H., Reddel, R., Braithwaite, A., & Print, C. (2016). A study of TP53 RNA splicing illustrates pitfalls of RNA-seq methodology. Cancer Research, 76(24), 7151-7159. doi: 10.1158/0008-5472.can-16-1624
Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137
Conference Contribution - Verbal presentation and other Conference outputs
Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia.
Mehta, S., Lasham, A., Woolley, A., Algie, M., Al Jabry, T., Ma, W., Fleming, N., Young, K., Parker, K., … Braithwaite, A. (2016, August-September). Role of YB-1 in cell cycle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Campbell, H., Fleming, N., Roth, I., Vennin, C., McCall, J., Mehta, S., Wiles, A., Williams, G., … Baird, M., & Braithwaite, A. W. (2016, August-September). IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the Δ133p53 isoform. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Nasef, N. A., Mehta, S., Powell, P., Marlow, G., Wileman, T., & Ferguson, L. R. (2015). Extracts of feijoa inhibit toll-like receptor 2 signaling and activate autophagy implicating a role in dietary control of IBD. PLoS ONE, 10(6), e0130910. doi: 10.1371/journal.pone.0130910
2014
Journal - Research Article
Nasef, N. A., Mehta, S., & Ferguson, L. R. (2014). Dietary interventions with the bacterial sensing machinery in the intestine: The plant polyphenol case. Frontiers in Genetics, 5, 64. doi: 10.3389/fgene.2014.00064
Nasef, N. A., Mehta, S., Murray, P., Marlow, G., & Ferguson, L. R. (2014). Anti-inflammatory activity of fruit fractions in vitro, mediated through toll-like receptor 4 and 2 in the context of inflammatory bowel disease. Nutrients, 6(11), 5265-5279. doi: 10.3390/nu6115265
2013
Conference Contribution - Poster Presentation (not in published proceedings)
Mehta, S. (2013, August). Use of clinicopathological and oncogenic pathway signatures to improve clinical decisions for colorectal cancer patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Wright, D., Mehta, S., Munro, F., Merrie, A., Print, C., & McCall, J. (2013, August). Impact of inconsistencies in clinic-pathological data on molecular and survival analyses. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Awarded Doctoral Degree
Mehta, S. Y. (2013). Combining clinicopathological and molecular pathway signatures for improving clinical decisions through an understanding of colorectal cancer biology (PhD). University of Auckland, Auckland, New Zealand. Retrieved from http://hdl.handle.net/2292/20770
2012
Journal - Research Article
Richter, S., Richter, J. P., Mehta, S. Y., Gribble, A. M., Sutherland-Smith, A. J., Stowell, K. M., … Wilson, W. R. (2012). Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular & Cellular Biochemistry, 364(1), 131-145. doi: 10.1007/s11010-011-1212-8
Conference Contribution - Verbal presentation and other Conference outputs
Mehta, S., Lasham, A., Wright, D., Black, M. A., Reeve, A., Guilford, P., McCall, J., … Print, C. (2012, August). Towards improving clinical decisions for colon cancer patients: A step closer to personalised medicine. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
